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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
    December 14, 2012 - This data, as well as information on our sample turn-around time, which was listed as unknown, are available … The report shows that the Oncotype DX assay has been successfully validated and size of the sample
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/stakeholders-engagement-others_white-paper.pdf
    September 01, 2013 - costs • Greater promotion of the network across populations • Reduced fracturing of patient sample … recruitment of individuals with a specific condition. 10 • Reduced fracturing of the patient sample
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prosthesis_research-protocol.pdf
    March 16, 2017 - • Any study design • No minimum sample size (except not case reports) • No minimum followup time … adverse effects) Study Design • Any study design, including qualitative studies • No minimum sample … of accessing a LLP Study Design • Any study design, including qualitative studies • No minimum sample … exposures, and comparators analyzed; outcome definitions; effect modifiers; enrolled and analyzed sample … These included descriptions of the study design, sample size, interventions, followup duration, outcomes
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-3-app-G.xlsx
    January 01, 2022 - Risk of bias of cannabis cohort studies Author, Year Did the Study Attempt To Enroll All (or a Random Sample
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-tables-f1-f2-2022-update_0.xlsx
    January 01, 2022 - Risk of bias of cannabis cohort studies Author, Year Did the Study Attempt To Enroll All (or a Random Sample
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-update-surv-rep-1-apps-G1-2.xlsx
    January 01, 2022 - Risk of bias of cannabis cohort studies Author, Year Did the Study Attempt to Enroll All (or a Random Sample
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
    May 18, 2011 - In addition, proponents point out that fecal DNA testing requires only a single whole- stool sampleSample Size KQs 1–6: We will not exclude studies based on sample size alone, although it may be considered … source of study funding, study design characteristics, recruitment setting/patient-inclusion criteria, sample … expression analyzed, the assay characteristics and laboratory setting, and the technique used for sample
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-omega-3_research-protocol.pdf
    September 02, 2016 - This spreadsheet will capture basic intervention, outcome, study design, sample size, and whether results … they meet additional operational eligibility criteria used in the original review (based on minimum sample … intake amounts of n-3 FA), we expect that the primary reason for exclusion will be based on small sample … and study design) but would not have been included in the original report (primarily due to small sample … We quantify such impact as a potential increase in total study population sample size (>20%), a change
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_executive.pdf
    April 01, 2012 - Similarly, studies where the entire sample were subjects with a cerebrovascular accident, dementias … Inadequate sample size was a factor in many studies. … Adequate sample size was an issue in these studies. … The second trial evaluated a dose escalation of fluoxetine in a small sample, and was suggestive of … A second study, a pilot with small sample size evaluating dose escalation, showed no effect.
  10. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_executive.pdf
    December 01, 2011 - (a) Do the differences in performance measures vary with sample characteristics? KQ 2. … the differences in sensitivity and specificity in stool samples tested within the same lab using the sample … nonstandard intervention for treatment or prevention of CDI be supported by a power analysis, adequate sample … Multicenter studies may be necessary to achieve adequate sample sizes. … How do • Few comparisons are • Comparison of diagnostic • Document stool sample different methods for
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_disposition-comments.pdf
    March 01, 2012 - In my own experience when a laboratory moves from testing any sample to only testing loose stools the … “Sample characteristics” should be “patient and stool sample characteristics.” … The descriptions of the sample, groups, and parts of the methods are not identical because there is … We reworded the sample description to clarify that all subjects had recurrent CDI. … The sample consisted of subjects who had recurrent CDI.
  12. effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-g.xlsx
    May 29, 2025 - assessments for comparative cohort studies Study Did the study attempt to enroll all (or a random sample
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper-2015.pdf
    January 01, 2015 - The objective of our methods project was to use a diverse sample of medical interventions to assess … Results of stratified analyses based on sample size, risk of bias, and magnitude of effect estimates … First, the size of our sample was limited. … Second, how representative our sample is remains unclear. … Influence of trial sample size on treatment effect estimates: meta- epidemiological study.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_disposition-comments.pdf
    October 23, 2012 - I would like to briefly comment on the discussion of detection bias (lack of blinding) and small sample … PwD) manifests itself with such large inter-person or intra person variability that a really large sampleSample size is of course also limited by attrition due to death/decline in this population. … of the interventions/exposures of interest, more studies need to be conducted with larger sample sizes … Sample size and design remain important considerations in terms of validity, but we agree that the
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
    November 22, 2011 - precision of estimates of analytic validity depends on the specific statistic used; generally, a sample … interest were used o Case–control studies o N>10 subjects (per arm, if there are ≥2 arms); smaller sample … trials o Nonrandomized comparative studies o N>10 subjects (per arm, if there are ≥2 arms); smaller sample … because our preliminary searches indicate that non–English- language studies are few and have small sample … those we have used for other CERs and will include elements that address population characteristics, sample
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
    September 01, 2014 - Core-needle biopsy, which retrieves a sample of tissue, and open surgical procedures are the most frequently … stereotactic guidance, ultrasound guidance, MRI guidance, other guidance, or freehand), how the biopsy sample … Sixty study arms used vacuum- assisted methods to obtain the biopsy sample; 80 used automated methods … MRI-guided biopsies were evaluated in only six studies with small sample sizes, leading to substantial … average and high risk of breast cancer All biopsy methods Insufficient – Few studies provided within-sample
  17. effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/patient-participant-generated-registries-guide-3rd-ed-addendum-white-paper.pdf
    February 01, 2018 - the Agency for Healthcare Research and Quality (AHRQ).7 While the survey represented a very small sample … About half of the registries in the sample are managed by advocacy organizations, with the others managed … While the sample from the PGR was subject to limitations and biases, the analysis provided rapid proof … T-Test to look at differences in progression rate between self-treating participants and a random sample … Other PGRs may validate the diagnosis for a sample of participants using medical record review or contact
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-immunodeficiency-virus-rapid-response.pdf
    May 01, 2025 - • All three non-comparative studies were small (sample size: 15 to 63), with follow-up duration … One study was conducted in the US,30 and two were in Brazil.31,32 Sample sizes were small. … We rated all three studies as poor quality (having high risk of bias), due to small sample size, high … Of these three included studies, two were small, with sample size of less than 25,31,32 and the third … All included studies were single-arm, non- comparative designs with small sample sizes, limiting causal
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
    September 01, 2012 - Studies should have a priori calculation of the sample size needed for determination of the desired … Sample size not an issue, in spite of the relatively low prevalence of PCDs, because the cohorts would … Resource use likely to be moderate; sample size would depend on number of respondents. … The feasibility of such studies generally does not depend on the desired sample size. … Studies should have a priori calculation of the sample size needed for determination of the desired
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
    August 01, 2012 - Followup times varied from 3 months to 13 years, with sample sizes of 40 to 399 patients. … of limitations in study design, including selection/ spectrum bias as well as (in one study) small sample … without adjustments for potential confounders and as C in the other five studies because of their small sample … performance of the SFLC assay varies depending on the type and distribution of PCDs in the study sample … Studies should have an a priori calculation of the sample size needed to determine the desired precision

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