-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_executive.pdf
March 01, 2017 - Although many putative risk
factors have been identified, the challenge
is to identify any interventions … Interventions represent one way to establish the veracity
of risk factors. … Results were extracted only from studies assessed as
having low to moderate risk of bias. … not the risk of CATD or of a
combined outcome of MCI or CATD compared to placebo … Raloxifene
may reduce risk of MCI.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
January 01, 2009 - multifocal disease, mastectomy is recommended based on
evidence that this population is at higher risk … In theory, the absolute
benefits of a new treatment depend on three factors: the patient risk of future … events without this treatment (prognosis), the relative effectiveness of the new
treatment, and the risks … The absolute risk reduction equals the patient
baseline risk times the relative risk reduction minus … the risks of treatment.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0648-140819.pdf
June 24, 2014 - Staff-Generated PICO
Population(s): Adults with or at risk of having gout
Intervention(s): Clinical … Does the risk of adverse effects differ according to patient baseline diet and
fluid intake?
c. … Does the risk of adverse effects differ according to joint vs. systemic
involvement in gout? … In adults with a history of gout, what is the evidence that pharmacological therapies
to reduce risk … Does the risk of adverse effects differ according to patient baseline diet and
fluid intake?
c.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_clinician.pdf
August 01, 2016 - Children with DBDs may be at greater risk for problems
in adolescence and later in life, such as substance … Discuss With Parents and Caregivers
of Children with DBDs
�� What DBDs are
�� The potential long-term risks
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-reporting-bias_methods.pdf
November 01, 2013 - Agency found that while published data indicated that benefits of the study drugs outweighed
their risks … , that the inclusion of unpublished data suggested that risks outweighed benefits for all
but one of … additional data (11 studies; 996 patients)
18
changed results from statistically significant (RR [relative … for reporting bias for this outcome (“ORB risk–” or “ARB risk–”). … the results were reported, then
the study is at risk of reporting bias for that outcome (“ORB risk
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
December 23, 2014 - Assessment of Methodological Risk of Bias of Individual Studies
Risk of bias of eligible studies will … across risk of bias approaches. … If the risk of bias
assessment tool is similar to our approach, we will separately assess risk of bias … We will calculate risk ratios (RR)
and absolute risk differences (RD) with the corresponding 95 percent … Chapter 8:
Assessing risk of bias in included studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/arthritis-knee-physical-therapy_research-protocol.pdf
April 01, 2010 - hypotheses and did not provide adequate
information on tested hypotheses (e.g., least square means, relative … risk).
8. … risk, and absolute risk differences. … For observational studies we will extract relative measures of the association
(relative risk, hazard … We will calculate differences in relative risk and absolute risk from the abstracted events by
using
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_clinician.pdf
May 01, 2016 - to 0.94) ���
Table 2: Comparative Effectiveness of Core-Needle Biopsy Methods in Women at Average Risk … Open surgical biopsy samples most or all of the lesion, so
it is considered to have a smaller risk of … However, open procedures may carry a greater risk
of complications, such as bleeding or infection, when … Studies on the accuracy of core-needle breast biopsies were
deemed to have moderate to high risk of … The applicability of findings to women at high risk
of breast cancer is uncertain because few studies
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
May 01, 2013 - Institute of Medicine,5
maternal postpartum depression has also been associated
with an increased risk … Summary judgments for these studies were assigned as
high risk of bias, low risk of bias, or unclear … Ten were judged to have a high risk of biased results; the
remainder were judged to be at low risk. … Two studies were rated low risk of
bias, 10 high risk of bias, and 3 unclear risk of bias. … Only one
study judged to be at high risk of bias provided a specific
estimate of the effect of a risk
-
effectivehealthcare.ahrq.gov/sites/default/files/s103.pdf
October 01, 2007 - func-
tion (which is useful for estimating cumulative incidence
rates in the presence of competing risks … Estimation of cumulative
incidence in the presence of competing risks. … The differential impact of risk
factors on mortality in hemodialysis and peritoneal dialysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/distributed-network-proof_research.pdf
June 01, 2010 - publish and subscribe” model), rather than requiring data holders to accept even a small
security risk … distributed health
information network architecture that will support secure data analyses on the risks … organizational structure required for a network to
support large-scale, population-based studies on the risks
-
effectivehealthcare.ahrq.gov/sites/default/files/implementation-package-unhealthy-alcohol-use-final.pdf
September 01, 2018 - that have good sensitivity and
specificity, or questionnaires that effectively identify behavioral risks … A paper pamphlet for patients titled Rethinking Drinking contains information about
health risks, recommended … Skyy has an
increased risk for? … What information regarding
safe drinking levels and health risks would you provide him with? … RESIDENT: What do you know about safe drinking levels and the risks of drinking to your health?
