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  1. effectivehealthcare.ahrq.gov/sites/default/files/adhd_disposition-comments.pdf
    October 01, 2011 - Also, the sample size should be mentioned, the denominator for the 44 CVAs and 21 TIAs. … Atomoxetine's sponsor reported that its safety sample was well over 3,000 subjects. … However, it is becoming clearer now from analyses done in the 2007 Swanson papers on the MTA Sample … The key paper by Molina et al in 2009 on the 8 year follow up of the MTA sample is also missing. … been helpful would have been to include the work of Ron Kessler using the US National Comorbidity Sample
  2. effectivehealthcare.ahrq.gov/products/ptsd-adult-treatment-update/research-protocol
    May 24, 2017 - For KQ 4, we have chosen a sample size cutoff of 500 for prospective cohort studies and case-control … nonrandomized controlled trials, prospective cohort studies with an eligible comparison group and a sample … size of at least 500, a case-control studies with a sample size of at least 500 a All other designs … and studies using included designs that do not meet the sample size criterion Language Studies published … We will reassess risk of bias in a random sample of 10 studies included in the prior review that continue
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-chronic-conditions-interventions_executive.pdf
    August 01, 2012 - Description of Included Studies In the 10 included trials, sample sizes ranged from 55 to 1,001, and … Summary of collaborative care intervention trials Author/Trial Name Disease Sample Size Quality Ratinga … Summary of collaborative care intervention trials (continued) Author/Trial Name Disease Sample Size … Summary of collaborative care intervention trials (continued) Author/Trial Name Disease Sample Size … or 12 months (or both) by those receiving the collaborative care intervention, and one as-treated sample
  4. effectivehealthcare.ahrq.gov/products/childhood-depression/protocol
    August 24, 2018 - Most notably, the developmental age of the sample (adolescent vs. younger children) is a critical component … age >12 and ≤18): randomized controlled trials (RCTs) Children (sample age ≤12): RCTs or controlled … All other designs and studies using included designs that do not meet the sample size criterion … When studies with sample sizes of 1,000 or more participants are available for a given intervention and … If large samples are not available, we plan to include studies with smaller sample sizes ****We anticipate
  5. effectivehealthcare.ahrq.gov/products/fatty-acids-cardiovascular-disease/research-protocol
    April 02, 2015 - Minimum sample sizes (All outcomes: To be determined) We will aim for a minimum of about 25 RCTs for … lipid outcomes We expect to include at least 50 RCTs We will choose RCTs based on a combination of sample … We expect to include at least 50 RCTs We will choose RCTs based on a combination of sample size, whether … These included descriptions of the study design, sample size intervention(s), follow-up duration, outcomes … Sample size (total)   Age   Sex   Race   Medical history   Risk type Options: DM
  6. effectivehealthcare.ahrq.gov/products/preoperative-testing/research-protocol
    May 14, 2013 - unnecessary followup from preoperative tests) Eligible retrospective studies must clearly include a sample … who ordered and followed up on the tests and in what setting they were ordered; outcome definitions; sample
  7. effectivehealthcare.ahrq.gov/products/mrsa-screening-2010/research-protocol
    June 02, 2011 - details: Statistical analyses (statistical test/estimation results) Test used Summary measures Sample … Preventive Services Task Force, 35 as follows: Was sample definition and selection prospective or retrospective
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
    January 01, 2010 - Source: www.effectivehealthcare.ahrq.gov Published Online: October 24, 2011 □ Summary measures □ Sample … Preventive Services Task Force,35 as follows: O Was sample definition and selection prospective
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/bipolar-disorder-treatment_research-protocol.pdf
    June 23, 2014 - catalogue one-off studies of interventions (only one study examining a particular intervention) with low sample … The form will be tested by investigators using an initial sample of included studies and will be finalized
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-update_research-protocol.pdf
    September 20, 2013 - After reviewing a sample of relevant articles, the team will assess the data-collection forms from the … publication, study location (e.g., country, city, state) and time period, population description, sample … will use established concepts of the quantity of evidence (e.g., numbers of studies, aggregate ending-sample … Complementary and alternative medicine use in a large pediatric autism sample. … A sample table is shown below: Date Section Original Protocol Revised Protocol Rationale This should
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
