-
effectivehealthcare.ahrq.gov/sites/default/files/fagerlin-presentation.pdf
May 29, 2025 - F or example, the
risks and
benefits across various treatments is not sufficient. … S imilarly, what is a higher risk: one out of ten, hundred,
a thousand? … One journal
presented
the data about the effectiveness of chemotherapy using relative risks. … Oncologists who got the relative risk information were more likely to say
that they would
prescribe … Behaviors are influenced
both
by beliefs and
by the feelings of risks.
-
effectivehealthcare.ahrq.gov/sites/default/files/s23.pdf
October 01, 2007 - and
Their Association With Stroke
Therapy
Relative
Risk
No. … Again, communication of frequency information
rather than relative risks is critical to debate. … Benefits and harms not presented in the same metric (ie,
relative risks for benefits and frequencies … For the most part, the articles discuss
relative estimates (relative risks or odds ratios; Fig. 1). … Benign breast disease—the risks of commu-
nicating risk �comments�.
-
effectivehealthcare.ahrq.gov/products/adhd-medicines-risks/abstract
-
effectivehealthcare.ahrq.gov/products/grant-manuscripts/increased-risks-abstract
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
February 01, 2014 - risk reductions or relative risk increases of aspirin on benefit
and harm outcomes did not change over … Applicability of Effects We assumed RR reductions in benefits or relative risk increases in harms, from … and equal for both groups (i.e. relative risk of 1.0). … risk reduction for MI of about 14 percent9 using the relative
risk method. … CI = confidence interval, MI = Myocardial infarction,
RR = Relative risk
Table A-2.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/models-care-adult-survivors-childhood-cancer-evidence-summary.pdf
February 01, 2022 - Summary
Main Points
Background and Purpose
Childhood cancer survivors are at increased risk … literature include
oncology care versus primary care, survivor and provider knowledge (e.g.,
survivor risks … as described by the Stakeholders:
“Survivors feel confident about sharing their history, know their risks … access relevant care and services” and “PCPs understand
a survivor’s history, know the survivor’s risks … to inform delivery
of survivorship-related care
Survivors can share
their history, know their
risks
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_executive.pdf
September 19, 2014 - The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain
Evidence-Based
Practice … receiver operating characteristic
curve (AUROC).34,35
For studies of interventions, we calculated relative … risks
(RR) and associated 95 percent confidence intervals (CI)
based on the information provided ( … The effectiveness and risks of long-term
opioid treatment of chronic pain. … The
Effectiveness and Risks of Long-Term Opioid Treatment
of Chronic Pain.
-
effectivehealthcare.ahrq.gov/sites/default/files/communicating_risk_media_wilkes.ppt
April 01, 2006 - , small differences between risks, and uncertainty around risks
Public Expectations
Public believes … million cases of breast cancer.
raloxifene is already used to prevent bone loss after menopause
NCI used relative … risk reductions in their promotion rather than absolute risk reductions
At the press release and conference … Why are risks minimized? … new possibilities
Tools to help patients better understand the health care system and risk
-
effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
October 01, 2007 - alone, however, cannot pro-
vide all the relevant information decision makers need to determine
the relative … risks and benefits when choosing the best treatment of
individual patients or weighing the implications … HOT indicates Hypertension Optimal Treatment Study; PPP, Primary Prevention Project; RRR, relative risk … reduction; RRI, relative risk increase. … have higher risks with surgery and are
more likely to die of other causes.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-245-breast-reconstruction-after-mastectomy-evidence-summary-updated-1.pdf
October 01, 2021 - The risks of seroma
or of unplanned repeat surgery for revision probably are comparable with
or without … Compared with IBR, AR may be associated with greater
risks of deep vein thrombosis or pulmonary embolism … However, ADM use and nonuse groups probably experience
comparable risks of seroma (summary adjOR 1.52 … ADM use
and nonuse groups may experience comparable risks of necrosis (summary adjOR 0.89,
95% CI 0.63 … ADM use impacts physical well-being, psychosocial well-being, satisfaction
with breasts, pain, or risks
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
March 01, 2013 - The risk difference is
more highly correlated with the control rate than is the relative risk or odds … difference (RD), relative risks (RR) and odds ratios (OR). … risk reduction or relative risk
