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Total Results: 46 records

Showing results for "risk".

1. Published Projects | SRDR
   srdrplus.ahrq.gov/published_projects?page=25
   June 27, 2021 - Objectives: Background: Pathogenic mutations in breast cancer susceptibility genes BRCA1 and BRCA2 increase risks … trials), and aromatase inhibitors (RR, 0.45 95% CI, 0.26 to 0.70; 2 trials) were associated with lower risks … Risk assessment with familial risk tools accurately identifies high-risk women for genetic counseling … of composite clinical outcomes (mortality, AIDS-defining events, or serious non-AIDS events) (relative … with decreased risk of HIV infection versus placebo or no PrEP (11 trials; relative risk [RR], 0.46

2. Published Projects | SRDR
   srdrplus.ahrq.gov/published_projects?page=55
   March 01, 2021 - complete blood count, and/or a basic metabolic panel did not affect procedure cancellations (2 RCTs, relative … risks [RRs] of 1.00 or 0.97), and there was no clinically important difference for total complications … They also mostly had high risk of bias due to lack of adjustment for patient and clinician factors, making … the cataract surgery studies are not reliably applicable to other patients undergoing other higher risk … Of these, all but 1 study were rated at medium or high risk of bias.

3. Published Projects | SRDR
   srdrplus.ahrq.gov/published_projects?page=11
   October 25, 2022 - of falls (likelihood of at least 1 fall 65% vs. 50%, relative risk [RR] 1.31, 95% confidence interval … Evidence on the accuracy of instruments for identifying patients at higher risk of glaucoma was limited … difference -4.2%) and increased risk of ocular adverse events (2 trials, RR 1.21, 95% CI 1.10 to 1.33 … of falls (likelihood of at least 1 fall 65% vs. 50%, relative risk [RR] 1.31, 95% confidence interval … Statin therapy was associated with decreased risk of all-cause mortality (relative risk [RR] 0.92, 95%

4. Published Projects | SRDR
   srdrplus.ahrq.gov/published_projects?page=21
   June 27, 2021 - use was identified through primary care-based screening with questions about drug use or drug-related risks … screened for drug use in primary care or other settings with questions about drug use or drug-related risks … In treatment-seeking populations with opioid use disorder, naltrexone (12 trials; relative risk [RR] … methadone or buprenorphine (4 trials; RR 0.75, 95% CI 0.59 to 0.82; NNT 2.9) were associated with decreased risk … Evidence on harms of pharmacotherapies was limited, but indicated no increased risk of serious adverse

5. Published Projects | SRDR
   srdrplus.ahrq.gov/published_projects?page=17
   November 22, 2023 - We documented observed rates and assessed the relative risks for key adverse events. … Regarding vaccines recommended for adults (KQ1), we found either no new evidence of increased risk for … Regarding vaccines recommended for pregnant women (KQ3), we found no evidence of increased risk for key … There is no evidence of increased risk of adverse events for vaccines currently recommended in pregnant … Evidence on kyphoplasty and risk of incident fracture was conflicting.

6. Published Projects | SRDR
   srdrplus.ahrq.gov/published_projects?page=49
   June 23, 2021 - Sulfonylureas had a fourfold higher risk of mild/moderate hypoglycemia compared with metformin alone, … and, in combination with metformin, had more than a fivefold increased risk compared with metformin … Thiazolidinediones had an increased risk of congestive heart failure relative to sulfonylureas and bone … We used random effects derived relative risks (RR) for most analyses and Peto’s Odds Ratios (OR) in comparisons … of prophylaxis on nonmajor orthopedic surgeries; Conclusions: In major orthopedic surgery, while the risk

7. Published Projects | SRDR
   srdrplus.ahrq.gov/published_projects
   February 28, 2024 - No studies were designed to test screening interventions focused on populations with the highest risks … The confidence interval for the relative risk spanned null (RR 0.79 [95% CI, 0.40 to 1.55]). … The evidence on an indicated urine screening strategy is very limited given the risks of bias inherent … Black and American Indian/Alaska Native people, who experience the highest risks for adverse pregnancy-related … identify individuals requiring further surveillance and evidence-based clinical management to decrease risks

8. Published Projects | SRDR
   srdrplus.ahrq.gov/published_projects?page=16
   July 29, 2022 - implement to reduce length of stay (LOS), with emphasis on medically complex or vulnerable patients at high-risk … Dual review was used to abstract study data, assess study-level risk of bias, and rate the strength of … There was a large increased risk of dizziness and sedation and a moderate increased risk of nausea (dizziness … : 6 RCTs, N=866, 30% vs. 8%, relative risk [RR] 3.57, 95% CI 2.42 to 5.60, I2=0%; sedation: 6 RCTs, N … We found moderate SOE for a large increased risk of dizziness (2 RCTs, 32% vs. 11%, RR 2.74, 95% CI 1.47

9. Published Projects | SRDR
   srdrplus.ahrq.gov/published_projects?page=7
   June 13, 2023 - Limitations: Two studies assessing the accuracy of the MVAP score oversampled participants at high risk … For treatment of LTBI, a large (N=27,830) good-quality randomized, controlled trial (RCT) found a relative … Treatment of LTBI with recommended regimens reduces the risk of progression to active TB. … For treatment of LTBI, a large (N=27,830) good-quality randomized, controlled trial (RCT) found a relative … Treatment of LTBI with recommended regimens reduces the risk of progression to active TB.

10. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=28
    June 27, 2021 - Based primarily on observational studies, long-term bisphosphonates may increase risks of radiologically … Low power to assess risks of incident clinical fractures. … of clinical fractures; and long-term estrogen reduces risk of incident hip fractures. … hip BMD, but doesn’t reduce nonvertebral fracture risk and may increase risk of AFF and ONJ. … increased risk of dementia and breast cancer.

11. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=47
    June 23, 2021 - Gray) in median survival duration, though bladder-preserving treatment was associated with increased risk … Cohort studies suggested that lymph node dissection was associated with lower risk of mortality than … , or a trend towards decreased risk, of mortality versus no neoadjuvant chemotherapy, including three … Four trials found adjuvant chemotherapy associated with decreased risk of mortality versus no adjuvant … of surgery at short-term followup (relative risk [RR] 0.62, 95% CI 0.41 to 0.92) (SOE: low).

12. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=24
    October 31, 2022 - READ MORE Published on June 27, 2021 Medication Use for the Risk Reduction of Primary Breast Cancer … Most models performed only slightly better than age alone as a risk predictor. … No studies evaluated optimal ages or frequencies of risk assessment. … Risks for thromboembolic events and endometrial cancer with tamoxifen were higher for older compared … Risks for invasive cancer were generally reduced in all population subgroups evaluated based on menopausal

13. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=18
    October 06, 2021 - Risk of bias varied; 25 trials were terminated early, predominantly due to poor accrual. … interval [CI], 0.69 to 1.73; 4 RCTs; low strength of evidence [SoE]) or death due to brain metastases (relative … risk [RR], 0.93; CI, 0.48 to 1.81; 3 RCTs; low SoE). … systemic therapy (RR, 1.44; CI, 1.03 to 2.00; 14 studies; moderate SoE) was associated with increased risks

14. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=8
    May 30, 2023 - For treatment of LTBI, a large (N=27,830) good-quality randomized, controlled trial (RCT) found a relative … Our meta-analyses found greater risk for hepatotoxicity with isoniazid than with rifampin (pooled RR, … Treatment of LTBI with recommended regimens reduces the risk of progression to active TB. … of bias (higher quality), 40percent (n=46) medium risk of bias, and 49 percent (n=56) high risk of bias … Later stage at detection was consistently associated with increased risk of melanoma mortality.

15. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=9
    January 17, 2023 - a screen-relevant population demonstrated an association of the initiation of LAMA or LABA with the risk … Absolute risk reductions in major CVD events in the trials ranged from 0.08 to 2.5 percent. … Sensitivity analyses restricted to more recent trials where usual care includes aggressive risk factor … bleeding risks. … Results of our review indicate differences in the risk-benefit profile between treatment formulations

16. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=54
    March 03, 2021 - whether the effectiveness of decision aids for decisions related to cancers differs by people’s average risk … We predefined three population groups of interest based on risk or presence of cancer (average cancer … risk, high cancer risk, early cancer). … Last updated on March 03, 2021 Objectives: Objectives: We focused on four questions: (1) What are the risks … The evidence is consistent that anthropometry identifies women at risk of developing subsequent type

17. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=13
    September 14, 2022 - basic study characteristics for included studies and outcomes for studies assessed as low to medium risk … Of these, 96 studies met comparator criteria to undergo risk of bias assessment; however only nine studies … were assessed as low or medium risk of bias and included in our analytic set. … mitigation strategies, dose-dependent risks of opioids, and management of opioid use disorder; for all … In patients with chronic pain, what are the risks of nonopioid pharmacologic agents for harms including

18. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=23
    June 27, 2021 - Evidence on harms was limited, with no evidence suggesting increased risk for serious treatment-related … likelihood of smoking initiation compared with control interventions (k=13, n=21,700; 7.4% vs. 9.2%; relative … risk [RR] 0.82, 95% confidence interval [CI] 0.73 to 0.92). … and assumed perfect implementation of risk-based screening. … An SVR after antiviral therapy was associated with decreased risk of all-cause mortality (13 studies,

19. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=50
    June 23, 2021 - Ibandronate and raloxifene reduce the risk of vertebral but not nonvertebral fractures. … Risedronate decreases the risk of vertebral and nonvertebral fracture among men with osteoporosis. … Decreased adherence to bisphosphonates is associated with less than optimal reduction in the risk of … Conclusions: There is a high level of evidence that shows that fracture risk reduction is greatest in … evidence is low for benefits of treatment for other populations, including men; for the benefits and risks

20. Published Projects | SRDR
    srdrplus.ahrq.gov/published_projects?page=6
    July 24, 2023 - July 13, 2022 Last updated on July 19, 2023 Objectives: Screening for Anxiety Depression and Suicide Risk … 2023 Objectives: READ MORE Published on June 20, 2023 Screening for Depression, Anxiety, and Suicide Risk … One RCT (n=443) of a suicide risk screening intervention found no reduction in suicidal ideation after … did not demonstrate an improvement over usual care, and one large (n=18,883) trial found an increased risk … There are numerous important gaps in the evidence for suicide risk screening in primary care settings