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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-future_research.pdf
    April 01, 2013 - If RCTs are not feasible, prospective cohort studies could be designed to enable larger samples, but … Resource use, size and duration Necessary to recruit large samples and follow for significant length … subgroups would provide most clinically meaningful information; likely necessary to recruit large samples … If RCTs are not feasible, prospective cohort studies could be designed to enable larger samples, but … Resource use, size and duration Necessary to recruit large samples and follow for significant length
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-5-draft-report.pdf
    February 05, 2024 - Community samples may or may not include Active Duty Military or veteran participants, as many studies … did not clarify these variables when describing community samples. … by population type Mixed = Any combination of active duty military, veteran, and community-based samples
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/continuous-outcomes-quantitative-synthesis_methods.pdf
    March 01, 2011 - participants, and comparing results to those from studies including mildly or moderately depressed samples … The percentage limits for the distribution of range in samples from a normal population (n less than
  4. effectivehealthcare.ahrq.gov/products/instrumental-variable-methods/research
    May 14, 2010 - an IV study will be underpowered to detect anything less than a very strong effect, even with large samples … In small samples, IV estimators based on 2SLS possess substantial finite sample bias. … to be more of a problem in the presence of many weak instruments and can persist even in very large samples
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
    April 01, 2010 - IV study will be underpowered to detect anything less than a very strong effect, even with large samples … In small samples, IV estimators based on 2SLS possess substantial finite sample bias. … be more of a problem in the presence of many weak instruments and can persist even in very large samples
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-205-predictors-trauma-care-evidence-summary.pdf
    April 01, 2018 - Analysis is also complicated by the fact that the registry studies usually have large samples, while … more clearly prospective studies we identified were often exploratory with small samples. … A substantial limitation in the evidence base was the lack of population-based samples where physiologic
  7. effectivehealthcare.ahrq.gov/sites/default/files/ch_9-user-guide-to-ocer_130129.pdf
    September 21, 2012 - 129 Abstract The feasibility of a study often rests on whether the projected number of accrued patients is adequate to address the scientific aims of the study. Accordingly, a rationale for the planned study size should be provided in observational comparative effectiveness research (CER) study protocols. This chap…
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/smoking-pregnancy-infants_disposition-comments.pdf
    February 25, 2014 - TEP) Introduction Background: The Report should read: “Multiple studies of large, representative samples … Specifically, we inserted the following text and cited seven references: “Multiple studies of representative samples … Inclusion of these studies with very small samples sizes cannot meet the criteria for “Internal Validity
  9. effectivehealthcare.ahrq.gov/products/juvenile-arthritis-dmards/research-protocol
    March 09, 2010 - DMARDs, their mechanisms of action, JIA approval status, and samples of significant warnings from the
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
    September 01, 2013 - FDA 510(k) summaries did not report analyses on samples from populations and genes of interest to our … However, they provided little information on the use of positive or negative control samples, the handling … Furthermore, details were not provided regarding the timing of obtaining samples for genetic analyses … , but samples were generally not obtained at the trial baseline. … Such planning must include a strategy for obtaining samples from all participants (or a random sample
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-future_research.pdf
    February 01, 2012 - and many of the research questions (e.g., between-drug effectiveness comparisons) may require large samples … would require about 29 people per group (the sample size listed for an effect size of 0.75 and two samples … comparisons of means14 (two-tailed test, α=.05, power=.80) Effect Size One Sample (Paired) Two Samples … that difference would require a much larger sample size, approximately 393 per group (ES, 0.20, two samples … Inference for proportions: comparing two independent samples [Computer software].
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_appendixes.pdf
    October 06, 2006 - Template for Draft Reports Appendix A: Search Strategies Appendix A: Search Strategies DIALOG MEDLINE®/EMBASE Search. Run on August 3, 2006 TOTAL = 3080 MEDLINE® = 1576 EMBASE = 1504 unique records EMBASE terminology is in bold s1 dt=randomized controlled trial OR randomized controlled tria…
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/long-term-care-adults-future_research.pdf
    July 01, 2013 - research design considerations that were mentioned included the need for studies with more generalizable samples … Need more generalizable samples. … research design considerations that were mentioned included the need for studies with more generalizable samples … scant Feasibility: Includes factors related to anticipated research designs, such as generalizable samples
  14. effectivehealthcare.ahrq.gov/products/health-outcomes-competing-risks/abstract
    February 11, 2010 - Developing Methods to Assess Health Outcomes in the Presence of Competing Risks for Effectiveness Research Research Report February 11, 2010 Findings from this study were published in the following journal articles. 1. Weiss CO, Segal JB, Varadhan R. Assessing the applicability of trial evidence to a…
  15. effectivehealthcare.ahrq.gov/sites/default/files/delilberative-methods-design-goold.pdf
    January 11, 2017 - Recruiting/Selecting Participants Slide 10 Recruiting/Selecting Participants Susan Dorr Goold, MD, MHSA, MA Professor of Internal Medicine and Health Management and Policy University of Michigan Slide 11 Alternatives to Random Sampling  Substantive representation o Based on extent to which groups a…
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research.pdf
    March 01, 2013 - reviews, meta- analysis, and synthesis in general are that the circumstances of each study and the samples … studies investigating the drug, and the thickness of each edge corresponds to the total number of samples … physicians in providing clinical understanding. 35 using 10000 Markov chain Monte Carlo (MCMC) samples … trace plots, we decided to use only a single MCMC chain, run for 5000 burn-in and 10000 production samples … number of studies investigating the drug, and the thickness of each edge implies the total number of samples
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-creating-efficiencies-extraction-data.pdf
    August 01, 2021 - Methods Research Report: Creating Efficiencies in the Extraction of Data From Randomized Trials Methods Research Report Creating Efficiencies in the Extraction of Data From Randomized Trials: A Prospective Evaluation of a Machine Learning and Text Mining Tool Methods Research Report Creating Efficie…
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-bias_methods.pdf
    July 01, 2012 - Systematic Bias Description Population Spectrum effect Tests may perform differently in various samples
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/metanalysis-proportion-rate-comparison_research.pdf
    November 01, 2013 - Simulation-Based Comparison of Methods and Meta-Analysis of Proportions and Rates Methods Research Report Simulation-Based Comparison of Methods for Meta- Analysis of Proportions and Rates Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaith…
  20. effectivehealthcare.ahrq.gov/products/grades-predictive-values/abstract
    September 14, 2015 - Testing the Predictive Validity of Strength of Evidence Grades Abstract September 14, 2015 Background Strength of evidence (SOE) and grades for conveying SOE assessments are ways to describe succinctly to stakeholders the findings and conclusions present in systematic reviews. The GRADE (Grading of Re…

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