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effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-risk-bias.ppt
June 01, 2012 - Selection bias The selection process determines the composition of the study sample. … Partial verification bias Only a selected sample of patients who underwent the index test is verified … Domain 1: Patient Selection
Was a consecutive or random sample of patients enrolled? … Did the whole sample or a random selection of the sample receive verification using a reference standard … For the question, “Did the whole sample or a random selection of the sample receive verification using
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
January 01, 2011 - designs, along
with other designs relevant to CER such as case-cohort designs (selecting a random sample … analysis
(e.g., blood levels, biologic materials for genetic
analyses) is collected for a random sample … (Note that the random
sample may contain cases.) … new-user design are clearly outlined in the
paper by Ray.36 Limitations include the reduction
in sample
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-interventions-disposition.pdf
May 26, 2017 - Peer
Reviewer #7
Methods Almost all of the studies reviewed are noted to have "small" sample size, … Moreover, most
studies noted as a limitation their small sample
size. … We selected a minimum sample size of 10 for
RCTs because we felt that the typically greater
controls … for bias and rigor helped to mitigate
limitations of a smaller sample size. … We scanned a random sample of non-English
abstracts (n=150) and identified few eligible
items.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
January 01, 2014 - (a) Do the differences in performance measures vary with sample characteristics? … (a) Do the differences in performance measures vary with sample characteristics? … The lower limit of
detection of the stool real-time PCR was 30 CFU/ml of
stool sample per reaction … (ID C. difficile
prototype [IDCd]) for
isolation of C. difficile
compared using three
different sample … (a) Do the differences in performance measures vary with sample characteristics?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd_research-protocol.pdf
August 10, 2010 - Sample size
There are no restrictions for study sample size. … Published Online: August 10, 2010
extraction, a calibration exercise will be conducted using a random sample … will include study characteristics (e.g., first author, country of
research origin, study design, sample … history of
treatment(s), age of first diagnosis, etc), study outcomes (both of benefit and of harm),
sample … explore the impact of key methodological study limitations, in particular 1) percent of
withdrawals, 2) sample
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-prognostic_methods.pdf
July 01, 2012 - Did the sample represent patients that would be tested
in clinical practice?
4. … Were the results externally validated using an independent sample or internally validated via boot strap … need to be noted.15
If the investigators fit a new prognostic test or prediction equation to the sample … data (test
development sample) by using the data to define cutoff levels or model its relationships … Comparing the
predictive values of diagnostic tests: sample
size and analysis for paired study designs
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
July 01, 2019 - D & E: Consider these high risk of bias situations
when pooling a small number of studies:
► Small sample … sizes: Results from small trials are less reliable even
when risk of bias is low.6
− If sample sizes … heterogeneity9
► Critiques of I2: Underestimates heterogeneity in random effects models;
increases as sample
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
August 01, 2012 - In addition, the study was not published in a pivotal journal, and the sample size
was not larger than … Evidence Table
Article ID /
Cohort/First
Author/Year
Participants
(age, sex,
condition)/
Sample … Article ID /
Cohort/First
Author/Year
Participants
(age, sex,
condition)/
Sample size
Inclusion … Article ID /
Cohort/First
Author/Year
Participants
(age, sex,
condition)/
Sample size
Inclusion … Article ID /
Cohort/First
Author/Year
Participants
(age, sex,
condition)/
Sample size
Inclusion
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveillance-report-3.xlsx
September 30, 2015 - controlled trials
Author, Year Study Design
Duration Setting
Country Eligibility Criteria Interventions Sample … Oral methadone (30 to 60 mg daily) (9 assigned, 6 f/u) Overall sample:
Mean age: 41 years
Female sex: … B (unmatched sample)
Mean age (SD): 55.6 (13.22) vs. 58.2 (12.82) years
Female sex: 9.88% vs. 9.49% … ); 38,716 (matched sample) Visit counts for physical therapy, pain clinics, chiropractic care, primary … HR 1.19 (95% CI 1.06 to 1.35) Insurance Fair
Salkar, 2021 Case-control, Medicare 5% National Sample
-
effectivehealthcare.ahrq.gov/sites/default/files/s158.pdf
October 01, 2007 - Validation study:
representative sample of Medicare beneficiaries. … infarction was essentially the
same before and after control for these additional covariates
in the stage 2 sample … calibration Yes Yes Yes
Validation study can be used to adjust multiple
associations
Yes (if random sample … files.41
External Validation Study
The Medicare Current Beneficiary Survey (MCBS) is
conducted on a sample … Two-stage case-control studies:
precision of parameter estimates and considerations in selecting sample
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/engaging-caregivers-appendix-c.xlsx
May 29, 2025 - nonrandomized studies
Author, Year (Study Design) Did the Study Attempt To Enroll All (or a Random Sample
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-276-ocd-appendix-g.xlsx
January 01, 2022 - 0.52 52 111 3 6 7 none NA
37431399 Lambe 2021 DWS TOCS TOCS max average one off 1 discovery sample … 0.88 128 38 3 161 330 none NA
37431399 Lambe 2021 DWS TOCS TOCS total score one off 1 validation sample … Key Question 1: Quality
PMID first_author Year Extractor Was a Consecutive or Random Sample of Patients … : We should discuss studies that enroll at least one clinical sample, e.g. … Lambe, AND a control sample.
