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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-evidence-summary-corticosteroids-asthma.pdf
October 01, 2017 - ICS controller • Does affect:
– The risk of exacerbations requiring oral corticosteroids (low SOE) … combined with LABA as controller and quick
relief vs. a higher ICS controller dose
• Reduces the risk … ICS and LABA as controller at the same ICS
dose
• Reduces the risk of exacerbations measured as a … ICS controller • Does not affect the risk of exacerbations, regardless of definition
(low SOE)
• … ICS and LABA as controller at the same ICS dose
• Reduces:
– The risk of exacerbations defined as
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-decision-support-tools_disposition-comments.pdf
December 23, 2014 - There is a world behind this (risk
communication science, framing risks in various ways (Gigerenzer, … , high risk, early cancer)
and additional intervention characteristics. … their average baseline risk.” … Change to : “accuracy of perception of
mortality risks . . .” … risk
probabilities but 22 studies were for prostate cancer.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/progestogens-preterm-birth_research-protocol.pdf
June 01, 2010 - critical gaps in our knowledge, particularly with regard to identifying and treating
women at high risk … If all at-risk
pregnant women were treated with 17-OHP, the aggregate medical cost savings could be … could be more than $2 billion.10
The ultimate goal in preventing preterm birth is to eliminate the risks … In general, the figure illustrates how the use of progestogens in women at risk
for preterm birth may … A woman’s risk of preterm birth is determined by risk factors such as
http://www.effectivehealthcare.ahrq.gov
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_surveillance.pdf
December 01, 2012 - of proximal and distal
DVT (relative risk reduction [RRR] 47 percent and
41 percent, respectively) … mechanical prophylaxis
(intermittent pneumatic compression and venous
foot pump) versus control, the risks … For example, if relative risk reduction (RRR) new / RRR old <=0.5 or RRR new / RRR old
>=1.5. … of proximal and distal DVT (relative
risk reduction [RRR] 47 percent and 41 percent, respectively), … mechanical
prophylaxis (intermittent pneumatic compression and venous foot pump) versus control,
the risks
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/worker-health_research-protocol.pdf
May 26, 2015 - mortality, morbidity, and
considerable financial and social costs.1-3 At the same time, modifiable risk … Community Preventive Services Task
Force recommends worksite interventions (assessments of health risks … A study with moderate risk of bias is susceptible to some risk of bias but
probably not enough to invalidate … A study assessed as high risk of bias has
significant risk of bias (e.g., stemming from serious issues … Two independent reviewers will assess risk of bias for each study.
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
January 01, 2011 - Incidence is generally
assessed as a risk/proportion over a fixed
time period (e.g., risk for 1-year … estimation of risk or rate
differences. … Controls were
only sampled from the “risk set.” … The cohort
design has the added advantage that absolute risks
or incidence rates can be estimated and … Statin
adherence and risk of accidents: a cautionary tale.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/grading.ppt
January 01, 2010 - grade
Four Required Domains: Risk of Bias
Four Required Domains: Risk of Bias
The risk of bias for … Risk-of-bias scores are denoted as high, medium, or low. … High risk of bias lowers the strength-of-evidence grade; low risk of bias raises the strength-of-evidence … Guiding Principles: Risk of Bias
Guiding Principles: Risk of Bias
The risk of bias based on the design … Guiding Principles: Risk of Bias Example
Guiding Principles: Risk of Bias Example
This is an example
-
effectivehealthcare.ahrq.gov/sites/default/files/grading.ppt
January 01, 2013 - grade
Four Required Domains: Risk of Bias
The risk of bias for an evidence base is derived from assessing … Risk-of-bias scores are denoted as high, medium, or low. … High risk of bias lowers the strength-of-evidence grade; low risk of bias raises the strength-of-evidence … DOI: 10.1016/j.jclinepi.2009.03.009
Guiding Principles: Risk of Bias
Risk of bias (given design … Guiding Principles: Risk of Bias
The risk of bias based on the design and conduct of the available studies
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-strength_methods.pdf
July 01, 2009 - Risk of Bias
As noted in Table 1, the risk of bias for an evidence base will be derived from assessment … of
the risk of bias in individual studies. … Risk of bias incorporates both study design and study
conduct. … High risk of bias lowers the strength-of-evidence
grade; low risk of bias raises it. … of
bias:
• Low risk of bias
• Medium risk of bias
• High risk of bias
Consistency The principal
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
October 20, 2011 - evaluated the effectiveness of treatment for HCV infection within the context of screening and
risk … Does becoming aware of positive HCV infection status decrease high-risk behaviors?
