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effectivehealthcare-admin.ahrq.gov/products/major-depressive-disorder/research
December 01, 2019 - Review method
Two investigators independently selected, extracted data from, and rated risk of bias … For risk of harms, we graded the strength of evidence as moderate for some outcomes of three comparisons … Patients treated with SGAs had a higher risk of experiencing adverse events or discontinuing treatment … SGAs, in general, lead to a higher risk of adverse events than nonpharmacological treatment options. … availability) following a discussion of the advantages and disadvantages of each treatment option, including risks
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effectivehealthcare-admin.ahrq.gov/products/acs-pci-adjunctive-devices/research-protocol
December 01, 2019 - For dichotomous outcomes, weighted averages will be reported as relative risks and risk differences with … expected, a DerSimonian and Laird random-effects model will be used when pooling data and calculating relative … risks, risk differences, and 95 percent confidence intervals. 9 When pooling continuous outcomes, weighted … This system uses four required domains—risk of bias, consistency, directness, and precision. … Risk of Bias
Risk of bias is the degree to which the included studies for any given outcome or comparison
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effectivehealthcare-admin.ahrq.gov/products/alcohol-misuse-drug-therapy/research
January 01, 2021 - Review Methods
Two investigators independently selected, extracted data from, and rated risk of bias … Compared with placebo, patients treated with acamprosate had a higher risk of anxiety, diarrhea, and … vomiting; those treated with naltrexone had a higher risk of dizziness, nausea, and vomiting. … In head-to-head studies, the risks of headache and vomiting were slightly higher for naltrexone than … Research Protocol
Dec 22, 2023
The Effect of Dietary Digestible Carbohydrate Intake on Risk
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
September 01, 2011 - nonpharmacologic
interventions versus controls by calculating mean
changes in depressive severity, relative … risks of
response, and relative risks of remission. … We attempted to determine mean changes in depressive
severity, relative risks of response, and relative … risks of
remission for pharmacologic versus control studies to
allow a comparison with similar outcomes
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer_executive.pdf
February 01, 2008 - All treatments have
risks of complications, although frequency and severity
may vary. … What are the comparative
risks, benefits, and outcomes of therapies? … risk disease. … However, the
relative risk of surgery-related complications adjusted
for patient age, race, and comorbidity … The
relative risk of surgery-related complications adjusted for
patient age, race, and comorbidity,
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effectivehealthcare-admin.ahrq.gov/products/nephropathy-contrast-induced/research
January 01, 2020 - Both reviewers assessed the risk of bias for each study. … We quantitatively pooled the results of studies that were sufficiently similar, using a 25-percent relative … with a diverse group of LOCMs (pooled relative risk, 0.80; 95% confidence interval [CI], 0.65 to 0.99 … When the analysis was stratified by route of administration, the aggregate pooled relative risk was 0.80 … We considered a 25-percent relative risk difference to be clinically important.
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effectivehealthcare-admin.ahrq.gov/products/headaches-pregnancy/research
June 01, 2022 - Thus, as discussed above, some harms, such as the risks of NSAIDs when used after 32 weeks of gestation … However, the risks involved in using the same drugs for treatment of other conditions (e.g., seizures … , psychosis, depression) may not translate well to the risks for women with primary headaches because … the underlying risks of fetal/child adverse effects may differ. … frequently used by clinicians and sometimes incorporated into discussions with patients about potential risks
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effectivehealthcare-admin.ahrq.gov/products/febrile-infants-diagnosis-management/research
December 01, 2019 - In studies reporting outcomes of delayed treatment for infants with SBI initially classified as low risk … Attempts to identify high-risk groups specifically, described in a minority of reports, were not as successful … followup care, although that information could be crucial to improving management strategies in the low-risk … Future studies should focus on identifying the risks associated with testing and management strategies
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effectivehealthcare-admin.ahrq.gov/products/eccs-2015/white-paper-2015-1
July 01, 2019 - is an author of over 100 articles and her research focuses on testing methods for communicating the risks
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effectivehealthcare-admin.ahrq.gov/products/worker-health/research
December 01, 2019 - Review methods
Pairs of reviewers independently selected, extracted data from, and rated the risk of … For the 15 studies eligible for KQ 2, we rated 10 as high risk of bias primarily because of selection … Effective interventions were informed by worker participation and highlighted the potential synergistic risks
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
October 17, 2012 - The overall risk of bias will be assessed as:
• Good (low risk of bias). … differences or relative risks using a DerSimonian and Laird random effects model. … differences or relative risks with 95% confidence intervals (CI) for the individual studies. … differences or relative risks using a
DerSimonian and Laird random effects
model. … differences or relative risks with 95%
confidence intervals (CI) for the
individual studies.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-bias-individual-studies_methods.pdf
March 01, 2012 - presenting data on
individual endpoints;33
2. selective outcome reporting—for example, reporting relative … Other study designs have specific and inherent risks of biases that
cannot be minimized. … observational studies into
the review and (2) when evaluating individual studies for design-specific risks … In assessing the risk of bias of studies, EPCs
should specify constructs and risks of bias specific … The final domain, “other sources of bias,”
includes design specific risks of bias, baseline imbalance
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/arthritis-psoriatric_research-protocol.pdf
December 06, 2010 - Many questions remain about the risks of these agents
across a spectrum of adverse events from relatively … Finally, very little is known about the benefits or risks of these
drugs in different patient subgroups … Like in RA trials, many
questions remain about the risks of these agents across a spectrum of adverse
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effectivehealthcare-admin.ahrq.gov/sites/default/files/mccormack-presentation.pdf
November 12, 2015 - But
all of us are at risk of low health literacy at one time or another. … I think this starts out with
talking about
presenting the benefits, and
the risks, and
doing … Weare looking at several differentprototypestrategies for benefits of
participating, risks of participating
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effectivehealthcare-admin.ahrq.gov/products/acs-depression/research-protocol
June 01, 2021 - are usually effective in the general population are less so among post-ACS patients, or carry certain risks … , or risk of bias, for each individual study based on the Cochrane Risk of Bias tool for randomized studies … Poor (high risk of bias). … Other risks: akathisia, restlessness, sedation, headache, nausea and vomiting
Olanzapine 6 … Other risks related to tricyclic antidepressants include altered cardiac conduction (prolonged QTc),
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effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-are-the-best-options-for-fertility-treatment-in-terms-of-safety-and-effectiveness
November 01, 2017 - Treatment option awareness
Describe any health-related risks, side effects, or harms that you are
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effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/cost-effective-long-term-care-of-the-frail-elderly
November 01, 2017 - Describe any health-related risks, side effects, or harms that you are concerned about.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/fraenkel.pdf
December 26, 2012 - patient level
• 3 sets of questions to
determine each
patient’s value
for differences in risks
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effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/please-help-find-something-to-ease-my-mothers-pain-with-restless-leg-syndrome-it-has-bothered-her-for-over-30-years-and-now-is-almost-unbearable-at-78-years-old-it-has-really-diminished-her-joy-in-life
November 01, 2017 - Describe any health-related risks, side effects, or harms that you are concerned about.
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effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/fibromyalgia-very-few-doctors-know-how-to-treat-this-pain-some-states-there-are-really-none-more-more-are-being-diagnosed-but-no-treatment-especially-with-severe-pain-fibro-brings-on-ibs-migrainesno-sleep-ect-a-lot-of-meds-h
November 01, 2017 - Describe any health-related risks, side effects, or harms that you are concerned about.