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effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism_disposition-comments.pdf
November 01, 2010 - With the assistance of
our technical experts, we selected a minimum sample size of 10 in
order to maximize … of
the Autism Diagnostic Interview - Revised in 2003 allowed
researchers to introduce metrics of sample … We have added rationale about our decisions regarding sample size
to the Methods section of the review … Thank you for your comment
Methods It was not clear from the EPC report why 10 was
used as a sample … By admitting "case study and
case-control designs" but excluding all "behavioral
studies with sample
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research-protocol.pdf
September 02, 2016 - This spreadsheet will capture basic intervention, outcome,
study design, sample size, and whether results … evidence map to include data on study design,
intervention type and duration, population, outcomes, and sample … We quantify such impact as a potential increase
in total study population sample size (>20%), a change … Estimating effect size under publication bias: small sample
properties and robustness of a random effects … With input from the TEP, study-design and sample-size filters will be
implemented, as needed, to contain
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effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-march-2023-grand-rounds-slides.pdf
January 01, 2023 - 8 2 19
Pre/Post† 11 0 0 3 14
Total 19 25 12 28 84
Study Design Considerations con’t
Study Sample … Sizes
• Sample size requirements vary by study purpose (establishing superiority vs. … equivalence)
• Sample size requirements vary by outcome measure, and baseline risk for the
outcome … data
• More common reason for low or insufficient rating
• Precision
• Often low due to inadequate sample … common: weaker study designs are common
- Lack of control for confounders
• Next most frequent: small sample
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
September 25, 2013 - We
agree that number of studies and sample size of each can
affect the performance of heterogeneity … The blood sample is further centrifuged at
higher speed to isolate platelet poor plasma (PPP). … Manipulation Required Prior to Measurement; Sample Matrix;
Materials Required; Pre-analystic Sample … • Differences in sample matrix. LTA uses plasma; VASP and
VerifyNow use whole blood. … • Sample transport (the VerifyNow test is point‐of‐care and can
be performed at the location of sample
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effectivehealthcare.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_june_2012.pdf
January 01, 2012 - uses Fetal Nucleic Acid
Technology to detect and isolate circulating fetal DNA from a maternal blood sample … Sequenom states that circulating fetal DNA can be
obtained from a maternal blood sample very early … using Fetal Nucleic Acid Technology to detect and isolate circulating fetal DNA from a maternal
blood sample … Sequenom states that circulating fetal DNA can be obtained from a
maternal blood sample very early … comfort relative to invasive tests, and the ability of most physician’s offices to
perform blood sample
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/genetic-testing-developmental-disabilities_research-protocol.pdf
September 30, 2014 - For example, some case series may not
report the study sample size in the abstract; other studies (e.g … Screening for subtle chromosomal
rearrangements in an Egyptian sample of
children with unexplained … Linearity of tests is established by testing a dilution series of a positive sample. … stabilizer (where appropriate), cross-contamination during sample processing,
inclusion of normal, … after adding a known amount of that analyte to
the sample.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-256-telehealth-women-disposition-comments.pdf
June 16, 2022 - marginalized populations, for example in the excluded study Glass et al.,
approximately 40% of the sample … They are not
a representative sample of the broader patient base. … And ignores unrepresentativeness of sample who participate
in telehealth studies. … and national
NZ sample) is problematic as the review includes two later studies that are
examining … They are not a representative sample.
Issue now addressed.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19-appendix-table-B-1.xlsx
January 24, 2022 - Sample collection post-infection:
T0: 2 months
T1: 3 months
T2: 5 months
T3: 7 months
T4: 8 months
T5 … flourescent multiplex immunoassay
In-house cytopathic effect-based microneutralization test FMIA: A sample … A sample was considered positive for N-IgG when N-IgG concentration was ≥0.58 BAU/ml. … Cross-sectional NA - serosurvey with one sample HCW Health care workers and first responders in New York … with documented past infection Two positive RT-PCR samples ≥90 days apart or a new RT-PCR positive sample
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children-future_research.pdf
February 01, 2012 - fact that we are dealing with rare diseases and the associated difficulty in
attaining appropriate sample … recruitment of sufficient number
of practices willing to be
randomized can be a constraint,
so sample … List of recently published studies
Research Gap Study Study Objective Research
Design
Sample Size … of recently published studies (continued)
Research Gap Study Study Objective Research
Design
Sample … of recently published studies (continued)
Research Gap Study Study Objective Research
Design
Sample
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-databases-methods_research.pdf
May 01, 2008 - LTC) and other
characteristics of the sample (e.g., demographics). … Aripiprazole and clozapine were not used by anyone in the sample with ADRD. … Care Research Report Number 4
Discussion
This study used a large nationally representative sample … Limiting our sample to only claims would restrict it to those who received medical attention over
