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461. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - The company also reported that 60 patients in FREEDOM-1 HBL had a 3.4% mean reduction in HbA1c, with … In November 2015, Aminian and colleagues reported that in Cleveland Clinic study results released on … Available data reported by the manufacturers suggest that Afrezza therapy was associated with reduced … of 2015; however, the company also reported a total corporate loss of more than $90 million for the … The company reported that more subjects in the insulin aspart group achieved the HbA1c target of 7%

462. Disposition of Comment Report for Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_disposition-comments.pdf
     May 20, 2013 - Three studies evaluated that issue and reported a change in management in 50-69% of patients. … In contrast there is a single method by which the wireless motility capsule is reported to be performed … The two studies that reported sensitivity and had non-gastroparetic controls We would love to have … It is hard to tell from the reported data in the article. … We referenced the tests since some centers have reported its use.

463. Cesarean-Birth-2010 Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cesarean-birth-2010_executive.pdf
     January 01, 2010 - A larger good-quality study that compared high- versus low-dose epidural reported significantly fewer … None of the remaining five studies reported a significant difference in use of cesarean. … Twelve observational studies reported achieving a reduction in cesarean of 5 percent or more. … Adverse Effects of Strategies To Reduce Cesarean Birth Eighteen studies included in the review reported … Most studies summarized obstetrics outcome measures traditionally reported in the literature such as

464. Disposition of Comments Report for Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_disposition-comments.pdf
     December 11, 2012 - page 54, Table 6 states median/range of age not reported -- it was as mean and range We apologize … We attempted to include all relevant data with footnotes or other delineation if the reported data … Within the literature of this report, patient and tumor characteristics were reported inconsistently … Peer Reviewer #5 Results page 60, table 8 states TTP and TTLP not reported, both are reported Based … Peer Reviewer #5 Results page 66, Table 10, indicates certain specific complication as not reported

465. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - In the interim, numerous case reports and clinical trials have reported that ketamine, particularly … The most commonly reported ketamine dosing protocol is a single, 0.5 mg/kg IV injection; ketamine appears … differentially greater treatment effects among female patients.14,38 Multiple small studies have reported … A 2012 National Institute of Mental Health trial reported that 79% of patients with BPD (n=15) responded … These experts were encouraged by reported clinical trial data demonstrating rapid symptom relief and

466. Communication and Dissemination Strategies To Facilitate the Use of Health-Related Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-evidence-communication_executive.pdf
     November 01, 2013 - They reported on seven unique trials about communication strategies. … In a third study, the targeted version was associated with greater likelihood of self-reported screening … One reported on the effects of alternative wordings of the overall strength of recommendations.34 Four … Three studies reported the effects of alternative nonnumeric presentations of uncertainty;34,38,40 … • All trials used self-reported data, which can be subject to social desirability bias.

467. Plasma-Cell-Dyscrasias-Sflc-Assay Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
     August 01, 2012 - Three studies reported industry-associated funding or authorship. … Paraprotein reduction was usually reported as part of a “hematologically complete” response. … A fourth study reported an abnormal SFLC ratio before relapse and a positive IFE test in nine patients … Only one study, of C quality, reported data on prediction of treatment response, so conclusions are … The traditional test comparators reported varied in each study.

468. Technical-Brief-31-Mobile-Health-Applications-For-Self-Management-Of-Diabetes (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tech-brief-31-mobile-applications-self-mgmt.pdf
     May 01, 2018 - If outcomes were prespecified and reported (performance and reporting bias) 6. … The app was last updated in May 2017, but the app size is not reported. … The amount of time each group spent with physicians or study staff was not reported. … Few studies reported whether providers or personnel were masked. … Therefore, we could not tell if these outcomes were selectively reported.

469. Ch 6-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_6-user-guide-to-ocer_130129.pdf
     October 30, 2012 - the research questions of interest, along with validation of outcomes or use of standardized patient reported … The types of COAs described are:5 Patient-reported outcome (PRO) assessment: A measurement based on … Clinician-reported outcome (ClinRO) assessment: An assessment that is determined by an observer with … Symptom burden: multiple symptoms and their impact as patient-reported outcomes. … Responsiveness and minimal important differences for patient reported outcomes.

470. Autism-Update Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-update_executive.pdf
     August 01, 2014 - For studies that were reported in the 2011 review and have followup data reported here, the evidence … Better quality studies reported positive effects of intervention on symptom severity, but multiple … Most studies reported short-term gains in either parent- rated social skills or directly tested emotion … Some studies reported improved outcomes with more intervention time and others reported no association … Similarly, no studies reported harms of intervention in terms of child, family, or system impact.

