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161. Management of Suicidal Thoughts and Behaviors in Youth: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-exe-sum.pdf
     April 01, 2025 - These interventions include acute safety planning, family-based crisis interventions, motivational interviewing … offered mostly in the context of an ED or inpatient setting, interventions characterized as acute safety … For example, acute safety planning interventions, which were designed to create a safety plan to manage … The uncertainty in the evidence does not mean that providers should not screen, treat, and safety plan … Intervention research with persons at high risk for suicidality: safety and ethical considerations.

162. Systematic Review on Nonopioid Pharmacologic Treatments for Chronic Pain: Surveillance Report 2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
     April 01, 2022 - Efficacy and safety of pregabalin for fibromyalgia in a population of Chinese subjects. … Efficacy and safety of pregabalin for fibromyalgia in a population of Chinese subjects. … Efficacy and safety of duloxetine in osteoarthritis or chronic low back pain? … PMU6 systematic review of the efficacy and safety of 5% lidocaine-medicated plaster vs. … Efficacy and safety of pregabalin for chronic neuropathic pain: a meta-analysis.

163. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-bone-fracture_research-protocol.pdf
     May 14, 2010 - The increasing prevalence and cost of osteoporosis has heightened interest in the effectiveness and safety … In addition, the assessment found new evidence on adherence and on the safety of some agents, including … Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/Safety- RelatedDrugLabelingChanges … /MedWatch/SafetyInformation/Safety-RelatedDrugLabelingChanges/ucm122109.htm� http://www.fda.gov/Safety … /MedWatch/SafetyInformation/Safety-RelatedDrugLabelingChanges/ucm122109.htm� http://www.fda.gov/Safety

164. Disposition of Comments: Comparative Effectiveness Review No. 238 Cervical Ripening in the Outpatient Setting (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-outpatient-setting-comments.pdf
     March 22, 2021 - The recommendations for changes include changing the conclusion to state that fetal safety is unknown … Further, the conclusion should reflect that there is no evidence of fetal safety due to the lack of … With regard to the comments on "no evidence of fetal safety due to the lack of inclusion of fetal … The conclusion should be more multicenter RCTs should be done to evaluate safety. … include a diverse population and specifically study Cervidil and Cytotec as methods with a goal of safety

165. Research Review Title: Infection Prevention and Control for the Emergency Medical Services and 911 Workforce (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-911-workforce-disposition-comments.pdf
     November 01, 2022 - NASEMSO General The use of 911 workforce seems to be a general term to discuss all of public safety. … That is not a normal use of the terminology for those who actually work in public safety. … Other than that I appreciated the conclusions and important reference to the need for safety culture … The Needlestick Safety & Prevention Act of 2000 was passed by the U.S. … Personnel need to understand that they have a role in their own safety.

166. Acute Treatments for Episodic Migraine: Surveillance Report 3 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-3.pdf
     August 01, 2022 - Cardiovascular safety of erenumab in patients with migraine and aura. … Effect of a change in lasmiditan dose on efficacy and safety in patients with migraine. … Long-term safety of rimegepant 75 mg for the acute treatment of migraine (Study 201). … Efficacy and safety of cutting therapy in the treatment of migraine. … Safety of dihydroergotamine for acute migraine treatment: reality vs perception.

167. FRN 27 - Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule-future_research.pdf
     May 01, 2013 - Comparative diagnostic accuracy and safety (gastric dysmotility/gastroparesis) 2 3. … WMC diagnostic accuracy and safety in gastroparesis subtypes 4 5. Thresholds 5 6. … Comparative diagnostic accuracy and safety (gastric dysmotility/gastroparesis) 2 3. … WMC diagnostic accuracy and safety in gastroparesis subtypes 4 5. Thresholds 5 6. … WMC diagnostic accuracy and safety in gastroparesis subtypes* 7 4 3 4 5 1 5 29 4 5.

168. Updating Current Effectiveness Reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-assessment-research-updates_research.pdf
     September 15, 2008 - attention on the strength and limits of evidence from research studies about the effectiveness and safety … Comparative Effectiveness and Safety of Analgesics for Osteoarthritis 09/2006 5. … Comparative Effectiveness and Safety of Oral Diabetes Medications for Adults With Type 2 Diabetes* 07 … Comparative Effectiveness, Safety, and Indications of Insulin Analogues in Premixed Formulations for … Summary of Assessments CER Title Number of conclusions assessed Safety issue?

169. Ace-Inhibitor-Arb-Update-Surveillance-160328 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update-surveillance-160328.pdf
     October 08, 2025 - $Comparison$of$the$efficacy$ and$safety$profiles$of$two$fixed"dose$combinations$of$antihypertensive$ … $Antihypertensive$efficacy$and$ safety$of$olmesartan$medoxomil$and$ramipril$in$elderly$patients$with … $Efficacy$and$safety$of$valsartan$compared$to$ enalapril$in$hypertensive$children:$a$12"week,$randomized … $This$double"blind,$controlled,$randomised$trial$compared$its$antihypertensive$efficacy$and$safety$vs … $Antihypertensive$efficacy$and$safety$of$olmesartan$medoxomil$and$ ramipril$in$elderly$patients$with

170. - (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease-future_research.pdf
     July 01, 2016 - In addition, they reported that the “efficacy and safety of long-term immunomodulation versus anti-TNF … KQ 3 What is the comparative safety of therapies alone or in combination used in adults and children … studies in children Possible research gaps Adults and Children • Safety studies designed to … outcomes associated with medication efficacy (such as disease flare and abscess) are safety outcomes … Study Design Observational studies may be too short in duration to observe some safety outcomes.

