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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-chronic-pain-appendix-g.xlsx
    January 12, 2021 - Risk of bias of cannabis cohort studies Author, year Did the study attempt to enroll all (or a random sample
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-272-genitourinary-syndrome-executive-summary.pdf
    July 01, 2024 - • Harms reporting was limited by sample sizes and short followup duration though most studies did … focused on natural products (i.e., herbal or botanical supplements and vitamins) and were small in sample … trials did not provide adequate statistical reporting) dDowngraded one level for imprecision (total sample … level for imprecision (SD crosses no-effect threshold) fDowngraded two levels for imprecision (total sample
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-studies_white-paper.pdf
    December 01, 2013 - We selected a 25 percent sample of the most recent eligible CERs. … Our final sample included 23 CERs published since November 2012. … We selected a 25 percent sample of the eligible CERs, based on most recent date of publication, due … From the eligible CERs, we initially selected a sample of 25 percent of the most recently published … Finally the subgroup analyses are based on a small sample size.
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper.pdf
    September 01, 2015 - In this sample, the EPC approach to GRADE could not reliably predict the likelihood that individual … our study was to determine the predictive validity of the EPC approach to GRADE based on a diverse sample … For example, in about 20 percent of our sample (presented in Table 1), confidence intervals cross both … Second, how representative our sample is remains unclear. … In addition, our sample was limited to RCTs, so findings are likely not generalizable to research based
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/calcineurin-inhibitor_research-protocol.pdf
    October 08, 2014 - for inclusion, but retrospective studies must use consecutive enrollment or enrollment of a random sample … Duplicate abstraction on a 10-percent random sample will be used to ensure accuracy. … ionization to analyze molecules; effective in detecting therapeutic levels of drugs in a biologic sampleSample of Search Strategy Table A-1. … Sample Risk of Bias Items ECRI Risk of Bias Item List for Controlled or Comparative studies 1.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_disposition-comments.pdf
    February 11, 2013 - compared one type of treatment with another, a wait-list control, or no treatment/placebo using a sample … Overall the report demonstrated the large gaps in knowledge, the small sample sizes, the lack of replication … clinical research in the trauma area) but I would not have much confidence in any study with small sample … Getting larger sample sizes in this area would be difficult because larger samples are quite costly … Sample size should have been given much greater weight in determination of strength of evidence.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/measuring-blood-pressure-future_research.pdf
    August 01, 2012 - Sample Size for a Randomized Controlled Trial for a Composite CVD Outcome Appendixes ....... 13 … This would require smaller sample sizes than for trials with CVD outcomes as the effect sizes would … An additional approach to decrease the necessary sample size would be to exclude individuals with a … Resource Use, Size, and Duration An RCT, especially one with a long duration and large sample size, … Sample size for a randomized controlled trial for a composite CVD outcome Total sample size for an
  8. effectivehealthcare.ahrq.gov/sites/default/files/pregnancy_hi_impact.pdf
    January 01, 2012 - A new blood test takes a sample of maternal blood during the first trimester in pregnant women interested … “Fetal Nucleic Acid Technology” to detect and isolate circulating fetal DNA from a maternal blood sample … “Fetal Nucleic Acid Technology” to detect and isolate circulating fetal DNA from a maternal blood sample … Sequenom states that circulating fetal DNA can be obtained from a maternal blood sample very early … comfort relative to invasive tests, and the ability of most any physician’s office to perform blood sample
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
    January 01, 2012 - Goudie, et al. assessed a sample of randomized controlled trials (RCTs) published in leading medical … Several publications have proposed methods which can be used to simulate sample size calculations and … Does the proposed study have adequate sample size and power? … Insufficient data: too few primary studies, or studies that are too small (sample size inadequate or … Evidence-based sample size calculations based upon updated meta-analysis.
  10. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_executive.pdf
    November 01, 2009 - Primary outcomes were explicitly stated in only three trials, which also reported a priori sample size … All trials enrolled a relatively small sample size, ranging from 15 to 393 patients, and studied different … Most eligible studies were noncomparative in nature and had small sample sizes.
