-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_executive.pdf
July 01, 2014 - in humans, but potential benefits
may warrant use of the drug in pregnant women despite
potential risks … in humans, but potential
benefits may warrant use of the drug in pregnant women
despite potential risks … women who did not use an
antidepressant during pregnancy but whose depression
status was unknown (relative … We know, however, that some baseline risks are associated
with depression during pregnancy; this fact … Nonpharmacological treatments are generally thought
to have fewer risks than antidepressants.
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
June 02, 2011 - protocol Yes No No
Conflict of interest No No Yes (optional domain of
publication bias )
Types of Risks … Each study design has specific risks
of bias that may differ depending on the clinical question. … classes of evidence into the review and (2) when
evaluating individual studies for design-specific risks … to include observational studies, then the review team
needs to evaluate each study based on the risks … presenting data on individual endpoints;
26
2. selective outcome reporting—for example, reporting relative
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/omega-3-maternity_executive.pdf
October 01, 2016 - observational studies found no
consistent effects of maternal or infant n-3
FA supplementation on risks … Key Question 3: Maternal or childhood adverse events:
– What are the short and long-term risks related … Breastfeeding women
o Term or preterm human infants at or after birth
– What are the short and long-term risks … Dermatitis, and Respiratory
Conditions
Additional outcomes newly included in the current report
were risks … for atopic dermatitis/eczema, risks for allergies,
and risks for respiratory illnesses, including asthma
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
March 01, 2022 - There may be a large increased risk of
dizziness and sedation and a moderate increased
risk of nausea … • Studies on the acute treatment of migraine that
compare relative risks of medication overuse … studies that looked at prior or early
postoperative opioid use found mostly strong
associations (e.g., relative … Outcomes
• Studies to assess risks and benefits including patient
anxiety and disproportionate access … with
antiresorptive osteoporosis drug treatment to best
place these risks in the context of the effects
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-seniors-pneumonia_research.pdf
May 01, 2008 - Observed Association Between Antidepressant Use and Pneumonia Risk Was Confounded by Comorbidity Measures … Health Care
Number 5
Research Reports
Observed Association Between Antidepressant Use
and Pneumonia Risk … The exposure odds ratio in
nested case-control studies with competing risks. … Risk factors for community-
acquired pneumonia diagnosed upon hospital
admission. … Risk of community-
acquired pneumonia and use of gastric acid-
suppressive drugs.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/COVID-19-pharmaceutical-treatments-rapid-review.pdf
March 01, 2024 - in risk. … There were no significant differences in risks for acute kidney injury,
cardiac arrhythmia, infection … Risks for acute kidney injury, hypertension,
hypotension, seizure, and transfusion-associated lung injury … Studies from other regions might also report elevated risks for additional serious adverse
events. … Assessment RoB: Low risk
Reporting RoB: Low risk
Overall RoB: Low risk
Pub.
-
effectivehealthcare.ahrq.gov/sites/default/files/s81.pdf
October 01, 2007 - commonly
used measure of discrimination, in this case equal to (sensi-
tivity � specificity)/2,22 and relative … risk (RR). … risk. … 31 38.21 0.0000
Diabetes Mellitus (CCS D-50)† 0.08 4 11 97 0.54 3 3.41 0.0134
*P value is for the relative … risk.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-de-novo-processes_methods.pdf
September 01, 2009 - Effectiveness Reviews
Key Points
• Using existing systematic reviews (SRs) has potential benefits and risks … Conversely, five main risks are associated with using existing SRs in CERs that
do not arise in a purely … The use of existing SRs to substitute for purely de novo CER methods may
provide benefits and risks. … to a CER’s comprehensiveness and transparency or the
risk of introducing bias. … of interest.6
Commonly Used SR Quality Instruments
In assessing the quality (i.e., assessing the risk
-
effectivehealthcare.ahrq.gov/sites/default/files/systematicreviewsreplacedenovo.pdf
September 01, 2009 - Effectiveness Reviews
Key Points
• Using existing systematic reviews (SRs) has potential benefits and risks … Conversely, five main risks are associated with using existing SRs in CERs that
do not arise in a purely … The use of existing SRs to substitute for purely de novo CER methods may
provide benefits and risks. … to a CER’s comprehensiveness and transparency or the
risk of introducing bias. … of interest.6
Commonly Used SR Quality Instruments
In assessing the quality (i.e., assessing the risk
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_appendixes.pdf
January 01, 2009 - Relative Risks (RRs): The ratio of an event occurring in an exposed group to an event
occurring in … results reported
as relative risk,
likely reflects
hazard ratio
Moorcroft,
1997
10
N=92 … risk, likely
reflects relative
risk
Sharples,
1993
5
N=67
Adult patients with CF accepted … risk, likely
reflects relative
risk
F-11
Appendix Table F2. … RR 3.25
(95%CI 1.27,
3.25)
NR Univariate results
reported as
relative risk, likely
reflects
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-transition-care_executive.pdf
May 01, 2014 - Effective Health Care Program
2
uncontrolled hypertension are the two highest population-
attributable risks … Risk-of-Bias Assessment of Individual Studies
To assess the risk of bias (internal validity) of studies … the risk of bias for each study. … For binary outcomes,
we calculated relative risks (RRs) and 95% confidence
intervals (CIs). … bNA entry for NNT indicates that the relative risk (95% CI) was not statistically significant, so we
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/community-health-worker-protocol.pdf
March 26, 2019 - and knowledge base, and increase funding for services.5, 8-11 On the other
hand, there are important risks … the overarching goal of this project is to assess the current
state of evidence of the processes, risks … ROBIS: A new tool to assess risk of bias in
systematic reviews was developed.
