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  1. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/aggression_research-protocol.pdf
    October 05, 2015 - First, a key clinical and policy question is how to best balance the benefits and risks of (a) seclusion … We envision a continuum of risk and behavior. … Assessment of Methodological Risk of Bias of Individual Studies To minimize risk of bias in observational … That is, a low-risk-of- bias nonrandomized study does not necessarily equal a low-risk-of-bias randomized … To determine risk of bias in a standardized way, we will use the Cochrane Risk of Bias tool to appraise
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
    October 20, 2011 - evaluated the effectiveness of treatment for HCV infection within the context of screening and risk … Does becoming aware of positive HCV infection status decrease high-risk behaviors? c. … High-risk sexual behaviors c. … Screening of the general population versus “targeted” high-risk groups (KQ 2) 3. … Assessment of Methodological Risk of Bias of Individual Studies We will assess the risk of bias
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
    April 18, 2017 - CVD, stroke, congestive heart failure, and kidney disease and lowering blood pressure lowers these risks … Assessment of Methodological Risk of Bias of Individual Studies We will assess the methodological risk … standardized mean differences (SMD), dichotomous incident and prevalence outcomes will be reported as relativerisks (RR), and mortality data will be reported as hazard ratios (HR), all together with the 95% confidence … non-linear dose-response meta- regressions to examine the associations between dietary intake levels and the risks
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/worker-health_research-protocol.pdf
    May 26, 2015 - mortality, morbidity, and considerable financial and social costs.1-3 At the same time, modifiable risk … Community Preventive Services Task Force recommends worksite interventions (assessments of health risks … A study with moderate risk of bias is susceptible to some risk of bias but probably not enough to invalidate … A study assessed as high risk of bias has significant risk of bias (e.g., stemming from serious issues … Two independent reviewers will assess risk of bias for each study.
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_consumer.pdf
    January 01, 2017 - What increases the risk of gout? The exact cause of gout is not known. … But, certain things may increase the risk of getting it. … Being overweight can also increase the risk of gout. … � Allopurinol (Zyloprim®) and febuxostat (Uloric®) do not lower the risk of a gout attack in the … In fact, these medicines can increase the risk of a gout attack when you first start to take them.
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/undescended-testicle_research-protocol.pdf
    September 02, 2011 - magnetic resonance angiography, which requires sedation or anesthesia and is thus not without immediate risks … An estimated 10 percent of all testicular tumors develop from an undescended testis, 9 and the relativerisk of incidence of a testicular tumor is about 40 times greater in men with cryptorchidism when … Although many clinicians advocate early orchiopexy to reduce the risk of testicular cancer associated … Assessing risk of bias in included studies. In: Higgins JPT, Green S, eds.
  7. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
    September 01, 2022 - Tools to assess the risk of bias in NRSIs are different from those used to assess risk of bias in RCTs … after mastectomy,18 have included single-group studies for (noncomparative) quantification of the risks … Assessing the Risk of Bias in NRSIs Existing instruments for assessing the risk of bias in NRSIs89, … This methodological heterogeneity can be due to many factors, including differences in risks of selection … Assessing risk of bias in a randomized trial.
  8. effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
    September 01, 2022 - Tools to assess the risk of bias in NRSIs are different from those used to assess risk of bias in RCTs … after mastectomy,18 have included single-group studies for (noncomparative) quantification of the risks … Assessing the Risk of Bias in NRSIs Existing instruments for assessing the risk of bias in NRSIs89, … This methodological heterogeneity can be due to many factors, including differences in risks of selection … Assessing risk of bias in a randomized trial.