171. Systematic Review on Acute Treatments for Episodic Migraine: Surveillance Report 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-1.pdf
     June 01, 2022 - Effect of a change in lasmiditan dose on efficacy and safety in patients with migraine. … Effect of a change in lasmiditan dose on efficacy and safety in patients with migraine. … Cardiovascular safety of erenumab in patients with migraine and aura. … Long- term safety of rimegepant 75 mg for the acute treatment of migraine (Study 201). … Safety of dihydroergotamine for acute migraine treatment: reality vs perception.

172. Psoriatic Arthritis Surveillance Assesment_CER 54_Low (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_surveillance.pdf
     March 01, 2013 - No safety warnings since publication of the CER update. … No safety warnings since publication of the CER update. … No safety warnings since publication of the CER update. … Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis … No safety issues noted.

173. Making Healthcare Safer IV Rapid Review: Patient Monitoring Systems To Prevent Failure To Rescue (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/patient-monitoring-systems-rapid-review.pdf
     December 01, 2024 - AHRQ’s listing of patient safety related toolkits (https://www.ahrq.gov/tools/index.html? … Making Healthcare Safer IV: A Continuous Updating of Patient Safety Harms and Practices. … Director, General Patient Safety Program Center for Quality Improvement and Patient Safety Agency for … Standard Patient safety/harm search string for all PSPs topics “patient safety”[mh] OR “patient … Standard Patient safety/harm search string for all PSPs topics [mh “patient safety”] OR “patient

174. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/atrial-fibrillation_research-protocol.pdf
     May 22, 2012 - Patients will benefit from more robust data on the comparative safety and effectiveness of different … Specifically: KQ 1: What are the comparative safety and effectiveness of pharmacological agents used … Do the comparative safety and effectiveness of these therapies differ among specific patient subgroups … Do the comparative safety and effectiveness of these therapies differ among specific patient subgroups … KQ 5: What are the comparative safety and effectiveness of newer procedural rhythm- control therapies

175. Systematic Review on Nonopioid Pharmacologic Treatments for Chronic Pain: Surveillance Report 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-pharm-chronic-pain.pdf
     April 01, 2022 - Efficacy and safety of pregabalin for fibromyalgia in a population of Chinese subjects. … Efficacy and safety of pregabalin for fibromyalgia in a population of Chinese subjects. … Efficacy and safety of duloxetine in osteoarthritis or chronic low back pain? … PMU6 systematic review of the efficacy and safety of 5% lidocaine-medicated plaster vs. … Efficacy and safety of pregabalin for chronic neuropathic pain: a meta-analysis.

176. Update Topic Brief CER 27 NSD FINAL_SJ final (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_overview.pdf
     January 17, 2014 - In adults age 18 or older with type 2 diabetes mellitus, what is the comparative safety of the following … Do safety and effectiveness of these treatment options (Table 2) differ across subgroups of adults with

177. Asthma-Immunotherapy-2010 Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_executive.pdf
     January 01, 2010 - Safety of subcutaneous immunotherapy in the pediatric population. … Forty-three studies of sublingual immunotherapy provided safety data. … Safety of sublingual immunotherapy in the pediatric population. … The available safety data supports the safety of specific immunotherapy, although local reactions were … The pediatric safety data are consistent with the overall safety results reported for subcutaneous and

178. Treatment of Hepatitis C Virus Infection in Adults: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
     April 01, 2013 - known as DEB025), a cyclophilin inhibitor, as research was suspended in April 2012 by the FDA due to safety … Open-label, multicenter, noncomparative, prospective observational study to evaluate efficacy and safety … NCT01497366: A phase 3, multicenter, randomized, active-controlled study to investigate the safety … Pegylated interferon alfa-2b Ribavirin Adult Senior Treatment efficacy Safety and tolerability … GS-7977 Ribavirin Placebo Adult Senior Efficacy 12 weeks after treatment completion Safety and

179. Comparative Effectiveness Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_appendixes.pdf
     January 01, 2006 - GI Safety in observational studies 149 Author, Year Sample size Population Duration (days … Trials of etoricoxib and lumiracoxib (Safety only) Author Year Randomization adequate? … Trials of etoricoxib and lumiracoxib (Safety only) Author Year Patient masked? … Safety Out of 29 NSAID combinations, 9 revealed clinically relevant differences in toxicity. … Etoricoxib (included for safety only) Appendix F. Evidence Table 10[1].

180. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ischemic-stroke-treatment_executive.pdf
     January 01, 2011 - A recent prospective, single-center pilot study reported on the safety and efficacy of a retrievable … Safety endpoints were typically monitored over shorter lengths of time, such as the first 24 hours or … Of the 71 total device reports, nearly half did not report data on effectiveness or safety outcomes after … Safety endpoint evidence for neurothrombectomy devices (n=1,311) (Reported as prospective/retrospective … We did not draw conclusions regarding their effectiveness or safety.