-
effectivehealthcare.ahrq.gov/sites/default/files/s13.pdf
October 01, 2007 - Historically, those who investigate the effects of mar-
keted pharmaceuticals have focused on the risk … Finally, in recent years, there has been
an increased focus on risk management of drugs (ie, modifi- … Variation
in risk can also depend on duration. … Patterns of risk related to last exposure can
also vary. … Managing the risks from medical
product use: creating a risk management framework. http://www.fda.
gov
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0129_07-13-2009.pdf
January 01, 2009 - 10
1
Results of Topic Selection Process & Next Steps
Cesarean birth in low-risk … The nominator is interested in which factors influence the probability of
cesarean birth in low-risk … women and which interventions are most effective at reducing
the risk of emergency and/or medically … Which interventions are most effective at reducing the risk of needing an emergency
and/or medically … Some of the
Healthy People 2010 objectives focus on reducing cesarean births among low-risk women.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/bladder-cancer-non-muscle-invasive_research-protocol.pdf
July 21, 2014 - number of available tests and testing strategies and potential trade-
offs in diagnostic accuracy, risks … groups, may be especially useful for patients in the intermediate and high risk groups. … of bias,” “medium risk of bias,” or “high
risk of bias.”15, 17
Studies rated “low risk of bias” will … We will not exclude studies rated as
being high risk of bias a priori, but high risk of bias studies … Each study evaluated will be independently reviewed for risk of bias by two team
members.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3_0.pdf
May 01, 2022 - There may be a large increased risk of
dizziness and sedation, and a moderate increased risk of nausea … -point scale
• SMD >0.8
• RR/OR ≥2.0
Abbreviations: MD = mean difference; OR = odds ratio; RR = relative … confidence interval; KQ = Key Question; MD = mean difference; RCT = randomized controlled trial; RR = relative … ; KQ = Key Question; MD = mean difference; OR = odds ratio; RCT = randomized controlled trial; RR = relative … General risks of harm with cannabinoids,
cannabis, and cannabis-based medicine
possibly relevant to
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-grading_methods.pdf
July 01, 2012 - When the treatment of a disease has high associated risks, multiple tests are often used to
assure the … false negatives depends on the severity of disease if there is a missed diagnosis, in addition
to the risks … from the testing itself (i.e., if the test is invasive and associated with risks in and of
itself). … of bias:
• Low risk of bias
• Medium risk of bias
• High risk of bias
Well designed and executed … Assessing risk of bias as a domain of quality in
medical test studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_executive.pdf
April 01, 2013 - profile
among adults with SMI at elevated risk of CVD. … factors in adults with SMI who
have elevated risk for CVD. … indices
(e.g., Framingham Risk Score). … These guidelines for the general population should
then be modified to consider the special risks for … or
cardiovascular events
Insufficient
information
Risk indices (e.g., Framingham Risk Score) and
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_executive.pdf
February 01, 2012 - Ewing’s
sarcoma family of tumors, and high-risk relapsed
Wilm’s tumor. … The four
required domains—risk of bias, consistency, directness,
and precision—were considered for … The decision to apply a high-risk procedure
such as HSCT to this population is not clear cut. … conditions addressed in this systematic review, evidence
is insufficient to draw conclusions as to the relative … risk-benefit ratio of HSCT versus other management
approaches.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
March 13, 2012 - A number of negative prognostic factors (factors associated with increased risk of
recurrence) have … Identifying the individuals in whom the potential benefits of chemotherapy outweigh
the risks is challenging … T4 tumor) may be inadequate for determining
individual risk. … On the other hand, introducing routine
testing without a clear understanding of benefits and risks could … obtained with standard risk factors?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
December 14, 2012 - exists to support the clinical utility of
the GEP tests to alter or improve health outcomes and the risks … The 5-year distant-metastasis free survival was
95% for low risk patients and 80% for high risk patients … The 3-year RFS
was 91% for Low Risk and 74% for High Risk patients with a HR of 2.9
(p=0.001).” … ColoPrint better
distinguishes low and high risk groups as compared to risk assessment
using current … ColoPrint better
distinguishes low and high risk groups as compared to risk assessment
using current
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-risk-bias.ppt
June 01, 2012 - Assessing risk of bias as a domain of quality in medical test studies. … Assessing risk of bias as a domain of quality in medical test studies. … Assessing risk of bias as a domain of quality in medical test studies. … Assessing risk of bias as a domain of quality in medical test studies. … (Risk: Low/High/Unclear)
QUADAS-2 Questions for Assessing Risk
-
effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-risk-bias.ppt
