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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-risk-of-bias.pdf
December 01, 2017 - Assessing the Risk of Bias in Systematic Reviews of Health Care Interventions
Assessing the Risk of … Defining Risk of Bias
• Risk of bias is:
► An assessment of the internal validity of the individual … Risk of Bias
There are five stages in assessing risk of bias. … Develop Protocol
Pilot test and train
Perform Assessment of Risk of Bias of Individual Studies
Use Risk … Use risk-of-bias assessment tools that can identify potential risk-of-bias categories specific to the
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-research-executive-summ.pdf
March 01, 2025 - Low SOE
for reduced
risk
Respiratory
infections
Potential reduced risk of more severe respiratory … ,
including risk of late-neonatal mortality and SUID. … Moderate
SOE for
increased
risk
Dental
caries
Approximate 54% increased risk of dental caries … We used established methods for determining the potential risks of bias and
certainty of our findings … prevent us from identifying a clear threshold
or precise “dose” of breastfeeding associated with reduced risks
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
March 01, 2011 - This risk should prompt routine
thromboprophylaxis; however, the associated elevated risk of bleeding … The length of the evaluation period will be considered when evaluating the benefits and risks (short-term … differences or relative risks by using a DerSimonian and Laird random effects model. … differences, or relative risks with 95 percent confidence intervals for the individual studies. … Prophylactic inferior vena cava (IVC) filter placement may increase the
relative risk of deep venous
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effectivehealthcare-admin.ahrq.gov/products/cervical-ripening/protocol
May 01, 2020 - The risks of CR are similar to those of spontaneous labor, compounded by known and theoretical iatrogenic … However, there are concerns regarding potential risks of outpatient CR to the woman and fetus in comparison … The risks of CR may be mitigated through the choice of CR method and clinical management. … Careful review of existing literature is needed to elucidate whether these risks occur more frequently … versus inpatient setting and whether maternal or fetal characteristics differentially affect these risks
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effectivehealthcare-admin.ahrq.gov/sites/default/files/communicating_risk_media_wilkes.ppt
April 01, 2006 - , small differences between risks, and uncertainty around risks
Public Expectations
Public believes … million cases of breast cancer.
raloxifene is already used to prevent bone loss after menopause
NCI used relative … risk reductions in their promotion rather than absolute risk reductions
At the press release and conference … Why are risks minimized? … new possibilities
Tools to help patients better understand the health care system and risk
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effectivehealthcare-admin.ahrq.gov/products/breast-reconstruction-mastectomy/research
March 01, 2022 - The risks of seroma or of unplanned repeat surgery for revision probably are comparable with or without … Risk of bias was moderate to high for most studies. … SoE) and may pose a greater risk of breast seroma (low SoE). … well-being, and patient satisfaction with breasts (all low SoE), and probably results in comparable risks … Whether or not ADM is used probably is associated with comparable risks of seroma and unplanned repeat
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effectivehealthcare-admin.ahrq.gov/products/kidney-disease-medicine/research
December 01, 2019 - proteinuria, nearly all with diabetes and hypertension, angiotensin converting enzyme inhibitors (ACEIs) (relative … (ARBs) (RR 0.77, 95 percent CI, 0.66 to 0.90) significantly reduced risk of end-stage renal disease … factors, ACEI treatment reduced mortality risk (RR 0.79, 95 percent CI, 0.66 to 0.96) versus placebo … In selected CKD patients, ACEI or ARB treatment reduces ESRD risk, ACEI treatment reduces mortality risk … , and statin treatment reduces risk of mortality, MI, and stroke.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
April 23, 2019 - Comment Response
Discussion Public Commenter
#7 (ASBMR)
Report should include a discussion on the relative … Needs presented on ES-16 are thoughtful
and focus on the need to carefully evaluate the benefits
and risks … However,
the clinical question was what is the evidence for
benefits and risks beyond 3 years. … A similar question should be asked about
adequacy of data to study the hypothetical risks (e.g.,
increased … There are several
statements about the benefits and risks of continued
treatment versus interruption
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effectivehealthcare-admin.ahrq.gov/products/bundled-payments-quality-effects/research-protocol
December 01, 2020 - adjustment of bundled payments, providers may select low-risk patients and avoid those with higher risks … The evidence of risks (e.g., patient selection) will also be summarized. … Analyzing shifts in economic risks to providers in proposed payment and delivery system reforms. … risk >5). … effect size that it could have occurred solely as a result of bias from confounding factors (e.g., relative
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/gestational-diabetes-screening-diagnosis_disposition-comments.pdf
January 01, 2020 - Long-term risks are not directly related to short
term outcomes. … .adjusted odd ratios
(aORs) of 1.75 relative to the mean cohort glucose values...'
