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Showing results for "samples".

21. Technical Brief 13: Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
    December 01, 2012 - GEP tests use defined protocols to evaluate the specimens to be analyzed: preparing the RNA samples, … This approach results in a non-standard approach to specimen-handing, especially for frozen samples, … 42 Core Gene Classifier (Eschrich 2005)19 Frozen samples Microdissected so >80% tumor cells … It is expected that 1,800 to 2,400 patients will be enrolled in order to obtain 575 analyzable samples …  Sample size (number of patients/specimens) o If samples are from previous studies, which studies?

22. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_executive.pdf
    December 01, 2011 - environments, C. difficile is also common in the community, being easily isolated from soil and water samples … that concurrently compared at least two diagnostic tests in the same laboratory using the same stool samples … excluded studies that used only intermediate outcomes, such as reduced spore count in environmental samples … would alter clinician samples suspected CDI decisionmaking • Unknown influence of patient and stool … Six rapid tests for direct detection of Clostridium difficile and its toxins in fecal samples compared

23. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_june_2012.pdf
    January 01, 2012 - They transfer milk from the donation container to a glass flask, mixing samples from about three to … PST workers then distribute the milk evenly into smaller glass bottles and prepare the samples for … Milk samples that have passed inspection are frozen and stored until delivered to a recipient’s hospital … When comparing our PST samples to previous published amino acid means, our PST samples had significantly … The authors concluded, “Risk scores for trisomy 21 and 18 were given for 397 of the 400 samples that

24. Hepatitis-C-Screening Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_executive.pdf
    November 01, 2012 - (APRI) vs. liver biopsy High For fibrosis, the median AUROC was 0.76 (range 0.58 to 0.95) in 44 samples … ELF) vs. liver biopsy Moderate For fibrosis, the median AUROC was 0.81 (range 0.72 to 0.87) in 7 samples … For cirrhosis, the median AUROC was 0.88 (range 0.78 to 0.91) in 6 samples reported in 3 studies. … Index vs. liver biopsy High For fibrosis, the median AUROC was 0.75 (range 0.60 to 0.86) in 16 samples … For cirrhosis, the median AUROC was 0.89 (range 0.88 to 0.94) in 8 samples reported in 7 studies.

25. Interventions Targeting Sensory Challenges in Children With Autism Spectrum Disorders - An Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-interventions-disposition.pdf
    May 26, 2017 - Comments Sensory interventions/Abstract: ”likely overlapping populations in four studies” should be ”samples … TEP Reviewer #2 Methods It seems to me that independence of samples is critical to evaluating risk … In the case where samples are not clearly independent (massage therapy), I think that there must inherently … We concur that potential overlap of samples is an important consideration that have noted explicitly … The same group repeating the same protocol in potentially overlapping samples seems to be the definition

26. Systematic Review of Calcineurin Inhibitors for Kidney Transplant | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/calcineurin-inhibitor/research-protocol
    October 14, 2014 - imperfect fidelity to monitoring protocols (i.e., variation in when clinical staff actually collect samples … Internal validity and reporting adequacy: Are both positive and negative control samples tested in the … Internal validity and reporting adequacy: Are positive control samples used in the study appropriately … Internal validity and reporting adequacy: Were the tests performed with positive or negative control samples … : For measuring the limit of detection of the test, has the absolute amount of the positive control samples

27. Menopause Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_executive.pdf
    March 01, 2015 - A burn-in of 20,000 samples was discarded and the subsequent 40,000 analyzed. … Effect estimates and accompanying 95% credible intervals were obtained from the samples. … Generally, the samples were not selected to represent populations with clinical depression or anxiety … However, extrapolating absolute rates from the WHI samples to the target population of this review is … enrolled women were menopausal or perimenopausal, but there were some differences in studies and samples

28. Liver-Cancer Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
    July 24, 2013 - technique’s test performance modified by use of various reference standards (e.g., explanted liver samples … technique’s test performance modified by use of various reference standards (e.g., explanted liver samples … technique’s test performance modified by use of various reference standards (e.g., explanted liver samples … test performance will be evaluated, including the reference standards used (e.g., explanted liver samples … test performance will be evaluated, including the reference standards used (e.g., explanted liver samples

29. Version-3-Immunity-After-Covid-19-Appendix-Table-B-1 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19-appendix-table-B-1.xlsx
    January 24, 2022 - ELISA Abbott Diagnostics IgG quantitative assay (anti-N) Wantai Diagnostics Total-Ig RBD assay (anti-S) Samples … gender, and severity of COVID-19 at study inclusion SOT data obtained during the study; control group samples … with SOT and matched IC control patients, with available peripheral blood mononuclear cells and serum samples … gender, and severity of COVID-19 at study inclusion SOT data obtained during the study; control group samples … with SOT and matched IC control patients, with available peripheral blood mononuclear cells and serum samples

30. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-executive.pdf
    December 01, 2009 - A core-needle biopsy is a procedure that involves removing small samples of breast tissue through a hollow … Multiple core-needle samples may be taken from the suspicious area. … The device uses vacuum suction to help remove tissue samples. … Multiple samples may be taken from the suspicious area without reinserting the needle.

