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Total Results: 2,116 records

Showing results for "risks".

161. Dispostion of Comments Report for Child and Adolescent Exposure to Trauma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_disposition-comments.pdf
     February 11, 2013 - and 2) “What are the relative potential risks/harms of alternative treatments (and no treatment)?” … the clinical value of the review would be greatly enhanced with much more attention to the harms and risks … benefits would appear to exclude a large amount of research that could independently speak to harms and risks … As noted, these “might be additional evidence of benefit” (and may also speak to harms/risks), so please … and clinically relevant (and may suggest a need for additional review and appraisal of evidence of risks

162. CARDIOVASCULAR (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cardiovascular-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - However, clinical experts estimate that from 14% to 44% of patients with AF have bleeding risks that … Overall, experts opined that the benefits of this intervention outweigh the risks. … prevent stroke in patients with AF, but an estimated 14% to 44% of patients with AF have bleeding risks … Clinical Pathway at Point of This Intervention A serious complication of AF is ischemic stroke.1,2 Risks … and the patient’s relative risks and benefits.1 Antithrombotic agents include vitamin K antagonists

163. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
     June 16, 2010 - • To decrease these risks, as well as the risk of serious cardio- and thrombovascular events, use … For binary data, the relative risk will be used as a measure of treatment effect. … Risks of blood transfusion. Anesthesiol Clin North America 2005;23(2): 241-52. 27. … Transfusion risks of yesterday and of today. Transfus Clin Biol 2003;10(1): 1-5. 29. … difference and relative risk scales.

164. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - Body fat distribution is also an important determinant of disease risk. … risks with liraglutide use. … The relative risks for minor complications, for example gastric ulcers and erosions were significantly … There are some risks involved in the intervention, but studies so far indicate that the treatment is … Studies better defining the potential long-term risks (breast cancer and cardiovascular risks) need

165. Restless-Legs Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
     December 16, 2011 - significantly impacts quality of life. 21,22 For individuals with mild or moderate symptoms, the risks … In addition, long- term risks and benefits of treatment are unclear for children and older adults with … Neither do we know the risks/benefits of the drugs for older adults who take several medications for … For each RCT, we will assess risk of bias using the Cochrane risk of bias tool. … We will assume a low risk of bias when RCTs meet all the quality criteria; a moderate risk of bias

166. Disposition of Comments for CER 166 Calcineurin Inhibitors (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
     March 15, 2016 - comparing the immunosuppressive regimens designed to reduce or eliminate exposure to CNI toxicity risks … be interesting to know if it is possible to identify at what point in the withdrawal process the risks … It is not clear where the benefits of minimization end and the risks of withdrawal begin. … By indirectly endorsing this perspective, this review risks exacerbating a trend toward overzealous … However, risks and benefits will vary greatly depending on what type of donor organ is being used,

167. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
     May 01, 2012 - interest in an observational study were evenly distributed among people who had approximately the same risks … Then the odds ratio (OR) (or hazards ratio [HR] or relative risk [RR]) for the other risk score categories … of that risk. … Presentation of stratified results Propensity Score Quintile 95% CI Relative Risk Lower Upper All … Adjustment for multiple cardiovascular risk factors using a summary risk score.

168. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
     March 24, 2017 - TEP #2 Methods Page 19, line 46 “Quality (Risk of Bias) Assessment of Individual Studies”. … For tramadol and tapentadol, we report in the abstract that “opioids have significant long-term risks … and low back pain, given lack of evidence for long-term benefit and increasing evidence of serious risks … NEVER SHOULD BE USED FOR DIABETIC PN but spinal cord stimulation had risks of serious complications … of bias, all oral drugs had significant side effects, and opioids have significant long-term risks

169. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
     March 24, 2017 - TEP #2 Methods Page 19, line 46 “Quality (Risk of Bias) Assessment of Individual Studies”. … For tramadol and tapentadol, we report in the abstract that “opioids have significant long-term risks … and low back pain, given lack of evidence for long-term benefit and increasing evidence of serious risks … NEVER SHOULD BE USED FOR DIABETIC PN but spinal cord stimulation had risks of serious complications … of bias, all oral drugs had significant side effects, and opioids have significant long-term risks

170. Progestogens-Preterm-Birth Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
     September 01, 2012 - spending in the United States.4 The ultimate goal in preventing preterm birth is to eliminate the risks … factors or cointerventions intended to further reduce risk of preterm birth. … Lack of large-scale, systematic evidence about potential risks of treatment is concerning to providers … of progestogen, to determine whether long-term outcomes are improved, and to rule out longer term risks … Progesterone and the risk of preterm birth among women with a short cervix.