-
effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1506.pdf
June 01, 2015 - Key Expert Comments: Programs such as MSHOP may address an unmet need for
reducing surgical risks … that clinicians would be likely to adopt a MSHOP-like
program based on the potential to decrease risks … Most experts commenting on this intervention agreed that an unmet need exists for reducing
surgical risks … Unmet need and health outcomes: An unmet need exists to decrease surgical risks and
complications, … biggest hurdle, which is patient compliance.67
Acceptance and adoption: The potential to decrease risks
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-202-bronchial-thermoplasty-asthma.pdf
December 01, 2017 - However, reduced risk of severe exacerbations was
suggested (low SOE), although the clinical importance … availabl
literature, BT may be modestly beneficial in some patients
with asthma, but is not without risks … The risk of adverse events is higher early in treatment,
while benefit is typically observed weeks to
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-child-adolesc-mental-health-grand-rounds.pptx
May 22, 2025 - of Bias
Strength of Evidence (SoE) across studies by considering risk of risk of bias, consistency, … from communities at risk. … The program uses cultural considerations to inform multi-component treatments designed to address risks … CAMS is guided by the Suicide Status Form (SSF), which is used to identify risks and contributors to … The program uses cultural considerations to inform multi-component treatments designed to address risks
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-protocol.pdf
September 24, 2024 - Assessment of Methodological Risk of Bias of Individual Studies
We define the risk of bias as the risk … Studies will be
rated as “low risk of bias,” “medium risk of bias,” or “high risk of bias.” … Studies rated “low risk of bias” are considered to have the least risk of bias, and their results are … 100-point scale
SMD >0.8
RR/OR ≥2.0
Abbreviations: MD = mean difference; OR = odds ratio; RR = relative … quality improvement; RCT = randomized controlled trial; ROSC = return of spontaneous circulation;
RR = relative
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-other-plant-based-treatments-evidence-summary_0.pdf
October 01, 2021 - There may be a large increased risk of dizziness and
sedation and a moderate increased risk of nausea … of
sedation, and large increased risk of nausea. … Synthetic THC is probably associated
with a large increased risk of dizziness. … -point scale
• SMD >0.8
• RR/OR ≥2.0
Abbreviations: MD = mean difference; OR = odds ratio; RR = relative … risk; SMD = standardized mean difference.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
January 01, 2023 - There may be a large increased
risk of dizziness and sedation and a moderately
increased risk of nausea … of sedation,
and large increased risk of nausea and dizziness … Extracted whole-plant products with higher THC
than CBD may be associated with large
increases in risk … • Studies on the acute treatment of migraine that
compare relative risks of medication-overuse … use of risk prediction instruments
impacts treatment decisions and outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/joint-replacement-evidence%20-summary.pdf
November 01, 2021 - o Prehabilitation prior to TKA may not increase the risk of harms (low SoE). … We assessed the risk of
bias and evaluated the SoE using standard methods. … Prehabilitation prior to TKA may not increase the risk
of harms (low SoE). … Post-acute rehabilitation may have comparable risks of harms among
various rehabilitation interventions … The included studies were mostly at moderate to
high risk of bias.
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_3-user-guide-to-ocer_130129.pdf
September 21, 2012 - For the relative risk model, u
i
=
log [prob(Y
i
(2)=1)] – log[prob(Y
i
(1)=1)]. … excluded from a randomized trial, but a treating
clinician may decide that the benefits outweigh the
risks … They used existing risk
models (Framingham and Reynolds risk scores), as
well as a prediction model … The average treatment effect (ATE) (relative risk)
was applied to calculate individual treatment
effects … Subgroup
analyses in randomised controlled trials:
quantifying the risks of false-positives and
false-negatives