increase, especially when the RR is below 2. … relative risks, especially
when event risks are high (> 10%). … A
similar table could also be used for reporting relative risk and NNT from binary data with minor
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-cardiovascular-elderly_research.pdf
February 01, 2009 - patients, evidence has been growing that conventional APM
use may be associated with even greater risks … models14 as well as
instrumental variable (IV) estimation.15-18 Because we observed previously9 that the relative … Antipsychotics and the risk of sudden
cardiac death. … Antipsychotics and
the risk of sudden cardiac death. … Antipsychotic
drugs in dementia: what should be made of
the risks? JAMA 2005;294:1963-1965.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
January 01, 2006 - Each class of medication or
supplement is associated with a unique
balance of risks and benefits. … • Rofecoxib was withdrawn from the market in
September 2004, primarily because of CV
risks. … • The CV risks and GI benefits associated with
different COX-2 selective NSAIDs may vary. … Celecoxib,
naproxen, piroxicam, and ibuprofen were not
associated with increased risks. … Assessments of
increased risk were modest (relative risks all <2.0),
and all of the main analyses were
-
effectivehealthcare.ahrq.gov/sites/default/files/politi.pdf
May 29, 2025 - Preference-‐Sensitive
Decisions
Preference-‐Sensitive Decisions:
• BCS vs. mastectomy for average risk … Decisions With Low Evidence:
• BCS vs. mastectomy for patients with unknown family
history/unknown BC risk … Slide
8: Informational Uncertainty
• Unavailable evidence (studies not yet conducted)
• Unknown risk … Recommendations
• Describe options and uncertainty (general terms)
• Focus less on quantitative risks … Explore the Decision
(Options, Benefits, Risks, Uncertainty)
3.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-229-opioid-treatments-chronic-pain-evidence-summary.pdf
April 01, 2020 - nonopioids alone, and opioids
plus nonopioids versus opioids alone at short-term
followup.16 Pooled relative … of overdose; risks
were higher at increased gabapentinoid doses (SOE: low). … of overdose;
risks were higher at increased gabapentinoid doses (SOE: low). … and risks related to opioid use
disorder, was lacking. … Annual Surveillance Report of Drug-Related Risks and
Outcomes--United States, 2017.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-fracture-prevention-evidence-summary.pdf
April 01, 2019 - In
women with osteoporosis, relative risk of incident
radiographic vertebral fracture with long-term … Relative risks for
these outcomes varied from 1 to >100 across
studies, likely related to heterogeneity … Relative risks appeared higher for radiologically
confirmed AFF than for cases defined only
by diagnostic … a subtrochanteric or
femoral shaft fracture will have AFF features,
and not the relative risk of sustaining … of ONJ.41-43 Relative risk estimates varied widely
between studies, likely due to heterogeneity in
-
effectivehealthcare.ahrq.gov/sites/default/files/bar-cohen_-eccs2012.pdf
January 01, 2012 - Health
Education
and
Decision Making
(3 of 4)
Questions to ask
when
interpreting
risks … and benefits
• Risk of what? … • How big
is the change in
risk?
… • How does this risk compare to other risks? … • What
would give patients a better idea
of the risks involved in
breast
cancer?
-
effectivehealthcare.ahrq.gov/sites/default/files/brooks_eccs2012.pdf
January 01, 2012 - whether to be screened for prostate cancer,
after receiving information about the uncertainties, risks … increases
the chance of findin prostate
cancer at an earlier stage.
• Screening might lower a man’s risk … tests
to
find it early.
• We don’t
yet
know
if the benefits of testing
outweigh the risks … Slide 16: Balanced Discussion of Pros
and Cons
Two
images displaying benefits and risks titled
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
February 01, 2018 - individual trials considered in
meta-analyses
- More likely to be consistent
even with differing baseline
risks … interpretable than OR
Odds Ratio
(OR)
- More likely to be consistent
even with differing baseline
risks … considered in
meta-analyses
- Not easily interpretable
- Can be misleading when interpreted like
relative … risks
- Widespread use in meta-analyses may
be because of convenience and history
rather than an assessment … differ in baseline risk
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
November 01, 2008 - However,
placebo-controlled RCTs may also provide important information on absolute and relative risks … 35
There was no clear tendency for randomized trials or
observational studies to report larger relative … risks. … outcomes were more than 0.20.
76
However, the 95-percent confidence intervals for
estimates of relative … risks for these three adverse events encompassed clinically significant
increases in risk (-13.5 percent