-Dale Steele Did All Patients Receive the Same Reference Standard?
-
effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
January 01, 2013 - followed for incidence of outcomes
Additional information required for analysis collected for a random sample … for analysis (e.g., blood levels, biologic materials for genetic analyses) is collected for a random sample … of the cohort and for all cases (note that the random sample may contain cases).
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-classification_research.pdf
December 01, 2010 - A sample of 30 studies was used to test the tool. … Further, the sample
of studies that we tested covered a wide range of topics. … Further, at
least one study of each design was included in the sample pool. … The sample of studies that
we tested covered a wide range of topics. … Sample size requirements
for reliability studies. Stat Med 1987;6:441-448.
37.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper.pdf
September 01, 2015 - In this sample, the EPC approach to GRADE could not reliably predict the likelihood that
individual … our study was to determine the predictive validity of the EPC approach to
GRADE based on a diverse sample … For example, in about 20 percent of our sample (presented in Table 1),
confidence intervals cross both … Second, how representative our sample is remains unclear. … In
addition, our sample was limited to RCTs, so findings are likely not generalizable to research
based
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-reviews-end-user_white-paper.pdf
April 01, 2016 - Sample Rapid Products
From an initial list of 11 recently completed (within the past 2 to 3 years) EPC … While based on a small sample, this project suggests that some discussion within the EPC
program may … However, our small sample size means that results may not be
representative of all end-users and we … Can you take a look at the sample of rapid review products we provided (see Table and
attachments): … Evidence
Inventory Sample
Acetylsalicylic Acid for Venous
Thromboembolism Prophylaxis: an
Update
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
January 01, 2010 - Transcription-mediated amplification of PCA3 and PSA mRNA in urine sample
b. … Do measures of AV vary by assay design, method of sample collection, etc.?
3.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fibromyalgia_executive.pdf
January 01, 2015 - At baseline, MDD
subgroup sample sizes were small in all RCTs, excluding
the pooled IPD RCT analyses … Sample sizes were small. … Adverse Effects Reporting
None of the 10 mixed-sample RCTs with subgroup
outcomes separately reported … In general, sample selection criteria were restrictive, and
the extent to which such select patient … Sample selection criteria were most
restrictive for pharmaceutical studies that excluded adults
with
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/measuring-blood-pressure-future_research.pdf
August 01, 2012 - Sample Size for a Randomized Controlled Trial for a Composite CVD Outcome
Appendixes
....... 13 … This would require smaller
sample sizes than for trials with CVD outcomes as the effect sizes would … An additional approach to decrease the necessary sample size would be to exclude
individuals with a … Resource Use, Size, and Duration
An RCT, especially one with a long duration and large sample size, … Sample size for a randomized controlled trial for a composite CVD outcome
Total sample size for an
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
January 01, 2012 - Goudie, et al. assessed a
sample of randomized controlled trials (RCTs) published in leading medical … Several publications have proposed methods which can be used to simulate sample size
calculations and … Does the proposed study have adequate sample size and power? … Insufficient data: too few primary studies, or studies that are too small (sample size inadequate or … Evidence-based sample size calculations
based upon updated meta-analysis.