-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-future_research.pdf
April 01, 2013 - If RCTs are not feasible, prospective
cohort studies could be designed to enable larger samples, but … Resource use, size and
duration
Necessary to recruit large samples and follow for significant length … subgroups would provide
most clinically meaningful information; likely necessary to recruit large samples … If RCTs are not feasible,
prospective cohort studies could be designed to enable larger samples, but … Resource use, size and
duration
Necessary to recruit large samples and follow for significant length
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-5-draft-report.pdf
February 05, 2024 - Community samples may or may
not include Active Duty Military or veteran participants, as many studies … did not clarify these
variables when describing community samples. … by population type
Mixed = Any combination of active duty military, veteran, and community-based samples
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/continuous-outcomes-quantitative-synthesis_methods.pdf
March 01, 2011 - participants, and comparing results to those from studies including mildly or
moderately depressed samples … The percentage limits for the
distribution of range in samples from a
normal population (n less than
-
effectivehealthcare.ahrq.gov/products/instrumental-variable-methods/research
May 14, 2010 - an IV study will be underpowered to detect anything less than a very strong effect, even with large samples … In small samples, IV estimators based on 2SLS possess substantial finite sample bias. … to be more of a problem in the presence of many weak instruments and can persist even in very large samples
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
April 01, 2010 - IV study will be underpowered to detect
anything less than a very strong effect, even with large samples … In small samples, IV estimators based on 2SLS possess substantial
finite sample bias. … be more of a problem in the presence of many weak instruments and can persist
even in very large samples
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-205-predictors-trauma-care-evidence-summary.pdf
April 01, 2018 - Analysis is also complicated by the fact
that the registry studies usually have large samples, while … more clearly prospective studies we identified were often
exploratory with small samples. … A substantial limitation in the evidence base was the
lack of population-based samples where physiologic
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_9-user-guide-to-ocer_130129.pdf
September 21, 2012 - 129
Abstract
The feasibility of a study often rests on whether the projected number of accrued patients is adequate
to address the scientific aims of the study. Accordingly, a rationale for the planned study size should
be provided in observational comparative effectiveness research (CER) study protocols. This chap…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/smoking-pregnancy-infants_disposition-comments.pdf
February 25, 2014 - TEP) Introduction
Background: The Report should read: “Multiple studies
of large, representative samples … Specifically, we inserted the following text and cited
seven references: “Multiple studies of representative
samples … Inclusion of these studies with very small samples
sizes cannot meet the criteria for “Internal Validity
-
effectivehealthcare.ahrq.gov/products/juvenile-arthritis-dmards/research-protocol
March 09, 2010 - DMARDs, their mechanisms of action, JIA approval status, and samples of significant warnings from the
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
September 01, 2013 - FDA 510(k)
summaries did not report analyses on samples from
populations and genes of interest to our … However,
they provided little information on the use of positive or
negative control samples, the handling … Furthermore, details were
not provided regarding the timing of obtaining samples for
genetic analyses … , but samples were generally not obtained
at the trial baseline. … Such planning must include a
strategy for obtaining samples from all participants (or
a random sample
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-future_research.pdf
February 01, 2012 - and many of the research questions (e.g., between-drug
effectiveness comparisons) may require large samples … would require about 29 people per group (the sample size listed for an
effect size of 0.75 and two samples … comparisons of means14
(two-tailed test, α=.05, power=.80)
Effect Size One Sample (Paired) Two Samples … that
difference would require a much larger sample size, approximately 393 per group (ES, 0.20, two
samples … Inference for proportions:
comparing two independent samples
[Computer software].
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_appendixes.pdf
October 06, 2006 - Template for Draft Reports
Appendix A: Search Strategies
Appendix A: Search Strategies
DIALOG MEDLINE®/EMBASE Search. Run on August 3, 2006
TOTAL = 3080
MEDLINE® = 1576
EMBASE = 1504 unique records
EMBASE terminology is in bold
s1
dt=randomized controlled trial OR randomized controlled tria…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/long-term-care-adults-future_research.pdf
July 01, 2013 - research design considerations that were mentioned
included the need for studies with more generalizable samples … Need more generalizable samples. … research design considerations that were mentioned
included the need for studies with more generalizable samples … scant
Feasibility: Includes factors related to anticipated research designs, such as generalizable samples
-
effectivehealthcare.ahrq.gov/products/health-outcomes-competing-risks/abstract
February 11, 2010 - Developing Methods to Assess Health Outcomes in the Presence of Competing Risks for Effectiveness Research
Research Report February 11, 2010
Findings from this study were published in the following journal articles.
1. Weiss CO, Segal JB, Varadhan R. Assessing the applicability of trial evidence to a…
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effectivehealthcare.ahrq.gov/sites/default/files/delilberative-methods-design-goold.pdf
January 11, 2017 - Recruiting/Selecting Participants
Slide 10
Recruiting/Selecting Participants
Susan Dorr Goold, MD, MHSA, MA
Professor of Internal Medicine and
Health Management and Policy
University of Michigan
Slide 11
Alternatives to Random Sampling
Substantive representation
o Based on extent to which groups a…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research.pdf
March 01, 2013 - reviews, meta-
analysis, and synthesis in general are that the circumstances of each study and the samples … studies
investigating the drug, and the thickness of each edge corresponds to the total number of samples … physicians in providing clinical
understanding.
35 using 10000
Markov chain Monte Carlo (MCMC) samples … trace plots, we
decided to use only a single MCMC chain, run for 5000 burn-in and 10000 production samples … number of studies investigating the drug, and the thickness of each edge implies the total number of samples
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-creating-efficiencies-extraction-data.pdf
August 01, 2021 - Methods Research Report: Creating Efficiencies in the Extraction of Data From Randomized Trials
Methods Research Report
Creating Efficiencies in the Extraction of Data From
Randomized Trials: A Prospective Evaluation of a
Machine Learning and Text Mining Tool
Methods Research Report
Creating Efficie…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-bias_methods.pdf
July 01, 2012 - Systematic Bias Description
Population
Spectrum effect
Tests may perform differently in various samples
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/metanalysis-proportion-rate-comparison_research.pdf
November 01, 2013 - Simulation-Based Comparison of Methods and Meta-Analysis of Proportions and Rates
Methods Research Report
Simulation-Based Comparison of Methods for Meta-
Analysis of Proportions and Rates
Prepared for:
Agency for Healthcare Research and Quality
U.S. Department of Health and Human Services
540 Gaith…
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effectivehealthcare.ahrq.gov/products/grades-predictive-values/abstract
September 14, 2015 - Testing the Predictive Validity of Strength of Evidence Grades
Abstract September 14, 2015
Background
Strength of evidence (SOE) and grades for conveying SOE assessments are ways to describe succinctly to stakeholders the findings and conclusions present in systematic reviews. The GRADE (Grading of Re…