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101. Comparative Effectiveness of Treatments for Noncyclic Chronic Pelvic Pain in Women | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/pelvic-pain/research-protocol
     December 01, 2020 - acceptable study size, we will use 100% Loss to follow-up: varies by study, to maximize acceptable sample … size Sample size: for an RCT with 2 groups, with 100% meeting criteria for CPP, with 0% loss to follow-up … Null hypothesis of effect size of 30%: need 176 per group, 352 total sample size would be smallest … acceptable Therefore, a conservative lower limit for sample size can be set at 50, to account for … of publication, study location (e.g., country, city, state) and time period, population description, sample

102. Chapter 11: Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-genetic/methods
     December 01, 2019 - reliability, types of samples, the specific analyte investigated, specific genotyping methods, timing of sample … DNA-based molecular methods and those using phenotypic assays. 16–18 For DNA-based tests, a variety of sample … discussion of this topic as it relates to genetic association studies has been published elsewhere. 36–37 Sample … Size Calculations When assessing internal validity of studies, it is important to assess whether sample

103. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/adhd_research-protocol.pdf
     August 10, 2010 - Sample size There are no restrictions for study sample size. … Published Online: August 10, 2010 extraction, a calibration exercise will be conducted using a random sample … will include study characteristics (e.g., first author, country of research origin, study design, sample … history of treatment(s), age of first diagnosis, etc), study outcomes (both of benefit and of harm), sample … explore the impact of key methodological study limitations, in particular 1) percent of withdrawals, 2) sample

104. Management of Renal Masses and Localized Renal Cell Carcinoma: Current State of the Evidence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/renal-cancer/clinician
     December 01, 2019 - Local recurrence-free survival 2 (217) Better results with RN, but all studies had a small sample

105. Research White Paper Managing Missing Data in Patient Registries Addendum Registries for Evaluating Patient Outcomes Third Edition (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
     February 01, 2018 - truncation results in data missing in the observed cohort due to non-enrollment, leading the study sample … However, limiting the registry enrollment to only those newly diagnosed patients would reduce the sample … Attaining and investigating a sample of data is also a good approach, as this may inform researchers … A review of the codes contained within the sample data should be performed to understand if different … Attaining and investigating a sample of data is critical to capturing these differences and ensuring

106. Disposition of Comments: CER 224, Treatment of Depression in Children and Adolescents: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-224-depression-children-comments.pdf
     April 10, 2020 - for non- pharmacological interventions was based on single (as opposed to pooled) RCTs with small sample … “Depression Chronicity: In a sample with comorbid depression and substance use disorder, those with … age >12 and ≤18]: RCTs, children [sample age ≤12]) to capture all available evidence.” … I may have missed where sample sizes were characterized—so was surprised in Table 7 to learn that Ns … There is no distinction between sample sizes in the hundreds and those with 10 or so per group- all

107. Liver-Cancer Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
     July 24, 2013 - Sample Size Studies with very small numbers of participants (n < 20) will not be included. … See Table 2 for a sample of the proposed search strategy. … Sample of proposed search strategy for Hepatocellular Carcinoma Imaging — Ovid MEDLINE® (1998–2013) … categories will be abstracted, including but not limited to: study design, year, setting, country, sample … We will also estimate publication bias by examining whether studies with smaller sample sizes tended

108. Renal-Cancer Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/renal-cancer_executive.pdf
     February 01, 2016 - Percutaneous renal mass sampling can be performed by fine needle aspiration with a reading of the sample … evidence included 2 prospective studies and 18 retrospective observational studies that ranged in sample … dNonrandomized studies must have a minimum sample size of 500 participants. Table A. … insufficient to identify any other strong predictors of malignant versus benign pathology in this sample … The presence of an on-site pathologist to assess the adequacy of the sample was also not universally

109. Renal-Cancer Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
     April 20, 2015 - Renal mass sampling can be done by fine needle aspiration with a reading of the sample by a cytopathologist … , or by core biopsy with a reading of the sample by a surgical pathologist. … A third reviewer will audit a random sample of articles by the first two reviewers to ensure consistency … of bias in diagnostic accuracy studies Domain 1: Patient Selection Was a consecutive or random sample

110. Methods Guide for Medical Test Reviews Chapter 11 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-genetic_methods.pdf
     July 01, 2012 - reliability, types of samples, the specific analyte investigated, specific genotyping methods, timing of sample … DNA-based molecular methods and those using phenotypic assays.16–18 For DNA-based tests, a variety of sample … discussion of this topic as it relates to genetic association studies has been published elsewhere.36–37 Sample … Size Calculations When assessing internal validity of studies, it is important to assess whether sample

111. Cer-276-Ocd-Appendix-G (xls file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-276-ocd-appendix-g.xlsx
     January 01, 2022 - 0.52 52 111 3 6 7 none NA 37431399 Lambe 2021 DWS TOCS TOCS max average one off 1 discovery sample … 0.88 128 38 3 161 330 none NA 37431399 Lambe 2021 DWS TOCS TOCS total score one off 1 validation sample … Key Question 1: Quality PMID first_author Year Extractor Was a Consecutive or Random Sample of Patients … : We should discuss studies that enroll at least one clinical sample, e.g. … Lambe, AND a control sample. -Dale Steele Did All Patients Receive the Same Reference Standard?

