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effectivehealthcare-admin.ahrq.gov/sites/default/files/analytic-frameworks.ppt
December 09, 2009 - DOI: 10.1016/s0749-3797(02)00415-4
http://www.ncbi.nlm.nih.gov/pubmed/11988383
Sample Working Framework … Sample Working Framework
Systematic reviews may examine the effects of screening, diagnosis, or treatment … DOI: 10.1016/s0749-3797(01)00261-6.
http://www.ncbi.nlm.nih.gov/pubmed/11306229
Sample Screening … Population
Intervention
Outcomes
Sample Screening and Treatment Framework
This slide is intended to
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effectivehealthcare-admin.ahrq.gov/sites/default/files/delilberative-methods-design-goold.pdf
January 11, 2017 - Recruiting/Selecting Participants
Slide 10
Recruiting/Selecting Participants
Susan Dorr Goold, MD, MHSA, MA
Professor of Internal Medicine and
Health Management and Policy
University of Michigan
Slide 11
Alternatives to Random Sampling
Substantive representation
o Based on extent to which groups a…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
December 01, 2012 - As shown in Table 6, this assay used microdissection of fixed, paraffin-embedded tissue
during sample … Handling
Sample Handling Technique for GEP Reliability (Reproducibility)
Time to Report
Results … Is there an effect of sample preparation, analysis, and/or tumor heterogeneity? … GEPs measure the activity or “expression” of multiple genes in a
single RNA sample, which may reflect … Sample size (number of patients/specimens)
o If samples are from previous studies, which studies?
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effectivehealthcare-admin.ahrq.gov/products/liver-cancer/research-protocol
December 01, 2019 - Sample Size
Studies with very small numbers of participants (n < 20) will not be included. … See Table 2 for a sample of the proposed search strategy. … Sample of proposed search strategy for Hepatocellular Carcinoma Imaging —Ovid MEDLINE® (1998–2013) … categories will be abstracted, including but not limited to: study design, year, setting, country, sample … We will also estimate publication bias by examining whether studies with smaller sample sizes tended
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/women-hiv_research-protocol.pdf
March 01, 2016 - menopause at an earlier age among HIV-infected women.4-9 However, many
of these studies have a small sample … We will include studies that have a sample size of at least 100. … Smaller sample sizes are
unlikely to result in precise estimates, and thus the utility of recording … Outlining Available Resources in A Purposeful Sample of Six States
We will outline which resources … appear to be available to older women who live with HIV in a
purposeful sample of six states, namely
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effectivehealthcare-admin.ahrq.gov/products/women-hiv/technical-brief
March 01, 2020 - We outline resources that are available to these women in a purposeful sample of six States (Rhode Island … In the sample of States, we found more HIV resources (testing, housing, medical and mental health, and
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
February 01, 2012 - Sample Size Estimates for Various Clinical Scenarios of Sensitivity and Specificity
With an Assumed … Sample Discussion Thread: Diagnosis ................................................................. … Sample Size Calculations For an RCT of Screening Versus no Screening for
Postoperative Complications … Due to its rarer occurrence, a mortality outcome would necessitate a larger sample size than
for an … Assuming a power of 90 percent,
the required total sample size (1:1 ratio in a two-arm RCT) for each
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/asd-interventions-disposition.pdf
May 26, 2017 - Peer
Reviewer #7
Methods Almost all of the studies reviewed are noted to have "small" sample size, … Moreover, most
studies noted as a limitation their small sample
size. … We selected a minimum sample size of 10 for
RCTs because we felt that the typically greater
controls … for bias and rigor helped to mitigate
limitations of a smaller sample size. … We scanned a random sample of non-English
abstracts (n=150) and identified few eligible
items.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/study-eligibility-criteria.ppt
January 01, 2000 - studies only)
Study population size (N > 200)
Study design (randomized controlled trials)
Some Sample … Sometimes it is helpful for the team to set criteria, then do a sample set of reviews, and reconvene … Publication
Using the Criteria
The rest of this module contains a number of questions and some sample … Exercise 3: Impact of Study-Size Criteria on Excluded Studies
The research team required a minimum sample … Studies
Based on expert opinion and a preliminary review of the literature, the team set a minimum sample
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
January 01, 2014 - (a) Do the differences in performance measures vary with sample characteristics? … (a) Do the differences in performance measures vary with sample characteristics? … The lower limit of
detection of the stool real-time PCR was 30 CFU/ml of
stool sample per reaction … (ID C. difficile
prototype [IDCd]) for
isolation of C. difficile
compared using three
different sample … (a) Do the differences in performance measures vary with sample characteristics?