June 01, 2012 - Assessing risk of bias as a domain of quality in medical test studies. … Assessing risk of bias as a domain of quality in medical test studies. … Assessing risk of bias as a domain of quality in medical test studies. … Assessing risk of bias as a domain of quality in medical test studies. … (Risk: Low/High/Unclear)
QUADAS-2 Questions for Assessing Risk
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-therapy-management_executive.pdf
November 01, 2014 - A broadly defined scope for this review risks including
studies that may be too different from each … A narrowly
defined scope for this review risks the omission of studies
that met the definition of MTM … In other words, we evaluated trials with potential
randomization failure for the same risks of bias … therapy management; NA = not applicable; OR = odds ratio;
RCT = randomized controlled trial; RRR = relative … risk ratio.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/bipolar-disorder-treatment_research-protocol.pdf
June 23, 2014 - when considering a specific treatment option versus no treatment, they would
need to consider the risks … We define a “direct”
harm as harm a patient risks by virtue of receiving the treatment and is part of … What can we do to mitigate the side effects of
pharmacological treatments that create other medical risks … quality.15 Study-level risk of bias must be assessed using validated
risk of bias tools appropriate … Using a random
effects model, we will calculate risk ratios (RR) and absolute risk differences (RD)
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
December 01, 2011 - The strength of
evidence for higher risks of weight gain with
mirtazapine than with other antidepressants … Severe Adverse Events
The strength of the evidence on the comparative risks
of second-generation antidepressants … trials and observational studies were too
small and study durations too short to assess the
comparative risks … yield
conflicting information about the comparative risk of seizures. … hepatotoxicity about the comparative risk of hepatotoxicity.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/postpartum-care-one-year-protocol-amendment.pdf
April 25, 2022 - parenthood, and consider future family planning, but also to mitigate immediate and lifelong
health risks … planning and contraception
o Adverse pregnancy outcomes associated with cardiometabolic disease
o Risks … Assessment of Methodological Risk of Bias of Individual Studies: We will evaluate each study for risk … The three
tools will include the Cochrane Risk of Bias Tool,20 the Risk of Bias in Nonrandomized Studies … Severe Maternal Morbidity and Risk of Mortality Beyond the
Postpartum Period.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-rapid-response-surgical-report-cards.pdf
November 01, 2023 - The
National Veterans Administration Surgical
Risk Study: risk adjustment for the
comparative assessment … Using risk-adjusted outcomes to
assess clinical practice: an overview of
issues pertaining to risk adjustment … The National Veterans Administration Surgical Risk
Study: risk adjustment for the comparative assessment … 30-day mortality (relative risk
[RR] 0.96, 95% CI, 0.89–
1.03), serious complications
(RR 0.96, 95% … Data Bank; O/E = observed vs expected ratio; PDSA = Plan Do Study Act; PE = pulmonary embolism; RR = relative
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/safety-vaccines-protocol.pdf
January 30, 2020 - Also, what are the risks of specific adverse events, the
frequency of events, and the certainty of the … frequency of potential side effects to
help them weigh the benefits of vaccines against potential risks … We will calculate the relative risk for the adverse events for all studies by
comparing the intervention … We will summarize the
absolute rate of adverse events as well as the relative risk, to facilitate the … Risk analysis : an official publication of
the Society for Risk Analysis. 2016;36(7):1297-314. doi:
-
effectivehealthcare.ahrq.gov/sites/default/files/decide16final-mortality-risk-in-copd-pts-using-theophylline.pdf
December 01, 2009 - Mortality risk in chronic obstructive pulmonary disease
patients using theophylline. … Compared to similar regimens, patients in regimens that included theophylline had
slightly increased risks … these increased risks were generally small (HR of 1.1 to 1.3). … patient-reported outcomes in a real-world setting will be necessary to quantify
both the benefits and risks … Inhaled
corticosteroids and the risk of a first
exacerbation in COPD patients.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-management_research.pdf
December 01, 2009 - Mortality risk in chronic obstructive pulmonary disease
patients using theophylline. … Compared to similar regimens, patients in regimens that included theophylline had
slightly increased risks … these increased risks were generally small (HR of 1.1 to 1.3). … patient-reported outcomes in a real-world setting will be necessary to quantify
both the benefits and risks … Inhaled
corticosteroids and the risk of a first
exacerbation in COPD patients.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-genetic_methods.pdf
July 01, 2012 - What health risks can be identified for follow-up testing and/or intervention?
35. … Tests for BRCA mutations may be used to predict the risk for breast and
ovarian cancer in high-risk … women (i.e., those with a family history suggesting increased risk). … Lyon, France: IARC Monogr Eval Carcinog
Risks Hum; 1999. p. 23-36.
45. … Genetic risk assessment: recommendation
statement.