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
    November 01, 2013 - Individual Study- Level Risk of Bias Assessments 2. … Combining evidence from studies with a high risk of bias and those with less risk can be problematic … of bias versus high risk of bias. … Selection in reported epidemiological risks: an empirical assessment. … Framework for examining risk of reporting bias Abbreviations: N = number; RRB = risk of reporting
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mrsa-screening-2010_executive.pdf
    January 01, 2010 - SOE was lowered by the high risk of bias. … SOE was lowered by the high risk of bias. … SOE was lowered by the high risk of bias. … SOE was lowered by the high risk of bias. … attempt to measure the favorable impact of screening for MRSA carriage while ignoring its potential risks
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/emt-naloxon_research-protocol.pdf
    November 29, 2016 - With administration using a preloaded IN system, there is no risk of needle stick injury. … of bias,” “medium risk of bias,” or “high risk of bias.” … Studies rated “low risk of bias” are considered to have the least risk of bias, and their results are … We will not exclude studies rated high risk of bias a priori, but high risk of bias studies will be … Risk Factors of Prescription Opioid Overdose Among Colorado Medicaid Beneficiaries.
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0086_04-01-2009.pdf
    January 01, 2009 - Description Nominator: Individual Nomination Summary: The nominator is interested in the risks … For the elderly taking cardiovascular medications, what are the comparative risks and benefits of commonly
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy_executive.pdf
    January 01, 2017 - We considered 67 studies to have low risk of bias, 110 to have moderate risk, and 41 to have high risk … cohort studies had high risk. … Eighteen studies had low risk of bias, 28 had moderate risk, and 13 had high risk. … Twenty-two studies had low risk of bias; 36 had moderate risk; and 12 had high risk. … balance needs for relief of illness-related outcomes (including missing school and work) with the risks
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/fibromyalgia_research-protocol.pdf
    April 03, 2014 - For randomized clinical trials (RCTs), we will assess the risk of bias using a modified Cochrane Risk … Similar to risk of bias for RCTs, the overall summary risk of bias will be weighted towards low for … Risk of bias of pooled analyses will depend in part on the risk of bias of the inputs (RCTs) and the … risk of bias in how the pooled analysis was conducted and reported. … good studies (low risk of bias) for high strength of evidence.
  15. effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
    January 01, 2011 - Incidence is generally assessed as a risk/proportion over a fixed time period (e.g., risk for 1-year … estimation of risk or rate differences. … Controls were only sampled from the “risk set.” … The cohort design has the added advantage that absolute risks or incidence rates can be estimated and … Statin adherence and risk of accidents: a cautionary tale.
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
    September 07, 2012 - Combs paper and the general need for larger datasets to assess harms such as IUFD and neonatal death risks … Results Page 53 of 518, the statement is made that “the meta-estimate combining these three trials is a relativerisk of 0.44 (95 percent CI: 0.26, 0.76)”. … I think the data indicating differential efficacy with different risks for preterm birth is sufficient … to allow the authors to make the statement that in future analyses, different risks would need to be
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-decision-support-tools_disposition-comments.pdf
    December 23, 2014 - There is a world behind this (risk communication science, framing risks in various ways (Gigerenzer, … , high risk, early cancer) and additional intervention characteristics. … their average baseline risk.” … Change to : “accuracy of perception of mortality risks . . .” … risk probabilities but 22 studies were for prostate cancer.
  18. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/field-triage-glascow_research-protocol.pdf
    February 25, 2016 - not address important issues specific to risk prediction studies. … correlates with actual risk), and risk reclassification rates (the proportion of patients correctly … reclassified using the risk prediction instrument into clinically relevant risk group), in addition … Two investigators will independently assess risk of bias for each study. … Studies rated “low” risk of bias have the least risk of bias, and their results are generally considered
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
    April 01, 2013 - Relative risk estimates ranged from 1.0 to 1.3 in the four trials and may have varied in part due to … Relative risk estimates ranged from 0.89 to 1.1. 5 Table 1. … risk estimates for SVR in men vs. … women, and no clear difference in relative risk estimates for Black vs. non-Black patients. … for risk of harms that were similar to the risk estimates based on all trials.
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/arthritis-knee-physical-therapy_research-protocol.pdf
    April 01, 2010 - hypotheses and did not provide adequate information on tested hypotheses (e.g., least square means, relativerisk). 8. … risk, and absolute risk differences. … For observational studies we will extract relative measures of the association (relative risk, hazard … We will calculate differences in relative risk and absolute risk from the abstracted events by using

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