the … The prevalence of dementia in a statewide
sample of new nursing home admissions aged 65
and older:
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-executive-170505.pdf
May 01, 2017 - were generally
well conducted, evidence remains insufficient for most
interventions due to small sample … In our scan of a random sample
of 150 non-English abstracts retrieved by our MEDLINE
search, only two … size that would
have been excluded in our 2011 review (which required
a sample size of 30) in the … Limitations of the Evidence Base
As noted, studies in the review had small sample sizes and
typically … Sample size and participant
followup were frequently insufficient to allow firm
conclusions.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-use-disorder_research-protocol.pdf
February 24, 2016 - Specific
sample questions to be asked of the Key Informants based on perspective are listed below
in … Sample Questions for Key Informants
Key Informant
Perspective
Sample Questions
Researchers … A sample search strategy is listed below in Table 2. … Sample Search Strategy
1. Opiate Substitution Treatment/
2. … Data Element Details
Study characteristics Study design
Inclusion/exclusion criteria
Sample
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism_research-protocol.pdf
December 09, 2009 - While controlled trials seem to be increasing,
much research is observational, generally with small sample … symptoms
• Relevant outcomes must be able to be abstracted from
data presented in the papers
• Sample … After reviewing a sample of relevant articles, the Methods and Content Leads will design the
data collection … publication, study location (e.g., country, city, state) and time period, population description,
sample … will use established concepts of the quantity of evidence (e.g., numbers of studies,
aggregate ending sample
-
effectivehealthcare.ahrq.gov/sites/default/files/therapies-for-autism-spectrum-disorder-2-9-2010.pdf
January 01, 2010 - While controlled trials seem to be increasing,
much research is observational, generally with small sample … symptoms
• Relevant outcomes must be able to be abstracted from
data presented in the papers
• Sample … After reviewing a sample of relevant articles, the Methods and Content Leads will design the
data collection … publication, study location (e.g., country, city, state) and time period, population description,
sample … will use established concepts of the quantity of evidence (e.g., numbers of studies,
aggregate ending sample
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-draft-appendices.pdf
January 01, 2025 - 2012 Report3
First Author, Year 2025 Report Disposition
Ahlstrand, 19954 Excluded for ineligible sample … size (less than 30 per arm)
Ala-Opas, 19875 Excluded for ineligible sample size (less than 30 per arm … )
Barcelo, 19936 Excluded for ineligible sample size (less than 30 per arm)
Borghi, 19937 Excluded … size (less than 30 per arm)
Premgamone, 200125 Excluded for ineligible sample size (less than 30 per … for ineligible sample size (less than 30 per arm)
Scholz, 198228 Excluded for ineligible sample size
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatic-fibrosis_white-paper.pdf
April 01, 2014 - Sample of Letter Sent to Authors
1
Background
Liver fibrosis and cirrhosis refer to scarring … 60).
9, 24-43
See Appendix A for a
list of studies included in this report and Appendix B for a sample … measures of diagnostic accuracy were reported, but other necessary information
was missing (e.g., sample … Sample of Letter Sent to Authors
Dear Dr. _____________,
We are researchers at the Pacific Northwest … Sample of Letter Sent to Authors
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
April 01, 2010 - First, standard IV estimators possess a finite sample bias which is
inversely proportional to the F … whether the instruments are sufficiently strong.
10
As discussed in the appendix, the
finite sample … Split-sample
Instrumental Variables Estimates of the
Return to Schooling. … In small samples, IV estimators based on 2SLS possess substantial
finite sample bias. … methods.
56,57
Finite sample
bias is likely to be more of a problem in the presence of many weak
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/registries-guide_executive.pdf
April 01, 2007 - effect, should one exist, or achieve a desired level of precision is specified, whether
or not the sample … For example, a registry might compare a random sample of patient data
(e.g. 5 percent to 20 percent … of patients and specific data variables) with patient charts or with a sample of
registry sites based … • Rigor can be enhanced by external validation for a sample of data and/or data review by an adjudication … • For studies of safety, effectiveness, and comparative effectiveness, a sample of data are compared
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
March 01, 2018 - Comparison of the sample size, primary outcome, and withdrawals due to adverse
events reported in the … Two reviewers compared the planned sample size, the primary outcome, and the analysis
plan specified … • Comparison of prespecified statistical plan
• Sample sizes, total. … Sample
Size
Followup
Published
literature only
Karmakar, 201435 Not found NA NA NA 28 6 weeks … Sample
Size
Followup
Published
literature
only
Thienel,
200441a
Not found NA NA NA 1269
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-knee-future_research.pdf
February 01, 2013 - Large
sample sizes and the identification, measurement, and appropriate adjustment for confounding … Recruitment that includes sufficient
numbers of patients in select subgroups allows sample to better … A large sample will be required and follow-up should extend
beyond treatment duration. … A large sample will be
required and follow-up should extend beyond
treatment duration. … A large sample will be
required and follow-up should extend beyond
treatment duration.