-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-statins/statin-use-in-adults-preventive-medication-november-2016
November 13, 2016 - For composite cardiovascular outcomes, relative risk estimates were very similar for men and women in … Although relative risk estimates across subgroups were similar, absolute benefits were greater in subgroups … Given similar relative risk estimates, the absolute benefits of statin therapy will be greater in populations … Statins: is it really time to reassess benefits and risks? … Risks associated with statin therapy: a systematic overview of randomized clinical trials.
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/folic-acid-for-the-prevention-of-neural-tube-defects-preventive-medication
August 01, 2023 - with folic acid supplementation taken before pregnancy (adjusted relative risk [aRR], 0.54 [95% CI, 0.31 … 2013. 6 The authors performed this stratified analysis because they found that the overall adjusted relative … new trials can be conducted on this topic
New studies must rely on observational data with inherent risks … comparisons and outcomes 31-41
Variable measures of outcomes and exposure, all observation studies with risks … 31 , 33 , 34 , 40 , 41
Variable measures of outcomes and exposure, all observational studies with risks
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/pnyU5fxhdBUtCdvJ3GyqzR
March 01, 2007 - Data Synthesis: Regular use of aspirin reduced the incidence of
colonic adenomas in RCTs (relative risk … The effect measure chosen for
synthesis was the relative risk (RR). … reduction; NNTB � number needed to treat for benefit; OR � odds ratio; RR � relative risk. … Confounders Controlled for in the Studies’ Adjusted Relative Risk Estimates for the Incidence of Colorectal … Confounders Controlled for in the Studies’ Adjusted Relative Risk Estimates for the Incidence of Colorectal
-
www.uspreventiveservicestaskforce.org/uspstf/recommendation/child-maltreatment-primary-care-interventions
March 19, 2024 - intervention, there were no group differences between intervention and control groups (3.9% vs 3.5%; relative … yielded inconsistent results. 1 In 1 trial, there were no differences reported in physical abuse (relative … risk, 1.45 [95% CI, 0.58-3.62]) or neglect (relative risk, 2.79 [95% CI, 0.98-7.91) between the intervention … “disadvantaged families” to prevent child maltreatment and recommends against screening, citing the risks … or legal risks related to Child Protective Services) and to engagement in preventive interventions (
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/_SfjkGNHBnLqn8ySe7kAdg
April 01, 2016 - Results of Sensitivity Analysis: Results are most sensitive to
the relative risk for hemorrhagic stroke … and CVD mortality but
are affected by all relative risk estimates, baseline GI bleeding
incidence and … No clear evidence
was found that aspirin changes the relative risk (RR) for
CVD death, fatal GI bleeding … , which corresponds with the data we used
to inform community-based bleeding risks (47). … We did
not account for heterogeneity in GI bleeding risks be-
yond age and sex.
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/LNtA2SDWjpsDwjXvsH4F5m
April 17, 2023 - with hypertensive disor-
ders during pregnancy are also important, since the preeclampsia
mortality risks … factor.34 Clinicians should also be
aware of the risks of poor health outcomes for populations at risk … −1.58 days
[95% CI, −8.10 to 4.94 days]), number of hypertensive disorders
of pregnancy diagnoses (relative … induction of labor for any reason and for reasons
related to hypertension or fetal distress.1,38,41,42 Relative … risks for all
these outcomes were close to or less than 1, with no statistically sig-
nificant differences
-
www.uspreventiveservicestaskforce.org/uspstf/document/decision-analysis-for-aspirin/aspirin-to-prevent-cardiovascular-disease-and-cancer
