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241. Archived: Comparative Effectiveness of Antiviral Treatment for Hepatitis C Virus Infection in Adults: A Systematic Review: Hepatitis C: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/comparative-effectiveness-of-antiviral-treatment-for-hepatitis-c-virus-infection-in-adults-a-systematic-review/hepatitis-c-screening-2013
     November 15, 2012 - The 1 trial that found no difference (RR, 1.0 [CI, 0.93 to 1.1]) reported high overall SVR rates (94% … No trial reported harms in patient subgroups. … Although all studies reported adjusted risk estimates, only 8 60 , 21 , 63 , 67-70 , 73 evaluated 5 … However, serious adverse events were reported in only 2 trials 21 , 29 , the absolute difference was … 82 Mach et al, 2011, Poland 27 Fair A: 138 B: 122 Not reported Not reported 100

242. Preexposure Prophylaxis for the Prevention of HIV Infection: Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/bQNXFv9Q5uaAQvWH6B7VWV
     June 11, 2019 - The adherence level, method for measuring adherence, and funding source of each trial are reported in … royalties from Roche and 1 reported funding from Gilead VOICE Marrazzo et al,27 2015 South Africa, … b Daily, oral dose unless specified. c Sample of patient who reported that they were taking PrEP. … No trial reported effects of PrEP on quality of life. … No other disclosures were reported.

243. Draft Recommendation: Lung Cancer: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/lung-cancer-screening1
     July 07, 2020 - Accuracy of Screening Tests The USPSTF reviewed several RCTs and cohort studies that reported on the … sensitivity, specificity, or predictive value of LDCT. 18 Not all of the reviewed studies reported all … In the studies that reported it, sensitivity ranged from 59% to 100%, specificity ranged from 26.4% to … In the NLST and NELSON trial, the reported sensitivities were 93.1% and 59%, respectively, and reported … Fourteen studies reported on the evaluation of false-positive results.

244. Interventions to Prevent Falls in Older Adults: Updated Evidence Report and Systematic Review of the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/nMb54adBfgajp8dG87kPcw
     April 17, 2018 - Few exercise trials reported fall-related fractures. … Fall-related fractures and injurious falls were not widely reported in the included trials, and while … Incident fractures and quality of life were rarely reported, and no studies reported disability. … Four of 26 multifactorial trials reported information on harms (n = 1466).18,23,25,32 Only 1 of these … the intervention and control groups.32 One trial reported 3 falls without injury during the exercise

245. Vo9Z9Bwjb4Wqkzastpydwx (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/Vo9Z9BWJb4WqkZaSTpYDWx
     October 01, 2013 - A recent study reported a prevalence of 4.7% in His- panics older than 40 years (3). … Nineteen additional primary studies reported mixed results with treatment; a few reported improvements … in visual field measurements with medical treatment, 7 reported no change, and 9 reported worsening … Eye redness was the most commonly reported adverse effect of topical medical treatments for glaucoma. … Studies of surgical procedures more commonly reported cataracts, in- fection, bleeding, and synechiae

246. Evidence Summary: Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: Preventive Medication | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/vitamin-supplementation-to-prevent-cvd-and-cancer-preventive-medication
     June 21, 2022 - cardiovascular disease, cancer, mortality, serious harms, or nonserious adverse events reported by at … The largest trial, COSMOS, reported that 3.4% of participants taking a multivitamin had died after a … significant and were not reported by any of the trials. … Conflict of Interest Disclosures: None reported. … Harms study design: Short-term nonserious harms reported, but lack of evidence of benefit.

247. Archived: Depression in Children and Adolescents: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/depression-in-children-and-adolescents-screening
     February 08, 2016 - In nationally representative U.S. surveys, about 8% of adolescents reported having major depression in … Among children and adolescents aged 8 to 15 years, 2% of males and 4% of females reported having MDD … males than for females, but neither of the BDI studies reported results by age or ethnicity. … collaborative care study reported outcomes at 52 weeks. … included worsening suicidal ideation or a suicide attempt; no completed suicides were reported).

248. Recommendation: High Blood Pressure in Children and Adolescents: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/blood-pressure-in-children-and-adolescents-hypertension-screening
     November 10, 2020 - Various measures of association were reported across studies. … Reported odds ratios (ORs) ranged from 1.1 to 4.5, risk ratios ranged from 1.45 to 3.60, and hazard ratios … Six fair-quality RCTs reported similar risks of adverse events between pharmacologic treatments and placebo … One fair-quality RCT reported similar risks for adverse events between a group receiving a combination … Dr Barry reported receiving grants and personal fees from Healthwise.  

249. Recommendation: Atrial Fibrillation: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/atrial-fibrillation-screening
     January 25, 2022 - In the fifth comparison, sensitivity for 1 of the devices was reported as 0.3 and specificity as 0.97 … . 27 The reason for the lower sensitivity reported in that study is uncertain. … Data on the accuracy of screening tests reported in or calculated from randomized clinical trials of … The study reported that the rate of a composite end point consisting of ischemic stroke, hemorrhagic … Several trials reported on the benefits of anticoagulant therapy for clinical AF.