31. Long-Term-Care-Adults Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/long-term-care-adults_executive.pdf
    November 01, 2012 - Applicability is limited; many of the samples are not generalizable (often small, limited by geography … Most of the studies were conducted on samples of Medicaid patients. … limited • More studies that trace change in status over time Applicability/generalizable populations • Samples … were often drawn from unique settings • More generalizable samples Differences within subgroups … • No studies performed subgroup analysis • More attention to samples that capture various subgroups

32. Breast-Biopsy-Update Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
    September 01, 2014 - need additional imaging, and 5–7 percent will have biopsies.2, 3 Three techniques for obtaining samples … Fine-needle aspiration samples cells and does not assess tissue architecture, is generally considered … Lesion samples obtained by core needle or surgical biopsy are Effective Health Care Program The Effective … Open surgical biopsy samples most or all of the lesion, and is therefore considered to have a smaller … vacuum to assist in tissue acquisition, the use of needles of varying diameter, and the numbers of samples

33. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
    December 01, 2015 - tuberculosis and antibiotic resistance for positive samples.106 For a clinician to fully determine an … Sputum samples tested positive for M. tuberculosis in 2.7% of samples tested by culture, 2.1% of samples … tested by the Xpert MTB/RIF test, and 1.3% of samples tested by microscopy. … MTB/RIF test sensitivity was 76.9% in smear-negative, culture-positive patients (296 of 385 samples … ), and 99.0% specific (2846 of 2876 non-tuberculosis samples).”

34. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1412.pdf
    December 22, 2014 - Sputum samples tested positive for M. tuberculosis in 2.7% of samples tested by culture, 2.1% of samples … tested by the Xpert MTB/RIF test, and 1.3% of samples tested by microscopy. … MTB/RIF test sensitivity was 76.9% in smear- negative, culture-positive patients (296 of 385 samples … ), and 99.0% specific (2846 of 2876 non- tuberculosis samples).” … Samples were analyzed by a combination of acid-fast smear, solid culture, liquid culture, and Xpert

35. Making Healthcare Safer IV Rapid Response_Active Surveillance Culturing of Clostridioides difficile and Multidrug-Resistant Organisms: Methicillin-Resistant Staphylococcus aureus, Carbapenem-Resistant Enterobacterales, and Candida auris (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-active-infection-rapid-response.pdf
    May 01, 2024 - Either perirectal or rectal swabs or stool samples can be used to detect colonization with toxigenic … polymerase chain reaction (PCR) testing to detect the C. difficile toxin B gene on perirectal swab samples … February 2015 were screened for colonization using PCR testing for C. difficile toxin B in stool samples … Samples were collected from rectal or perirectal areas or from fecal incontinence bags and tested using … In this pre-post study, the authors compared single testing of stool samples upon admission to weekly

36. Dispostion of Comments Report for Child and Adolescent Exposure to Trauma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_disposition-comments.pdf
    February 11, 2013 - In the trauma field RCTs give at best average results in small convenience samples. … carry a high probability that such confounders will not balance out such confounders and these small samples … have a significant probability of being biased with respect to random “population” samples.. … Getting larger sample sizes in this area would be difficult because larger samples are quite costly … Given the small samples and diversity of intervention models, there is little that can be generalized

37. Machine Learning Methods in Systematic Reviews: Identifying Quality Improvement Intervention Evaluations (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/machine-learning-quality_research.pdf
    September 01, 2012 - We explored different prediction algorithms and tested results against reference samples screened by … Across two reference samples, the predictive performance of the machine learning approach demonstrated … Predictive Performance Test Reference Samples The critical test for the machine learning approach … Both literature reviewers reviewed the citations in the reference samples independently. … By the time reference samples were drawn, reviewers may have had a refined understanding of the kind

38. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-genetic.ppt
    June 01, 2012 - Are there legal issues regarding consent, ownership of data and/or samples, patents, licensing … What types of samples were used? How were samples obtained? … How were samples handled and stored prior to analysis? Analytic What type of assay was used? … When were samples analyzed (compared to when they were collected)? … For example, genome-wide association studies or other large collaborative efforts may pool samples of

39. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-genetic.ppt
    June 01, 2012 - Are there legal issues regarding consent, ownership of data and/or samples, patents, licensing … What types of samples were used? How were samples obtained? … How were samples handled and stored prior to analysis? Analytic What type of assay was used? … When were samples analyzed (compared to when they were collected)? … For example, genome-wide association studies or other large collaborative efforts may pool samples of

40. Calcineurin_Inhibitors_Protocol_FINAL_10-07-2014 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/calcineurin-inhibitor_research-protocol.pdf
    October 08, 2014 - imperfect fidelity to monitoring protocols (i.e., variation in when clinical staff actually collect samples … Internal validity and reporting adequacy: Are both positive and negative control samples tested in … Internal validity and reporting adequacy: Are positive control samples used in the study appropriately … Internal validity and reporting adequacy: Were the tests performed with positive or negative control samples … : For measuring the limit of detection of the test, has the absolute amount of the positive control samples