-
effectivehealthcare-admin.ahrq.gov/products/antipsychotics-children-update/research-2017
April 01, 2020 - also cause adverse effects including weight gain, high triglyceride levels, extrapyramidal symptoms, sedation … treatment probably increase short-term risk for high triglyceride levels, extrapyramidal symptoms, sedation
-
effectivehealthcare-admin.ahrq.gov/products/nonopioid-chronic-pain/research
June 01, 2022 - adverse events were seen with pregabalin (blurred vision, cognitive effects, dizziness, peripheral edema, sedation … , and weight gain), gabapentin (blurred vision, cognitive effects, sedation, weight gain), and cannabis
-
effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/pico-1-populations-children-with-infantile-hemangiomas-ihs-interventions-early-referral-comparators-delayed-referral-outcomess-minimization-of-functional-impairment-andor-cosmetic-deformity-pico-2-populations-children-with
November 01, 2017 - long-term cosmetic deformity
Pain and/or bleeding associated with ulceration
Avoidance of unnecessary sedation … corticosteroids
Risks of laser treatment (changes in skin pigmentation, ulceration)
Risks associated with sedation
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
January 01, 2024 - There may be a large increased risk of dizziness and
sedation (SOE: low) and a moderate increased risk … associated with small
improvement in pain severity (SOE: low), but with increased risk of WAEs (SOE:
low), sedation … Studies)
[SOE]
Dizziness
Effect Size (N
Studies)
[SOE]
Nausea
Effect Size (N
Studies)
[SOE]
Sedation … placebo, these interventions resulted in greater risk of common adverse
events (dizziness, nausea, sedation
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-236-mental-health-pregnancy-evidence-summary.pdf
April 01, 2021 - • Brexanolone probably improves depressive symptoms; it may increase the risk of
sedation or somnolence … in the third trimester or within 4 weeks
of birth, brexanolone may be associated with the risk of sedation
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5_0.xlsx
November 04, 2021 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0_0.xlsx
February 16, 2022 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - Consistent with prior
evidence, gabapentin was associated with increased risk of dizziness, sedation … in
cognitive AEs
• SOE: Low. based
on 8 RCTs
Large increase in
dizziness, peripheral
edema, sedation … (n=366) found
increased risk of
dizziness.6,7,9
1 RCT (n=306) found
increased risk of SAEs,
sedation … THC/CBD
associated with large
increase in WAEs,
dizziness, nausea, but no
increase in SAEs or
sedation … SOE for large increase in risk for cognitive effects, moderate SOE for large increase in risk for
sedation
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antipsychotics-children_executive.pdf
February 01, 2012 - Other common side effects are
dry mouth and sedation. … Patient-, parent- or care
impressions symptoms side effects provider-reported
outcomes
Depression Tics Sedation … difference.
sexual AE (1 RCT, 1 PCS)
Haloperidol vs. risperidone Low No significant difference.
(2 RCTs)
Sedation … SGA (continued)
Sedation Clozapine vs. olanzapine Low No significant difference.