112. App-D-Opioid-Chronic-Pain-Surveillance-Report-3 (xls file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveillance-report-3.xlsx
     September 30, 2015 - controlled trials Author, Year Study Design Duration Setting Country Eligibility Criteria Interventions Sample … Oral methadone (30 to 60 mg daily) (9 assigned, 6 f/u) Overall sample: Mean age: 41 years Female sex: … B (unmatched sample) Mean age (SD): 55.6 (13.22) vs. 58.2 (12.82) years Female sex: 9.88% vs. 9.49% … ); 38,716 (matched sample) Visit counts for physical therapy, pain clinics, chiropractic care, primary … HR 1.19 (95% CI 1.06 to 1.35) Insurance Fair Salkar, 2021 Case-control, Medicare 5% National Sample

113. Genetic Testing for Developmental and Intellectual Disabilities | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/genetic-testing-developmental-disabilities/research-protocol
     December 01, 2019 - For example, some case series may not report the study sample size in the abstract; other studies (e.g … Screening for subtle chromosomal rearrangements in an Egyptian sample of children with unexplained mental … Linearity of tests is established by testing a dilution series of a positive sample. … tissue with the diseased tissue of interest, tissue from a source additional to the desired sample ( … after adding a known amount of that analyte to the sample.

114. Cystic-Fibrosis-Hgh Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
     August 01, 2012 - In addition, the study was not published in a pivotal journal, and the sample size was not larger than … Evidence Table Article ID / Cohort/First Author/Year Participants (age, sex, condition)/ Sample … Article ID / Cohort/First Author/Year Participants (age, sex, condition)/ Sample size Inclusion … Article ID / Cohort/First Author/Year Participants (age, sex, condition)/ Sample size Inclusion … Article ID / Cohort/First Author/Year Participants (age, sex, condition)/ Sample size Inclusion

115. Machine-Learning-Tools-Appendix-C (xls file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/machine-learning-tools-appendix-c.xlsx
     January 01, 2024 - Because we used a convenience sample, the findings may be prone to selection bias. … Because we used a convenience sample, the findings may be prone to selection bias. … Because we used a convenience sample, the findings may be prone to selection bias. … Because we used a convenience sample, the findings may be prone to selection bias. … Because we used a convenience sample, the findings may be prone to selection bias.

116. Transcript Deliberativemethodswebinar (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/transcript_deliberativemethodswebinar.pdf
     April 19, 2012 - And the reason, generally, for a random sample of participants in a project, whether it’s a research … or a policy project or whatever, is to have a proportionally- representative sample of the population … Then a random sample should get you a statistically-proportional sample that represents, in various … So I guess what I would say is -- next slide -- that there are -- So that’s why you use a random sample … , not just the statistical representativeness of your sample, if you will.

117. Making Healthcare Safer IV Rapid Response_Active Surveillance Culturing of Clostridioides difficile and Multidrug-Resistant Organisms: Methicillin-Resistant Staphylococcus aureus, Carbapenem-Resistant Enterobacterales, and Candida auris (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs4-active-infection-rapid-response.pdf
     May 01, 2024 - A randomly selected 10 percent sample of excluded references were checked by a second reviewer at the … A second team member checked a 10 percent sample of citations to verify that important studies were … A second team member checked a randomly selected 10 percent sample of the excluded citations at full-text … Sample times for surveillance of S. aureus transmission to monitor effectiveness and provide feedback … Sample sizes for surveillance of S. aureus transmission to monitor effectiveness and provide feedback

118. Rapid-Reviews-End-User White-Paper (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/rapid-reviews-end-user_white-paper.pdf
     April 01, 2016 - Sample Rapid Products From an initial list of 11 recently completed (within the past 2 to 3 years) EPC … While based on a small sample, this project suggests that some discussion within the EPC program may … However, our small sample size means that results may not be representative of all end-users and we … Can you take a look at the sample of rapid review products we provided (see Table and attachments): … Evidence Inventory Sample Acetylsalicylic Acid for Venous Thromboembolism Prophylaxis: an Update

119. Fibromyalgia Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/fibromyalgia_executive.pdf
     January 01, 2015 - At baseline, MDD subgroup sample sizes were small in all RCTs, excluding the pooled IPD RCT analyses … Sample sizes were small. … Adverse Effects Reporting None of the 10 mixed-sample RCTs with subgroup outcomes separately reported … In general, sample selection criteria were restrictive, and the extent to which such select patient … Sample selection criteria were most restrictive for pharmaceutical studies that excluded adults with

120. Transparency of Reporting Requirements: Tympanostomy Tubes | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/transparency-tympanostomy/research-protocol
     March 01, 2021 - This spreadsheet will capture basic intervention, outcome, study design, sample size, and whether results … evidence map to include data on study design, intervention type and duration, population, outcomes, and sample … We quantify such impact as a potential increase in total study population sample size (>20%), a change … Estimating effect size under publication bias: small sample properties and robustness of a random effects … With input from the TEP, study-design and sample-size filters will be implemented, as needed, to contain