171. Comparative Effectiveness of β-Adrenergic Antagonists on the Risk of Rehospitalization in Adults with Heart Failure (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-rehospitalization_research.pdf
     November 01, 2007 - risks of rehospitalization for heart failure within 12 months were not significantly different among … nebivolol (1.25 to 10 mg per day) or placebo.(17) Patients in the nebivolol arm had a 14% (P=0.039) lower relative … each β-blocker before and after the index hospitalization, there was no significant difference in the relative … Of note, there was a 28-29% higher adjusted relative risks of rehospitalization associated with receiving … Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.

172. Nephropathy-Contrast-Induced Executive-2016 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
     January 01, 2016 - Pooled risks were calculated using a random- effects model using the DerSimonian and Laird method.8 … administration of contrast) with IOCM compared with a diverse group of LOCMs (pooled relative risk … However, the point estimate of this reduction did not exceed a minimally important relative risk difference … RCTs that have been published since those three meta-analyses, we obtained a similar estimate of the relative … risk.

173. Disposition of Comments Report for Noninvasive Technologies for the Diagnosis of Coronary Artery Disease in Women (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_disposition-comments.pdf
     June 12, 2012 - other tweaks from invasive cardiologists, but from my "doc in a box" vantage point of benefits and risks … According to the Joint Commission’s latest Sentinel Alert, the risks associated with the use of ionizing … Feinstein, Steven (International Contrast Ultrasound Society) General 1 Radiation Risks of Diagnostic … We have added more details about the radiation risk to the Safety Concerns and Risks section. … The review includes 11 studies reporting safety concerns and risks, including three studies that show

174. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
     March 01, 2011 - This risk should prompt routine thromboprophylaxis; however, the associated elevated risk of bleeding …  The length of the evaluation period will be considered when evaluating the benefits and risks (short-term … differences or relative risks by using a DerSimonian and Laird random effects model. … differences, or relative risks with 95 percent confidence intervals for the individual studies. … Prophylactic inferior vena cava (IVC) filter placement may increase the relative risk of deep venous

175. Making Healthcare Safer IV Rapid Review: Supply Chain Disruption Monitoring Programs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/monitoring-programs-rapid-research.pdf
     April 01, 2025 - Supply chain shortages ranked second among Top 10 risks facing healthcare organizations [Internet]. … The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. … ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. … Pharmaceutical supply chain risks: A systematic review. … Insights for a risk-assessment tool to manage medicines' shortages.

176. Major-Depressive-Disorder Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_research-protocol.pdf
     November 24, 2014 - KQ 3a: In adult patients with MDD, what are the comparative risks of harms between SGAs and nonpharmacological … KQ 3b: Do the risks of treatment harms vary by MDD severity? … KQ 4: Do the benefits and risks of harms of these treatment options differ by subgroups of patients … Assessment of Methodological Risk of Bias of Individual Studies: To assess the risk of bias (internal … and nonpharmacological therapies KQ3a: In adult patients with MDD, what are the comparative risks

177. CER 217 Management of Infertility Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-217-infertility-evidence-summary.pdf
     May 01, 2019 - Different treatments also carry different safety risks. … There are known short-term risks such as ovarian hyperstimulation syndrome (OHSS) or acute risks associated … Surgery may have additional longer-term risks which may affect subsequent fertility (such as scarring … of these procedures, with no evidence on potential longer term risks. … Risks of adverse longer term maternal cancer outcomes were generally not increased after adjustment

178. Ch 10-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_10-user-guide-to-ocer_130129.pdf
     January 01, 2011 - fixed followup and is rare, Poisson regression with robust standard errors can be used to estimate relative … risks and get correct confidence intervals.8-9 For count data, Poisson regression can also be used … Otherwise, there are risks with regards to interpretation of study findings. … Relative risk regression in medical research: models, contrasts, estimators, and algorithms. … Adjustment for multiple cardiovascular risk factors using a summary risk score.

179. medication-assisted-treatment-protocol-160224 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-use-disorder_research-protocol.pdf
     February 24, 2016 - .11,12 Compared with OUD due to prescription drugs, OUD related to heroin is associated with additional risks … detoxification and abstinence in reducing the frequency and quantity of opioid use as well as the risk … The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain. … The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a

180. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
     April 23, 2019 - Comment Response Discussion Public Commenter #7 (ASBMR) Report should include a discussion on the relative … Needs presented on ES-16 are thoughtful and focus on the need to carefully evaluate the benefits and risks … However, the clinical question was what is the evidence for benefits and risks beyond 3 years. … A similar question should be asked about adequacy of data to study the hypothetical risks (e.g., increased … There are several statements about the benefits and risks of continued treatment versus interruption