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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_disposition-comments.pdf
    April 02, 2013 - We did not use a numerical scoring system to determine the risk of bias. … to discuss the studies with “high risk of bias,” while noting that caveat. … This means that <10% of trauma exposed (lifetime) are at risk of PTSD. … to identify who is at risk are not feasible. … on risk confirming that exposure itself is one of the weakest risk predictors and use of this as a
  2. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests_executive.pdf
    February 01, 2006 - For women with relevant demographic risk factors (e.g., age, family history) and clinical risk factors … For women at this average level of risk of cancer after an abnormal mammogram, based upon the tests’ … the risk that she has cancer even if the test is negative. … acceptable level of risk for a diagnostic test to reliably preclude biopsy, none of these tests was … sufficiently accurate to replace biopsy for women at average risk of breast cancer.
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-executive-170523.pdf
    May 01, 2017 - difference in cumulative hazard of recurrent AOM or in efficacy, defined as one minus the adjusted relativeRisk of bias for various outcomes in high risk populations was rated as high. … Risk of bias was rated moderate overall. … Tympanostomy tube outcomes in children at risk and not at-risk for developmental delays. … Panel 1: Epidemiology, natural history, and risk factors.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/care-adults-down-syndrome-protocol.pdf
    July 09, 2024 - , and race.15-17 With the increase in life expectancy, knowledge of the physical and mental health risks … Assessment of Methodological Risk of Bias of Individual Studies Risk of bias of included KQ studies … We will calculate risk ratios (RR) and absolute risk differences (RD) with the corresponding 95 percent … difference ROB Risk of bias ROBINS-I Risk OF Bias In Non-Randomized Studies-of Interventions … or risk?
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/misuse-adhd-prescription-rapid-research.pdf
    July 01, 2025 - Systematic Review: Nonmedical Use of Prescription Stimulants: Risk Factors, Outcomes, and Risk Reduction … Risk of Incident Psychosis and Mania With Prescription Amphetamines. … reduced when studies had serious risk of bias. … reported more symptomatology than low-risk non- users (p .001)] Why? … .001) and perceptions of not having to worry about potential negative side effects and other health risks
  6. effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_disposition-comments.pdf
    January 01, 2015 - Most results were presented as relative risks. … Some of this, however, is difficult to clinically interpret because relative risks may be high yet … While the relative risk was 1.0 in ADOPT, the absolute risk difference was 0.1% (indicating a slightly … Therefore, baseline risks were different in the trials. … We have clarified that these are relative risk reductions from randomized controlled trials when used
  7. effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1506.pdf
    June 01, 2015 -  Key Expert Comments: Programs such as MSHOP may address an unmet need for reducing surgical risks … that clinicians would be likely to adopt a MSHOP-like program based on the potential to decrease risks … Most experts commenting on this intervention agreed that an unmet need exists for reducing surgical risks … Unmet need and health outcomes: An unmet need exists to decrease surgical risks and complications, … biggest hurdle, which is patient compliance.67 Acceptance and adoption: The potential to decrease risks
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/fiber-intake-protocol.pdf
    August 15, 2023 - study for risk of bias and methodological quality during data extraction. … , is at high risk, then the trial will be considered to be at moderate risk of bias • If two or more … risk, then the trial will be considered to be at high risk of bias • Trials with no identified risk … of bias or quality issues will be considered to be at low risk of bias If pertinent, the risk of … Polygenic risk scores: from research tools to clinical instruments.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-tables-F1-F-2.xlsx
    January 01, 2023 - Risk of bias of cannabis RCTs Author, Year Randomization Adequate? … Risk of bias of cannabis RCTs Table F-2. ROB Cohort Studies Table F-2. … Risk of bias of cannabis cohort studies Author, Year Did the Study Attempt To Enroll All (or a Random … Risk of Bias Bestard, 2011 Yes Yes Yes No Yes Yes/No No Yes Moderate Campbell, 2018 Yes Unclear Yes … Risk of bias of cannabis cohort studies
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-tables-G1-2.xlsx
    January 01, 2022 - Risk of bias of cannabis RCTs Author, Year Randomization Adequate? … Risk of bias of cannabis RCTs Table G-2. ROB Cohort Studies Table G-2. … Risk of bias of cannabis cohort studies Author, Year Did the Study Attempt To Enroll All (or a Random … Risk of Bias Bestard, 2011 Yes Yes Yes No Yes Yes/No No Yes Moderate Campbell, 2018 Yes Unclear Yes … Risk of bias of cannabis cohort studies
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-1-app-G.xlsx