c. … High-risk sexual behaviors
c. … Screening of the general population versus “targeted” high-risk groups (KQ 2)
3. … Assessment of Methodological Risk of Bias of Individual Studies
We will assess the risk of bias
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/aggression_research-protocol.pdf
October 05, 2015 - First, a key clinical and policy question is how to best balance the benefits and
risks of (a) seclusion … We envision a continuum of risk and behavior. … Assessment of Methodological Risk of Bias of Individual Studies
To minimize risk of bias in observational … That is, a low-risk-of-
bias nonrandomized study does not necessarily equal a low-risk-of-bias randomized … To determine risk of bias in a standardized way, we will use the Cochrane Risk of
Bias tool to appraise
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
April 20, 2015 - renal mass (oncologic outcomes, renal functional outcomes, complications) as well as
competing health risks … Assessment of Methodological Risk of Bias of Individual Studies: The assessment of risk of
bias of … Risk of bias judgment
Overall bias Risk of bias judgment
Table 4. … Risk: Low/High/Unclear
Archived: This report is greater than 3 years old. … of
bias:
• Low risk of bias
• Medium risk of bias
• High risk of bias
Well designed and executed
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
February 01, 2008 - proposed by Follman and colleagues.43
For dichotomous endpoints, weighted averages will be reported as relative … risks with
associated 95 percent confidence intervals. … expected, a DerSimonian and Laird random-effects model will be used when pooling data and
calculating relative … risks and 95 percent confidence intervals. … The risk of bias will be assessed
through the evaluation of both design and study limitations.
-
effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update_executive.pdf
January 01, 2018 - for ROB.
g Downgraded for ROB and imprecision because of small event rates; confidence intervals of relative … risks ranged between 0.02 to 5.0,
to 0.06 to 48.1).
13
Bipolar Disorder
Of 19 studies examining … Risks for somnolence and EPS symptoms
may be of little or no difference for low- versus high-
dose risperidone … in risk for akathisia. … It may increase risk for any EPS
symptoms.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy_executive.pdf
January 01, 2017 - We considered 67 studies to have low risk of bias,
110 to have moderate risk, and 41 to have high risk … cohort studies had high risk. … Eighteen
studies had low risk of bias, 28 had moderate risk, and
13 had high risk. … Twenty-two studies had
low risk of bias; 36 had moderate risk; and 12 had high
risk. … balance
needs for relief of illness-related outcomes (including
missing school and work) with the risks
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_disposition-comments.pdf
September 10, 2014 - Also, in Table C, it is not clear whether “high risk” refers to
high risk women, or a high risk lesion … Because
over-diagnosis is the end result of lead time (due
to screening) and competing risks (specifically … Because
over-diagnosis is the end result of lead time (due
to screening) and competing risks (specifically … , regardless of patient risk. … to assess risk of bias.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_consumer.pdf
January 01, 2017 - What increases the risk of gout?
The exact cause of gout is not known. … But, certain things may
increase the risk of getting it. … Being overweight can also
increase the risk of gout. … � Allopurinol (Zyloprim®) and febuxostat (Uloric®) do not lower the
risk of a gout attack in the … In fact, these medicines can increase the risk of a gout attack when you first start
to take them.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0319_06-17-2009.pdf
January 01, 2009 - whether these serum biomarkers
provide evidence for the diagnosis or prognosis of sepsis for patients at risk … For patients at risk for, or in, sepsis, are there serum biomarkers available for the
diagnosis and … For patients at risk for, or in, sepsis, does C reactive protein provide any utility in
their management … For patients at risk for, or in, sepsis, does procalcitonin provide any utility in their
Sepsis Biomarkers … For patients at risk for, or in, sepsis, does cortisol provide any utility in their
management?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-nomination-apbi-breast-cancer.pdf
April 01, 2017 - define a group of patients with low-risk DCIS
for whom observation confers a low absolute risk of IBTR … of IBTR.17 When analyzed by the ECOG 5194
risk criteria, the risk was 2% for patients meeting these … low-risk criteria. … However, given the low risk of IBTR in
low-risk DCIS with wide local excision alone, coupled
with favorable … results following APBI for low-risk DCIS
in several series, the task force recommends inclusion of
low-risk
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
September 20, 2013 - a lesion will be classified as benign or as high risk (e.g., atypical ductal
hyperplasia [ADH]) or … Assessment of Methodological Risk of Bias of Individual Studies
We will assess the risk of bias for … We discuss the handling of high risk of bias studies in sections E and F below. … levels of risk of bias will lead to downgrading the strength of the
evidence. … of cancer (women at “average risk” vs. those at “high risk” may
affect estimated test performance because