1.75-fold is a relative … gain are
more/equally important for adverse outcomes and clinicians
do not rely on isolated OGTT relative … risks or odd ratios but
on women individual multifactorial absolute risks. … Research indicates
that IGT and GDM carry similar risks of adverse outcomes.
-
effectivehealthcare-admin.ahrq.gov/products/meditation/research-protocol
December 01, 2019 - The overall risk of bias will be assessed as:
Good (low risk of bias). … , or relative risks using a DerSimonian and Laird random-effects model. … differences, or relative risks with 95 percent confidence intervals for the individual studies. … or relative risks using a DerSimonian and Laird random effects model. … differences or relative risks with 95% confidence intervals (CI) for the individual studies.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/breast-cancer-risk-reduction_research.pdf
October 25, 2010 - of how to communicate
benefits and risks to patients 77.8% 4
How clinicians are weighing
the risks … Individualized risks
2) Education
a. … Studies of how doctors are weighing the
risks and benefits of medications to reduce
breast cancer risk … of how to communicate
benefits and risks to patients 77.8% 4
How clinicians are weighing
the risks … Analysis
of odds ratio of increased relative risk of
developing breast cancer in different groups
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_executive.pdf
August 01, 2013 - trials (RCTs)
including 28,000 patients with nonvalvular AF, warfarin
therapy led to a 64 percent relative … since
2000 that were comparative assessments of tools for
predicting thromboembolic and bleeding risks … hazard ratio; KQ = Key Question; LAA = left atrial appendage; RCT =
randomized controlled trial; RR = relative … Given the risks associated
with AF, the growing number of patients with AF, and
the costs and risks … A population-based study of the
long-term risks associated with atrial fibrillation: 20-year follow-
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
March 01, 2012 - would provide a more
accurate value than an estimation from relative risks. … Peer Reviewer #1 Results 1.Provide relative risks and confidence intervals for
studies included. … Calculation of relative risk and
odds ratio, whether pooled or not, was conducted using the
raw numerical … The individual study
relative risk or odds ratio (depending on the pooled effect)
along with its confidence … When only
one trial was available we report the calculated relative risk or
odds ratio with the confidence
-
effectivehealthcare-admin.ahrq.gov/products/acs-pci-adjunctive-devices/research-protocol
December 01, 2019 - For dichotomous outcomes, weighted averages will be reported as relative risks and risk differences with … expected, a DerSimonian and Laird random-effects model will be used when pooling data and calculating relative … risks, risk differences, and 95 percent confidence intervals. 9 When pooling continuous outcomes, weighted … This system uses four required domains—risk of bias, consistency, directness, and precision. … Risk of Bias
Risk of bias is the degree to which the included studies for any given outcome or comparison
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effectivehealthcare-admin.ahrq.gov/sites/default/files/bar-cohen_-eccs2012.pdf
January 01, 2012 - Health
Education
and
Decision Making
(3 of 4)
Questions to ask
when
interpreting
risks … and benefits
• Risk of what? … • How big
is the change in
risk?
… • How does this risk compare to other risks? … • What
would give patients a better idea
of the risks involved in
breast
cancer?
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/future05-breastcancer-10-5-2010final.pdf
September 01, 2010 - What is best method to communicate risks?
4) Influences
a. … Individualized risks
2) Education
a. … Studies of how doctors are weighing the
risks and benefits of medications to reduce
breast cancer risk … Analysis
of odds ratio of increased relative risk of
developing breast cancer in different groups … Benefits and
risks of raloxifene by vertebral fracture
status.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
August 01, 2024 - We evaluated risk of bias (RoB) using the
Cochrane RoB2 tool for RCTs and the ROBINS-I tool for NRSIs … • Most of the studies are assessed with high risk of bias. … GI-gastrointestinal; GU-genitourinary; RCT- randomized controlled trial; yrs- years; vs.- versus;
RR- relative … measurement
between trials, inadequately addressing attrition, multiple comparisons testing, and
competing risks … interventions and comparators, lack of power calculations, and inadequately addressing
missing data, competing risks
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
October 01, 2015 - Pooled risks were calculated using a
random-effects model using the method of DerSimonian
and Laird … 2,000 based on an
expected 0.1 probability of CIN in the comparison group
and a minimally important relative … of 10,000 based on an expected
0.02 probability in the comparison group and a minimally
important relative … risk difference of 25 percent. … such
risk factors.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
March 01, 2024 - • We found too few studies reporting on diversion to quantify the risk of diversion
of pharmacological … We converted to scale-independent standardized mean differences (SMD) and
relative risks (RR) together … The risk of bias in included studies varied
considerably. … We found too few studies reporting on diversion to quantify the risk of diversion
of pharmacological … Medication therapy remains a central
treatment modality, though with a risk of side effects, even as