-
effectivehealthcare.ahrq.gov/sites/default/files/worker-health_executive.pdf
April 01, 2016 - Risk-of-Bias Assessment
To assess the risk of bias (internal validity) of studies
eligible for KQ 2, … A study
assessed as high risk of bias has significant risk of
bias (e.g., stemming from serious errors … We
rated 5 RCTs as medium risk of bias27,28,46,49,50 and the
other 10 studies as high risk of bias … interventions included comprehensive
program content that highlighted the potential additive
or synergistic risks … and included comprehensive
program content that highlighted the potential
additive or synergistic risks
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
November 27, 2012 - diagnosed, and
patients who are diagnosed late or not at all face
substantial morbidity and mortality – risks … interferon alfa-2a vs. dual
therapy with pegylated interferon alfa-2b, and found no
difference in the relative … Results (p.43) Triple therapy with Telaprevir was associated with
increased risk of anemia. … diagnosed, and
patients who are diagnosed late or not at all face
substantial morbidity and mortality – risks … Risk factors for the rising rates of primary liver cancer in the United States.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout-management-disposition-160721.pdf
March 15, 2016 - of
chronic gout (e.g., taking a long term
medication to lower serum urate, with the
concomitant risks … We are not saying
that the benefits exceeding the risks of such
a strategy is not a plausible outcome … accompanied by metabolic syndrome and in addition
to adverse effects noted, there are significant risks … Any evidence on the magnitude of these risks and whether
urate lowering changes them? … Essentially, the current report risks boxing in primary care providers to inferior quality of
care for
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
April 01, 2013 - Relative risk estimates ranged from 1.0 to 1.3 in the four
trials and may have varied in part due to … Relative risk estimates ranged from 0.89 to 1.1.
5
Table 1. … risk estimates for SVR in men vs. … women, and no clear difference in relative risk estimates for
Black vs. non-Black patients. … for risk of
harms that were similar to the risk estimates based on all
trials.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
January 01, 2007 - addition, clinicians
must consider concerns about specific medications
conferring excess cardiovascular risks … (absolute risk
difference of ~2 percent). … The absolute risk difference between
groups was ~2%. … The absolute risk
differences were ~8-14%. … The between-group absolute risk differences were ~ 5-15%.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
November 01, 2013 - Individual Study-
Level Risk of Bias
Assessments
2. … Combining evidence from studies with a high risk of bias and those with less risk can be
problematic … of
bias versus high risk of bias. … Selection in reported epidemiological risks:
an empirical assessment. … Framework for examining risk of reporting bias
Abbreviations: N = number; RRB = risk of reporting
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-omega-3_research-protocol.pdf
September 02, 2016 - IF HIGH RISK OF BIAS, EXPLAIN IN NOTES. … IF HIGH RISK OF BIAS,
EXPLAIN IN NOTES. … IF HIGH
RISK OF BIAS, EXPLAIN IN NOTES. … , DM) ** Including diet but not CVD
risk factors ** Including CVD risk factors, but not diet ** Neither … IF HIGH RISK OF BIAS, EXPLAIN IN NOTES.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-research-methods_research-protocol.pdf
February 08, 2017 - What are the risks of bias in studies of how programs, policies or built environment
changes affect … What are the risks of bias in studies of how programs, policies or built
environment changes affect … In
addition to using the EPHPP tool to provide an overall risk of bias assessment, we will assess
risk … KQ5: What are the important gaps related to risks of bias in population-level data
sources used to … What are the risks of bias in studies of how programs, policies or built
environment changes affect