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1. Draft Research Plan: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/brca-related-cancer-risk-assessment-genetic-counseling-testing
   January 18, 2024 - . ║ Posttest counseling includes interpretation of results, determination of eligibility for risk-reducing … interventions, and patient decision making. ¶ Risk-reducing interventions include early detection through … screening (earlier and more frequent screening or use of additional screening methods), use of risk-reducing … medications (aromatase inhibitors and tamoxifen), and risk-reducing surgery (mastectomy, salpingo-oophorectomy … medications, or risk-reducing surgery vs. no intervention or alternative approaches Other comparisons

2. Final Research Plan: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/brca-related-cancer-risk-assessment-genetic-counseling-testing
   April 11, 2024 - . ║ Posttest counseling includes interpretation of results, determination of eligibility for risk-reducing … interventions, and patient decision making. ¶ Risk-reducing interventions include early detection through … medications (aromatase inhibitors, tamoxifen), and risk-reducing surgery or procedures (e.g. , mastectomy … Posttest counseling vs. usual care or alternative approaches KQs 4, 5: Intensive screening, risk-reducing … medications, or risk-reducing surgery vs. no intervention or alternative approaches Other comparisons

3. Final Research Plan: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing
   August 24, 2017 - e Posttest counseling includes interpretation of results, determination of eligibility for risk-reducing … screening, use of additional screening methods), use of risk-reducing medications (aromatase inhibitors … , tamoxifen, raloxifene), and risk-reducing surgery (mastectomy, salpingo-oophorectomy, other procedures … What are the adverse effects of risk-reducing interventions for BRCA-related cancer? … , and risk-reducing surgery and ethical, legal, and social implications.)

4. Recommendation: Breast Cancer: Medication Use to Reduce Risk | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/recommendation/breast-cancer-medications-for-risk-reduction
   September 03, 2019 - breast cancer aged 35 years or older The USPSTF recommends that clinicians offer to prescribe risk-reducing … Potential Benefits of Risk-Reducing Medications The USPSTF found convincing evidence that risk-reducing … Potential Harms of Risk-Reducing Medications The USPSTF found convincing evidence that tamoxifen and … Further information on comprehensive management strategies, including risk-reducing medications, for … See below for more information on potential harms from risk-reducing medications.

5. Draft Research Plan: Breast Cancer: Medication to Reduce Risk | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/breast-cancer-medication-use-reduce-risk
   December 28, 2023 - What is the effectiveness of risk-reducing medications on primary invasive breast cancer, breast cancer … What are the perspectives and preferences of patients on breast cancer risk and the use of risk-reducing … What are the current practices of primary care clinicians on breast cancer risk-reducing medications … the findings are broadly representative of the U.S. population eligible for the breast cancer risk-reducing … This could include noting the effectiveness of risk-reducing medications for preventing triple negative

6. Final Research Plan: Breast Cancer: Medication to Reduce Risk | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/breast-cancer-medication-use-reduce-risk
   March 21, 2024 - What is the effectiveness of risk-reducing medications on primary breast cancer, breast cancer mortality … What are the perspectives and preferences of patients on breast cancer risk and the use of risk-reducing … current practices of primary care clinicians on breast cancer risk assessment and provision of risk-reducing … the findings are broadly representative of the U.S. population eligible for the breast cancer risk-reducing … This could include noting the effectiveness of risk-reducing medications for preventing triple negative

7. Medication Use to Reduce Risk of Breast Cancer: US Preventive Services Task Force Recommendation Statement (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/3Kwu7j_WfCFQSnSzqrDWwt
   June 20, 2019 - The USPSTF found convincing evidence that risk-reducing medications (tamoxifen, raloxifene, or aromatase … CONCLUSIONS AND RECOMMENDATION The USPSTF recommends that clinicians offer to prescribe risk-reducing … (B recommendation) The USPSTF recommends against the routine use of risk-reducing medications, such as … Potential Benefits of Risk-Reducing Medications The USPSTF found convincing evidence that risk-reducing … See below for more information on potential harms from risk- reducing medications.

8. Final Recommendation Statement: Breast Cancer: Medication Use to Reduce Risk | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/RecommendationStatementFinal/breast-cancer-medications-for-risk-reduction
   September 03, 2019 - Potential Benefits of Risk-Reducing Medications The USPSTF found convincing evidence that risk-reducing … Potential Harms of Risk-Reducing Medications The USPSTF found convincing evidence that tamoxifen and … Further information on comprehensive management strategies, including risk-reducing medications, for … See below for more information on potential harms from risk-reducing medications. … Risk-Reducing Medications A systematic review of trials conducted for the USPSTF found that compared

9. Archived: Final Research Plan: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan11/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing-2013
   December 15, 2012 - relatives known to have deleterious mutations may come directly to genetic counseling); use of risk-reducing … include, but may not be limited to, immediate and long-term harms associated with breast imaging, risk-reducing … medications, and risk-reducing surgery and ethical, legal, and social implications … more frequent mammography, breast MRI), use of medications (e.g., tamoxifen, raloxifene), and risk-reducing … medications, and risk-reducing surgery; and ethical, legal, and social implications.

