-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
March 01, 2012 - reduction
resulting from treatments vary between individuals with
different risks for fracture as … with different risks for fracture
as determined by bone mineral density, risk
assessment score, prior … risk. … How does fracture risk reduction resulting from treatments vary between individuals with different risks … Given the established adverse
events associated with treatment, and newly identified
risks such as
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/multiple-sclerosis_executive.pdf
April 01, 2015 - • Because of high risk of bias and small sample sizes,
evidence is insufficient to address the risks … Eight observational studies (all high risk of bias)
addressed the risks of rebound disease activity … Twelve observational studies (all high risk of bias)
addressed the benefits and risks to mothers and … Thus, personal
preferences about risks take on more weight. … Multiple sclerosis
patients’ benefit-risk preferences: serious adverse event risks versus
treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-prevention_research-protocol.pdf
November 03, 2011 - risk).
6. … risk, and absolute risk differences. … We will evaluate the
strength of the association, defining a priori a large effect when relative risk … is >2 or <0.5 and a
very large effect when relative risk is >5 or <0.2.
47
We will define low magnitude … of the effect
when relative risk is significant but <2.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
May 31, 2017 - e.g., odds ratio, relative risk, hazards ratio); (2) discrimination
(e.g., area under the receiver operating … of bias,” “medium risk of bias,” or “high risk of bias.” … Adjusted risk estimates may include odds ratios, risk ratios, and hazard ratios. … (e.g., odds
ratio, relative risk,
hazards ratio); (2)
discrimination (e.g.,
area under the
receiver … (e.g., odds
ratio, relative risk,
hazards ratio); (2)
discrimination (e.g.,
area under the
receiver
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-summary.pdf
November 01, 2020 - gabapentin, and valproate may have
similar adverse effect profiles, but lamotrigine may have a low risk … Lamotrigine may have a lower risk of
adverse effects: no increased risk of spontaneous abortion, stillbirth … particular) (low to moderate SoE for specific adverse
effects) and antihistamines (moderate SoE) had low risks … no increased risk or unknown risk of
other fetal/child AEs, this table includes only the indicator for … increased risk.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_clinician.pdf
September 01, 2016 - .
�� Low-level evidence suggests that the risk of adverse
events and the rates of discontinuation due … statistically significant difference; CBT = cognitive behavioral therapy; CI = confidence interval; RR = relative … risk;
SGA = second-generation antidepressant; SOE = strength of evidence
Table 1: Summary of the … Black Box Warnings for Drugs Used
To Treat MDD
Drug(s) FDA Black Box Warning
All SGAs �� Increased risks … effective nonpharmacological and pharmacological
treatment options are available for MDD
�� The risks
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
October 01, 2012 - Relative risk
reduction was not significantly
different than in similar patients
who did not have … commission on Human
medicines concluded that
the benefits of rosiglitazone
no longer outweigh its
risks … cohort study of the
association of eGFR,
proteinuria and adverse
clinical outcomes found
that the risks … Renal outcomes in hypertensive Black
patients at high cardiovascular risk. … Relative risk reduction was not
significantly different than in similar
patients who did not have
-
effectivehealthcare.ahrq.gov/sites/default/files/politi.pdf
May 29, 2025 - Preference-‐Sensitive
Decisions
Preference-‐Sensitive Decisions:
• BCS vs. mastectomy for average risk … Decisions With Low Evidence:
• BCS vs. mastectomy for patients with unknown family
history/unknown BC risk … Slide
8: Informational Uncertainty
• Unavailable evidence (studies not yet conducted)
• Unknown risk … Recommendations
• Describe options and uncertainty (general terms)
• Focus less on quantitative risks … Explore the Decision
(Options, Benefits, Risks, Uncertainty)
3.
-
effectivehealthcare.ahrq.gov/sites/default/files/han.pdf
December 26, 2012 - based input for shared decision
making, by providing
estimates of the individual probabilities of risks … Slide 21: Representing
indeterminacy in risk estimates: new approaches
• Limited
evidence on … effectiveness
o No apparent effects on risk perceptions
o Increase subjective uncertainty about
… One bar shows risk
as a solid bar.
The other shows risk
as a blurred bar.
… Slide 25: Methodological problems
• Separation of strength of recommendation (risk) vs. quality
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-review-masks-prevention-covid-version-1.pdf
December 01, 2021 - in risk of clinical
respiratory illness. … Risk
factors for SARS infection within hospitals in Hanoi,
Vietnam. … incidence of SARS-CoV-2 infection by use of personal protective equipment (PPE) by
health workers
Relative … Risk factors for SARS infection within
hospitals in Hanoi, Vietnam. … Risk of Bias Assessments
Appendix E. Ongoing Studies
Report References
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-seniors-pneumonia_research.pdf
May 01, 2008 - Observed Association Between Antidepressant Use and Pneumonia Risk Was Confounded by Comorbidity Measures … Health Care
Number 5
Research Reports
Observed Association Between Antidepressant Use
and Pneumonia Risk … The exposure odds ratio in
nested case-control studies with competing risks. … Risk factors for community-
acquired pneumonia diagnosed upon hospital
admission. … Risk of community-
acquired pneumonia and use of gastric acid-
suppressive drugs.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-stone-prevention_research-protocol.pdf
June 15, 2011 - RevMan) version 5.0
software.
