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effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
September 20, 2013 - Fine-needle aspiration, which retrieves a sample of cells, is
generally considered less sensitive than … both core-needle and open biopsy methods.7 Core-needle
biopsy, which retrieves a sample of tissue, … Sometimes a vacuum device is used to assist in removing the tissue sample through the needle. … After using the images to determine where to
sample, the needle is inserted. … After using the images to determine where to sample, the needle is
inserted.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-prepub-final-research-table-rct.xlsx
May 29, 2025 - Quality Rating Non-randomized
Cohort
Author, year Did the study attempt to enroll all (or a random sample … Yes/No/Unclear Risk of Bias
Low/Moderate/High
For yes: attempted to enroll random sample of or all
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-jaw-rapid-response.pdf
May 01, 2025 - treatment group vs
comparator group)
● Clinical practice guidelines
● Primary studies must have sample … size, and sample representative of the true population.39 The remaining six cohort studies,
evaluated … Size
Medication
Confounder
Adjustment
Outcomes
Assessed
Treatment or Control
Group (Sample … Size
Medication
Confounder
Adjustment
Outcomes
Assessed
Treatment or Control
Group (Sample … The majority (5 out of 7) of the included cohort studies were large (sample
size >1000) and were drawn
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/smoking-pregnancy-infants_disposition-comments.pdf
February 25, 2014 - = 0.30) the sample size per
E + C Group. … The justification for
this unacceptable sample size criteria in the Report makes
no sense. … (See CDC Epi-Info/Estimation of sample sizes + Fleiss). … Although it is commonly used, a minimum sample size
of 50 has no intrinsic value as a cutoff. … Rather the
decision about sample size should be based on the
purpose of the review and the methods
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effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epilepsy-infographic.pdf
May 29, 2025 - New Evidence Report on Treatments for Infantile Epilepsies
This Is a Sample Two Line
Infographic Arial
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/wheelchair-users-amended-protocol.pdf
June 21, 2019 - Study sample sizes will be ≥30
for MS and SCI, and ≥20 for CP. … “Study sample
sizes will be ≥30
for MS and SCI,
and ≥20 for CP.” … “Studies with the
following sample
sizes: MS (n≥30),
CP (n≥20), SCI
(n≥30).” … “Study sample
sizes will be ≥30
for MS and ≥20
for SCI and CP.” … “Studies with the
following sample
sizes: MS (n≥30),
CP (n≥20), SCI
(n≥20).”
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effectivehealthcare.ahrq.gov/sites/default/files/analytic-frameworks.ppt
December 09, 2009 - DOI: 10.1016/s0749-3797(02)00415-4
http://www.ncbi.nlm.nih.gov/pubmed/11988383
Sample Working Framework … Sample Working Framework
Systematic reviews may examine the effects of screening, diagnosis, or treatment … DOI: 10.1016/s0749-3797(01)00261-6.
http://www.ncbi.nlm.nih.gov/pubmed/11306229
Sample Screening … Population
Intervention
Outcomes
Sample Screening and Treatment Framework
This slide is intended to
-
effectivehealthcare.ahrq.gov/sites/default/files/study-eligibility-criteria.ppt
January 01, 2000 - studies only)
Study population size (N > 200)
Study design (randomized controlled trials)
Some Sample … Sometimes it is helpful for the team to set criteria, then do a sample set of reviews, and reconvene … Publication
Using the Criteria
The rest of this module contains a number of questions and some sample … Exercise 3: Impact of Study-Size Criteria on Excluded Studies
The research team required a minimum sample … Studies
Based on expert opinion and a preliminary review of the literature, the team set a minimum sample
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
February 01, 2012 - Sample Size Estimates for Various Clinical Scenarios of Sensitivity and Specificity
With an Assumed … Sample Discussion Thread: Diagnosis ................................................................. … Sample Size Calculations For an RCT of Screening Versus no Screening for
Postoperative Complications … Due to its rarer occurrence, a mortality outcome would necessitate a larger sample size than
for an … Assuming a power of 90 percent,
the required total sample size (1:1 ratio in a two-arm RCT) for each
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-future_research.pdf
May 01, 2012 - Sample size is another important consideration in planning future research. … sample
size issues after the detailed descriptions of each research need. … See the following section regarding
sample size estimates. … See Table 3 in sample size section. … Each sample size was determined by generating
2,000 simulated datasets and identifying the minimum sample