  11. effectivehealthcare.ahrq.gov/products/transparency-tympanostomy/research-protocol
    September 03, 2016 - This spreadsheet will capture basic intervention, outcome, study design, sample size, and whether results … evidence map to include data on study design, intervention type and duration, population, outcomes, and sample … We quantify such impact as a potential increase in total study population sample size (>20%), a change … Estimating effect size under publication bias: small sample properties and robustness of a random effects … With input from the TEP, study-design and sample-size filters will be implemented, as needed, to contain
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research-protocol.pdf
    September 02, 2016 - This spreadsheet will capture basic intervention, outcome, study design, sample size, and whether results … evidence map to include data on study design, intervention type and duration, population, outcomes, and sample … We quantify such impact as a potential increase in total study population sample size (>20%), a change … Estimating effect size under publication bias: small sample properties and robustness of a random effects … With input from the TEP, study-design and sample-size filters will be implemented, as needed, to contain
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/pelvic-pain_research-protocol.pdf
    February 16, 2011 - • Loss to followup: varies by study; to maximize acceptable sample size, we will assume 0 percent … • Statistic: use the two-tailed z-test and the t-test for sample size. … • Sample size: for an RCT with 2 groups, with 100 percent meeting the diagnostic criteria for CPP … • Null hypothesis of effect size of 50 percent: need 64 subjects per study group; a total sample … • Null hypothesis of effect size of 30 percent: need 176 subjects per group; a total sample size
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
    February 01, 2012 - Sample Discussion Thread: Treatment ................................................................. … Sample Size Calculation for an RCT of Behavioral Interventions To Improve Compliance With CPAP, MAD, … We specifically considered the feasibility of the research questions focusing on potential sample size … size in the thousands, while using surrogate outcomes would need smaller sample sizes. … size in the thousands, while using surrogate outcomes would need smaller sample sizes.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism_disposition-comments.pdf
    November 01, 2010 - With the assistance of our technical experts, we selected a minimum sample size of 10 in order to maximize … of the Autism Diagnostic Interview - Revised in 2003 allowed researchers to introduce metrics of sample … We have added rationale about our decisions regarding sample size to the Methods section of the review … Thank you for your comment Methods It was not clear from the EPC report why 10 was used as a sample … By admitting "case study and case-control designs" but excluding all "behavioral studies with sample
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
    September 25, 2013 - We agree that number of studies and sample size of each can affect the performance of heterogeneity … The blood sample is further centrifuged at higher speed to isolate platelet poor plasma (PPP). … Manipulation Required Prior to Measurement; Sample Matrix; Materials Required; Pre-analystic Sample … • Differences in sample matrix. LTA uses plasma; VASP and VerifyNow use whole blood. … • Sample transport (the VerifyNow test is point‐of‐care and can be performed at the location of sample
  17. effectivehealthcare.ahrq.gov/products/equivalence/research
    June 22, 2012 - The second project assessed the methodology used for a random sample of 50 recent systematic reviews
  18. effectivehealthcare.ahrq.gov/products/treatment-effects-estimates-tool/research
    December 02, 2009 - We will present sample code and results from analyses of simulated data.
  19. effectivehealthcare.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_june_2012.pdf
    January 01, 2012 - uses Fetal Nucleic Acid Technology to detect and isolate circulating fetal DNA from a maternal blood sample … Sequenom states that circulating fetal DNA can be obtained from a maternal blood sample very early … using Fetal Nucleic Acid Technology to detect and isolate circulating fetal DNA from a maternal blood sample … Sequenom states that circulating fetal DNA can be obtained from a maternal blood sample very early … comfort relative to invasive tests, and the ability of most physician’s offices to perform blood sample
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-256-telehealth-women-disposition-comments.pdf
    June 16, 2022 - marginalized populations, for example in the excluded study Glass et al., approximately 40% of the sample … They are not a representative sample of the broader patient base. … And ignores unrepresentativeness of sample who participate in telehealth studies. … and national NZ sample) is problematic as the review includes two later studies that are examining … They are not a representative sample. Issue now addressed.

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