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  1. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/menopausal-hormone-therapy-preventive-medication
    December 12, 2017 - risk of a beneficial or harmful change in risks (eg, increase or reduction of cardiovascular events) … Absent meta-analytic estimates, relative risks of outcomes of interest were based primarily on a recent … WHIMS did not find an elevated risk of mild cognitive impairment. 72 Based on the WHI data, risks for … risks instead of hazard ratios. … Relative risks (RRs) were calculated to determine absolute risk reductions and increases presented in
  2. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/menopausal-hormone-therapy-preventive-medication-december-2017
    December 12, 2017 - risk of a beneficial or harmful change in risks (eg, increase or reduction of cardiovascular events) … Absent meta-analytic estimates, relative risks of outcomes of interest were based primarily on a recent … WHIMS did not find an elevated risk of mild cognitive impairment. 72 Based on the WHI data, risks for … risks instead of hazard ratios. … Relative risks (RRs) were calculated to determine absolute risk reductions and increases presented in
  3. www.uspreventiveservicestaskforce.org/uspstf/document/postmenopausal-hormone-replacement-therapy-for-primary-preve/v2-menopausal-hormone-therapy-preventive-medicatio
    August 21, 2002 - studies including three meta-analyses (relative risks range from 1.21 to 1.40). 71-73 Risk increases … with longer duration of use (relative risks range from 1.23 to 1.35 based on all six meta-analyses that … for breast cancer (relative risks range from 0.85 to 1.14 from 8 meta-analyses). 40 , 71-77 No meta-analyses … Except for CHD, rates are similar when WHI hazard ratios rather than relative risks from our review are … In many cases, a variety of relative risks was available for certain outcomes, and we selected a value
  4. www.uspreventiveservicestaskforce.org/uspstf/document/postmenopausal-hormone-replacement-therapy-for-primary-preve/menopausal-hormone-therapy-preventive-medication-2002-2005
    August 21, 2002 - studies including three meta-analyses (relative risks range from 1.21 to 1.40). 71-73 Risk increases … with longer duration of use (relative risks range from 1.23 to 1.35 based on all six meta-analyses that … for breast cancer (relative risks range from 0.85 to 1.14 from 8 meta-analyses). 40 , 71-77 No meta-analyses … Except for CHD, rates are similar when WHI hazard ratios rather than relative risks from our review are … In many cases, a variety of relative risks was available for certain outcomes, and we selected a value
  5. www.uspreventiveservicestaskforce.org/home/getfilebytoken/sQ7hREGwnBm8Wh-LEFWP4F
    October 01, 2002 - studies including 3 meta- analyses (relative risks range from 1.21 to 1.40).71-73 Risk increases with … longer duration of use (relative risks range from 1.23 to 1.35 based on all 6 meta- Postmenopausal … for breast cancer (relative risks range from 0.85 to 1.14 from 8 meta-analyses).40,71-77 No meta-analyses … Except for CHD, rates are similar when WHI hazard ratios rather than relative risks from our review are … In many cases, a variety of relative risks was available for certain outcomes, and we selected a value
  6. www.uspreventiveservicestaskforce.org/home/getfilebytoken/j69Hq5ALvzg74e-ngkzSep
    April 01, 2016 - outcome, we calcu- lated a range of expected event rates after aspirin in- tervention using the pooled relative … Baseline Estimates of Major Bleeding Risks (Trial vs. … Risk for Outcome, events per 1000 person-years Relative Risk (95% CI) Events Caused per 1000 Person-Years … as reported by included cohort studies. ¶ Using cohort baseline risk and trial relative risks to estimate … why persons with these risks have been excluded from trials.
  7. www.uspreventiveservicestaskforce.org/uspstf/recommendation/breast-cancer-medications-for-risk-reduction-2013
    September 15, 2013 - that treatment with tamoxifen or raloxifene can significantly reduce the relative risk (RR) for invasive … Breast Cancer Prevention Trial; IBC = invasive breast cancer; WHI = Women's Health Initiative; RR = relative … Breast Cancer Prevention Trial; IBC = invasive breast cancer; WHI = Women's Health Initiative; RR = relative … Breast Cancer Prevention Trial; IBC = invasive breast cancer; WHI = Women's Health Initiative; RR = relative … Breast Cancer Prevention Trial; IBC = invasive breast cancer; WHI = Women's Health Initiative; RR = relative
  8. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-bleeding-risks-with-aspirin-use/aspirin-to-prevent-cardiovascular-disease-and-cancer
    April 11, 2016 - outcome, we calculated a range of expected event rates after aspirin intervention using the pooled relative … events will vary depending on individual baseline bleeding risks. … why persons with these risks have been excluded from trials. … Level † Baseline Risk for Outcome, events per 1000 person-years Relative Risk (95% CI) Events … ¶ Using cohort baseline risk and trial relative risks to estimate events caused or prevented.
  9. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-bleeding-risks-with-aspirin-use/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
    April 11, 2016 - outcome, we calculated a range of expected event rates after aspirin intervention using the pooled relative … events will vary depending on individual baseline bleeding risks. … why persons with these risks have been excluded from trials. … Level † Baseline Risk for Outcome, events per 1000 person-years Relative Risk (95% CI) Events … ¶ Using cohort baseline risk and trial relative risks to estimate events caused or prevented.