250. Archived: Final Evidence Summary: Falls Prevention in Older Adults: Counseling and Preventive Medication | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary24/falls-prevention-in-older-adults-counseling-and-preventive-medication
     December 15, 2010 - Data on potential harms of interventions were scant and often not reported. … Only 5 fair-quality trials explicitly reported additional adverse effects. … Three of these trials reported other adverse effects. … None of these trials reported additional adverse events. … However, these outcomes were much less commonly reported: only 20 of the included trials reported outcomes

251. JAMA JATS (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/pKa4_DYwzuyD6RDgYzLMbo
     August 22, 2018 - Two RCTs reported on harms of screening.14,15 Both were in- cluded in KQ1; detailed results are reported … All reported on IPV, and 4 (n = 5308) found no significant difference between groups in Figure 3. … c Age range, 20 to 62 years. d Only African American reported. e Age range, 18 to 70 years. f Overall … percentage of pregnancy was not reported. … Few RCTs reported on harms of interventions.

252. Archived: Final Evidence Summary: Falls Prevention in Older Adults: Counseling and Preventive Medication | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary24/falls-prevention-in-older-adults-counseling-and-preventive-medication-2012
     December 15, 2010 - Data on potential harms of interventions were scant and often not reported. … Only 5 fair-quality trials explicitly reported additional adverse effects. … Three of these trials reported other adverse effects. … None of these trials reported additional adverse events. … However, these outcomes were much less commonly reported: only 20 of the included trials reported outcomes

253. Evidence Summary: Elevated Blood Lead Levels in Children and Pregnant Women: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/elevated-blood-lead-levels-in-childhood-and-pregnancy-screening
     April 16, 2019 - Where reported, mean age range was 9 to 31 months. 18 , 19 Seven studies were conducted in urban or … Three of 4 studies reported diagnostic accuracy of capillary sampling at a blood lead level cutoff of … One study reported the diagnostic accuracy of a clinical questionnaire for pregnant women, 24 and 1 … No harms were reported. … Conflict of Interest Disclosures: None reported.

254. Evidence Summary: Peripheral Artery Disease and Cardiovascular Disease: Screening and Risk Assessment With the Ankle-Brachial Index | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/peripheral-artery-disease-in-adults-screening-with-the-ankle-brachial-index
     July 10, 2018 - Two exercise trials (n = 932) in screen-relevant populations reported no differences in quality of life … These are presented where available but were rarely reported. … Neither trial showed statistically significant between-group differences in self-reported quality of … Both the AAA and the POPADAD trials reported bleeding harms associated with use of 100 mg of aspirin … The POPADAD trial reported a nonsignificant reduction in fatal hemorrhagic CVA in the aspirin group,

255. Archived: Final Evidence Summary: Child Maltreatment: Primary Care Interventions | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary13/child-maltreatment-primary-care-interventions-2013
     January 15, 2013 - Ten trials of early childhood home visitation reported reduced CPS reports, emergency department visits … Two other trials reported no differences in child maltreatment between groups 45 , 46 . … No adverse effects were reported by participants (Dubowitz H. Personal communication.). … Documented and self-reported child abuse and adult pain in a community sample. … Self-reported physical abuse (CTS) Mean injury score (CIS) Self-reported spanking (FSS, CIS) Self-reported

256. Evidence Summary: High Body Mass Index in Children and Adolescents: Interventions | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/obesity-in-children-and-adolescents-screening
     June 18, 2024 - Crude between-group effect estimates were calculated if they were not reported. … in only 14 studies (n = 2558); 13 of these reported a measure of quality of life. … Longer-term maintenance after medication withdrawal was not reported for any of the other medications … None of the pharmacotherapy studies reported behavioral outcomes. Harms of Interventions KQ4. … Conflict of Interest Disclosures: None reported.

257. Screening for Obesity in Children and Adolescents: Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/DMDPeSf_nEUM-HrVrX6c7U
     June 20, 2017 - Trials with 52 a Data presented in this table are limited to trials that reported BMI z score. … .3 One trial reported no group differences in the per­ centage of participants screening positive for … No trials reported on other health outcomes, such as morbidity asso­ ciated with type 2 diabetes or … Among trials that reported race/ethnicity, 25% to 89% of participants were white. … No other disclosures are reported.

258. Evidence Summary: Lipid Disorders in Children and Adolescents: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/lipid-disorders-in-children-screening
     July 18, 2023 - Three US studies (n = 395,465) reported prevalence of phenotypically defined FH of 0.2% to 0.4% (1:250 … Harms reported in the short-term drug trials were similar in the intervention and control groups. … No treatment trials reported long-term health outcomes. … No treatment trials reported long-term health outcomes. Treatment Harms KQ5. … Conflict of Interest Disclosures: None reported.

259. Recommendation: Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/intimate-partner-violence-and-abuse-of-elderly-and-vulnerable-adults-screening
     October 23, 2018 - Four studies reported on the accuracy of 5 screening tools for identifying ongoing or current abuse. … Five RCTs enrolled women during the perinatal period; all reported on IPV outcomes. … Two RCTs reported on depression, and both found benefit in favor of the intervention (only 1 found a … Five good- or fair-quality RCTs assessing IPV interventions reported on harms. … No other disclosures were reported.

260. Screening for Abdominal Aortic Aneurysm: US Preventive Services Task Force Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/HyxpKaXv6BVDKBHQ74yWeL
     December 10, 2019 - Previous prevalence rates of AAA reported in population-based screening studies ranged from 1.6% to 7.2% … No comparisons in the unscreened group were reported.1,39 None of the 4 population-based screening RCTs … no differences in all-cause mortality effect by sex or age.1,36,37 The UKSAT trial reported no difference … Dr Barry reported receiving grants and personal fees from Healthwise, a nonprofit, outside the submitted … No other disclosures were reported. Funding/Support: The USPSTF is an independent, voluntary body.