April 11, 2016 - Results of Sensitivity Analysis: Results are most sensitive to the relative risk for hemorrhagic stroke … and CVD mortality but are affected by all relative risk estimates, baseline GI bleeding incidence and … No clear evidence was found that aspirin changes the relative risk (RR) for CVD death, fatal GI bleeding … for heterogeneity in GI bleeding risks beyond age and sex. … Bleeding risks with aspirin use for primary prevention in adults: a systematic evidence review for the
-
www.uspreventiveservicestaskforce.org/uspstf/document/decision-analysis-for-aspirin/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
April 11, 2016 - Results of Sensitivity Analysis: Results are most sensitive to the relative risk for hemorrhagic stroke … and CVD mortality but are affected by all relative risk estimates, baseline GI bleeding incidence and … No clear evidence was found that aspirin changes the relative risk (RR) for CVD death, fatal GI bleeding … for heterogeneity in GI bleeding risks beyond age and sex. … Bleeding risks with aspirin use for primary prevention in adults: a systematic evidence review for the
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/-qaKjceN9BTy-oh7EFwXtk
January 14, 2025 - Screening was associated with reduced hip (pooled relative risk
[RR], 0.83 [95% CI, 0.73-0.93]; 3 RCTs … of events/total (%)
Screened ControlSource
All
Relative risk
(95% CI)
3.724.5/11.54375 632/5405 ( … difference
per 1000 (95% CI)
0.2 71
Pooled relative risk (95% CI)
No. of
studies
No. of participants … With
event TotalOutcomes
Benefits of treatment (KQ4)
Pooled relative
risk (95% CI)
Hip
6 98 12 055Bisphosphonates … ;
RR, relative risk; SCORE, Simple Calculated Osteoporosis Risk Estimation; SOFSURF, Study of Osteoporotic
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/R_cAa3AjFGQ2np_aQnzQGA
February 11, 2025 - Screening was associated with reduced hip (pooled relative risk
[RR], 0.83 [95% CI, 0.73-0.93]; 3 RCTs … of events/total (%)
Screened ControlSource
All
Relative risk
(95% CI)
3.724.5/11.54375 632/5405 ( … difference
per 1000 (95% CI)
0.2 71
Pooled relative risk (95% CI)
No. of
studies
No. of participants … With
event TotalOutcomes
Benefits of treatment (KQ4)
Pooled relative
risk (95% CI)
Hip
6 98 12 055Bisphosphonates … ;
RR, relative risk; SCORE, Simple Calculated Osteoporosis Risk Estimation; SOFSURF, Study of Osteoporotic
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/vxPM4Bo9RXZGUDH6MWnDht
May 01, 2013 - in the likelihood of a suicide
attempt or deliberate self-harm compared with usual care
recipients (relative … Psy-
chotherapy did not reduce suicide attempts in adolescents
at 6 to 18 months (relative risk, 0.99 … 0.62 (0.33 to 1.13)
0.31 (0.12 to 0.78)
0.41 (0.04 to 3.82)
0.68 (0.56 to 0.83)
(0.48 to 0.98)
Relative … Psychotherapy reduced the risk for suicide attempts by 32% (relative risk, 0.68
[95% CI, 0.56 to 0.83 … Thus, different age groups seem to have different treatment
needs and risks.
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/Z3BVaJRtyu8drWSHWYT_Yf
August 27, 2019 - to Reduce Risk of Breast Cancer
Population Women aged ≥35 y at increased risk for breast cancer Women … aged ≥35 y not at increased risk for breast cancer
Recommendation
Offer to prescribe risk-reducing … clinical risk assessment tools or
assessing breast cancer risk factors without using a formal tool. … Alternatively, clinicians may use combinations of risk factors to identify women at increased risk. … Some examples of combinations of
multiple risk factors in women at increased risk include (but are not
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/VpT-c4bnmvHFRPyKgPwb2Z
December 01, 2010 - address the risks
and deficiencies identified in the assessment (8). … Thus, primary analyses estimated relative risk for falling by
using random-effects models (20, 21). … After 12 months, the relative risk for falling between the
intervention group and usual care was 0.86 … affect the
overall statistical significance for comprehensive interven-
tions (relative risk, 0.88 [CI … risk reduction
was attenuated but remained statistically significant (relative
risk, 0.83 [CI, 0.71
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/bQNXFv9Q5uaAQvWH6B7VWV
June 11, 2019 - (11 trials; relative risk [RR],
0.46 [95% CI, 0.33-0.66]; I2 = 67%; absolute risk reduction [ARD], − … Data Synthesis
