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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_executive.pdf
    September 19, 2014 - risk prediction instruments, we attempted to create two-by-two tables from information provided (sample … risks (RR) and associated 95 percent confidence intervals (CI) based on the information provided (sample … , the country in which the study was conducted, the characteristics of the patient sample (e.g., age … Substance use disorders in a primary care sample receiving daily opioid therapy. … Addiction Severity Index in a chronic pain sample receiving opioid therapy.
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/heart-failure-natriuretic-peptide_research-protocol.pdf
    December 20, 2011 - Prior to performing the data extraction, a calibration exercise will be conducted using a random sample … The following will also be extracted: blood sample type for BNP measurement (plasma or serum), assay … accuracy outcomes, and the effect size for treatment monitoring; this domain is related to study sample … Loss to follow-up (from sample to study population) is not associated with key characteristics (i.e. … , the study data adequately represent the sample), sufficient to limit potential bias.
  3. effectivehealthcare-admin.ahrq.gov/products/antipsychotics-children-update/research-protocol
    April 01, 2020 - We do not have a minimum sample size for inclusion, nor do we have a minimum threshold for extent of … The modified form will be pilot tested using a sample of the original CER's studies by all review team … For dichotomous outcomes, we will report counts or proportions, and sample size, by study arm. … We will assess precision (precise or imprecise) on the basis of sample size and, if size is adequate … Where there are at least ten studies having variable sample sizes in a meta-analysis, we will analyze
  4. effectivehealthcare-admin.ahrq.gov/products/hemorrhage-postpartum/research-protocol
    December 01, 2019 - We will not require a minimum sample size for comparative studies addressing Key Questions 1-4. … For estimating sample size, we used the one-tailed z-test and the t-test. … and the possibility of an effect size for continuous outcomes as large as 0.80 or more, the smallest sample … of the numerous possible harm outcomes and study designs, we were not able to determine a specific sample … that balances the need for smaller studies of specialized populations with the need for studies with sample
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
    June 15, 2010 - Sample size: There are no restrictions for study sample size. … Prior to performing the data extraction, a calibration exercise will be conducted using a random sample … will include study characteristics (e.g., first author, country of research origin, study design, sample … size, sample size calculation or power estimate); clinical indications; and study duration or length … Source: www.effectivehealthcare.ahrq.gov Published Online: June 15, 2010 withdrawals; 2) sample
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/autism-adolescents_research-protocol.pdf
    March 29, 2011 - A cutoff sample size of 20 provides a balance, allowing us to review and comment on adequate literature … In particular, the TEP noted that a sample size of 20 for studies of all types of interventions (e.g … ., medical, behavioral, etc.) takes into account the typically smaller sample sizes in the ASD literature … After reviewing a sample of relevant articles, the Methods and Content Leads will design the data-collection … publication, study location (e.g., country, city, state) and time period, population description, sample
  7. effectivehealthcare-admin.ahrq.gov/products/racial-disparities-health-healthcare/protocol
    March 01, 2023 - CQ 4: Select a sample of approximately 5-10 healthcare algorithms and algorithm-informed decision tools … CQ 4 To address CQ 4, we will identify and select sample algorithms, abstract relevant data, and appraise … Algorithm sample identification and selection. … Figure 3: Framework for algorithm sample selection and data abstraction Algorithm appraisal. … Each sample algorithm will be evaluated qualitatively or quantitatively, as feasible, to determine the
  8. effectivehealthcare-admin.ahrq.gov/products/patient-safety-telehealth/protocol
    July 01, 2023 - A second team member will check a 10% sample of citations to verify that important studies were not excluded … A second team member will check a 10% sample of the full text reviews to verify that important studies
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/abnormal-uterine-bleeding_research-protocol.pdf
    November 21, 2011 - We will not stipulate a minimum study sample size for included clinical research studies. … Ideally, studies will include an explanation of the sample size analysis (e.g., power calculation … Assessments of individual study eligibility based upon sample size will be conducted and fully described … of publication, study location (e.g., city, state), enrollment period, population description, sample … use established concepts of the quantity of evidence (e.g., numbers of studies, aggregate ending-sample
  10. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-266-cdd-app-tabs-D2-D5.xlsx
    January 01, 2008 - RoB NRSI Author, Year Did the Study Attempt To Enroll All (or a Random Sample of) Patients Meeting Inclusion … Criteria (Inception Cohort), or a Consecutive Sample? … Diagnostic Accuracy Author, Year Cohort: Consecutive or Random Sample?