10. Clinical Summary: Medication Use to Reduce Risk of Breast Cancer (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/Z3BVaJRtyu8drWSHWYT_Yf
    Women aged ≥35 y not at increased risk for breast cancer Recommendation Offer to prescribe risk-reducing … medications, such as tamoxifen, raloxifene, or aromatase inhibitors Grade: B Do not routinely use risk-reducing … When considering prescribing breast cancer risk-reducing medications, the potential benefit of risk reduction … Risk-Reducing Medications Tamoxifen, raloxifene, and aromatase inhibitors all reduce primary breast

11. Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/MzHhsgTBL37rRvvJfkfgMZ
    August 20, 2019 - (Includes immediate and long-term harms associated with screening, risk-reducing medications, and risk-reducing … medications, and risk-reducing surgery when performed for prevention purposes. … Six observational studies (7 articles; n = 2546) of risk- reducing mastectomy,105-110,118 2 of risk-reducing … Risk reducing mastectomy: outcomes in 10 European centres. … Breast cancer after bilateral risk-reducing mastectomy.

12. Evidence Summary: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing
    August 20, 2019 - medications; and risk-reducing surgery, including mastectomy and salpingo-oophorectomy. … Six observational studies (7 articles; n = 2546) of risk-reducing mastectomy, 105-110 , 118 2 of risk-reducing … Use of risk-reducing medications in mutation carriers has also not been studied. … Risk reducing mastectomy: outcomes in 10 European centres. … , and risk-reducing surgery when performed for prevention purposes.

13. 3W8Wr9Wwayaqujwmjo Bl- (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/3w8Wr9wwAyAqUJWmJo_bL-
    February 01, 2014 - Interventions included intensive screening, risk- reducing medications, and risk-reducing surgery. … Only risk-reducing medications approved by the U.S. … Risk-Reducing Medications Breast Cancer. … Risk-Reducing Surgery Bilateral Mastectomy. … Effectiveness of risk-reducing interventions No studies of intensive screening or risk-reducing medications

14. Final Research Plan: Breast Cancer: Medication Use to Reduce Risk | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/breast-cancer-medications-for-risk-reduction
    July 20, 2017 - Does the effectiveness of risk-reducing medications vary by timing of initiation or duration of use? … Does the effectiveness of risk-reducing medications persist beyond discontinuation of use? … Do the harms of risk-reducing medications vary by timing of initiation or duration of use? … Do the harms of risk-reducing medications persist beyond discontinuation of use? … contextual question about current clinician and patient attitudes and practices regarding use of risk-reducing

15. Archived: Evidence Summary: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary17/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing-2013
    December 15, 2013 - Interventions included intensive screening, risk-reducing medications, and risk-reducing surgery. … Only risk-reducing medications approved by the U.S. … Risk-Reducing Medications Breast Cancer. … Risk-Reducing Surgery Bilateral Mastectomy. … Effectiveness of risk-reducing interventions No studies of intensive screening or risk-reducing

16. Clinical Summary: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/y3mQMyN2Y8mxKvPPXjM6kV
    This includes intensive screening, risk-reducing medications, and risk-reducing mastectomy and salpingo-oophorectomy … Relevant USPSTF Recommendations The USPSTF recommends that clinicians offer to prescribe risk-reducing

17. Archived: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing-2013
    December 24, 2013 - In high-risk women and those who are BRCA mutation carriers, cohort studies of risk-reducing surgery … In cohort studies of high-risk women and those who are BRCA mutation carriers, risk-reducing surgery … Data on the long-term physical harms of risk-reducing mastectomy are limited. … Breast cancer after bilateral risk-reducing mastectomy. Clin Genet . 2011;79(5):431-7. 29. … Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation.

18. Pzrh6M8Vucdvmsabwkaqa2 (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/Pzrh6m8vUcdvmsaBwKaQA2
    February 01, 2014 - The USPSTF also reviewed interventions aimed at reducing the risk for BRCA-related cancer in women with … potentially harmful BRCA mutations, includ- ing intensive cancer screening, medications, and risk-reducing … Data on the long-term physical harms of risk-reducing mastectomy are limited. … Breast cancer after bilateral risk-reducing mastectomy. Clin Genet. 2011;79:431-7. … Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation.

19. Recommendation: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing
    August 20, 2019 - This includes intensive screening, risk-reducing medications, and risk-reducing mastectomy and salpingo-oophorectomy … Relevant USPSTF Recommendations The USPSTF recommends that clinicians offer to prescribe risk-reducing … This includes intensive screening, risk-reducing medications, and risk-reducing mastectomy and salpingo-oophorectomy … Risk reducing mastectomy: outcomes in 10 European centres. … Breast cancer after bilateral risk-reducing mastectomy. Clin Genet . 2011;79(5):431-437. 96.

20. Summary of USPSTF Draft Recommendation: Behavioral Counseling Interventions to Support Breastfeeding (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/QH2JxjAo7FmcfCBy8c_65Y
    November 18, 2024 - Breastfeeding can improve the health of babies, including reducing the risk of infections, and may have … Breastfeeding can help babies stay healthy by reducing their risk of infections and making it less likely