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201. C- Evidence-based Practice Center Technical Brief Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-disorders-imaging_research-protocol.pdf
     August 05, 2010 - Evidence-based Practice Center Technical Brief Protocol Project Title: Technical Brief - Use and Safety … What are the potential safety issues and harms of positional MRI technologies? … : What published studies have reported on the diagnostic performance, efficacy/effectiveness or safety … Additional data regarding the use and safety of positional MRI may be added based on the results of … treatment decisions d. impact on clinical and functional outcomes vii Adverse events, harms and safety

202. Disposition of Comments CER 214 Stroke Prevention in Patients With Atrial Fibrillation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-214-afib-disposition-comments.pdf
     October 30, 2019 - What is a “cumulative primary safety rate”? … If this is really looking at safety, then it seems very low (90% unsafe). … (safety on treatment population). Reference: Patel MR, Mahaffey KW, Garg J, et al. … (safety on treatment population). Reference: Patel MR, Mahaffey KW, Garg J, et al. … The safety population is used, which is the same population used in other DOAC trials to assess safety

203. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/angina-heart-attack-treatments_research-protocol.pdf
     December 11, 2012 - What are the comparative effectiveness (dose and timing) and comparative safety of an intravenous ( … What are the comparative effectiveness (dose and timing) and comparative safety of coadministration … Do the effectiveness and safety vary based on which initial anticoagulant is used or the combination … Do the effectiveness and safety vary based on the dose of aspirin used? b. … Do the effectiveness and safety vary by oral antiplatelet therapy and PPI? c.

204. Executive Summary: ADHD Diagnosis and Treatment in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
     March 01, 2024 - • Despite the large body of research, comparative effectiveness and safety information is limited … Despite the large body of research, comparative effectiveness and safety information is limited. … Studies did not provide information on key comparative effectiveness and safety outcomes, and SoE is

205. Santa_ECCS2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/santa_eccs2012.pdf
     February 01, 2013 - Slide 29: Identified Issues From  Professional Societies • Harmonization • Safety • Use of brand … names • Cost estimates From  Consumers • Safety • Plain  language • Knowing  who the professional …  societies are • Measurement • Cost Slide 30: Safety • Safety is the most powerful issue that … attracts consumers. • What  does safety include?

206. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
     August 05, 2010 - Evidence-based Practice Center Systematic Review Protocol Project Title: Comparative Effectiveness and Safety … Systematic Review This report will serve as an update to the 2006 report Comparative Effectiveness and Safety … In addition, efficacy and safety may vary for individual drugs within a class. … We will also include studies that report safety in patients with rheumatoid arthritis or were taking … Comparative effectiveness and safety of analgesics for osteoarthritis.

207. Strategies for Patient, Family and Caregiver Engagement: Technical Brief Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-family-engagement-protocol.pdf
     December 31, 2019 - Hospitalized patients' participation and its impact on quality of care and patient safety. … Scoping review and approach to appraisal of interventions intended to involve patients in patient safety … Speaking up about safety concerns: multi-setting qualitative study of patients' views and experiences … Moving Forward with Patient- and Family-Centered Care: Partnerships for Quality and Safety. 2019. … Evaluation of Patient and Family Engagement Strategies to Improve Medication Safety.

208. Disposition of Comments Report for Comparative Effectiveness Review No. 131 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/crohns-disease_disposition-comments.pdf
     February 25, 2014 - This is why most safety data come from post marketing observational studies. … studies invested the agents at various doses to determine safety parameters. … that RCTs typically are not designed to assess all important safety related outcomes. … All patients in global safety summary were Crohn’s Disease patients. … Please consider inclusion of this safety data.

209. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - However, experts generally indicated a need for more trials to determine the safety and efficacy of … One expert with a research perspective noted the limited amount of long-term safety and efficacy data … However, some experts expressed concern regarding long-term safety and efficacy and the potential for … The fourth trial (SCALE™ Sleep Apnea; n=340) was a safety and efficacy trial investigating once-daily … A prospective, randomized multicenter study to evaluate the safety and efficacy of the ReShape Duo

210. Disposition of Comments Report for Stroke Prevention in Atrial Fibrillation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_disposition-comments.pdf
     August 23, 2013 - (safety on treatment population). … (safety on treatment population). … HR 0.23;95% CI,0.09, 0.61, p=0.003 (safety on treatment population). … (safety on treatment population). … 75) and younger patients for both efficacy and safety.

211. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
     May 07, 2010 - control, cardiovascular risk reduction, cardiovascular events, quality of life, and other outcomes) and safety … major cardiovascular events [myocardial infarction , stroke] and measures of quality of life) o Safety … diabetes) Adverse Events •Weight gain •Impaired renal function •Angioedema •Cough •Hyperkalemia Safety … demographics and data needed for determining outcomes (intermediate outcomes, health outcomes, and safety … The safety outcomes will be framed to help identify angioedema and hyperkalemia, which are both adverse

212. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia_executive.pdf
     May 01, 2006 - What are the comparative efficacy and safety of epoetin (alfa or beta) and darbepoetin? 2. … How do alternative dosing strategies affect the comparative efficacy and safety of epoetin and darbepoetin … treatment or alternative criteria for discontinuing therapy or duration of therapy affect the efficacy and safety … Conclusions Comparative efficacy and safety of epoetin and darbepoetin Three sets of trials were summarized … cancer (n=351), showed poorer overall survival for patients treated with epoetin; this prompted an FDA safety

213. Juvenile-Arthritis-Dmards Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_surveillance.pdf
     March 14, 2013 - Is the portion of the CER that is probably or certainly out of date an issue of safety (a drug withdrawn … We did not identify any studies that provide reliable information on the comparative safety or rates … A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of … Safety profiles were similar Key Question 5: What is the validity, reliability, responsiveness, and … We did not identify any studies that provide reliable information on the comparative safety or rates

214. Juvenile-Arthritis-Dmards Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_surveillance.pdf
     March 14, 2013 - Is the portion of the CER that is probably or certainly out of date an issue of safety (a drug withdrawn … We did not identify any studies that provide reliable information on the comparative safety or rates … A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of … Safety profiles were similar Key Question 5: What is the validity, reliability, responsiveness, and … We did not identify any studies that provide reliable information on the comparative safety or rates

215. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
     September 01, 2011 - All studies of safety were addressed in KQ3. … Amgen considers this omission to be significant because of the body of data, especially safety data, … Some examples of imbalances in adverse event rates that favor the safety of placebo over adalimumab … We did not include safety data on adalimumab in Table 7 because of the absence of a comparator for … The fact that there is little usable information about the effectiveness and safety of many of the

216. App-F-Surv-Report-2-Acute-Pain (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f-surv-report-2-acute-pain.xlsx
     October 08, 2025 - Yes No No No Yes No/No Yes Yes Yes Fair Cooper, 2021 Yes Yes Yes Unclear Yes Yes Yes No/No Yes; for safety

217. App-F-Surv-Report-3-Acute-Pain (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f-surv-report-3-acute-pain.xlsx
     October 08, 2025 - Yes No No No Yes No/No Yes Yes Yes Fair Cooper, 2021 Yes Yes Yes Unclear Yes Yes Yes No/No Yes; for safety

218. Naik (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/naik.pdf
     January 01, 2009 - explicit communication • Communication is critical to  Decision Making o Limits quality  and  safety …  and social norms define most interactions o Quality: achieving appropriate outcomes, ensuring safety …  Redundancy can  aide outcomes  But poses safety risks—communication can mitigate o Reducing waste

219. Comparative Effectiveness Review No. 258_Diagnostic Errors in the Emergency Department: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/diagnostic-error-executive-summary.pdf
     August 01, 2023 - facilitate the rapid development and deployment of solutions to address this critically important patient safety … Diagnostic error in the emergency department: learning from national patient safety incident report … Improving Diagnostic Quality and Safety Final Report. 2017. … BMJ quality & safety. 2018 Jul;27(7):567- 70. doi: 10.1136/bmjqs-2018-007945.

220. Stroke-Atrial-Fibrillation Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_executive.pdf
     August 01, 2013 - Also, synthesis of the evidence on the safety and timing of restarting patients on VKAs or antithrombin … • Two studies investigating the safety of dabigatran versus warfarin in the periprocedural period … Strategies for Switching Between Warfarin and Novel Oral Anticoagulants There is currently no safety … Stroke Prevention After a Hemorrhagic Event There is currently no safety or effectiveness evidence … Thus, there is a need for studies assessing the safety and effectiveness of different combinations