Meta-analysis was conducted to calculate pooled relative risks
(RRs) for effects of PrEP … 0.73 (0.25-2.10) 0
Abbreviations: MSM, men who have
sex with men; PrEP, preexposure
prophylaxis; RR, relative … difference; ARR, adjusted relative risk; AUROC, area under the receiver
operating characteristics curve … ; PrEP, preexposure prophylaxis; PWID, people
who inject drugs; RCT, randomized clinical trial; RR, relative
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/JcwfLrEqaaxP6DPEQvxgUs
February 18, 2020 - , similar relative risk estimates were observed
among those classified at a higher vs lower CVD event … risk.10,23
Given similar relative risk reductions, the absolute magnitude
of benefit that an intervention … It is possible that
the relative risk reduction in this group is higher than in adults with
a lower LDL-C … =articlePDF%26utm_content=jama.2016.15450
without severe dyslipidemia at baseline.6 Given similar relative … Cardiovascular benefits and diabetes risks
of statin therapy in primary prevention: an analysis
from
-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/peripheral-artery-disease-in-adults-screening-with-the-ankle-brachial-index
July 10, 2018 - [95% CI, 0.99-2.97]) and no statistically significant increase in major gastrointestinal bleeding (relative … bleeding requiring hospital admission was similar in the aspirin and control groups (0.5% vs 0.5%; relative … Bleeding risks with aspirin use for primary prevention in adults: a systematic review for the U.S. … f Relative risk.
Return to Table of Contents
Table 3. … POPADAD, Prevention of Progression of Arterial Disease and Diabetes; RCT, randomized clinical trial; RR, relative
-
www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/menopausal-hormone-therapy-postmenopausal-persons-primary-prevention-chronic-conditions
April 19, 2022 - disease events in persons treated with estrogen plus progestin compared with placebo (2.8% vs. 2.6%; relative … risk [RR], 1.12 [95% CI, 0.94 to 1.33]) during a mean followup of 4 years. … if alternative therapies are not tolerated, based on a careful assessment of individual benefits and risks … Estrogen plus progestin and risk of venous thrombosis. JAMA . 2004;292(13):1573-1580. 26. … Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause.
-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/atrial-fibrillation-screening-with-electrocardiography
August 07, 2018 - Warfarin (mean, 1.5 years) was associated with a reduced risk of ischemic stroke (relative risk [RR], … For KQ4 and KQ5, relative risks (RRs) and 95% CIs were calculated for all-cause mortality, cardiovascular-related … Relative Risk of All-Cause Mortality and Selected Health Outcomes for Warfarin Compared With Controls … Relative Risk of Major Bleeding, Major Extracranial Bleeding, and Intracranial Hemorrhage for Warfarin … NOAC, novel oral anticoagulant; NR, not reported; OR, odds ratio; RCT, randomized clinical trial; RR, relative
-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/atrial-fibrillation-screening-with-electrocardiography-august-2018
August 07, 2018 - Warfarin (mean, 1.5 years) was associated with a reduced risk of ischemic stroke (relative risk [RR], … For KQ4 and KQ5, relative risks (RRs) and 95% CIs were calculated for all-cause mortality, cardiovascular-related … Relative Risk of All-Cause Mortality and Selected Health Outcomes for Warfarin Compared With Controls … Relative Risk of Major Bleeding, Major Extracranial Bleeding, and Intracranial Hemorrhage for Warfarin … NOAC, novel oral anticoagulant; NR, not reported; OR, odds ratio; RCT, randomized clinical trial; RR, relative
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/Hfz3GBNZhq5j4SXUt8R2d5
September 28, 2021 - Clinical Risk Assessment for Preeclampsiaa
Risk level Risk factors Recommendation
Highb • History of … It is strengthened by new evidence from
additional trials demonstrating reduced risks of perinatal mortality … Assess Risk. … It is strengthened by new evi-
dence from additional trials supporting reduced risks of perinatal
mortality … The USPSTF found evidence of a reduction in risk for preterm
birth (pooled relative risk [RR], 0.80 [