(1 RCT, 1 PCS, 1 RCS … Sedation Aripiprazole vs. placebo (4 RCTs) Low Significant effect in favor of placebo
(RR = 2.7, 95%
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/surveillance-report-3-nonopioid-pharm-chronic-pain.pdf
July 01, 2022 - from
Surveillance Report 2 found
increased risk of WAEs and
nonsignificantly increased
risk of sedation … 95% CI,
1.88 to 5.34, I2=0%)
• Dizziness (28 RCTs): RR
2.85 (95% CI, 2.43 to
3.34, I2=36%)
• Sedation … THC/CBD associated with
large increase in WAEs,
dizziness, nausea, but no
increase in SAEs or
sedation … 4.48 (95% CI, 2.77 to
7.22, I2=0%)
• Nausea (2 RCTs): RR
2.11 (95% CI, 1.20 to
3.72, I2=0%)
• Sedation … Gabapentin/pregabalin harms, sedation
Abbreviations: CI=confidence interval; CPP=chronic pelvic pain
-
effectivehealthcare-admin.ahrq.gov/products/tinnitus/research
December 01, 2019 - The SOE for the adverse effect of sedation in pharmacological studies was judged insufficient.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antipsychotics-children-surveillance-150120.pdf
October 01, 2014 - One review (Ching & Pringsheim, 2012) found
increased weight gain and higher risk ratios for
sedation … Notable side effects must be
considered, however, such as weight gain, sedation, drooling, and tremor … The most common AEs were sedation (26.5%),
somnolence (23.5%), headache (22.2%), and insomnia (13.6% … Eight patients (20.0%) experienced moderate to severe sedation and eight
(20.0%) experienced increased … For nearly all outcomes ratios for sedation and increased risk for weight regard to new evidence
and
-
effectivehealthcare-admin.ahrq.gov/products/preoperative-testing/research-protocol
December 01, 2019 - any elective or ambulatory surgical or other invasive procedure that commonly requires anesthesia or sedation … team member; cataract surgery will be included regardless of local practice regarding anesthesia or sedation … surgeries)
Exclude patients undergoing nonsurgical diagnostic procedures that may require anesthesia or sedation … after routine preoperative testing in patients undergoing surgery or procedures requiring anesthesia or sedation … plan to explore differences across:
Types of and indications for surgery
Types of anesthesia or sedation
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0215_01-06-2010.pdf
January 01, 2010 - Effective Health Care
Topic Number(s): 0239
Document Completion Date: 8-13-10
1
Results of Topic Selection Process & Next Steps
Treatment of restless legs syndrome will go forward for refinement as a systematic review. The scope
of this topic, including populations, interventions, comparato…
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
March 01, 2022 - Primary: efficacy outcomes (i.e., pain, overall function, adverse effects (e.g., dizziness, nausea, sedation … Size (N Studies)
[SOE]a Dizziness
Effect Size (N Studies)
[SOE]a Nausea
Effect Size (N Studies)
[SOE]a Sedation … Cannabis products associated with increased risk of adverse events (dizziness, sedation, nausea); studies
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-table-e5-2022-update_0.xlsx
January 01, 2022 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/preoperative-testing_research-protocol.pdf
May 14, 2013 - surgical
or
other
invasive
procedure
that
commonly
requires
anesthesia
or
sedation … will
be
included
regardless
of
local
practice
regarding
anesthesia
or
sedation … undergoing
nonsurgical
diagnostic
procedures
that
may
require
anesthesia
or
sedation … routine preoperative testing in patients
undergoing surgery or procedures requiring anesthesia or sedation—administered … to explore differences across:
• Types of and indications for surgery
• Types of anesthesia or sedation
-
effectivehealthcare-admin.ahrq.gov/products/suicide-prevention/research-protocol
January 01, 2020 - Skip to main content
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-220-analgesics-acute-pain-summary.pdf
September 01, 2019 - events, such
as vomiting and subsequent airway
obstruction, respiratory depression,
hypotension, and sedation … at 15 min.
dInsufficient for drowsiness, changes in RAAS, reduced GCS, sleepiness/tired, confusion, sedation … , difficulty
concentrating.
eFor dizziness, sedation.
fInconclusive for mild sedation.
gFor dizziness
-
effectivehealthcare-admin.ahrq.gov/products/migraine-emergency/research-protocol
December 01, 2019 - Addressing sedation as an adverse event.
The followup period for longer term outcome studies. … regular activities
Patient satisfaction with experience
Adverse effects of intervention(s)
Sedation … with experience
Quality of life/return to activities
Adverse effects of intervention(s):
Sedation … in the ED, Visual Analog Scale score at discharge, and relapse after 48 hours) and safety (e.g., sedation … Agents for procedural sedation
Ketamine 1
Ketalar
IV, IM
Ketofol
NA
IV
Propofol