33
Random effects models will be used to generate pooled estimates of relative … risks and
95 percent confidence intervals. … The risk of bias—based on
study design and conduct—will be rated low, medium, or high. … Prospective study of beverage use and the risk of
kidney stones. … History of kidney stones as a possible risk
factor for chronic kidney disease.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ped-mindfulness-protocol-amendment.pdf
February 05, 2025 - Assessment of Methodological Risk of Bias of Individual Studies: We define the risk of bias
as the risk … We will assess the risk of
bias for each included study using the Cochrane Risk of Bias 2 (ROB2) tool … 100-point scale
SMD >0.8
RR/OR ≥2.0
Abbreviations: MD = mean difference; OR = odds ratio; RR = relative … risk; SMD = standardized mean difference. … Strategies; PedsQL = Pediatric Quality of Life Inventory; RADS =
Reynolds Adolescent Depression Scale; RR = relative
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioids-chronic-pain-surveillance-report-1-final.pdf
April 01, 2022 - increased likelihood of experiencing a pain
response (>30% reduction in pain intensity, 60% vs. 35%, relative … In patients with chronic pain, what are the risks of opioids versus placebo
or no opioid on: (1) opioid … In patients with chronic pain, what are the comparative risks of opioids
versus nonopioid therapies … In patients with chronic pain, what are the comparative risks of opioids
plus nonopioid interventions … Risk Assessment and Risk Mitigation Strategies:
a.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-2.pdf
April 01, 2022 - mitigation
strategies, dose-dependent risks of opioids, and management of opioid use disorder, all … In patients with chronic pain, what are the risks of opioids versus placebo
or no opioid on: (1) opioid … In patients with chronic pain, what are the comparative risks of opioids
versus nonopioid therapies … In patients with chronic pain, what are the comparative risks of opioids
plus nonopioid interventions … Experiencing the Risks of
Overutilizing Opioids Among Patients With
Non-Tumor Chronic Pain in Ambulant
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-review-masks-prevention-covid-version-2.pdf
December 01, 2021 - of infection with SARS-CoV-2, 15 studies on risk
of infection with SARS-CoV-1, and one study on risk … in risk of clinical
respiratory illness. … Risk
factors for SARS infection within hospitals in Hanoi,
Vietnam. … incidence of SARS-CoV-2 infection by use of personal protective equipment (PPE) by
health workers
Relative … Risk factors for SARS infection within
hospitals in Hanoi, Vietnam.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-opioid-stewardship-protocol.pdf
July 01, 2023 - However, opioids also carry well known risks,
including for overdose, misuse, and opioid use disorder … tapering of opioids
causing withdrawal, distress, and suicidal ideation.3 Thus, any approach to mitigate risks … The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic
Pain. … Pain Management and the Opioid Epidemic:
Balancing Societal and Individual Benefits and Risks of Prescription … The Cochrane Collaboration's tool for assessing risk of bias in
randomised trials.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatigue-sleepiness-protocol.pdf
July 01, 2023 - Patient safety risks due to fatigue and sleepiness of
healthcare workers were not addressed in MHS … Fatigue Risk Management in the Workplace. … How effective are Fatigue Risk Management
Systems (FRMS)? A review. … The Cochrane Collaboration's tool for assessing risk
of bias in randomised trials. … ROBINS-I: a tool for assessing risk of bias in non-
randomised studies of interventions.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cesarean-birth-2010_executive.pdf
January 01, 2010 - reduce fear
of labor, education about how to push in labor, and
preemptive management of specific risks … of using a partogram
to graph labor progress along with active management to
augment labor (7.4%, relative … We did not include studies
focused only on high-risk populations. … Previous cesarean
delivery and risks of placenta previa and placental abruption. … Physician
contribution to a cesarean delivery risk model.
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
January 01, 2015 - strength of evidence that sulfonylurea
monotherapy was associated with a 50-percent to
70-percent higher relative … difference; RR = relative risk; SOE =
strength of evidence. … Sulfonylurea
monotherapy was associated with a 50-percent to
70-percent higher relative risk of cardiovascular … These other
monotherapies’ effects on body weight vary, as do their
risks, such as congestive heart … medications on weight, hypoglycemia, and
gastrointestinal and other side effects; tolerance of
unknown risks