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Showing results for "risk".

461. Clopidogrel after Drug-Eluting Stent Implantation: Is current practice sufficient (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stent-clopidogrel-practice_research.pdf
     March 01, 2009 - The extended use of clopidogrel in drug-eluting stent patients may be associated with a reduced risk … key parameters for subsequent research in this area. 25 Extended clopidogrel therapy has its own risks … Estimation of Cumulative Incidence in the Presence of Competing Risks. … at 12 months Death MI* Death/ MI # at risk at 24 months DES+C† 252 0 0 0 230 DES-C … DES-C comparison is 0.020 DES+C DES-C BMS-C BMS+C Number at Risk DES+C 600

462. Disposition of Comments Report for Treatment for Hepatitis C Virus Infection in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
     November 27, 2012 - diagnosed, and patients who are diagnosed late or not at all face substantial morbidity and mortality – risks … interferon alfa-2a vs. dual therapy with pegylated interferon alfa-2b, and found no difference in the relative … Results (p.43) Triple therapy with Telaprevir was associated with increased risk of anemia. … diagnosed, and patients who are diagnosed late or not at all face substantial morbidity and mortality – risks … Risk factors for the rising rates of primary liver cancer in the United States.

463. Management of Uterine Fibroids - Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-195-uterine-fibroids-final.pdf
     December 01, 2017 - in the first year of diagnosis.8,9 Purpose of Review To review treatment effectiveness and the risk … . 2 Treatment options differ in fundamental aspects such as cost, invasiveness, recovery time, risks … Unfortunately, the published literature does not contain enough detail to stratify risks by age, menopausal … from those with lower risk. … Risk factors for surgically removed fibroids in a large cohort of teachers.

464. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - Indeed, the ongoing use of rFVIIa by physicians faced with life-threatening hemorrhage despite the risks … because it is easy to interpret and the risks for different outcomes were similar across studies, such … difference or relative risk for MAs. … Assessment of potential risks and benefits in each individual case is important. … Any decision regarding risks and benefits must be driven by the unique conditions for a given patient

465. ADHD-Update-protocol-160818 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-update_research-protocol.pdf
     August 18, 2016 - Many risk factors have been associated with ADHD. … Individuals with ADHD are at risk for negative outcomes associated with risk-taking behaviors such as … InformationbyDrugClass/ucm283449.htm ) and ensure that our included adverse effects reflect listed potential risks … , or risk of bias, for each individual study based on the Cochrane Risk of Bias29 tool for randomized … • Poor (high risk of bias).

466. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update--Executive Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update_executive.pdf
     January 01, 2018 - for ROB. g Downgraded for ROB and imprecision because of small event rates; confidence intervals of relative … risks ranged between 0.02 to 5.0, to 0.06 to 48.1). 13 Bipolar Disorder Of 19 studies examining … Risks for somnolence and EPS symptoms may be of little or no difference for low- versus high- dose risperidone … in risk for akathisia. … It may increase risk for any EPS symptoms.

467. Migraine-Emergency Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_executive.pdf
     November 01, 2012 - For each adverse-effect category, risks (i.e., incidence rates) were pooled using a random-effects … bias, 20 (28.2 percent) had low risk, and 8 (11.3 percent) had high risk of bias. … The risk in those who received placebo was 1 percent (95% CI, 0 to 4 percent). … Consequently, the risk of publication bias should be low. … Assessing risk of bias in included studies. In: Higgins JP, Green S, eds.

468. Appendicitis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_executive.pdf
     December 01, 2015 - .11 In addition, the use of modalities that involve ionizing radiation (e.g., CT) entails greater risks … The low- and high-risk cutoff values can be used to define three patient groups at different risk for … When studies reported results at multiple cutpoints, we performed analyses at low-risk and high- risk … risk of bias. … Cancer risks from diagnostic radiology. Br J Radiol. 2008 May;81(965):362-78. PMID: 18440940.

469. Smoking-Pregnancy-Infants Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/smoking-pregnancy-infants_research-protocol.pdf
     March 11, 2013 - , and placenta previa.10-13 Health risks to the fetus include low birth weight, restricted growth, and … Global health risks: mortality and burden of disease attributable to selected major risks. … Prenatal smoking and risk of intrapartum stillbirth. … [Awareness and knowledge about risks of drinking during pregnancy in pregnant Lebanese women]. … Nicotine replacement therapies during pregnancy: what do we know about the balance between benefits and risks

470. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/selecting-evidence.ppt
     January 01, 2010 - Risk of bias speaks to the internal validity of a study. … these biases is that unpublished trials may provide evidence of harms that would shift the balance of risks … Reviewers must consider whether or not the risk of bias can be fully assessed. … for an adverse event than another and for quantifying the risk. … for an adverse event than another and for quantifying the risk.

471. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/selecting-evidence.ppt
     January 01, 2010 - Risk of bias speaks to the internal validity of a study. … these biases is that unpublished trials may provide evidence of harms that would shift the balance of risks … Reviewers must consider whether or not the risk of bias can be fully assessed. … for an adverse event than another and for quantifying the risk. … for an adverse event than another and for quantifying the risk.

472. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/registries-guide_executive.pdf
     April 01, 2007 - include the perceived relevance, importance, or scientific credibility of the registry, as well as the risks … with the public health urgency of a problem, the types of interventions that are available, and the risks … • For safety studies, the risks and/or benefits of products, devices, or processes under study are … quantitatively evaluated beyond simply evaluating statistical significance (e.g., rates, proportions, and/or relative … risks are reported)

473. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vaccine-safety_research-protocol.pdf
     September 18, 2012 - of hepatitis A infection Hepatitis B All unvaccinated adults at risk for hepatitis B infection … assessment of AEs for all vaccines and include searches for studies that address the severity of, relative … risk for, and risk factors for each AE type. … For each AE associated with a particular vaccine, what are the risk factors for the AE (including age … The absolute risk of serious adverse events (SAEs) will also be computed.

474. MS Protocol draft_12_12-13 clean[2] (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
     December 17, 2013 - Assessment of Methodological Risk of Bias of Individual Studies Risk of bias of eligible studies will … Investigators will consult to reconcile any discrepancies in overall risk of bias assessments. … Studies assessed with an overall high risk of bias will not be included in evidence synthesis due to … Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, eds. … Development of the RTI item bank on risk of bias and precision of observational studies.

475. Integrating Stakeholder Preferences in Comparative Effectiveness Research: Potential Uses of Multi-Criteria Decision Analysis Techniques (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/mcda_webinar_transcript2.pdf
     August 27, 2012 - All subjects were given both absolute risk and relative risk levels in the background information. … Half were shown absolute and half were shown relative risk as a tradeoff question. … In each case, risk tolerance measures as a maximum acceptable risk was greater for the absolute risk … treatment than for the relative risk treatment. … It turns out that it did matter for MI risks, however. Next slide.

476. CARDIOVASCULAR (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cardiovascular-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - However, clinical experts estimate that from 14% to 44% of patients with AF have bleeding risks that … Overall, experts opined that the benefits of this intervention outweigh the risks. … prevent stroke in patients with AF, but an estimated 14% to 44% of patients with AF have bleeding risks … Clinical Pathway at Point of This Intervention A serious complication of AF is ischemic stroke.1,2 Risks … and the patient’s relative risks and benefits.1 Antithrombotic agents include vitamin K antagonists

477. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_june_2012.pdf
     January 01, 2012 - of the infants in the prenatal-surgery group and in 98% of those in the postnatal-surgery group (relative … with one research expert expecting wide acceptance based on parents “wishing to decrease substantive risks … In all 50 cases of trisomy 21, the risk score for trisomy 21 was ≥99%, and the risk score for trisomy … In all 50 cases of trisomy 18, the risk score for trisomy 21 was ≤0.01%, and the risk score for trisomy … In the remaining 297 cases, the risk score for trisomy 21 was ≤0.01%, and the risk score for trisomy

478. Heart-Failure-Transition-Care Clinician (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_clinician.pdf
     October 01, 2015 - also recommends initiating multidisciplinary-HF disease-management programs for patients at high risk … Interventions Versus Usual Care for HF Intervention Outcome at 3–6 Months N Studies N Subjects Finding Relative … Risk (95% CI) NNT* SOE Home-visiting programs All-cause readmission 9 1563 ò 0.75 (0.68 to 0.86) 9 … no difference vs. control; − = evidence is insufficient * An NA entry for NNT indicates that the relative … risk (95% CI) was not statistically significant and that an NNT was not calculated. ** The composite

479. Urinary-Incontinence-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_executive.pdf
     April 01, 2012 - For Key Questions 2 and 3, we calculated relative risk, absolute risk differences, number needed to … Trospium did not resolve UI in subgroups with more than five episodes of UI per day (relative risk [ … For instance, relative risks of ventricular arrhythmias (adjusted RR 5.5, 95% CI, 1.3 to 22.3) or … NNT Number needed to treat PFMT Pelvic floor muscle training RCT Randomized controlled trial RR Relative … Urinary antispasmodic use and the risks of ventricular arrhythmia and sudden death in older patients

480. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-treatment_research-protocol.pdf
     September 29, 2011 - However, optimal medical therapies, PCI, and CABG have very different approaches, risks, and potential … Coronary disease risk factors such as diabetes, chronic kidney disease, or other comorbid disease? … Coronary disease risk factors such as diabetes, chronic kidney disease, or other comorbid disease? … Coronary disease risk factors such as diabetes, chronic kidney disease, or other comorbid disease? … treatment options (Key Questions 1b, 2b, 3b) and whether there are significant safety concerns or risks