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Total Results: 2,111 records

Showing results for "risk".

2061. Disposition of Comments Report for Cardiac Troponins Used as Diagnostic and Prognostic Tests in Patients Wtih Kidney Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_disposition-comments.pdf
      August 11, 2014 - Does this portend increased cardiovascular risk? … This is the primary use of troponin for risk stratification. … of the systematic review) is the lack of therapeutics that can be engaged to reduce cardiovascular risks … evaluating a biomarker in how much it discriminates and re-classifies individuals into higher and lower risks … Elevation of this biomarker is associated with an increased risk.

2062. Appendicitis Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
      December 09, 2013 - of modalities that involve ionizing radiation (e.g., CT) may entail additional radiation- related risks … Assessment of Methodological Risk of Bias of Individual Studies We will assess the risk of bias for … We discuss the handling of high risk of bias studies in Sections E and F. … risk of bias item on the results of the meta-analysis. … risk of bias will lead to downgrading the strength of the evidence.

2063. Stem-Cell-Children Surveillance (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_surveillance.pdf
      October 29, 2012 - Ewing’s sarcoma family of tumors, and high-risk relapsed Wilm’s tumor. … For example, if relative risk reduction (RRR) new / RRR old <=0.5 or RRR new / RRR old >=1.5. … In other words the reduction in the risk of death has moved from 30% to 10%. … For risk differences and weighted mean differences, we applied the criterion directly to the previous … Ewing’s sarcoma family of tumors, and high-risk relapsed Wilm’s tumor.

2064. Restless-Legs Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
      December 16, 2011 - significantly impacts quality of life. 21,22 For individuals with mild or moderate symptoms, the risks … In addition, long- term risks and benefits of treatment are unclear for children and older adults with … Neither do we know the risks/benefits of the drugs for older adults who take several medications for … For each RCT, we will assess risk of bias using the Cochrane risk of bias tool. … We will assume a low risk of bias when RCTs meet all the quality criteria; a moderate risk of bias

2065. Cancer-Pancreas Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-pancreas_research-protocol.pdf
      August 09, 2013 - High risk encompasses those with either a genetic or familial risks such as having two or more first-degree … For sufficient quality, see section D below on risk of bias. … of bias or moderate/high risk of bias. … another risk-of-bias category for other outcomes because the risk of bias can depend on the outcome … / or risk factors/ 37 (risk$ or screen$ or hereditary or inherit$ or gene$ or family history).ti

2066. Omega-3-Maternity Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/omega-3-maternity_research-protocol.pdf
      May 18, 2015 - Maternal or childhood adverse events: – What are the short and long term risks related to maternal intake … Breastfeeding women • Term or preterm human infants at or after birth – What are the short and long term risks … Risk of bias among RCTs will be assessed using the Cochrane Risk of Bias tool,12 which evaluates risk … all exposures in a study, allow for the grouping of data by study, and allow for different baseline risks … The Cochrane Collaboration's tool for assessing risk of bias in randomised trials.

2067. Comparative Effectiveness of Medications in Patients with Epilepsy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
      March 01, 2012 - Risk of nausea is nonsignificantly decreased by 34 percent when LEV is used versus CBZ-CR”. … Pellock, M.D., American Epilepsy Society President 2011 Results Issues concerning AED risks and … apporpriate statement would be that there was insuffient to low SOE for switching to increase short term risks … A combined CER risks obscuring these vital differences and diluting clinical points of special relevance … Suggesting that this should be used for policy recommendations risks harming children by restricting

2068. Untitled (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
      February 17, 2016 - However, prophylaxis with pharmacologic strategies also has risks including major bleeding, prosthetic … for likely PE risk reduction. … of DVT compared to no VTE prophylaxis and increases the risk of minor bleeding. … For RCTs, we will use the Cochrane risk of bias tool,3 which asks about risk of selection bias, performance … Preventing blood pooling lowers the risk of blood clots forming.

2069. heart-failure-readmission-protocol-130611 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_research-protocol.pdf
      June 10, 2013 - years of age.11 Coronary disease and uncontrolled hypertension are the highest population-attributable risks … Assessment of Methodological Risk of Bias of Individual Studies To assess the risk of bias (i.e., … A study with moderate risk of bias is susceptible to some risk of bias but probably not enough to invalidate … A study assessed as having high risk of bias has significant risk of bias (e.g., stemming from serious … Two independent reviewers will assess risk of bias for each study.

