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effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-future_research.pdf
April 01, 2013 - • What biomarkers help predict treatment response? … • What biomarkers help predict treatment response? … 4 2
What biomarkers help predict treatment response? … • What biomarkers help predict treatment response? … • What biomarkers help predict treatment response?
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effectivehealthcare.ahrq.gov/sites/default/files/grading.ppt
January 01, 2013 - Additional Domains
Four “discretionary” domains:
Dose-response association
Plausible confounders … If dose-response association is present, the reviewer may upgrade the strength of evidence. … Additional Domains: Dose-Response Scores
Three scores are possible for dose-response:
Present: dose-response … Not present: no dose-response pattern observed (dose-response relationship not present)
Not applicable … for dose response.
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effectivehealthcare.ahrq.gov/products/psoriasis-chronic/research-protocol
September 27, 2011 - The presence of activated T cells within psoriatic plaques and the response to T cell-directed therapy … to conventional therapy, including intolerance and refractory response to infliximab; reducing signs … TNF-α
Treatment for reducing signs and symptoms of Crohn's disease and maintaining clinical response … in adult patients with active moderate-to-severe disease with an inadequate response to conventional … Variance imputation for overviews of clinical trials with continuous response.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-disease-ace-inhibitor-arb-disposition.pdf
March 10, 2010 - Source: www.effectivehealthcare.ahrq.gov
Published Online: March 10, 2010
2
Section Comment Response … Source: www.effectivehealthcare.ahrq.gov
Published Online: March 10, 2010
3
Section Comment Response … Source: www.effectivehealthcare.ahrq.gov
Published Online: March 10, 2010
4
Section Comment Response … Source: www.effectivehealthcare.ahrq.gov
Published Online: March 10, 2010
5
Section Comment Response … Source: www.effectivehealthcare.ahrq.gov
Published Online: March 10, 2010
6
Section Comment Response
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-illness-disparities_research-protocol.pdf
July 01, 2015 - to access to accurate diagnosis, health care services, and treatment; quality of
health care; and response … health care coverage;
(c) improving quality of health care; and (d) improving adherence to treatment, response … health care, including health care coverage;
(c) improving quality of health care; and (d) improving response … health care coverage; (c) improving quality of health care; and (d) improving
adherence to treatment, response … In instances where evidence from empirical studies informs the response, we will first
provide a summary
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/deprescribing-protocol.pdf
July 01, 2023 - Deprescribing to Reduce Medication Harms in Older Adults
1
Evidence-based Practice Center Rapid Response … Purpose of the Review
The overall purpose of this rapid response is to summarize the most relevant and … Methodologic Approach
For this rapid response, strategic adjustments will be made to streamline traditional … Final Report on Prioritization of Patient Safety Practices for a New
Rapid Review or Rapid Response. … procedure-manual-appendix-vi-criteria-assessing-internal-validity-individual-studies
Evidence-based Practice Center Rapid Response
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_disposition-comments.pdf
January 07, 2016 - # Commentator
and Affiliation
Section Comment Response … # Commentator
and Affiliation
Section Comment Response … # Commentator
and Affiliation
Section Comment Response … # Commentator
and Affiliation
Section Comment Response … # Commentator
and Affiliation
Section Comment Response
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effectivehealthcare.ahrq.gov/products/rapid-review-production/white-paper
January 29, 2015 - approaches” use databases of extracted study elements and programming to generate meta-analyses in response … complement these findings and provide additional considerations for those interested in establishing a rapid response
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/stakeholders-engagement-others_research-2011.pdf
January 01, 2011 - Contact individual stakeholders and document results of
individual responses for calculation of overall response … stakeholder group
Document recruitment dates
Report invitation and
participation rates (similar to
response
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0262_05-11-2007.pdf
January 01, 2007 - Does this make a clinical difference in response to treatment?
8. … Are there clinical predictors of response to the (above) interventions?
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effectivehealthcare.ahrq.gov/sites/default/files/interactive_media_epstein_respondent.pdf
January 01, 2009 - Program
Web
site
(http://www.effectivehealthcare.ahrq.gov/index.cfm)
Slide
1:
Response … enacted
Slide
12:
How
can
IM
promote
disclosure,
clarification
and
response
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-treatments-chronic-pain.pdf
December 01, 2021 - Pain
response is the dichotomous assessment whether
patients’ improvement meet an established
threshold … Pain response based on clinician assessments
was also acceptable and noted where they are
reported. … vs. placebo short-
term
Cannabis was associated with a
moderate improvement in short-
term pain response … in neuropathic pain
• SOE: Low, based on 2
RCTs
1 new RCT (n=339) found no
difference in pain response … spray associated with a moderate effect on
the likelihood of achieving at least a 30 percent pain response
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effectivehealthcare.ahrq.gov/products/cancer-anemia/research
May 23, 2006 - alternative thresholds to initiate or discontinue treatment and whether there are early predictors of response
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
April 01, 2013 - Additional domains were used when appropriate: dose-
response association, impact of plausible residual … changes in median
values in response to therapy. … Eight studies assessed mean
or median change from baseline in response to therapy. … – Consider further development of data on the use of
echocardiography to measure exercise response … Long-term response to calcium
channel blockers in idiopathic pulmonary arterial hypertension.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-2007_executive.pdf
January 01, 2007 - The evidence is insufficient to determine factors that
can reliably predict response or nonresponse in … The relative risk (RR) of response was
statistically significantly greater for escitalopram
than for … Speed of response. … Response to a second agent. … Maintenance of Response or Remission (KQ
2a)
Efficacy and effectiveness.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0094_04-09-2009.pdf
January 01, 2009 - For children with ASD whose condition is not improving in response to
behavioral intervention, what … For children with ASD who fail to develop communicative speech in response
to early behavioral intervention
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0365_10-28-2010.pdf
January 01, 2010 - patient characteristics (including those listed below) are associated with
variations in treatment response … Acute stress disorder (ASD) and PTSD are similar psychological disorders that develop in response
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_disposition-comments.pdf
September 01, 2011 - Treatment-
resistant depressed patients show a good
response to mindfulness-based cognitive
therapy … Subjects receiving sham treatment do not experience such
sensations, have a lower "placebo response" … This data, which
is obviously the substance of the answer to KQ 1a, involves
estimates of response … The durability of effect reported following an acute response to TMS,
including the relapse rates in … "Durability of
antidepressant response to vagus nerve stimulation (VNS)."
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/evidence-examples_white-paper.pdf
April 01, 2014 - selective outcome reporting, and selective analysis reporting), as well as additional domains of
dose-response … The review teams included
reports of at least 10 children to obtain evidence on response to treatment … These three additional
domains include dose-response association, plausible confounding that would decrease … In childhood cancer survivors, a linear dose-response relationship was
observed between primary neoplasms … Although both of these studies were observational designs, the dose-response relationships
observed
-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1506.pdf
June 01, 2015 - to two or more NSAIDs or patients who have had an inadequate response to
TNF inhibitors … Patients who had never received
treatment with TNF inhibitors had ASAS20 response rates of 60.0%, 66.3% … Patients given secukinumab 150 mg had significantly higher ASAS20 response rates than
patients given … to two or more NSAIDs or patients who have had an inadequate response to
TNF inhibitors. … Patients receiving secukinumab 75, 150, or 300 mg SC had significantly higher ACR20
response rates