-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf
May 01, 2012 - What are the comparative risks, benefits, and outcomes of therapies? … However, the adjusted
relative risk of surgery-related
complications was lower in
patients treated … What are the comparative risks, benefits, and outcomes of therapies? … What are the comparative risks, benefits, and outcomes of therapies? … However, the adjusted
relative risk of surgery-related
complications was lower in patients treated
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia_executive.pdf
May 01, 2006 - Hb response rates:
Number of studies reporting 6 15 3
Patients analyzed 2,205 3,293 659
Pooled relative … Transfusion rates:
Number of studies reporting 6 34 4
Patients analyzed 2,158 5,210 950
Pooled relative … Thromboembolic events:
Number of studies reporting 3 30 1
Patients analyzed 1,879 6,092 314
Pooled relative … meaningfully different.
3 Since there was only one trial, this result is a single-study (not pooled) relative … risk.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-mortality-elderly_research.pdf
March 01, 2009 - Cox proportional hazards models were used to compare risks of developing the
specific cause of death … with dementia.
1
“Black box” warnings were added to labels of all
atypical APMs describing these risks … mainly from studies in younger populations,
some have suggested that conventional APMs could pose risks … the first warnings regarding atypical agents and
stroke, to avoid overestimating cerebrovascular risks … Antipsychotic drugs
in dementia: what should be made of the risks?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_disposition-comments.pdf
August 01, 2012 - on benefits and risks of
screening, monitoring and treatment. … has been made to
describe the impact of CKD stage (e.g., 1
versus 2 versus 3) on the benefits and
risks … Stages 1 to 3 CKD
conferred significant increases in the relative risk of all 5
parameters assessed … factors (e.g. diabetes,
hypertension, etc.) on the benefits and
risks of CKD screening, monitoring … factors including race on the
benefits and risks of CKD screening,
monitoring and treatment.
-
effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
April 01, 2020 - Harms and adverse events:
– What are the risks of nonopioid
pharmacologic agents for harms including … points on a 0 to 100-point scale
• SMD >0.8
• RR/OR ≥2.0
MD = mean difference; OR = odds ratio; RR = relative … response with SNRI antidepressants
(odds ratio [OR] 1.61 to 2.33) while we found a
moderate effect (relative … ).15 Differences in magnitude could be due to
the addition of 15 studies in our report, reporting
relative … risks rather than odds ratios, and using
direct comparisons rather than network analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
June 02, 2011 - protocol Yes No No
Conflict of interest No No Yes (optional domain of
publication bias )
Types of Risks … Each study design has specific risks
of bias that may differ depending on the clinical question. … classes of evidence into the review and (2) when
evaluating individual studies for design-specific risks … to include observational studies, then the review team
needs to evaluate each study based on the risks … presenting data on individual endpoints;
26
2. selective outcome reporting—for example, reporting relative
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/impact-healthcare-algorithms-racial-ethnic-disparities-March-3.pdf
July 01, 2023 - risk
Novel risk prediction algorithm for cardiovascular disease
COAG for warfarin dosing
Added health … outcome variables 1 USPSTF-2020 for lung cancer risk
Added measures of SDOH 1 Novel risk prediction … Novel risk prediction algorithm for postpartum depression
Donor Risk Index for liver transplant suitability … deployed in health systems
but regulation is not enough, and
clinicians cannot bear all liability risks … How can the AI RMF help organizations manage the risks from AI bias?
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-236-maternal-fetal-child-outcomes-disposition-comments.pdf
April 15, 2021 - In response, the EPC
added a table to the discussion section on absolute risks of harms when available … presented in the
context of the likelihood that this complication will occur
and the difference in the relative … column whether the
effect is a benefit or a harm and indicate
the magnitude of effect in terms of relative … risks in the results column. … The key information about treatment risks, harms,
and evidence can still be provided without relying
-
effectivehealthcare.ahrq.gov/sites/default/files/zikmund.pdf
May 29, 2025 - Am I at high risk or not?” … that is
higher
to this
degree.”
• “My risk is
this.”
• “My (group’s) risk is
this, … OR “My risk is
this
i I do X, which is higher than my risk i I do Y which is that.”
• “My risk … risk for
me than that is.”
• “I have bad risk.”
• “My risk is
worse.”
• Unclear without background … knowledge
• “My risk is
worse than their
risk is.”