2070. Obesity-Child Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/obesity-child_executive.pdf
      March 31, 2010 - , or high risk of bias. … We assessed risk of bias as described above. … , or high), this was the risk category we assigned to that group. … Only one study, with a high risk of bias Table C. … limitations as an indirect measure of adiposity, and it is not an ideal indicator for cardiometabolic risks

2071. Hi Les, (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
      January 01, 2009 - multifocal disease, mastectomy is recommended based on evidence that this population is at higher risk … In theory, the absolute benefits of a new treatment depend on three factors: the patient risk of future … events without this treatment (prognosis), the relative effectiveness of the new treatment, and the risks … The absolute risk reduction equals the patient baseline risk times the relative risk reduction minus … the risks of treatment.

2072. Tinnitus Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/tinnitus_executive.pdf
      August 01, 2013 - Data Extraction, Assessment of Risk of Bias, and Applicability Standardized and validated scales were … Only single studies with high risk of bias evaluated TRT and yoga. 12 Table E. … Only single studies with high risk of bias evaluated TRT and relaxation. … Only single studies with high risk of bias evaluated TRT and other interventions. … Effect- size estimates were inconsistent or imprecise, and risk of bias was moderate.

2073. Traumatic Brain Injury and Depression (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-brain-injury-surveillance-160902.pdf
      January 30, 2014 - which"treatment" modalities"are"equivalent"or"superior"with"respect"to"benefits,"shortK"and"longKterm"risks … which"treatment"modalities"are"equivalent"or" superior"with"respect"to"benefits,"shortK"and"longKterm"risks … which$treatment$modalities$are$equivalent$or$superior$with$respect$to$ benefits,$short"$and$long"term$risks … $Even$after$adjusting$for$ other$risk$factors$(e.g.,$predeployment$mental$health$status,$severity$of … which$treatment$modalities$are$equivalent$or$superior$with$respect$to$ benefits,$short"$and$long"term$risks

2074. Maternal and Fetal Effects of Mental Health Treatments in Pregnant and Breastfeeding Women: A Systematic Review of Pharmacological Interventions (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/protocol-pharm-pregnant-women_0.pdf
      December 05, 2018 - careful review of the evidence is critical for patients and clinicians to make informed decisions about risks … Assessment of Methodological Risk of Bias of Individual Studies. … Antidepressant use during pregnancy: the benefit-risk ratio. … Risks and benefits of psychotropic medication in pregnancy: cohort studies based on UK electronic primary … Antidepressant use in pregnancy and the risk of cardiac defects.

2075. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_disposition-comments.pdf
      September 01, 2011 - That is the whole point of assessment of study risk of bias and applicability. … Both of these studies which have a low risk of bias and do not involve double counting. … The risk of bias among the included studies overall is moderate to high. … That is the whole point of assessment of study risk of bias and applicability. … All studies based on those designs are included and assessed for risk of bias.

2076. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
      September 01, 2014 - Therapeutic decision-making involves assessment of the trade-offs between potential risks and potential … If the potential risks are not defined, then the decision-maker in not sufficiently well informed to … on CV risk score and those that treat just based on LDL. … set up to fail—there are no trials to adequately answer the question about long term benefits and risks … Change to: “among patients at high and moderate CHD risk, defined as a 10-year CHD risk greater than

2077. Urinary-Incontinence-Treatment Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
      September 30, 2010 - hypotheses and did not provide adequate information on tested hypotheses (e.g., least square means, relative … risk); 2. … risk, and absolute risk differences (ARD). … Poor (high risk of bias). … We will calculate relative risk and absolute risk difference from the abstracted events using Meta-analyst91

2078. Fibromyalgia Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/fibromyalgia_executive.pdf
      January 01, 2015 - Quality (Risk-of-Bias) Assessment of Individual Studies The risk of bias of eligible studies was assessed … For RCTs we assessed the risk of bias using a modified Cochrane risk-of-bias tool.42 We used additional … risk of bias … All assessed unique outcomes in disparate subgroups and all had high risk of bias. … In assessing risk of bias, we assessed typical risk-of-bias domains for RCTs and added subgroup questions

2079. Traumatic-Brain-Injury-Rehabilitation Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_executive.pdf
      June 01, 2012 - Risk of Bias Assessment of Individual Studies Risk of bias assessment forms were developed specifically … For RCTs, we modified the Cochrane Risk of Bias Tool26 by adding items to capture potential risk of … Investigators consulted to reconcile discrepancies in overall risk of bias assessments. … Of these eight studies, one was rated low risk of bias, and seven were rated moderate risk of bias. … Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, eds.

2080. Liver-Cancer Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
      July 24, 2013 - Institute’s Surveillance, Epidemiology, and End Results Cancer Statistics Review found that the lifetime risk … The population of high-risk patients is defined, as per the AASLD clinical guidelines, as composed … o Key Question 2  Patients at high risk for HCC in whom a suspicious lesion(s) has been detected … Each study evaluated will be dual reviewed for risk of bias by two team members. … Other definitions of high risk patients as defined by the primary studies will be accepted.