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21. Evidence Summary: Prevention of Acquisition of HIV: Preexposure Prophylaxis | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/prevention-of-human-immunodeficiency-virus-hiv-infection-pre-exposure-prophylaxis
    August 22, 2023 - Randomized trial of clinical safety of daily oral tenofovir disoproxil fumarate among HIV-uninfected … Safety and adherence to intermittent pre-exposure prophylaxis (PrEP) for HIV-1 in African men who have … Safety and efficacy of a dapivirine vaginal ring for HIV prevention in women. … Safety and feasibility of antiretroviral preexposure prophylaxis for adolescent men who have sex with … Risk, safety and sex among male PrEP users: time for a new understanding.

22. Screening Women for Intimate Partner Violence: A Systematic Review to Update teh 2004 USPSTF Recommendation (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/MjwZ4vRLZDVUSnfMA6SrDo
    June 01, 2012 - Counseling for IPV emphasized safety behaviors and information on community resources. … Counseling for IPV emphasized safety behaviors and information on community resources. … Counseling for IPV emphasized safety behaviors and information on community resources. … Compared with baseline, both groups adopted more safety behaviors by 24 mo. … Some women commented on the need for privacy and safety and had concerns about direct IPV questions.

23. Archived: Prevention of Human Immunodeficiency Virus (HIV) Infection: Preexposure Prophylaxis | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/prevention-of-human-immunodeficiency-virus-hiv-infection-pre-exposure-prophylaxis-june-2019
    June 11, 2019 - Research is needed on the safety and effectiveness of PrEP during pregnancy and breastfeeding. … Research is also needed on the long-term safety and effectiveness of PrEP. … Safety and feasibility of antiretroviral preexposure prophylaxis for adolescent men who have sex with … Randomized trial of clinical safety of daily oral tenofovir disoproxil fumarate among HIV-uninfected … An HIV preexposure prophylaxis demonstration project and safety study for young MSM.

24. Screening for Intimate Partner Violence and for Caregiver Abuse of Older and Vulnerable Adults: An Evidence Report and Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/RrE4_peSk5zVH3cCf77at3
    June 24, 2025 - the key questions that the review will address to allow the USPSTF to evaluate the effectiveness and safety … information about re- ferral options and an additional clinical assessment was conducted to assess safety … , and received information about referral options Women with a positive response to safety questionsb … If questions indicated a safety concern, the ED clinician was notified and a referral was made to the … Safety-promoting behaviors of community-dwelling abused Chinese women after an advocacy intervention:

25. Archived: Evidence Summary: Tobacco Smoking Cessation in Adults, Including Pregnant Women: Behavioral and Pharmacotherapy Interventions | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/behavioral-counseling-and-pharmacotherapy-interventions-for-/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions-september-2015
    September 21, 2015 - Purpose: To review the effectiveness and safety of pharmacotherapy and behavioral interventions for … Data on the effectiveness and safety of electronic nicotine delivery systems are limited. … smoking cessation, 8-13 our review also synthesized the primary trial evidence on the efficacy and safety … decided a priori to conduct a de novo search for primary evidence related to the effectiveness and safety … Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta-analysis.

26. Archived: Tobacco Smoking Cessation in Adults, Including Pregnant Women: Behavioral and Pharmacotherapy Interventions | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions-september-2015
    September 21, 2015 - direct patients who smoke tobacco to other cessation interventions with established effectiveness and safety … ENDS may be used as an option for quitting conventional smoking, further research is needed on the safety … In 2012, the FDA issued a safety communication indicating a nonsignificant increase in major adverse … EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes subsitute: a prospective … Chantix (varenicline): safety communication—updated safety review on the risk of cardiovascular adverse

27. Screening for Intimate Partner Violence and Abuse of Elderly and Vulnerable Adults: USPSTF Recommendation Statement (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/aSTzfuKHZtT8_PjfJjuck5
    March 01, 2013 - Counseling generally includes infor- mation on safety behaviors and community resources. … One study used a 20-minute nurse case management protocol focusing on a safety plan, supportive care, … Intimate partner violence introduces significant safety issues that compel a provider to be fully informed … Research is needed in all areas related to screening and treatment in men, as well as re- porting, safety … The counseling emphasized safety behaviors and information on community resources.

28. Archived: Final Evidence Review: Genital Herpes: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-review55/genital-herpes-screening-2005
    March 15, 2005 - Safety profiles for all treatments were comparable. … Safety profiles were comparable between groups. … Safety profiles between groups were comparable. … The study did not examine safety of the neonate. … The study did not examine safety of the neonate.

29. Screening for Genital Herpes Simplex: A Brief Update (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/ZzZp7_aoJn73k9z25w_-qr
    March 01, 2005 - There is limited evidence of acyclovir use and safety during pregnancy. … The safety of valacyclovir and placebo were comparable, with adverse experiences being infrequent and … Safety profiles for all treatments were comparable. Good Table 2. … Neonatal outcomes were similar between groups, and the study did not examine neonatal safety. 16 … There is limited evidence on the safety of antiviral treatments during pregnancy.

