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Showing results for "safety".
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361. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
     September 01, 2011 - may increasingly lead to long-term disease remission, there are many unanswered questions about the safety … How do the efficacy, effectiveness, safety, and adverse effects of treatment with DMARDs differ among … How do the efficacy, effectiveness, Insufficient Only one study—an RCT of methotrexate versus safety, … We did not identify any studies that provide reliable information on the comparative safety or rates

362. Supplemental Project To Assess the Transparency of Reporting for Trials Evaluating Treatment for Infertility (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-infertility_research.pdf
     June 01, 2017 - The objectives of this SR are to evaluate the comparative safety and effectiveness of treatment strategies … The KQs are listed below: KQ 1: What are the comparative safety and effectiveness of available treatment … KQ 2: What are the comparative safety and effectiveness of available treatment strategies for women … KQ 4: What are the comparative safety and effectiveness of available treatments for women with tubal

363. Comparative Effectiveness of Adjunctive Devices to Remove Thrombi or Protect Against Distal Embolization in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention of Native Vessels (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_disposition-comments.pdf
     March 01, 2012 - I think it is also important to note that safety is UNCLEAR given sparse data and lack of power. … Insufficient evidence compared between devices, and safety remains unclear. … Safety, because of potential type II error, is mostly unclear. … Due to type II error, the safety of these devices is unclear.

364. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/arthritis_hi_impact.pdf
     January 01, 2014 - IL-1 may be a problematic target with respect to safety in the gout patient population, however, and … and tolerability due to safety concerns over infections reported in trials thus far. … These safety concerns may present barriers to approval or barriers to diffusion if approved. … These safety concerns may present significant barriers to approval and diffusion if approved. … SLE: belimumab safety, efficacy sustained over 6 years. [internet].

365. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-emergency_research-protocol.pdf
     July 18, 2011 - Question 5 Does the effectiveness and safety of the parenteral pharmacological interventions vary … Question 6 Does the effectiveness and safety of adding parenteral or oral CSs to acute parenteral … Safety: RCTs, NRCTs, and prospective cohort studies. … Dodick D, Lipton RB, Martin V, et al, for the Triptan Cardiovascular Safety Expert Panel. … Consensus statement: cardiovascular safety profile of triptans (5-HT agonists) in the acute treatment

366. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0352_09-22-2010.pdf
     January 01, 2010 - depression treatment will be a good companion to an in-process AHRQ EHC Program review titled Efficacy and Safety

367. #14 SUBSTANCE ABUSE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - available at a discount, close to Federal Supply Schedule pricing, for colleges, universities, public safety … have unintended consequences, such as promoting continued opioid abuse by increasing the perceived safety … Each device has a sealed product indicator window; a removable needle safety guard; and the auto-injector … auto-injectors, the Evzio carton contains a “trainer” device, which has an identical size, shape, and safety … solution to a reference product; a user-experience study with adult and juvenile volunteers; and a safety

368. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_research-protocol.pdf
     October 18, 2010 - such as delay in delivery) are therefore common and meta-analyses are used to assess efficacy and safety … Further, they indicated that the lack of information on the safety of the treatment as well as the cost … Given the lack of efficacy, effectiveness, and safety data, as well as substantial cost, it is clear … Finally, published RCTs do not provide the necessary insight into questions regarding the safety of … Further, observational studies have been identified that explore issues of terbutaline safety.

369. Menopause Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_executive.pdf
     March 01, 2015 - Although no salient long term benefits were identified, neither were safety signals apparent. … Safety data are also needed for the broad array of herbs and botanicals used to treat menopausal symptoms … and efficacy, but the manufacturers are not required to submit the safety or efficacy data to FDA. … Although the gap is most concerning regarding safety, efficacy issues are important as well. … some nonhormone therapies, with reasonable certainty (i.e., moderate or greater SOE), significant safety

370. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol.pdf
     June 10, 2024 - adherence.96, 106-108 Purpose of the Review This systematic review will assess the comparative safety … How do comparative safety and effectiveness vary by patient characteristics, such as age, sex/gender … Safety of therapeutic methylphenidate in adults: a systematic review of the evidence. … Safety and tolerability of once versus twice daily atomoxetine in adults with ADHD. … Efficacy, safety and variability in pharmacotherapy for adults with attention deficit hyperactivity

371. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol-amendment.pdf
     January 08, 2025 - adherence.96, 106-108 Purpose of the Review This systematic review will assess the comparative safety … How do comparative safety and effectiveness vary by patient characteristics, such as age, sex, race, … Safety of therapeutic methylphenidate in adults: a systematic review of the evidence. … Safety and tolerability of once versus twice daily atomoxetine in adults with ADHD. … Efficacy, safety and variability in pharmacotherapy for adults with attention deficit hyperactivity

372. Disposition of Comments Report for Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_disposition-comments.pdf
     January 01, 2010 - Further, small studies [Phase I (safety); Phase II (dose- ranging; mechanistic)] may show effects which … subcutaneous immunotherapy, there are few studies of SLIT in moderate or severe asthmatics, and the safety … off label use of licensed products for SLIT by physicians who are falsely comforted by the current safety … The mandate of this AHRQ report is to provide evidence for the effect and safety of allergen immunotherapy … controlled European clinical trials that demonstrated clinical efficacy and a sufficient degree of safety

373. Ch 5-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_5-user-guide-to-ocer_130129.pdf
     January 01, 2012 - A comparison between aripiprazole, an antipsychotic agent with a relatively favorable metabolic safety … data sources can be linked to enhance the validity of observational comparative effectiveness and safety … same indication does not necessarily remove confounding by severity.21 For clinical effectiveness or safety … comparators, as explained in the previous section, are generally more appropriate, particularly for safety … appropriate when comparing two treatments with expected differences in the timing of beneficial or safety

374. Disposition of Comments for Psychological Treatments and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_disposition-comments.pdf
     April 03, 2013 - …" a) Seeking Safety (SS) was designed for both genders. … The relevant paragraph was (and still is) in the Seeking Safety results section titled Prevention … We agree that this study has some limitations that limit what we can conclude about seeking safety … Further studies would be needed to determine whether seeking safety is efficacious for improving … We also changed it to “seeking safety” rather than “safety seeking” to be consistent with wording

375. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - It is unfair to label all companies as profit-driven over safety- driven. … Further, this trial was designed primarily as a safety and proof-of- concept trial. … Unfortunately, the two large, randomized controlled trials on the efficacy and safety of rFVIIa in … Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. … Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage.

376. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_june_2012.pdf
     January 01, 2012 - significantly increased the regulatory bar for gaining approval—specifically regarding preapproval safety … data and postmarket safety evaluation—set forth by the U.S. … Kushner and colleagues announced results from a phase III clinical trial (SEQUEL) evaluating the safety … 2011, Allison and colleagues announced results from a 56-week clinical trial (EQUIP) evaluating the safety … Safety and efficacy study of EndoBarrier in subjects with type II diabetes and obesity.

377. Ch 6-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_6-user-guide-to-ocer_130129.pdf
     October 30, 2012 - The varying definitions of MACE included one related to safety only [composite of death, MI, and stent … thrombosis (ST)], and two relating to both safety and effectiveness [composite of death, MI, ST, … The safety-only definition of MACE yielded a hazard ratio of 1.75 (p<0.05), indicating that patients … However, for the composite of safety and effectiveness endpoints, the risk of 1-year MACE was greatly … For example, once a safety signal has been identified and publicized, physicians have been alerted

378. Urinary-Incontinence-Treatment Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
     October 29, 2012 - • There are no safety concerns Summary Decision: This CER’s priority for updating is Low … magnitude/direction of changes in estimates, potential changes in practice or therapy preference, safety … Safety surveillance alerts: None Conclusion: Up to date Key Questions # 2 Signals from studies … Safety surveillance alerts: None Conclusion: 5/11 conclusions are possibly out of date 17 … Efficacy  and  safety  of  oxybutynin   chloride  topical  gel  for  women  with

379. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0265_02-29-2008.pdf
     January 01, 2008 - How do the effectiveness and safety of pharmacologic and nonpharmacologic pain management interventions

380. AHRQ's Evidence-based Practice Center Division Annual Report 2021: Solving the Puzzle for Evidence-Based Decision Making (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2021.pdf
     January 01, 2021 - National Highway Traffic Safety Administration funding opportunity on airway management (2021) Prehospital … Safety of Vaccines Used for Routine Immunization in the United States: An Update DOI: 10.23970/AHRQEPCCER244 … Safety of vaccines used for routine immunization in the United States: An updated systematic review … National Highway Traffic Safety Administration (NHTSA) 5. … Agency for Healthcare Research and Quality (AHRQ) - Center for Quality Improvement and Patient Safety