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221. Disposition of Comments Report for Recurrent Nephrolithiasis in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
     July 26, 2012 - Of 8 trials that reported prevalence of hyperoxaluria, 3 defined it. … Of 7 trials that reported prevalence of hypocitraturia, 4 defined it. … and reported it as an important clinical outcome. … it in all studies that reported recurrent stones. … Most trials reported some baseline biochemical data.

222. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
     January 01, 2007 - For leflunomide vs. sulfasalazine, data are limited to one RCT with 2-year followup that reported that … No differences in tolerability were reported for leflunomide, methotrexate, and sulfasalazine in three … One study in patients with early RA, however, reported improved DAS scores at 18 months with combination … It reported less radiographic progression over 12 months with either (1) metho- trexate, sulfasalazine … A prospective, population-based cohort study from Sweden, enrolling more than 1,100 patients, reported

223. Management of Infantile Hemangioma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_clinician.pdf
     June 01, 2016 - Minor adverse effects such as cold extremities, diarrhea, rash, and sleep changes were also reported … with the pulse dye laser, with hypopigmentation being reported more frequently. ��� Bleeding 1 121 … ��Case series have reported associations between multiple cutaneous IH lesions and increased risk for … ��A proportion of children with IH were reported to have limited or no response to beta-blockers. … The type of IH was not consistently reported.

224. Systematic Review on Acute Treatments for Episodic Migraine: Surveillance Report 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-1.pdf
     June 01, 2022 - No significant adverse events were reported. SOE low. … No patients reported adverse events (Appendix Table E-6). … No adverse events were reported in either groups. … Significantly more adverse events were reported in the lasmiditan groups. … No significant adverse events were reported.

225. Disposition of Comments for Treatment of Glaucoma: Comparative Effectiveness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_disposition-comments.pdf
     April 01, 2012 - Finally, KQ2 asks if treatment improves patient-reported outcomes. … It is therefore not reported as a complication in any studies we found. … This would require that such harms be reported with enough detail to do so. … This would require that such harms be reported with enough detail to do so. … Patient reported outcomes are not the only final outcome, however.

226. Future Research Needs for First- and Second-Generation Antipsychotics for Children and Young Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-future_research.pdf
     February 01, 2012 - For Key Question (KQ) 1, with few exceptions, the Comparative Effectiveness Review (CER)1 reported … Where an interclass difference was noted, the strength of evidence (SOE) grade was reported as low. … The CER reported insufficient studies to allow for within-class efficacy/effectiveness comparisons with … Short- and long-term outcomes were reported in nine studies examining pervasive developmental disorders … The CER reported that the results of subgroup and regression analyses were often poorly described in

227. CER 218 Evidence Summary: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-fracture-prevention-evidence-summary.pdf
     April 01, 2019 - No tests of interaction were reported for these BMD stratified results. … †Results reported for raloxifene 60 mg/d and 120 mg/day groups pooled together. … ‡Results reported for raloxifene 60 mg/d dose group. … The single trial of long-term zoledronate versus placebo reported no cases of AFF or ONJ in either … **Results reported for raloxifene 60 mg/d dose group.

228. Mental-Illness-Heart Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_executive.pdf
     April 01, 2013 - reported all-cause mortality. … reported CVD mortality. … • Two studies reported significant benefits of multicondition lifestyle interventions for self-reported … Studies reported each outcome separately; only one reported an overall CVD risk score, which was unaffected … mortality was not reported.

229. Ptsd-Adult-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_executive.pdf
     April 01, 2013 - We conducted quantitative synthesis using meta-analyses of outcomes reported by multiple studies that … the outcome Insufficient Depression symptoms No included studies reported the outcome Insufficient … Unlike the studies of psychological treatments, which often reported loss of PTSD diagnosis as an … Most of the subgroup analyses (those reported by included studies and those that we conducted of our … ) in addition to measures of PTSD symptoms (more commonly reported).

230. Evidence Summary-Comparative-Effectiveness-Review-213-Lower-Limb-Prostheses (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-213-lower-limb-protheses-evidence-summary.pdf
     September 01, 2018 - Three of the 11 instruments were also reported to have evidence of test reliability when evaluated … Floor and ceiling percentages were reported for LCI-4, and no such effects were found. … However, all but one study reported only correlations of the instrument results with occurrence or … Both AMPSIMM and LCI-5 were reported to be correlated with future functional status. … No study reported on “major problems” with prostheses. 14 Ta bl e G .

231. Clopidogrel after Drug-Eluting Stent Implantation: Is current practice sufficient (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stent-clopidogrel-practice_research.pdf
     March 01, 2009 - Eisenstein reported receiving research grants from Medtronic Vascular. Dr. … Anstrom reported receiving research support from National Institutes of Health/National Heart, Lung … Harrington reported receiving research grants from Boston Scientific, Cordis Corporation, Medtronic … Peterson reported receiving research funding from Bristol-Myers Squibb and Sanofi. Dr. … No attempt was made to verify patient reported medication use.

232. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy_disposition-comments.pdf
     March 11, 2010 - The studies rarely reported data from these two populations separately; we have added text to clarify … Not all of the studies reported how many patients were enrolled; the number of breast lesions studied … to get the malignant category; others reported “benign”, “in situ” and “invasive” categories. … We included any clinician factors reported by the studies. … This may be true; however, the reported data are insufficient to substantiate this speculation.

233. Smoking-Pregnancy-Infants Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/smoking-pregnancy-infants_executive.pdf
     February 01, 2014 - Only 15 studies reported biochemically validated cessation after birth. … Intervention Harms for Pregnant and Postpartum Women We identified four studies that reported harms … None of the studies reported a higher incidence of adverse events in women receiving interventions … None of the studies that evaluated relapse prevention interventions reported harms data. … Harms data were rarely reported. References 1. Centers for Disease Control and Prevention.

234. Appendix-E-Table-E5 0 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5_0.xlsx
     May 29, 2025 - Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid Use Outcomes Adverse Events Other Reported … NR NR NR NR Median 120 NR Overall N Baseline: 1,514 4-year followup: 1,217 Groups unclear A: Self-reported … Moderate 33764103 Gruber, 2021 Prospective cohort U.S Mixed musculoskeletal Mixed Mean 53 62* *only reported … IQR = interquartile range; IV = intravenous; NA = not applicable; NPP = neuropathic pain; NR = not reported

235. Cannabis-App-F5-Table-Surveillance-Report-2 0 0 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0_0.xlsx
     May 29, 2025 - Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid Use Outcomes Adverse Events Other Reported … NR NR NR NR Median 120 NR Overall N Baseline: 1,514 4-year followup: 1,217 Groups unclear A: Self-reported … Moderate 33764103 Gruber, 2021 Prospective cohort U.S Mixed musculoskeletal Mixed Mean 53 62* *only reported … IQR = interquartile range; IV = intravenous; NA = not applicable; NPP = neuropathic pain; NR = not reported

236. Disposition of Comments CER 219 Antipsychotics for the Prevention and Treatment of Delirium (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
     September 03, 2019 - However, as we have detailed in the Results section, most of the studies reported median values. … Ideally, the studies would have reported hazard ratios, which could have been pooled. … Nonetheless, some response to this, or commentary on what has been reported in other studies may be … We strongly recommend reorganizing the report so that outcomes based on subpopulations are reported … Known risk factors for delirium such as pre-existing cognitive impairment should also be reported.

237. App-D-Opioid-Chronic-Pain-Surveillance-Report-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveillance-report-2.xlsx
     September 30, 2015 - level (0 to 10, 10 high): 5.7 Level of functioning (VAS, 0 to 100) 58 Urine + for opiates: 63% Self-reported … 89% Screened: 65 Eligible: 25 Randomized: 19 Analyzed: 19 LTFU: 9 Outcomes at 6 month follow-up not reported … indicate clear differences between treatments for pain, functioning, depression, or drug use Harms not reported … in 2 consecutive rounds before the last round of followup B) Intermittent opioid use: opioid use reported … in any one of the rounds C) No use: no opioid use reported in any rounds Enrolled: 4,172 Analyzed: 4,172

238. Prostate-Cancer-Therapies-Update Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_executive.pdf
     December 01, 2014 - Multiple publications were used only when each publication had unique data not reported in the most … Although these subgroup analyses reported data on overall survival, all-cause mortality, or prostate … Both the Prostate Cancer Intervention Versus Observation Trial (PIVOT) and SPCG-4 studies reported … Adverse events such as urinary incontinence and erectile dysfunction were mostly reported among men … In contrast, investigators in the SPCG-4 trial24 reported that the advantages of RP over WW in all-

239. Weight-Loss-Surgery Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_executive.pdf
     June 01, 2013 - Improvements in glucose control outcomes have been reported as early as 1 month post-surgery. … One, a case series of LAGB patients in Italy, reported followup at 5 years for 29 of the 210 initial … Only one death was reported—an LAGB patient with complications of a gastric perforation. … Data reported on adverse events also have several limitations. … The study we identified reported outcomes at 6 to 12 months.

240. Linking Dental Services to Treatment Outcomes for Diabetes: A Rapid Response Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-outcomes-diabetes-rapid-research.pdf
     November 01, 2024 - Glycemic control was the outcome reported in these URs. … The heterogeneity reported in this SR varied between 70-80%. … URs: Low, medium, medium-high; GRADE of Evidence: Not reported. … NR • Moderate to high heterogeneity reported in studies. … Four RCTs reported on this outcome.