  10. www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary28/menopausal-hormone-therapy-preventive-medication
    November 01, 2022 - heterogeneity in effects between studies. 15 The outcome measure for all quantitative analyses was the relativerisk (RR) of a beneficial or harmful change in risks. … Most increased risks were not statistically different anymore after stopping hormone therapy. … ; NA, not applicable; NR, not reported; PE, pulmonary embolism; RCT, randomized clinical trial; RR, relative … applicable; NR, not reported; OR, odds ratio; PE, pulmonary embolism; RCT, randomized clinical trial; RR, relative
  11. www.uspreventiveservicestaskforce.org/home/getfilebytoken/zVVRY6wa4Sgj-EJb3BRcVy
    November 01, 2013 - that treatment with tamoxifen or raloxifene can significantly reduce the relative risk (RR) for invasive … BCPT � Breast Cancer Prevention Trial; IBC � invasive breast cancer; RR � relative risk; STAR � Study … BCPT � Breast Cancer Prevention Trial; IBC � invasive breast cancer; RR � relative risk; STAR � Study … BCPT � Breast Cancer Prevention Trial; IBC � invasive breast cancer; RR � relative risk; STAR � Study … BCPT � Breast Cancer Prevention Trial; IBC � invasive breast cancer; RR � relative risk; STAR � Study
  12. www.uspreventiveservicestaskforce.org/home/getfilebytoken/Rn7dRezgMx5syB-erQKoKt
    November 01, 2022 - for the US Preventive Services Task Force on the benefits and harms of hormone therapy in reducing risks … Participants using estrogen only compared with placebo had significantly lower risks for diabetes over … Risks per 10 000 persons were statistically significantly increased for gallbladder disease over 7.1 … (RR) of a beneficial or harmful change in risks. … applicable; NR, not reported; OR, odds ratio; PE, pulmonary embolism; RCT, randomized clinical trial; RR, relative
  13. www.uspreventiveservicestaskforce.org/uspstf/recommendation/postmenopausal-hormone-prophylaxis-preventive-medication-1996
    January 01, 1996 - largest and best-designed studies, the beneficial effect was most evident in current users of estrogen (relative … likely to benefit from therapy, but that risks may outweigh benefits among women at increased risk of … possible risks vs. potential benefits of therapy. … The balance of benefits and risks of estrogen therapy in women at increased risk of breast cancer is … Relative risks and benefits of long-term estrogen replacement therapy: a decision analysis.
  14. www.uspreventiveservicestaskforce.org/uspstf/document/final-modeling-study/aspirin-to-prevent-cardiovascular-disease-preventive-medication
    April 26, 2022 - In all scenarios, non-CRC benefits and harms were assumed to take effect immediately, and relative risks … estimate was lower and had a narrower confidence interval compared with the corresponding finding in 2016 (relative … for CRC incidence and affects fatal major gastrointestinal bleeding risks. … constant over time, but lifetime net benefits of aspirin would be higher if these relative risks decreased … CVD Parameter Relative
  15. www.uspreventiveservicestaskforce.org/home/getfilebytoken/4fdC2JLwP_um_yZe4WZRaa
    April 01, 2009 - prevention studies of aspirin have found the following: Clinician Fact Sheet Aspirin use in women y 17% relativerelative risk reduction for MI y No effect on stroke or all-cause mortality y Talk With Your … Harms from aspirin include the risks of serious upper GI bleeding and hemorrhagic stroke. … this risk in women. … For these individuals, the benefits and risks of using aspirin are closely balanced.
  16. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nsaids/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication
    March 15, 2007 - Confounders Addressed in Adjusted Relative Risks among the Included Case-Control Studies: Use of Nonaspirin … Confounders Addressed in Adjusted Relative Risks among the Included Case-Control Studies: Duration of … We chose relative risk as the effect measure. … Confounders Addressed in Adjusted Relative Risks among the Included Case-Control Studies: Use of Nonaspirin … Confounders Addressed in Adjusted Relative Risks among the Included Case-Control Studies: Duration of
  17. www.uspreventiveservicestaskforce.org/home/getfilebytoken/cjWWvkNrCHGUqu4jScs8Ak
    October 05, 2005 - The clinician can motivate patients to consider a quit attempt with the “5 R’s”: Relevance, Risks, Rewards … RISKS Ask the patient to identify potential negative consequences of tobacco use.
  18. www.uspreventiveservicestaskforce.org/home/getfilebytoken/V7SNHdqvUyT7e2hQt5HbFp
    December 12, 2017 - Absent meta-analytic esti- mates, relative risks of outcomes of interest were based primarily on a recent … WHIMS did not find an elevated risk of mild cog- nitive impairment.72 Based on the WHI data, risks for … Point estimate is slightly different from estimate reported in Manson et al15 because of the use of relativerisks instead of hazard ratios. … Relative risks (RRs) were calculated to determine absolute risk reductions and increases presented in
  19. www.uspreventiveservicestaskforce.org/uspstf/recommendation/v2-menopausal-hormone-therapy-preventive-medicatio
    May 09, 2005 - Women and their clinicians should discuss the balance of risks and benefits before deciding to initiate … For example, for combined estrogen and progestin, some risks (such as the risks for venous thromboembolism … meta-analysis of 22 trials of estrogen reported an overall 27-percent reduction in non-vertebral fractures (relative … Results of a meta-analysis of 29 good-quality observational studies of endometrial cancer reported a relativerisk of 2.3 for users of unopposed estrogen compared with nonusers.21 Risks increased with increasing
  20. www.uspreventiveservicestaskforce.org/uspstf/recommendation/menopausal-hormone-therapy-preventive-medication-2002-2005
    May 09, 2005 - Women and their clinicians should discuss the balance of risks and benefits before deciding to initiate … For example, for combined estrogen and progestin, some risks (such as the risks for venous thromboembolism … meta-analysis of 22 trials of estrogen reported an overall 27-percent reduction in non-vertebral fractures (relative … Results of a meta-analysis of 29 good-quality observational studies of endometrial cancer reported a relativerisk of 2.3 for users of unopposed estrogen compared with nonusers.21 Risks increased with increasing

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