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-presentation-format_research.pdf
January 01, 2019 - information (EVSI) or expected value of sample information for specific parameters (EVSI-P).P0F
a … designs, one can proceed to calculate EVSI, the expected value of information from a sample n (and compare … information; EVSI-P = expected value of partial sample information; IPD = individual participant data … EVPI over
willingness-to-pay graph plots the expected value of a hypothetical study with infinite sample … A survey
of a large and representative sample of potential users of future research needs assessments
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-disposition.pdf
May 26, 2017 - TEP Reviewer
#4
Methods Almost all of the studies reviewed are noted to have "small" sample
size, … Moreover, most studies noted as a
limitation their small sample size. … for
bias and rigor helped to mitigate limitations of a
smaller sample size. … Manufacturer-funded studies
also tend to have larger sample sizes than many academic studies. … We scanned a random sample of non-English
abstracts (n=150) and identified few eligible items.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/women-hiv_research-protocol.pdf
March 01, 2016 - menopause at an earlier age among HIV-infected women.4-9 However, many
of these studies have a small sample … We will include studies that have a sample size of at least 100. … Smaller sample sizes are
unlikely to result in precise estimates, and thus the utility of recording … Outlining Available Resources in A Purposeful Sample of Six States
We will outline which resources … appear to be available to older women who live with HIV in a
purposeful sample of six states, namely
-
effectivehealthcare.ahrq.gov/sites/default/files/s96.pdf
October 01, 2007 - NEISS-CADEs operates in 63 hospital EDs, selected as
a stratified probability sample of all hospitals … in the United
States and its territories with a minimum of 6 beds and a
24-hour ED.12,13 The sample … We used data collected from a convenience sample of
6 NEISS-CADES hospitals from January 1, 2004 to June … No pediatric
specialty hospital was included in this sample. … The NEISS sample (design and implementation)
1997 to present.
-
effectivehealthcare.ahrq.gov/sites/default/files/c-diff-infections-nomination-140925.pdf
February 19, 2014 - (a) Do the differences in performance measures vary with sample characteristics? … § Do the differences in performance measures vary with sample characteristics?
§ KQ 2.
-
effectivehealthcare.ahrq.gov/sites/default/files/delilberative-methods-design-goold.pdf
May 29, 2025 - Recruiting/Selecting Participants
Slide 10
Recruiting/Selecting Participants
Susan Dorr Goold, MD, MHSA, MA
Professor of Internal Medicine and
Health Management and Policy
University of Michigan
Slide 11
Alternatives to Random Sampling
Substantive representation
o Based on extent to which groups a…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
March 13, 2012 - Gene expression is determined by analyzing RNA in the sample, generally using either
reverse transcriptase … ;
derivation, validation, or both), sample size, and study goal (analytic validity,
clinical validity … (Lack of
reproducibility could result from both preanalytic factors [e.g., sample
preparation] as well … Sample size (number of patients/specimens)
o If samples are from previous studies, which studies? … GEPs measure the
activity or “expression” of multiple genes in a single RNA sample, which may reflect
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
October 26, 2012 - Generalizability will depend on population
sample. … Multiple sites may be
needed to reach adequate sample sizes. … Multiple sites may be needed to reach
adequate sample sizes. … Generalizability
will depend on population sample. … Multiple sites may be needed to reach
adequate sample sizes.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
December 01, 2012 - As shown in Table 6, this assay used microdissection of fixed, paraffin-embedded tissue
during sample … Handling
Sample Handling Technique for GEP Reliability
(Reproducibility)
Time to Report
Results … Is there an effect of sample preparation, analysis, and/or tumor heterogeneity? … GEPs measure the activity or “expression” of multiple genes in a
single RNA sample, which may reflect … Sample size (number of patients/specimens)
o If samples are from previous studies, which studies?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-risk-bias.ppt
June 01, 2012 - Selection bias The selection process determines the composition of the study sample. … Partial verification bias Only a selected sample of patients who underwent the index test is verified … Domain 1: Patient Selection
Was a consecutive or random sample of patients enrolled? … Did the whole sample or a random selection of the sample receive verification using a reference standard … For the question, “Did the whole sample or a random selection of the sample receive verification using