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441. Colorectal-Cancer-Protocol_130520 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-staging_research-protocol.pdf
     May 20, 2013 - The adverse events and harms reported by any studies included to address any of the other questions … We will include data from time points and outcomes reported from groups of patients with at least 10 … of “Yes” indicates that the study reported a protection against bias on that aspect. … an answer of “Yes” indicates that the study reported a protection against bias on that aspect. … If the study reported data for a single diagnostic threshold, was the threshold chosen a priori?

442. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1406.pdf
     June 01, 2014 - Reported total costs for the procedure range from about $2,900 to $7,600. … The cost of PRP therapy has been reported to range from $500 to $1,500 per injection, appearing to … Mean symptom improvement of all patients who reported outcomes was nearly 60% at 24 months after … Investigators reported “rapid and progressive improvement of algofunctional indices that approached … No serious adverse events were reported.

443. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-risk-bias.ppt
     June 01, 2012 - term=19884616 Commonly Reported Sources of Systematic Error in Studies of Medical Test Performance … shows the commonly reported sources of systematic error in studies of medical test performance, as reported … These problems are often not reported in test efficacy studies; the interpretable results are simply … Commonly Reported Sources of Systematic Error in Studies of Medical Test Performance (2 of 2) Sources … Definitions should be decided in advance and clearly reported.

444. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-risk-bias.ppt
     June 01, 2012 - term=19884616 Commonly Reported Sources of Systematic Error in Studies of Medical Test Performance … shows the commonly reported sources of systematic error in studies of medical test performance, as reported … These problems are often not reported in test efficacy studies; the interpretable results are simply … Commonly Reported Sources of Systematic Error in Studies of Medical Test Performance (2 of 2) Sources … Definitions should be decided in advance and clearly reported.

445. Disposition of Comments for Evidence Report 224 Omega-3 Fatty Acids (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/omega-3-maternity_disposition-comments.pdf
     October 12, 2016 - The key questions are repeatedly reported and repeatedly answered, very clearly and explicitly. … maternal weight gains by intervention group or exposure quantile reported it as group means, and … The Almaas article is a 7-year followup to the study first reported by Westerberg and Henriksen: we … In the column labeled "Results," we provided the name of the test (outcome measure) as reported in … Horvath et al.7 reported on high risk pregnancies and Szajewska et al.8 reported on low risk pregnancies

446. Colorectal-Surgery-Preparation Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
     March 26, 2013 - colorectal surgeons routinely employed OMBP.10 A recent study (2007–2009) of 24 Michigan hospitals reported … This is proposed as an explanation for why some studies have reported greater infection rates with OMBP … Because adverse events are commonly not well reported in surgical trials, including studies of OMBP … Decreased infection rates have been reported when oral antibiotics are added to intravenous antibiotics … We will contact authors (1) to clarify information reported in the papers that is hard to interpret

447. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - Treatment success with no serious complications was reported in more than 90% of patients in these … The U.S. centers have performed more than 80 of an estimated 900 POEM operations reported worldwide … Phase III trials reported that patients with SBS treated with teduglutide can significantly reduce … Researchers reported that no specific complications related to the surgery occurred. … reported mild chest pain.

448. Data Points 13: Use of Preoperative Breast MRI among older women with ductal carcinoma in situ and locally invasive breast cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-mri-utilization_research.pdf
     August 01, 2012 - Unknowns are included but not reported. … ER status: We used SEER reported Estrogen Receptor (ER) and Pro- gesterone Receptor (PR) testing results … vs. 6.8%, respectively; p-value <0.001).22 However, studies by Solin, et al., and Hwang, et al., reported … In a study of 5,405 patients, Katipamula, et al., reported that 54 percent of patients receiving MRI … had mastectomy compared with just 36 percent of patients without MRI.25 Bleicher, et al., reported

449. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1512.pdf
     December 29, 2015 - This effect is reported by investigators to be mediated by increased chemokine production, which … Investigators have reported data from two of these clinical trials showing that more patients treated … When lesinurad was combined with xanthine oxidase inhibitors, commonly reported adverse events were … Similar adverse event rates were reported for secukinumab 75 mg (57.5%), 150 mg (62.5%), and placebo … of patients in the pooled secukinumab group and 58.2% of patients in the placebo group reported an

450. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
     December 04, 2015 - reported)_!medication!dose.!! Comparators! Placebo/no!treatment,!any!other!antipsychotic,!or!same! … We will extract data from the primary source first and then add outcome data reported in the secondary … For our outcomes of “any” AE or “major” AE limiting treatment, we will use the data reported by the … For quality of life and other continuous patient/parent/clinician-reported measures, we will use an … by the relevant studies and choose the outcomes reported by the most studies, to a maximum of four

451. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1506.pdf
     November 01, 2016 - According to a manufacturer press release, positive preliminary results reported from one phase III … Clinical trials: Four phase III trials are ongoing;7-10 positive preliminary results have been reported … In preliminary results derived from the first 6 months of study, a manufacturer’s press release reported … Additional, smaller trials reported improvements in bone mineral density loss, menstrual pain, and … However, one expert with a health systems perspective differed, suggesting that the side effects reported

452. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1512.pdf
     November 01, 2016 - According to a manufacturer press release, positive preliminary results reported from a completed phase … Clinical trials: Three phase III trials are ongoing;7-9 positive preliminary results have been reported … In preliminary results derived from the first 6 months of study, a manufacturer’s press release reported … Additional, smaller trials reported improvements in bone mineral density loss, menstrual pain, and … However, one expert with a health systems perspective differed, suggesting that the side effects reported

453. Hepatic-Fibrosis White-Paper (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatic-fibrosis_white-paper.pdf
     April 01, 2014 - However, 17 of the 172 included studies reported diagnostic accuracy results that were discordant from … We defined studies with discrepancies as those in which reported measures of diagnostic accuracy were … cutoff values for a positive test, based on the reported sample size, prevalence of the condition … Of the 17 studies in which there was a discrepancy between reported results for diagnostic accuracy … For the Lok Index, no studies reported accuracy for diagnosis of fibrosis in the original report.

454. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
     July 01, 2011 - For each comparison, separate tables include all the studies that reported specific outcomes. … The remaining models reported lower diagnostic sensitivities and specificities. … The heterogeneity of analyzed and reported potential predictors greatly limits these conclusions. … No adverse event with potentially long- term consequences was reported. … Substantial jaw pain was reported in about 2–4% of patients, but no study reported on the long-term

455. Abnormal-Uterine-Bleeding Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_executive.pdf
     March 01, 2013 - published research article examining the practice patterns for medical treatment of AUB, authors reported … The most recent study found similar reductions in patient-reported assessments of bleeding severity … Both biologic and self-reported symptoms of bleeding severity were improved. … The treatments were equally effective, reducing the patient-reported bleeding score by 67 percent in … The studies in this review reported harms profiles for common symptoms similar to 9 package insert

456. Data Points 14: Use of Endocrine Therapy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-endocrine-therapy_research.pdf
     August 01, 2012 - Other cat- egories are included in the cohort but not reported (e.g., unknown and diffuse). … Unknowns are included but not reported. … State assistance: We considered recipi- ents of State assistance to be those with a State Reported Dual … 33.8 31.9 27.2 30.3 * Numerator <11 or denominator <30. † Louisiana cases diagnosed in 2005 are not reported … That summary of 13 studies reported that between 15 percent and 53 percent of postmenopausal breast

457. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
     December 16, 2011 - We will report outcomes only if quantitative data are reported or can be derived from graphs. … We will report adverse events as they are reported by the authors of the study. … We will extract data from the primary publication first and then any additional outcome data reported … We will calculate p-values when they are not reported. 26 For KQ1, we will construct 2x2 tables … If no event is reported in one treatment arm, a correction factor of 0.5 will be added to each cell

458. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - fecal microbiota therapy for irritable bowel disease that are in clinical trials but have not yet reported … Some experts also cited adverse event rates up to 24% reported in some vedolizumab trials and the unknown … Pricing for rifaximin is reported on the online pharmacy-pricing aggregator GoodRx at about $1,270 … repeat the same treatment regimen up to two more times.6 Clinical trials: In October 2014, Salix reported … Adverse events rates were similar, with adverse events reported in 43% of rifaximin patients and 46%

459. Cerebral-Palsy-Feeding Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cerebral-palsy-feeding_executive.pdf
     March 01, 2013 - The epidemiologic Oxford Feeding Study reported significant correlations between severity of motor … This figure includes 12 unique primary research studies (reported in 14 publications) described in … The three other case series with growth data also reported significant pre-post increases in weight, … Overall, rates of peritonitis were low, ranging from 2 to 5 percent, one study reported minor site … Studies typically reported some positive effects on mealtime length and eating efficiency; however,

460. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - -based online aggregator of prescription drug prices, reported prices ranging from about $622 to … Weight loss in pounds or kilograms was not reported.6 The authors reported that at 48 weeks, which … The authors reported that the vagal nerve block group achieved a mean 24.4% excess weight loss (9.2% … Adults given 3 mg liraglutide reported weight loss of 9.2% compared with 3.5% in the placebo group … Patients in the active treatment group also reported improved health-related quality of life.