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221. Comparative Effectiveness of Angiotensin Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), and Direct Renin Inhibitors for Treating Essential Hypertension – An Update of the 2007 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/ace-inhibitor-arb-update/research-protocol
     December 01, 2019 - cough (estimated incidence 5% - 20%) and angioedema (estimated incidence 0.1% to 0.2%, with a lesser reported … We will include studies with patients of mixed ages and mixed diagnoses only if results were reported … Primary Outcomes Blood pressure control (we will prefer seated trough blood pressure, where reported … essential hypertension - Exclude if no patients have essential hypertension or if results not reported … Population of interest = adults (≥ 18 years) - Exclude if all subjects < 18 or if results not reported

222. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
     September 01, 2014 - This has been reported consistently throughout the report. … If any studies fail to define it, we suggest that the omission be reported. … monotherapy arm reported 3 patients out of 258. … This has been reported consistently throughout the report. … This has been reported consistently throughout the report.

223. Management of Postpartum Hemorrhage | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/hemorrhage-postpartum/research
     December 01, 2019 - Fifty studies reported harms of interventions for PPH management: 11 good quality and 39 poor. … Some studies with longer term followup reported adverse effects on future fertility and menstrual changes … Studies also reported need for reoperation after hysterectomy.

224. Interventions To Improve Patient Adherence to Hepatitis C Treatment: Comparative Effectiveness | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/hepatitis-c-treatment-adherence/research
     December 01, 2019 - None of the studies reported data on important health outcomes, such as liver complications, mortality … quality of life appeared to improve with interventions in two studies, no statistical significance was reported … Two studies reported no harms associated with the interventions.

225. Treatment for Glaucoma: Comparative Effectiveness | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/glaucoma-treatment/research
     December 01, 2019 - We also found insufficient evidence comparing treatment versus no treatment on patient-reported outcomes … intermediate outcomes (IOP, optic nerve structure, or visual field) and visual impairment or patient-reported … evidence addressing direct or indirect links between glaucoma treatment and visual impairment or patient-reported

226. Treatments for Fibromyalgia in Adult Subgroups | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/fibromyalgia/research
     December 01, 2019 - Adults with fibromyalgia and major depressive disorder (MDD) were studied most often; drug studies also reported … Most interaction results were reported in text; only two RCTs and five pooled RCT analyses displayed … Adverse effects were reported for the MDD subgroup in one duloxetine pooled analysis; these were similar

227. Home-Based Primary Care Interventions | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/home-based-care/research
     December 01, 2019 - Evidence about clinical outcomes was limited to studies that reported no significant differences in function … In studies that reported on the impact of patient characteristics, moderate evidence indicated that frail … No adverse events were reported.

228. Quantitative Synthesis: Chapter 2. Presenting Different Effects for Different Data Types (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
     February 01, 2018 - . - Not commonly reported in individual trials. … rare or differs substantially across studies Risk Ratio (RR) - Easily interpretable - Commonly reported … Odds Ratio (OR) - More likely to be consistent even with differing baseline risks - Commonly reported … as standardized mean difference or ratio of means. ► May be computed, if means for each group are reported … measures are reported (e.g., confidence interval, P-value, z-statistics).

229. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
     January 01, 2014 - Data for the UA or NSTEMI population individually was reported in PLATO. … Data for the UA or NSTEMI population individually was reported in PLATO. … We reported the intermediate outcomes when available. … In contrast, bleeding data by subgroup are reported for ticagrelor. … A majority reported TIMI bleeding definitions.

230. Omega-3 Fatty Acids and Maternal and Child Health: An Update (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/omega-3-maternity_executive.pdf
     October 01, 2016 - the only RCT identified in the original systematic review); only two reported significant results. … The original review included six RCTs in preterm infants that reported cognitive outcomes, while the … The other RCTs reported mixed results. … The current report identified 20 RCTs that reported on adverse events. … Most RCTs were also small in size, although most reported doing power calculations.

231. Supplemental Project To Assess the Transparency of Reporting for Strategies To Improve Mental Health Care for Children and Adolescents | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/transparency-mental-health/research
     December 01, 2020 - Were results reported in clinicaltrials.gov for any of the studies? … If they were, what were the differences, if any, in the results reported in the peer reviewed literature … Proportion of Studies Reported in Clinicaltrials.gov (KQ 1) We identified 17 studies, reported in 17 … articles 4-19 (including two studies in a single article, 4 and one study reported in two articles … Authors who attempt to register studies on their own reported difficulties.