    March 01, 2013 - Although the use of a composite outcome as the primary outcome in a clinical trial can reduce sample … In meta-analysis, sample size is less of a concern than in clinical trials, and thus the motivation … Clinical Trials Composite outcomes can improve statistical efficiency, increasing power for a given sample … Recommendations Descriptive study information Include information for each study describing the sample … present tables or a graphical representation of the data (forest plot) including: The comparison type, sample
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_executive.pdf
    December 01, 2015 - We verified the data extraction and risk-of-bias assessment in a random sample of 368 noncomparative … Furthermore, multivariable models were often developed and evaluated in the same patient sample. … of diagnostic scores, multivariable models were often developed and evaluated in the same patient sample … Many had sample sizes that were too small to reliably detect small or moderate differences between … • In contrast to the RCTs, NRCSs of alternative testing strategies attained large sample sizes but
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/preoperative-testing_research-protocol.pdf
    May 14, 2013 - preoperative  tests)     • Eligible  retrospective  studies  must  clearly  include  a  sample … who ordered and followed up on the tests and in what setting they were ordered; outcome definitions; sample
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
    April 30, 2014 - We have provided additional study design recommendations, particularly with respect to sample size … We have clarified that we were referring to the majority of studies when discussing small sample sizes … We have provided details about the sample size requirements for such a trial. … We believe that the required sample size is not prohibitive (even for a small size consortium) given … , pelvic abscess, etc.), and that the study will need to be stratified by anatomical segment, the sample
  15. effectivehealthcare.ahrq.gov/products/preterm-birth-terbutaline-pump/research-protocol
    August 05, 2010 - Further, the two RCTs included in a published Cochrane review had small sample sizes (52 and 42 participants … Observational studies identified through our scoping literature search consistently have larger sample … setting, duration of followup Population characteristics: inclusion/exclusion criteria, maternal sample … x Randomization sequence generation x Allocation concealment 4 x Adequate sample … Assessment of Loss to Followup: Since the reported sample size could represent either the total number
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
    September 08, 2011 -  Statistical analyses (statistical test/estimation results) Test used Summary measures Sample … selection of items proposed by Deeks et al. 13 to inform the USPSTF approach, as follows: o Was sample … o Did the whole sample or a random selection of the sample, receive verification using a reference standard
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment-future_research.pdf
    January 01, 2014 - However, the study sample is non-randomized and, therefore, subject to bias. … However, the study sample is non-randomized and, therefore, subject to bias. … Both studies were more than 20 years old, had small sample sizes, and found no benefit for systemic … Standards for Estimating Proper Sample Sizes Well-developed statistical methods for estimating the size … …for estimating proper sample sizes.
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/single-group-studies_white-paper.pdf
    January 01, 2013 - authors planned to use single group studies, selection criteria for single group studies (minimum sample … However, this interpretation is limited by the small sample size. F Figure 2. … Finally, our empirical review was conducted among the small sample of CERs that had been prepared by … in the randomized two arm trial designs (though the two arm studies required a 2–4 fold increased sample
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment-update_research-protocol.pdf
    December 31, 2017 - military settings Other settings Study design KQs 1–3: Randomized controlled trials (RCTs) of any sample … size of at least 500,a case-control studies with a sample size of at least 500a All other designs … and studies using included designs that do not meet the sample size criterion Language Studies … For KQ 4, we have chosen a sample size cutoff of 500 for prospective cohort studies and case-control … We will reassess risk of bias in a random sample of 10 studies included in the prior review that continue
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_disposition-comments.pdf
    June 07, 2013 - non-English articles still have English abstracts (at least in PubMed), providing some information like sample … Exploring potential sample size and effect sizes from abstracts in the non-English literature (or translating … in our review only 2 studies (both assessing acute harms) were excluded specifically based on this sampleSample sizes for the specific studies are included in the study characteristic tables. … It would be helpful to mention the sample size needed for a BRCA1+ population, which would be smaller

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