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www.uspreventiveservicestaskforce.org/uspstf/document/postmenopausal-hormone-replacement-therapy-for-primary-preve/v2-menopausal-hormone-therapy-preventive-medicatio
August 21, 2002 - studies including three meta-analyses (relative risks range from 1.21 to 1.40). 71-73 Risk increases … with longer duration of use (relative risks range from 1.23 to 1.35 based on all six meta-analyses that … for breast cancer (relative risks range from 0.85 to 1.14 from 8 meta-analyses). 40 , 71-77
No meta-analyses … Except for CHD, rates are similar when WHI hazard ratios rather than relative risks from our review are … In many cases, a variety of relative risks was available for certain outcomes, and we selected a value
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www.uspreventiveservicestaskforce.org/uspstf/document/postmenopausal-hormone-replacement-therapy-for-primary-preve/menopausal-hormone-therapy-preventive-medication-2002-2005
August 21, 2002 - studies including three meta-analyses (relative risks range from 1.21 to 1.40). 71-73 Risk increases … with longer duration of use (relative risks range from 1.23 to 1.35 based on all six meta-analyses that … for breast cancer (relative risks range from 0.85 to 1.14 from 8 meta-analyses). 40 , 71-77
No meta-analyses … Except for CHD, rates are similar when WHI hazard ratios rather than relative risks from our review are … In many cases, a variety of relative risks was available for certain outcomes, and we selected a value
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/sQ7hREGwnBm8Wh-LEFWP4F
October 01, 2002 - studies including 3 meta-
analyses (relative risks range from 1.21 to 1.40).71-73
Risk increases with … longer duration of use (relative
risks range from 1.23 to 1.35 based on all 6 meta-
Postmenopausal … for
breast cancer (relative risks range from 0.85 to 1.14
from 8 meta-analyses).40,71-77
No meta-analyses … Except for
CHD, rates are similar when WHI hazard ratios
rather than relative risks from our review are … In many cases, a variety of relative risks was available
for certain outcomes, and we selected a value
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/j69Hq5ALvzg74e-ngkzSep
April 01, 2016 - outcome, we calcu-
lated a range of expected event rates after aspirin in-
tervention using the pooled relative … Baseline Estimates of Major Bleeding Risks
(Trial vs. … Risk for Outcome,
events per 1000 person-years
Relative Risk (95% CI) Events Caused per 1000
Person-Years … as reported by included cohort studies.
¶ Using cohort baseline risk and trial relative risks to estimate … why persons with these risks have
been excluded from trials.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/menopausal-hormone-therapy-preventive-medication
December 12, 2017 - risk of a beneficial or harmful change in risks (eg, increase or reduction of cardiovascular events) … Absent meta-analytic estimates, relative risks of outcomes of interest were based primarily on a recent … WHIMS did not find an elevated risk of mild cognitive impairment. 72
Based on the WHI data, risks for … risks instead of hazard ratios. … Relative risks (RRs) were calculated to determine absolute risk reductions and increases presented in
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/menopausal-hormone-therapy-preventive-medication-december-2017
December 12, 2017 - risk of a beneficial or harmful change in risks (eg, increase or reduction of cardiovascular events) … Absent meta-analytic estimates, relative risks of outcomes of interest were based primarily on a recent … WHIMS did not find an elevated risk of mild cognitive impairment. 72
Based on the WHI data, risks for … risks instead of hazard ratios. … Relative risks (RRs) were calculated to determine absolute risk reductions and increases presented in
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-bleeding-risks-with-aspirin-use/aspirin-to-prevent-cardiovascular-disease-and-cancer
April 11, 2016 - outcome, we calculated a range of expected event rates after aspirin intervention using the pooled relative … events will vary depending on individual baseline bleeding risks. … why persons with these risks have been excluded from trials. … Level †
Baseline Risk for Outcome,
events per 1000 person-years
Relative Risk (95% CI)
Events … ¶ Using cohort baseline risk and trial relative risks to estimate events caused or prevented.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-bleeding-risks-with-aspirin-use/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
April 11, 2016 - outcome, we calculated a range of expected event rates after aspirin intervention using the pooled relative … events will vary depending on individual baseline bleeding risks. … why persons with these risks have been excluded from trials. … Level †
Baseline Risk for Outcome,
events per 1000 person-years
Relative Risk (95% CI)
Events … ¶ Using cohort baseline risk and trial relative risks to estimate events caused or prevented.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/breast-cancer-medications-for-risk-reduction-2013
September 15, 2013 - that treatment with tamoxifen or raloxifene can significantly reduce the relative risk (RR) for invasive … Breast Cancer Prevention Trial; IBC = invasive breast cancer; WHI = Women's Health Initiative; RR = relative … Breast Cancer Prevention Trial; IBC = invasive breast cancer; WHI = Women's Health Initiative; RR = relative … Breast Cancer Prevention Trial; IBC = invasive breast cancer; WHI = Women's Health Initiative; RR = relative … Breast Cancer Prevention Trial; IBC = invasive breast cancer; WHI = Women's Health Initiative; RR = relative
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary28/menopausal-hormone-therapy-preventive-medication
November 01, 2022 - heterogeneity in effects between studies. 15
