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461. Ear-Infection Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ear-infection_executive.pdf
     May 01, 2013 - No studies reported use of health services or balance outcomes. … Tympanostomy Tubes Versus Watchful Waiting/Myringotomy Meta-analyses reported by Browning et al.15 … In the one exception where a difference favoring TT was reported, the investigators used a teacher … Harms or Tolerability Six of the treatment comparisons included in the review reported on harms. … Few significant differences in harms were reported.

462. Glaucoma-Treatment Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_executive.pdf
     April 01, 2012 - KQ 2: Does treatment of open-angle glaucoma improve patient-reported outcomes? … We included outcomes reported at 6 months (2–9 months) and 1 year (10–18 months) as reported in included … The exception was circadian medical treatment studies in which the investigators reported outcomes … Each item query required a “yes,” “no,” or “unable to determine/not reported” response. … Visual acuity was only irregularly reported, if at all.

463. Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/topic-nomination-apbi-breast-cancer.pdf
     April 01, 2017 - The Austrian Multi Institutional study has reported its findings specifically for age.7 In this phase … Among APBI registry studies that have updated results, Shah reported no difference by age in invasive … pain, and decreased patient-reported quality of life compared with WBI alone.30-33 In contrast, other … studies have reported outcomes with IORT followed by WBI that appear acceptable and comparable to either … These biologic considerations, coupled with the current follow-up reported from the ELIOT and TARGIT

464. Disposition of Comments Report for Childhood Obesity Prevention Programs: A Comparative Effectiveness Review and Meta-Analysis (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/obesity-child_disposition-comments.pdf
     June 10, 2013 - Although few trials reported negative effects, few actually looked for them. … Most studies (all but 1) reported on the intervention versus a control or usual care. … We would have extracted cost data if available – no studies reported on costs. … We analyzed the last reported time point for studies that were eligible for the meta analyses. … Cost was not reported as an outcome in any of the studies we included in this review.

465. Case Study Comparing Bayesian and Frequentist Approaches for Multiple Treatment Comparisons (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research.pdf
     March 01, 2013 - We pooled the trials that reported UI at baseline and also those trials that reported UI-related outcomes … Chapple, 200414 Not reported Study: RCT Sample: 728 Not reported Fesoterodine Placebo Not reported … Not reported Darifenacin Placebo Not reported Choo, 200817 Men and women aged ≥18 years with symptoms … Staskin, 200769 Not reported Trospium Study Group. … Staskin, 200470 Not reported RCT USA N: 658 Not reported Trospium chloride 20- mg twice daily

466. Obesity (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1306.pdf
     July 01, 2013 - The American Heart Association reported in 2011 that among children and adolescents aged 2–19 years … The reported weight loss achieved on average was between 9% and 10% of body weight. … Authors reported the following:6,7 Patients treated with [Qsymia] had significant, sustained weight … The authors reported the following:8 Least-squares (LS) mean weight loss for phentermine-topiramate … Psychiatric AEs were reported by 11% and 12% of subjects in each arm, respectively. 12 The

467. Obesity (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1406.pdf
     June 01, 2014 - The reported weight loss achieved on average was between 9% and 10% of total body weight. … based online aggregator of prescription drug prices reported prices ranging from about $575 to $612 … group was 31.8%±21.3% and in the control group was 18.3%±20.9% (p=0.1371).6 The authors reported … Psychiatric AEs were reported by 11% and 12% of subjects in each arm, respectively. … As of June 2014, GoodRx, an online aggregator of prescription drug prices, reported prices ranging

468. For persons with PTSD (and those exposed to traumatic event/s as defined by DSM-IV-TR or ICD-10), what is the comparative effectiveness of different psychotherapy modalities/psychological treatments? o Is EMDR an effective treatment for… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-persons-with-ptsd-and-those-exposed-to-traumatic-events-as-defined-by-dsm-iv-tr-or-icd-10-what-is-the-comparative-effectiveness-of-different-psychotherapy-modalitiespsychological-treatments-o-is-emdr-an-effective-treatme
     November 01, 2017 - part, to evidence of higher rates of PTSD among soldiers returning from Persian Gulf than previously reported … Furthermore, the IOM reported insufficient evidence in support of EMDR, coping skills training, and cognitive … IOM (2007) reported inadequate evidence to determine the efficacy of pharmacotherapies in the treatment … of PTSD, and NICE reported that “drug treatments should not be a routine first-line treatment for adults

469. Psychosocial and Pharmacologic Interventions for Disruptive Behavior Disorders in Children and Adolescents: Current State of the Evidence (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_clinician.pdf
     August 01, 2016 - Adverse effects of medications reported in included studies were mild or moderate, but the ability … mediate effectiveness. �� Given that studies of pharmacologic interventions were short term, harms reported … studies were generally mild or moderate and fairly immediate in nature: �– Adverse events frequently reported … Additionally, many of the studies included mixed populations and reported outcomes of overlapping symptoms

470. Glaucoma-Treatment Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/glaucoma-treatment_research-protocol.pdf
     November 16, 2010 - open-angle glaucoma with a specific focus on the effects of treatment on visual impairment, patient-reported … Including treatment convenience as a patient-reported outcome. … Does treatment of open-angle glaucoma improve patient-reported outcomes? Key Question 3. … Diabetic Retinopathy Study [ETDRS] or the Snellen Eye Test) among the treatment groups of interest as reported … , the National Eye Institute Visual Functioning Questionnaire (NEI- VFQ)—for the following patient-reported

471. Antipsychotics-Adults Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_executive.pdf
     August 01, 2012 - • Patient-reported outcomes. • Ability to obtain and retain employment and succeed in job duties … We reported factors that may potentially limit the applicability of the results. … The most commonly reported other outcome was response rate. … Few studies reported on health care system utilization or patient-important outcomes. … A variety of AEs associated with numerous physiological systems were reported.