• “My risk is
bad and worse if I do X.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-3.pdf
June 01, 2022 - difference: CI = confidence interval; KQ = Key Question; RCT = randomized controlled
trial; RR = relative … scale, 95% confidence interval [CI] −0.93 to −0.67,
I2=71%), likelihood of a pain response (44 trials, relative … mitigation strategies, dose-
dependent risks of opioids, and management of opioid use disorder; for … In patients with chronic pain, what are the comparative risks of opioids
versus nonopioid therapies … adverse events; CI = confidence interval; MD = mean difference; RCT = randomized controlled trial; RR = relative
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-afib-update_research-protocol-amended.pdf
October 27, 2017 - Treatment Description
to better understand the relative … risks and benefits of these drugs
based on individual patient characteristics. … A population-based study of the long-term risks associated
with atrial fibrillation: 20-year follow-up … "[Mesh] OR risk[tiab] OR risks[tiab] OR "Predictive Value of Tests"[Mesh] OR predict[tiab]
OR predicts … "[Mesh] OR risk[tiab] OR risks[tiab] OR "Safety"[Mesh] OR safety[tiab] OR safe[tiab] OR
"Incidence"[
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-other-plant-based-treatments-evidence-summary_0.pdf
October 01, 2021 - There may be a large increased risk of dizziness and
sedation and a moderate increased risk of nausea … of
sedation, and large increased risk of nausea. … Synthetic THC is probably associated
with a large increased risk of dizziness. … -point scale
• SMD >0.8
• RR/OR ≥2.0
Abbreviations: MD = mean difference; OR = odds ratio; RR = relative … risk; SMD = standardized mean difference.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_executive.pdf
July 01, 2014 - in humans, but potential benefits
may warrant use of the drug in pregnant women despite
potential risks … in humans, but potential
benefits may warrant use of the drug in pregnant women
despite potential risks … women who did not use an
antidepressant during pregnancy but whose depression
status was unknown (relative … We know, however, that some baseline risks are associated
with depression during pregnancy; this fact … Nonpharmacological treatments are generally thought
to have fewer risks than antidepressants.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/models-care-adult-survivors-childhood-cancer-evidence-summary.pdf
February 01, 2022 - Summary
Main Points
Background and Purpose
Childhood cancer survivors are at increased risk … literature include
oncology care versus primary care, survivor and provider knowledge (e.g.,
survivor risks … as described by the Stakeholders:
“Survivors feel confident about sharing their history, know their risks … access relevant care and services” and “PCPs understand
a survivor’s history, know the survivor’s risks … to inform delivery
of survivorship-related care
Survivors can share
their history, know their
risks
-
effectivehealthcare.ahrq.gov/sites/default/files/s81.pdf
October 01, 2007 - commonly
used measure of discrimination, in this case equal to (sensi-
tivity � specificity)/2,22 and relative … risk (RR). … risk. … 31 38.21 0.0000
Diabetes Mellitus (CCS D-50)† 0.08 4 11 97 0.54 3 3.41 0.0134
*P value is for the relative … risk.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer_executive.pdf
February 01, 2008 - All treatments have
risks of complications, although frequency and severity
may vary. … What are the comparative
risks, benefits, and outcomes of therapies? … risk disease. … However, the
relative risk of surgery-related complications adjusted
for patient age, race, and comorbidity … The
relative risk of surgery-related complications adjusted for
patient age, race, and comorbidity,
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-protocol.pdf
September 24, 2024 - Assessment of Methodological Risk of Bias of Individual Studies
We define the risk of bias as the risk … Studies will be
rated as “low risk of bias,” “medium risk of bias,” or “high risk of bias.” … Studies rated “low risk of bias” are considered to have the least risk of bias, and their results are … 100-point scale
SMD >0.8
RR/OR ≥2.0
Abbreviations: MD = mean difference; OR = odds ratio; RR = relative … quality improvement; RCT = randomized controlled trial; ROSC = return of spontaneous circulation;
RR = relative
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-treatments-chronic-pain-protocol.pdf
December 19, 2018 - Research and Quality (AHRQ) commissioned a
comparative effectiveness review on the effectiveness and risks … assessment and initiate long-term opioid therapy only when benefits are
likely to exceed risks; use … Risk Assessment and Risk Mitigation Strategies
a. … Annual Surveillance Report of Drug-Related
Risks and Outcomes — United States, 2017. … Annual surveillance report of drug-related risks
and outcomes — United States, 2018.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
March 01, 2022 - There may be a large increased risk of
dizziness and sedation and a moderate increased
risk of nausea … • Studies on the acute treatment of migraine that
compare relative risks of medication overuse … studies that looked at prior or early
postoperative opioid use found mostly strong
associations (e.g., relative … Outcomes
• Studies to assess risks and benefits including patient
anxiety and disproportionate access … with
antiresorptive osteoporosis drug treatment to best
place these risks in the context of the effects
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_executive.pdf
October 01, 2015 - number of available tests and testing strategies,
and potential tradeoffs in diagnostic accuracy, risks … We calculated relative risks (RRs)
and associated 95% confidence intervals (CIs) based on
the information … risk of adverse
events (SOE: low) … optimized administration to be associated with lower
risk of recurrence and increased risk of local … NMIBC = non–muscle-invasive bladder cancer; NMP22 = nuclear matrix protein 22; OR = odds ratio;
RR = relative