    January 01, 2023 - Risk of bias of cannabis RCTs Author, Year Randomization Adequate? … Risk of bias of cannabis RCTs Table G-2. ROB Cohort Studies Table G-2. … Risk of bias of cannabis cohort studies Author, Year Did the Study Attempt To Enroll All (or a Random … Risk of Bias Bestard, 2011 Yes Yes Yes No Yes Yes/No No Yes Moderate Campbell, 2018 Yes Unclear Yes … Risk of bias of cannabis cohort studies
  12. Brooks_ECCS2012 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/brooks_eccs2012.pdf
    January 01, 2012 - whether to be screened for prostate cancer,   after receiving information about the uncertainties, risks … increases  the chance of findin prostate  cancer at an earlier stage. • Screening might lower a man’s risk … tests  to  find it early. • We don’t  yet  know  if the benefits of testing  outweigh the risks … Slide 16: Balanced Discussion of Pros  and Cons Two  images displaying benefits and risks titled
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-infection-prevention-mdro-rapid-research.pdf
    April 01, 2024 - prevention and control practice (for example, for interventions of long duration, the pooled random effects relative … Unclear risk High risk Low risk Low risk Unclear risk McConeghy et al., 201744 Unclear risk Low … risk High risk Low risk Low risk Unclear risk Miller et al, 202346 Low risk Unclear risk High risk … Low risk Low risk Low risk Ray et al., 201751 Unclear risk Low risk High risk Low risk High risk Unclear … risk Salgado et al., 201352 Low risk Unclear risk Low risk Low risk Low risk Unclear risk Table
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
    March 13, 2012 - A number of negative prognostic factors (factors associated with increased risk of recurrence) have … Identifying the individuals in whom the potential benefits of chemotherapy outweigh the risks is challenging … T4 tumor) may be inadequate for determining individual risk. … On the other hand, introducing routine testing without a clear understanding of benefits and risks could … obtained with standard risk factors?
  15. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
    December 01, 2011 - The strength of evidence for higher risks of weight gain with mirtazapine than with other antidepressants … Severe Adverse Events The strength of the evidence on the comparative risks of second-generation antidepressants … trials and observational studies were too small and study durations too short to assess the comparative risks … yield conflicting information about the comparative risk of seizures. … hepatotoxicity about the comparative risk of hepatotoxicity.
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/bipolar-disorder-treatment_research-protocol.pdf
    June 23, 2014 - when considering a specific treatment option versus no treatment, they would need to consider the risks … We define a “direct” harm as harm a patient risks by virtue of receiving the treatment and is part of … What can we do to mitigate the side effects of pharmacological treatments that create other medical risks … quality.15 Study-level risk of bias must be assessed using validated risk of bias tools appropriate … Using a random effects model, we will calculate risk ratios (RR) and absolute risk differences (RD)
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopausal-symptoms-protocol-final.pdf
    October 15, 2024 - For estrogen alone, although the risks of blood clots and stroke were higher during treatment, there … was no elevated risk and possibly a reduced risk of breast cancer. … The benefits and risks of this customized strategy have not been studied.20-22 Understanding how to … For trials and NRSIs, we will synthesize dichotomous outcomes using relative effect measures (e.g., relativerisk, hazard ratios, odds ratios).
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopausal-symptoms-protocol.pdf
    October 15, 2024 - For estrogen alone, although the risks of blood clots and stroke were higher during treatment, there … was no elevated risk and possibly a reduced risk of breast cancer. … The benefits and risks of this customized strategy have not been studied.20-22 Understanding how to … For trials and NRSIs, we will synthesize dichotomous outcomes using relative effect measures (e.g., relativerisk, hazard ratios, odds ratios).
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-evidence-communication_executive.pdf
    November 01, 2013 - Risk-of-Bias Assessment of Individual Studies Two reviewers independently rated the risk of bias of … uncertainty are as follows: • Communicating precision—Studies found mixed effects of presenting numeric risks … Benefts for me or risks for others: a cross- culture investigation of the effects of message frames and … Does information about risks and benefts improve the decision-making process in cancer screening - … Impact of information about risks and benefts of cancer screening on intended participation.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-911-workforce-mental-health-protocol-amendment.pdf
    January 22, 2024 - EMS clinicians have been shown to be at high risk for anxiety, depression, posttraumatic stress disorder … Assessment of Risk of Bias in Individual Studies: We will evaluate each study for risk of bias and methodological … As reported data allow, we will primarily evaluate relative risks (RRs) for dichotomous outcomes https … The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. Bmj. … ROBINS-I: a tool for assessing risk of bias in non- randomised studies of interventions. Bmj.

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