472. Crosscutting-Horizon-Scan-High-Impact-1412 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - In this trial, Pambianco et al. reported that patients undergoing Sedasys-mediated propofol sedation … Among the 496 patients receiving Sedasys-delivered propofol, no serious adverse events were reported … results of a clinical trial of 111 subjects who ingested 7,144 ingestible markers.23 They reported … No definitive marker-related adverse effects were reported.”23 Another report from a clinical trial … of 30 patients reported similar detection accuracy of the system.28 These investigators reported four

473. Evidence-Summary-CER-206-Sodium-And-Potassium-Intake-Effects-On-Chronic-Disease-Outcomes-And-Risk (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-206-evidence-summary-sodium-potassium.pdf
     June 01, 2018 - interventions to restrict sodium intake or increase potassium intake, used a comparator group, and reported … lower risk for kidney stones in cohort studies of adults (low SoE, based on 4 prospective cohorts [reported … In contrast, the Graudal review reported significant increases in cholesterol and triglycerides, possibly … Instead they reported only on studies that assessed effects of sodium reduction on BP outcomes in … • Few RCTs reported sodium/potassium ratios.

474. The Effectiveness of Indoor Allergen Reduction and the Role of Bronchial Thermoplasty in the Management of Asthma (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/asthma-nonpharmacologic-treatment_research-protocol.pdf
     October 04, 2016 - Patient Criteria To be included, a study must have reported data obtained from patients who have received … If data were reported separately for patients with asthma, then all analyses will use the asthma specific … Studies will be included if at least 85 percent of patients were adults, or if outcomes data are reported … We will include data from time points and outcomes reported from studies with at least 20 patients ( … When meta-analysis is impossible (due to limitations of reported data) or is judged to be inappropriate

475. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - fecal microbiota therapy for irritable bowel disease that are in clinical trials but have not yet reported … Food and Drug Administration (FDA) approval was based reported that patients with SBS experienced a … The researchers also reported that the most common adverse events “included headache (35%), nausea … The most commonly reported (≥10%) adverse reactions in patients treated…across all clinical studies … Many of these adverse reactions were reported in association with the underlying disease and/or use

476. Technical Brief 13: Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
     December 01, 2012 - In 2011, Gröne21 reported on the inability to validate the GEP results of Wang (2004)33 and Barrier … The information presented in Table 3 shows that numerous GEP assays have been reported. … authors reported a number of measurements including PCR amplification efficiency, linearity over a … In 2012 at the ASCO Annual Meeting, O’Connell et al., reported another independent validation of the … In 2012 at the ASCO Annual Meeting, Roth et al., reported results for validation of both the Genomic

477. Disposition of Comments for Screening for Glaucoma: Comparative Effectiveness (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/glaucoma-screening_disposition-comments.pdf
     April 01, 2012 - Had we identified any studies that included visual acuity as an outcome, we would have reported this … Quality of life and other patient reported outcomes would be assessed and compared among those who … We noted that we planned to include other harms as reported in included studies so the occurrence of … acute angle closure attacks would have been reported if identified from the literature. … Data was reported in the abstract for standard commercially available parameters using the standard

478. Obesity (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - The American Heart Association reported in 2011 that among children and adolescents aged 2–19 years … The reported weight loss achieved on average was between 9% and 10% of total body weight. … Psychiatric AEs were reported by 11% and 12% of subjects in each arm, respectively. 12 The … The authors reported the following results:68 At 1 year, 55.4% of patients (883 of 1595) receiving … The study authors reported the following:69 More patients lost ≥5% body weight with lorcaserin BID

479. Disposition of Comments for Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_disposition-comments.pdf
     December 16, 2014 - Lack of blinding is less concerning for studies relying on vital statistics or self-reported quality … We have now reported that apart from RCTs, well- designed observational studies are needed to provide … EBRT reported at meeting and abstract- agree not published but authors could comment (results NS for … EBRT that was reported in a meeting abstract. … The strength of evidence grading was reported only for patient-oriented outcomes.

480. Effects of Dietary Sodium and Potassium Intake on Chronic Disease (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
     April 18, 2017 - composition of salt substitute with intervention/exposure adherence measure, and food diaries with reported … validation, use of a published food frequency questionnaire, or partial or spot urine without reported … validation, use of a published food frequency questionnaire, or partial or spot urine without reported … Continuous outcomes will be reported as standardized mean differences (SMD), dichotomous incident and … prevalence outcomes will be reported as relative risks (RR), and mortality data will be reported as