471. An Evidence Review of Active Surveillance in Men with Localized Prostate Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_disposition-comments.pdf
     December 01, 2011 - While few studies have reported on this population, demographic trends point to substantial growth … We described age-related results as they were analyzed and reported in the original studies. … We have reported estimates of the change in population mortality rates. … Few reported why and how often patients and clinicians chose to not follow protocols. … We have provided additional details on the interaction analyses reported by the SPCG trial.

472. Antipsychotics-Children-Surveillance-150120 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children-surveillance-150120.pdf
     October 01, 2014 - • Patient-, parent-, or care provider-reported outcomes, including levels of physical activity or … The search strategy is reported in Appendix C. … Eight studies reported the effects of antipsychotics No new studies comparing antipsychotics with One … Eleven studies on bipolar disorders reported symptom improvement. … Quetiapine was generally well tolerated with a profile broadly similar to that reported in adult and

473. Disposition of Comments for Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis -- Update of a 2007 Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_disposition-comments.pdf
     March 01, 2012 - We reported OR for all of our own analyses of adverse events as we customarily do. … and discovered that what was being reported was, in fact, hot flashes and flushing. … the symptom with one term and others reported it with the other term. … , and only one pooled risk difference and odds ratio are now reported. … The cited article contained no such analysis, and reported no such conclusion.

474. Pressure-Ulcer-Prevention Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-prevention_executive.pdf
     May 01, 2013 - condition, affecting an estimated 3 million adults in the United States.2 In 2006, pressure ulcers were reported … We noted discrepancies between calculated and reported results when present. … and whether risk estimates (when reported) were adjusted for potential confounders. … Harms were reported in only 16 of 72 trials of preventive interventions and were poorly reported when … Only about half of the studies reported funding source.

475. Trauma-Child-Interventions Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_executive.pdf
     February 01, 2013 - low attrition, and reported methods and outcomes clearly and precisely. … For the cluster of school-based therapies, we first reported on specific individualized approaches … no improvement in one or all outcomes evaluated.17,29,30,33,37,38 One26 of 5 interventions reported … in 6 studies17,26,30,33,38,39 evaluating anxiety symptoms reported improvements; 4 interventions … reported in 5 studies14,26,27,31,33 out of 10 interventions reported in 12 studies14,17,26,27,29-

476. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_2012-12-10.pdf
     January 01, 2012 - Reported costs of Bydureon from 11 U.S. pharmacies range from $354 to $469 per month or about $4,250 … ES-6 ITCA 650 is a proprietary formulation of exenatide that has been reported to remain stable at … In November 2012, the company reported that the drug was successfully delivered continuously and … Reported cost of an injection is about $1,170. … Eighty-five percent of those enrolled continued, and the company reported that sustained reductions

477. Protocol: Imaging for Pretreatment Staging of Small Cell Lung Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-staging_research-protocol.pdf
     December 08, 2014 - an included outcome that was not reported by other publications of that study, or (b) a publication … with lower patient enrollment reported longer follow up data for an outcome. … At least 85 percent of patients must have been aged 18 years or older, or data must have been reported … Each question can be answered “yes,” “no,” or “not reported,” and each is phrased such that an answer … of “yes” indicates that the study reported a protection against bias on that aspect.

478. Disposition of Comments for Use of Natriuretic Peptide Measurement in the Management of Heart Failure (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
     November 20, 2013 - Rev 3 Can’t find Page 274 line 22– there is a HR reported with no unit . … Atrial fibrillation has been evaluated where it was reported. … We feel that we have reported this fairly from our findings in this review. … We reported only those values that were reported by the author and did not calculate LR+ or LR – if … not reported.

479. Technical Brief Disposition of Comments Report for Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
     December 14, 2012 - The Mayo study is expected to be reported in late 2012. … Nitsche, et al, J Onkologie, 2012 (English language abstract included) reported on the n=135 stage II … Nitsche reported that ColoPrint identified most stage II patients (73%) as low risk. … Tabernero reported “ColoPrint classifies two-thirds of the stage II patients as Low Risk. … The predictive assay (eleven gene expression treatment score) was not validated as reported in the

480. uterine-fibroids-protocol-160301 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
     March 01, 2016 - Prior reviews have reported on the effectiveness preoperative adjunctive treatments such as gonadotropin … We will summarize data related to symptom status and prioritize patient-reported measures. … in resources such as ClinicalTrials.gov to determine if prespecified outcomes are not reported in the … Age-specific incidence rates for self-reported uterine leiomyomata in the Black Women's Health Study … Self-reported heavy bleeding associated with uterine leiomyomata.