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/asd-medical-disposition.pdf
May 26, 2017 - TEP Reviewer
#4
Methods Almost all of the studies reviewed are noted to have "small" sample
size, … Moreover, most studies noted as a
limitation their small sample size. … for
bias and rigor helped to mitigate limitations of a
smaller sample size. … Manufacturer-funded studies
also tend to have larger sample sizes than many academic studies. … We scanned a random sample of non-English
abstracts (n=150) and identified few eligible items.
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effectivehealthcare-admin.ahrq.gov/health-topics/pneumocystis-infections
To diagnose PCP, doctors use a microscope to look for the fungus in a sample of lung fluid or tissue.
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effectivehealthcare-admin.ahrq.gov/products/renal-cancer/research-protocol
December 01, 2019 - Renal mass sampling can be done by fine needle aspiration with a reading of the sample by a cytopathologist … , or by core biopsy with a reading of the sample by a surgical pathologist. … A third reviewer will audit a random sample of articles by the first two reviewers to ensure consistency … studies
Domain
Question
Domain 1: Patient Selection
Was a consecutive or random sample
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effectivehealthcare-admin.ahrq.gov/products/adhd/research-protocol
December 01, 2019 - Sample size
There are no restrictions for study sample size. … Prior to performing the data extraction, a calibration exercise will be conducted using a random sample … data will include study characteristics (e.g., first author, country of research origin, study design, sample … history of treatment(s), age of first diagnosis, etc), study outcomes (both of benefit and of harm), sample … explore the impact of key methodological study limitations, in particular 1) percent of withdrawals, 2) sample
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effectivehealthcare-admin.ahrq.gov/sites/default/files/c-diff-infections-nomination-140925.pdf
February 19, 2014 - (a) Do the differences in performance measures vary with sample characteristics? … § Do the differences in performance measures vary with sample characteristics?
§ KQ 2.
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effectivehealthcare-admin.ahrq.gov/products/congestive-heart-failure-medicines/research
January 01, 2020 - However, the effectiveness of H-ISDN in a community sample of African-Americans and other racial/ethnic … We excluded 366,249 patients (62% of the total) and took a random sample of 20% of Whites (excluding … Our sample was >98% male, limiting the generalizability of our findings to women. … We also excluded approximately 20% of our sample who lacked racial or ethnic identifiers, as well as … This large sample allowed us to evaluate outcomes in multiple subgroups.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/adhd-future_research.pdf
May 01, 2012 - Sample size is another important consideration in planning future research. … sample
size issues after the detailed descriptions of each research need. … See the following section regarding
sample size estimates. … See Table 3 in sample size section. … Each sample size was determined by generating
2,000 simulated datasets and identifying the minimum sample
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effectivehealthcare-admin.ahrq.gov/products/peripheral-artery-disease-effectiveness/abstract
December 01, 2019 - Detailed chart review will be conducted on a random sample of patients (n=3500) from the registry togather … effectiveness analyses comparing surgical versus endovascular approaches will focus on the chart review sample
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effectivehealthcare-admin.ahrq.gov/products/pressure-ulcer-treatment/research
December 01, 2019 - These studies examined a wide range of interventions, but sample sizes often were small. … Future research with larger sample sizes, more rigorous adherence to methodological standards for clinical
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effectivehealthcare-admin.ahrq.gov/products/improving-evidence-synthesis/white-paper
April 01, 2021 - data sources: a literature review for relevant publications and frameworks, a review of a convenience sample … In the purposive sample of 43 systematic reviews, the use of the term "insufficient" covered both instances