The outcome measure for all quantitative analyses was the relative … risk (RR) of a beneficial or harmful change in risks. … Most increased risks were not statistically different anymore after stopping hormone therapy. … ; NA, not applicable; NR, not reported; PE, pulmonary embolism; RCT, randomized clinical trial; RR, relative … applicable; NR, not reported; OR, odds ratio; PE, pulmonary embolism; RCT, randomized clinical trial; RR, relative
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/zVVRY6wa4Sgj-EJb3BRcVy
November 01, 2013 - that treatment
with tamoxifen or raloxifene can significantly reduce the
relative risk (RR) for invasive … BCPT � Breast Cancer Prevention Trial; IBC � invasive breast cancer;
RR � relative risk; STAR � Study … BCPT � Breast Cancer Prevention Trial; IBC � invasive breast cancer;
RR � relative risk; STAR � Study … BCPT � Breast Cancer Prevention Trial; IBC � invasive breast cancer;
RR � relative risk; STAR � Study … BCPT � Breast Cancer Prevention Trial; IBC � invasive breast cancer;
RR � relative risk; STAR � Study
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Rn7dRezgMx5syB-erQKoKt
November 01, 2022 - for the US Preventive Services Task Force on the benefits and
harms of hormone therapy in reducing risks … Participants using estrogen only compared with placebo had significantly lower risks for
diabetes over … Risks per
10 000 persons were statistically significantly increased for gallbladder disease over 7.1 … (RR) of a beneficial or harmful change in risks. … applicable; NR, not
reported; OR, odds ratio; PE, pulmonary embolism; RCT, randomized clinical trial; RR, relative
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/postmenopausal-hormone-prophylaxis-preventive-medication-1996
January 01, 1996 - largest and best-designed studies, the beneficial effect was most evident in current users of estrogen (relative … likely to benefit from therapy, but that risks may outweigh benefits among women at increased risk of … possible risks vs. potential benefits of therapy. … The balance of benefits and risks of estrogen therapy in women at increased risk of breast cancer is … Relative risks and benefits of long-term estrogen replacement therapy: a decision analysis.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-modeling-study/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - In all scenarios, non-CRC benefits and harms were assumed to take effect immediately, and relative risks … estimate was lower and had a narrower confidence interval compared with the corresponding finding in 2016 (relative … for CRC incidence and affects fatal major gastrointestinal bleeding risks. … constant over time, but lifetime net benefits of aspirin would be higher if these relative risks decreased … CVD
Parameter
Relative
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/4fdC2JLwP_um_yZe4WZRaa
April 01, 2009 - prevention studies of aspirin have found the following:
Clinician Fact Sheet
Aspirin use in women
y 17% relative … relative risk reduction
for MI
y No effect on stroke or
all-cause mortality
y Talk With Your … Harms from aspirin include the risks of serious upper GI bleeding and hemorrhagic
stroke. … this risk in women. … For these individuals,
the benefits and risks of using aspirin are closely balanced.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breast-cancer--brca-testing-ovarian-cancer-screeni
September 15, 2005 - risks for breast and ovarian cancer in moderate- and high-risk groups. … All chemoprevention trials reported relative risk (RR) estimates, and the logarithm of the RR (logRR) … Sampling Distribution for Relative Risk
When developing the outcomes table, the estimates of relative … Risk
(95% CI)
Type
Treat-
ment
Group, n
Placebo
Group, n
Relative Risk … Relative Risks for Breast Cancer in Chemoprevention Trials
Error bars represent 95% CIs.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breast-and-ovarian-cancer-brca-testing-screening-2005
September 15, 2005 - risks for breast and ovarian cancer in moderate- and high-risk groups. … All chemoprevention trials reported relative risk (RR) estimates, and the logarithm of the RR (logRR) … Sampling Distribution for Relative Risk
When developing the outcomes table, the estimates of relative … Risk
(95% CI)
Type
Treat-
ment
Group, n
Placebo
Group, n
Relative Risk … Relative Risks for Breast Cancer in Chemoprevention Trials
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/3HxQuXnyqHpUKNqjB7hWBw
September 01, 2005 - risks for breast
and ovarian cancer in moderate- and high-risk groups. … All chemoprevention trials reported relative
risk (RR) estimates, and the logarithm of the RR (logRR) … Combining all trials in a meta-analysis resulted in a
relative risk for total breast cancer of 0.62 ( … The relative risk (0.39 [CI, 0.20 to 0.79]) was
further reduced for estrogen receptor–positive breast … Relative risks for breast cancer in chemoprevention
trials.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/cjWWvkNrCHGUqu4jScs8Ak
October 05, 2005 - The clinician can motivate patients to consider a quit attempt
with the “5 R’s”: Relevance, Risks, Rewards … RISKS
Ask the patient to identify potential
negative consequences of tobacco use.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nsaids/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication
March 15, 2007 - Confounders Addressed in Adjusted Relative Risks among the Included Case-Control Studies: Use of Nonaspirin … Confounders Addressed in Adjusted Relative Risks among the Included Case-Control Studies: Duration of … We chose relative risk as the effect measure. … Confounders Addressed in Adjusted Relative Risks among the Included Case-Control Studies: Use of Nonaspirin … Confounders Addressed in Adjusted Relative Risks among the Included Case-Control Studies: Duration of