30. Reconsidering the Approach to Prevention Recommendations for Older Adults - Figure 2 | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/reconsidering-approach-prevention-recommendations-older-adults-figure-2
    December 01, 2010 - fall hazards, adding grab bars and handrails, and modifying the environment to improve mobility and safety

31. Preexposure Prophylaxis for the Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statement (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/poDYcagnw7SqKNNbrFt_CV
    June 11, 2019 - Research is needed on the safety and effectiveness of PrEP during pregnancy and breastfeeding. … Research is also needed on the long- term safety and effectiveness of PrEP. … Safety and feasibility of antiretroviral preexposure prophylaxis for adolescent men who have sex with … Randomized trial of clinical safety of daily oral tenofovir disoproxil fumarate among HIV-uninfected … An HIV preexposure prophylaxis demonstration project and safety study for young MSM.

32. Archived: Evidence Summary: NSAIDs: Aspirin/NSAIDs for Prevention of Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nsaids/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication-2007
    March 15, 2007 - These developments have resulted in uncertainty about the safety of COX-2 inhibitors and non-ASA NSAIDs … Outcome trials of COX-2 selective inhibitors: global safety evaluation does not promise benefits. … Celecoxib Long-term Arthritis Safety Study. JAMA 2000;284:1247-55. [PMID: 10979111] 75. … Celecoxib Valdecoxib Cardiovascular Safety. … Arthritis & Drug Safety and Risk Management Advisory Committee Briefing Package.

33. Nonsteroidal Anti-inflammatory Drugs and Cyclooxygenase-2 Inhibitors for Primary Prevention of Colorectal Cancer: A Systematic Review (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/EppFbhnDEX5UtYWrTkLEhT
    March 01, 2007 - These develop- ments have resulted in uncertainty about the safety of COX-2 inhibitors and non-ASA NSAIDs … Outcome trials of COX-2 selective inhibitors: global safety evaluation does not promise benefits. … Celecoxib Long-term Arthritis Safety Study. JAMA. 2000;284: 1247-55. [PMID: 10979111] 75. … Celecoxib Valde- coxib Cardiovascular Safety. … Arthritis & Drug Safety and Risk Management Advisory Committee Briefing Package.

34. Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons: Clinician Summary of USPSTF Recommendations (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/fUBAvD-8M4xWhBsdqvpsvf
    January 01, 2021 - Clinicians should direct patients to other cessation interventions with proven effectiveness and established safety

35. Final Research Plan: Chronic Obstructive Pulmonary Disease: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/chronic-obstructive-pulmonary-disease-screening
    October 08, 2020 - Study Designs KQs 1, 2: RCTs KQ 3: RCTS included for KQ2, large registry studies of drug safety

36. Preexposure Prophylaxis for the Prevention of HIV: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/KFZpoMBYuoo8TRW6nhRev8
    October 23, 2023 - levels at lower tenofovir se- rum levels, potentially increasing effectiveness and bone and kid- ney safety … Randomized trial of clinical safety of daily oral tenofovir disoproxil fumarate among HIV-uninfected … Safety and efficacy of a dapivirine vaginal ring for HIV prevention in women. … Safety and feasibility of antiretroviral preexposure prophylaxis for adolescent men who have sex with … Risk, safety and sex among male PrEP users: time for a new understanding.

37. Archived: Evidence Summary: Cognitive Impairment in Older Adults: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary28/cognitive-impairment-in-older-adults-screening-2014
    October 22, 2013 - The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicentre … Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre … Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia … Long-term efficacy and safety of celecoxib in Alzheimer's disease. … Comparative cardiovascular safety of dementia medications: a cross-national study.

38. Screening for Hepatitis C Virus Infection in Adolescents and Adults: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/WEqCV3NvnZAeLdC_pp6nVK
    October 01, 2018 - Efficacy and safety of ombitasvir/paritaprevir/r and dasabuvir compared to IFN-containing regimens in … Efficacy and safety of elbasvir/grazoprevir in participants with hepatitis C virus genotype 1, 4, or … Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus genotype 5 … Efficacy and safety of 12 weeks of elbasvir ± grazoprevir ± ribavirin in participants with hepatitis … Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (

39. Evidence Summary: Tobacco Smoking Cessation in Adults, Including Pregnant Persons: Interventions | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions
    January 19, 2021 - Objective: To systematically review the effectiveness and safety of pharmacotherapy, behavioral interventions … Data on the effectiveness and safety of electronic cigarettes for smoking cessation among adults are … Data on the effectiveness and safety of electronic cigarettes for smoking cessation among adults are … Efficacy and safety of varenicline for smoking cessation in schizophrenia: a meta-analysis. … Correction: EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute

40. Screening for and Management of Obesity in Adults: USPSTF Recommendation Statement (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/Bd9Cgr5WNueNbmfsPxUKDP
    September 01, 2012 - harms of orlistat because of recent FDA reports of rare severe liver disease and a lack of long-term safety … possible harms of orlistat because of recent FDA reports of severe liver disease and a lack of long-term safety … FDA Drug Safety Communication: Completed Safety Review of Xenical/Alli (Orlistat) and Severe Liver Injury