-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/reliability-testing-grading-evidence_research.pdf
May 01, 2012 - Exercise considered straightforward by study
team
RA Benefits:
ACR20
response
5 studies
19 … The project
team created electronic response forms to collect information from reviewers through … in agreement with the most popular
response among all reviewers; otherwise it was coded as 0. … We tested whether the likelihood of a
reviewer‘s response agreed with the most popular response, through … 1 if the response was the most popular response and 0 otherwise) and the stratification
(subgroup)
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-225-substance-abuse-adolescents-comments.pdf
May 21, 2020 - field_product_pub_date
https://doi.org/10.23970/AHRQEPCCER225
Summary of Peer Reviewer Comments and Author Response … substance-use-disorders-adolescents/research
Published Online: May 21, 2020
3
Commentator
& Affiliation
Section Comment Response
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/psoriasis-chronic_research-protocol.pdf
January 10, 2012 - The
presence of activated T cells within psoriatic plaques and the response to T cell-directed therapy … to
conventional therapy, including intolerance and refractory response to infliximab; reducing
signs … TNF-α Treatment for reducing signs and symptoms of
Crohn's disease and maintaining clinical response … in adult patients with active moderate-to-severe
disease with an inadequate response to
conventional … Variance imputation for overviews of clinical trials with
continuous response.
-
effectivehealthcare.ahrq.gov/products/asthma-nitric-oxide/research-protocol
September 12, 2016 - used to support the diagnosis of asthma as well as monitor the disease activity (inflammation) and the response … difficult given the inherent variability in the disease, the non-specific nature of many measures of response … In addition to have some possible advantages over other tests to select treatment and measure response … What is the clinical utility of FeNO measurements to monitor response to treatment in individuals ages … NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
September 06, 2016 - to support
the diagnosis of asthma as well as monitor the disease activity (inflammation) and the
response … assess
which treatments are likely to be most helpful to a given patient 12, 13and/or to follow the
response … In addition to have some possible advantages over other tests to select
treatment and measure response … 1.d: What is the clinical utility of FeNO measurements to monitor response to
treatment in individuals … NO chemical events in the human
airway during the immediate and late antigen-induced asthmatic response
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
September 01, 2011 - These categories
are useful in examining potential
differences in treatment response and
prognosis. … 4.0
- Pediatric Quality of Life Inventory
Rheumatology Module (PedsQL-RM)
• Composite measures of response … and intra-rater reliability, internal
reliability, construct validity, responsiveness
(standardized response … The
current response criteria of the ACR Pediatric 30, a
composite measure that includes articular … The current response criteria of the ACR
10
Pediatric 30 definition of improvement, a composite
measure
-
effectivehealthcare.ahrq.gov/products/major-depressive-disorder/research-protocol
June 19, 2014 - Several recent studies have highlighted differences in response to pharmacotherapy based on baseline … to two types of antidepressants (imipramine or paroxetine) begins to outpace placebo response only when … In response to that advice, we modified KQs 1b, 2b, and 3b to include moderate MDD, and we removed the … SGA + other pharmacotherapies
Outcomes
Efficacy: response, remission, speed of response, speed … Severity of depression and response to antidepressants and placebo: an analysis of the Food and Drug
-
effectivehealthcare.ahrq.gov/products/evidence-examples/white-paper
April 23, 2014 - selective outcome reporting, and selective analysis reporting), as well as additional domains of dose-response
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/pneumonia-antibiotic-treatment_research-protocol.pdf
July 19, 2013 - This target is based upon retrospective clinical data correlating clinical
response with specific Cmax … Clinical response or mechanical ventilation?
b. Morbidity or mortality?
c. … Clinical response or mechanical ventilation?
