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1241. Urinary-Incontinence-Treatment Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_executive.pdf
      April 01, 2012 - Several retrospective observational studies analyzed the long-term comparative effectiveness and safety … safety was rarely available in RCTs, despite high discontinuation rates suggesting that there were … drugs’ adverse effects in clinical practice could provide information about long-term comparative safety … • Evidence is insufficient for the long-term safety of pharmacological treatments. … Safety profile of tolterodine as used in general practice in England: results of prescription-event

1242. Crosscutting-Horizon-Scan-High-Impact-1412 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1412.pdf
      December 01, 2014 - Although propofol may be preferred for these reasons, safety concerns complicate its use. … benefits of wider access to ES-4 propofol-mediated sedation were significant enough to offset safety … The intent is to improve seniors’ safety, clinical outcomes, and quality of care and to reduce admissions … The primary endpoint was a composite safety measure (area under the curve of oxygen desaturation [AUCDesat … the Sedasys can be used.7 The FDA approval requires that EES conduct two postmarketing studies on safety

1243. Gout Executive-2016 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout_executive-2016.pdf
      January 01, 2016 - The safety of tests used to diagnose gout also needs to be considered. … Potential safety concerns include acute physical discomfort from joint aspiration and long-term effects … Therefore, we have undertaken a systematic review of studies examining the accuracy and safety of tests … The focus of this report is on evaluating the validity and safety of existing diagnostic methods for … Summary of findings on comparative accuracy and safety of gout diagnostic methods Outcomes Level

1244. Arthritis-Knee-Physical-Therapy Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/arthritis-knee-physical-therapy_research-protocol.pdf
      April 01, 2010 - integration or reintegration Injury prevention or reduction with use of devices and equipment Safety … o Long-term outcomes (>3 months) • Settings Outpatient and home-based care settings • Safety … We will monitor the FDA Web site for warnings and safety information for all eligible devices. … Evidence-based Practice Center Systematic Review Protocol Outpatient and home-based care settings • Safety

1245. S29 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/s29.pdf
      October 01, 2007 - They pointed out that if existing evidence suggested that 2 or more drugs had comparable efficacy and safety … whether less expensive is as effective) Would not be a significant factor; medication effectiveness and safety … Would not have similar evidence-base for both drugs; 1 yr not sufficient to evaluate safety or side effect … Choose study drugs (treatment arms) for which there is no evidence of differential effectiveness or safety

1246. Arthritis and Nontraumatic Joint Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1506.pdf
      June 01, 2015 - Novartis Pharmaceuticals. 16 week efficacy and 2 year long term safety and efficacy of secukinumab … Novartis Pharmaceuticals. 16 week efficacy and 5 year long term efficacy, safety and tolerability … anti-interleukin-17a monoclonal antibody, improves active psoriatic arthritis: 24-week efficacy and safety … antibody, improves active psoriatic arthritis and inhibits radiographic progression: efficacy and safety … 17a-monoclonal-antibody-improves-active-psoriatic-arthritis-and-inhibits-radiographic-progression-efficacy-and-safety-data-from-a-phase

1247. Urinary-Incontinence-Treatment Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
      September 30, 2010 - Minnesota Pulsegen device Certificate of Approval for Use of GS Symbol No. 95 44 083; LGA, Equipment Safety … Twin (Vitacon AS, Trondheim, Norway) Vaginal cones Mabella cones (Vitacon AS, Trond-heim, Norway) Safety … We will monitor the FDA website for warnings and safety information for all eligible drugs and devices … will analyze the harmful effects of drugs from all sources including efficacy, effectiveness, and safety … Clinical efficacy and safety of tolterodine in the treatment of overactive bladder: a pooled analysis

1248. Arthritis and Nontraumatic Joint Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/01_arthritis_potential_high_impact_2012-12-10.pdf
      January 01, 2012 - pricing than injectable biologic therapies, but some experts expressed strong concerns regarding its safety … stated MSC therapy is investigational because of insufficient evidence or insufficient long-term safety … Both groups had similar safety profiles. 29 In a study of patients with knee OA (Outerbridge grades … such as a hospital blood bank or blood processing laboratory) according to standard blood processing safety … These safety concerns could present significant barriers to diffusion.

1249. Insulin Delivery and Glucose Monitoring Methods: Future Research Needs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar_research.pdf
      August 01, 2015 - Study design: Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention … Study design: Endpoint Classification: Safety Study Intervention Model: Single Group Assignment … Study design: Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention … Study design: Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention … Study design: Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention

1250. Long-Term-Care-Adults Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/long-term-care-adults_research-protocol.pdf
      December 20, 2011 - medication administration, medication) management  Activity program  General oversight and safety … medication administration, medication management  Activity program  General oversight and safety … Reported harms are safety, inadequate preventive care, unnecessary hospitalizations, and concerns about