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-infertility_research.pdf
    June 01, 2017 - other trial registration numbers and then trial characteristics, including: condition, intervention, sample … Two trials with a combined sample size of 340 patients were completed more than 3 years ago, indicating … Three studies did not report the sample size in CT.gov and thus were classified as discrepant. … Both trials were applicable to KQ 1 and had a combined sample size of 340 patients.
  12. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
    July 13, 2011 - head-to- head comparisons: double-blind, placebo-controlled RCTs Minimum study duration 6 weeks Sample … fair quality, controlled observational studies Minimum study duration For all studies: 3 months Sample … studies: 3 months Study population Adult inpatients and outpatients with recurrent depression Sample … inpatients and outpatients with major depressive disorder, dysthymia, or subsyndromal depression Sample
  13. effectivehealthcare-admin.ahrq.gov/products/menopause/research-protocol
    December 01, 2019 - different target population (the treatment indication being chronic disease prevention in the study sample … series Exclude Case reports Exclude Minimum duration 5 years b 1 year c Sample … series Exclude Case reports Exclude Minimum duration 5 years a 1 year b Sample … Include Case reports (life-threatening events) Include Minimum duration None Sample … series Exclude Case reports Exclude Minimum duration 5 years a 1 year b Sample
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/joint-replacement-disposition-comments.pdf
    November 03, 2021 - significant benefit when two active forms of treatment are compared (compounded by the issues of small sample
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/medical-test-reviews-genetic.ppt
    June 01, 2012 - Factors Obtaining, preserving, and storing samples before analysis Analytic Factors Type of assay, sample … Analytic variables include the type of assay chosen and its reliability, the type of sample, the methods … term=12181099 DNA-Based Assays Analyze the DNA itself Use a variety of sample sources (e.g., blood … A variety of DNA sample sources are available, such as blood, cheek swabs, and hair. … term=19141767 Sample Size Calculations It is important to assess whether sample size calculations
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/medical-test-reviews-genetic.ppt
    June 01, 2012 - Factors Obtaining, preserving, and storing samples before analysis Analytic Factors Type of assay, sample … Analytic variables include the type of assay chosen and its reliability, the type of sample, the methods … term=12181099 DNA-Based Assays Analyze the DNA itself Use a variety of sample sources (e.g., blood … A variety of DNA sample sources are available, such as blood, cheek swabs, and hair. … term=19141767 Sample Size Calculations It is important to assess whether sample size calculations
  17. effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/racial-disparities-health-healthcare-protocol.pdf
    January 06, 2022 - CQ 4: Select a sample of approximately 5-10 healthcare algorithms and algorithm-informed decision tools … Insufficient sample size 10 10. Labeling bias Model Training / Development 11. … CQ 4 To address CQ 4, we will identify and select sample algorithms, abstract relevant data, and … Algorithm sample identification and selection. … Figure 3: Framework for algorithm sample selection and data abstraction Algorithm appraisal.
  18. S50 (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/s50.pdf
    October 01, 2007 - RCTs use relatively simple computations and fairly small sample sizes, which were well suited to the … enormous resources are expended to locate individuals who meet selection criteria and achieve desired sample … For example, PBE-CPI studies to date have had sample sizes ranging from 1000 to 2500 patients and have … RCTs with similar sample sizes can cost more than 20 times as much and answer only a few questions. … Models for sample selection bias. Annu Rev Sociol. 1992;18:327–350. 13. Newhouse JP, McClellan M.
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0255_06-25-2010.pdf
    January 01, 2010 - identified that comprehensively examine the role of all possible intravascular techniques with a literature sample
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/diabetes-behavior-programs_disposition-comments.pdf
    September 28, 2015 - Peer Reviewer 1 Methods It is not clear whether the mean differences were weighted by sample size and … If not, then small and large studies Studies were weighted by sample size and variance. … T2DM based on whether the majority of the sample (>75%) were of one disease is somewhat questionable … Peer Reviewer 4 Results Table 10, I would suggest to adding the sample size in each node. … We have added the sample sizes.

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