b. Morbidity or mortality? … It also considers other
optional domains that may be relevant for some scenarios, such as dose-response … Clinical response to aminoglycoside therapy:
importance of the ratio of peak concentration to minimal
-
effectivehealthcare.ahrq.gov/sites/default/files/use_of_handheld_osheroff_respondent.pdf
January 01, 2009 - www.effectivehealthcare.ahrq.gov/index.cfm)
Slide
1:
Ebell/Handheld
Decision
Support:
Osheroff
Response
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
November 22, 2011 - There are currently two basic approaches for trying to determine whether a patient will have a
poor response … is taking clopidogrel to see whether the platelets actually have become less prone to
aggregate in response … all other reviews reached favorable
conclusions regarding the use of CYP2C19 genetic testing for response … Clinical implications of clopidogrel non-
response in cardiovascular patients: a systematic review and … System of Oversight of Genetic Testing: A Response to the Charge of the Secretary of
Health and Human
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
August 01, 2024 - with 5FU plus cisplatin likely
does not increase overall or progression-free survival and complete response … capecitabine plus MMC, triplet CRT with
paclitaxel plus capecitabine plus MMC may increase complete response … Abbreviations: CI- confidence interval; CRT- chemoradiation; LR- locoregional; CR- complete response;
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_clinician.pdf
June 01, 2016 - beta-blockers
(atenolol or nadolol)
Improvement
in IH
3 studies
(100 subjects)
Equivalent response … Other domains that were
considered, as appropriate, included dose-response association, plausible confounding … ��A proportion of children with IH were reported to have
limited or no response to beta-blockers. … However, the
studies were too small to determine factors that might
have affected response to these
-
effectivehealthcare.ahrq.gov/products/pneumonia-antibiotic-treatment/research-protocol
July 19, 2013 - This target is based upon retrospective clinical data correlating clinical response with specific C max … reduce the morbidity and mortality associated with suboptimal antibiotic therapy, improve clinical response … /PD measures to inform decisions about dosing or monitoring antibiotic treatment impact:
Clinical response … It also considers other optional domains that may be relevant for some scenarios, such as dose-response … Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-grading_methods.pdf
July 01, 2012 - domains of risk of bias, directness, consistency,
and precision, as well as publication bias, dose response … Dose-response
association
This association, either across or
within studies, refers to a pattern … The dose-response association may support an
underlying mechanism of detection and potential
relevance … The dose-response association may support an underlying mechanism of detection
and potential relevance … From Turcios RM, et al.21
#Consider the additional domains of strength of association, dose-response
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-sepsis.pdf
July 01, 2023 - additional details.1
Sepsis is a life-threatening medical emergency involving an extreme immune response … to
an infection, most commonly bacterial, wherein the body’s own immune response causes
damage to … Final Report on Prioritization of Patient Safety Practices for
a New Rapid Review or Rapid Response … Sepsis is a life-threatening medical emergency involving an extreme immune response to an infection, … most commonly bacterial, wherein the body’s own immune response causes damage to tissues and organs.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/engaging-caregivers-protocol.pdf
August 04, 2023 - covered in previous Making Healthcare Safer (MHS)
reports, differs from the concurrent MHS IV rapid response … it only addresses care transitions in multiple healthcare settings, whereas
the scope of the rapid response … Third, unlike the rapid response, this topic includes interventions targeted at
caregivers who are … interventions targeted
at patients without the presence of a family caregiver, whereas the rapid response … Final report on prioritization of patient
safety practices for a new rapid review
or rapid response
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-lumbar-spondylolisthesis.pdf
March 01, 2021 - Clinical Response Pain intensity, pain
interference, physical
function & mobility, and
psychological … interference, physical function & mobility, and psychological well-
being are critical to measuring clinical response … Clinical Response Use of morphine-equivalent
pain medication
Use of morphine-equivalent pain medication … Use of opioids 30 days post-treatment is considered an adverse event and is captured under Clinical
Response
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-lumbar-spondylolisthesis.pdf
March 01, 2021 - Clinical Response Pain intensity, pain
interference, physical
function & mobility, and
psychological … interference, physical function & mobility, and psychological well-
being are critical to measuring clinical response … Clinical Response Use of morphine-equivalent
pain medication
Use of morphine-equivalent pain medication … Use of opioids 30 days post-treatment is considered an adverse event and is captured under Clinical
Response
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/infantile-hemangioma_executive.pdf
January 01, 2016 - atenolol
in two studies and better response to nadolol versus
propranolol in one small study. … between propranolol and
atenolol in 2 studies; better response to nadolol vs. … IH
and greater response to laser among mixed IH
(p=NR). … • Characteristics that may influence response to beta-
blockers. … Ulcerated hemangiomas: clinical
characteristics and response to therapy.