232. Disposition of Comments for CER 195 Management of Uterine Fibroids (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-195-disposition-comments-uterine-fibroids.pdf
     December 14, 2017 - One study reported reduction in days of bleeding (significance not reported), and four reported improvement … Three of four studies reported no effect on fibroid size; one reported a higher rate of uterine growth … We summarize harms as reported in the studies meeting our criteria. … As noted, few studies reported effect modifier data to allow for such comparisons. … We added this material: "One study reported a four percent reduction in size and those that reported

233. Evidence Summary: Comparative Effectiveness Review No. 245_Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-245-breast-reconstruction-after-mastectomy-evidence-summary-updated-1.pdf
     October 01, 2021 - found a large body of evidence, it included many single group studies and relatively few studies reported … When subgroup data were reported, statistical analyses evaluating heterogeneity of treatment effects … were not reported. … Errata The original systematic review reported that autologous reconstruction (AR) with deep inferior … Upon re-review of the studies, we found that only a single study reported relevant data for this comparison

234. Undescended-Testicle Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/undescended-testicle_executive.pdf
     December 01, 2012 - Both studies reported 100-percent sensitivity, indicating that no nonviable testicles were missed. … No harms of hormonal treatment were reported. … Eleven studies reported outcomes following either one-stage FS orchiopexy, two-stage FS orchiopexy, … Reported harms of hormonal treatments were mild and transient. … In all studies, reported harms had receded by 6-month followup, if not before.

235. PKU Surveillance Assessment_CER 56_Low (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/phenylketonuria_surveillance.pdf
     January 15, 2013 - The study reported that timing of maternal metabolic control, defined as the No studies identified … PKU patients reported higher physical well-being and HRQoL than age-matched healthy controls during … One small case series reported on IQ and nutritional outcomes for up to 1 year on 5 mg/kg/day BH4 … Of the 10 studies examining the effectiveness of BH4 in participants with PKU, 4 studies reported … PKU patients reported higher physical well-being and HRQoL than age-matched healthy controls during

236. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ptsd4-final-protocol.pdf
     October 01, 2022 - Indicate if subgroup analyses are reported (Y/N) n. … Between-group effect sizes for all reported anxiety outcomes n. … Between-group effect sizes for all reported sleep outcomes o. … Between-group effect sizes for all reported anger outcomes p. … Results for all reported substance use outcomes s.

237. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ptsd-protocol-2021_0.pdf
     January 01, 2021 - Indicate if subgroup analyses are reported (Y/N) n. … Between-group effect sizes for all reported anxiety outcomes n. … Between-group effect sizes for all reported sleep outcomes o. … Between-group effect sizes for all reported anger outcomes p. … Results for all reported substance use outcomes s.

238. Cancer-Pancreas Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-pancreas_executive.pdf
     September 01, 2014 - an included outcome that was not reported by other publications of that study, or (b) a publication … with lower patient enrollment reported longer followup data for an outcome. … If a study reported multiple populations, it must have reported data separately for one or more of … It found only one such study, which reported on only 50 patients. … The large majority of pancreas-specific studies reported the procedural harms of EUS-FNA.

239. App-D-Opioid-Chronic-Pain-Surveill-Report-1 (xls file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveill-report-1.xlsx
     September 30, 2015 - level (0 to 10, 10 high): 5.7 Level of functioning (VAS, 0 to 100) 58 Urine + for opiates: 63% Self-reported … 89% Screened: 65 Eligible: 25 Randomized: 19 Analyzed: 19 LTFU: 9 Outcomes at 6 month follow-up not reported … indicate clear differences between treatments for pain, functioning, depression, or drug use Harms not reported … in 2 consecutive rounds before the last round of followup B) Intermittent opioid use: opioid use reported … in any one of the rounds C) No use: no opioid use reported in any rounds Enrolled: 4,172 Analyzed: 4,172

240. Asthma-Treatment Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/asthma-treatment_executive.pdf
     May 01, 2011 - Lack of blinding may also be problematic for self-reported outcomes, where social desirability could … All but one42 explicitly reported encouraging daily home practice. … Another trial with a very intensive intervention reported a very large effect size at 2- and 4-week … All four trials in this group reported on change in FEV1 (Table A).21,23,24,29 No trial found group … Subgroup analyses of teens and/or emerging adults were not reported.