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July 01, 2019 - Quantitative Synthesis: Chapter 1. Decision To Combine Trials
Quantitative Synthesis
Chapter 1. Decision to combine trials
Prepared for:
The Agency for Healthcare Research and Quality (AHRQ)
Training Modules for Systematic Reviews Methods Guide
www.ahrq.gov
Presenter
Presentation Notes
Prioritization and Selecti…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_executive.pdf
January 01, 2016 - infections with antibiotic-resistant
bacteria each year, causing approximately
23,000 deaths.1 Although reasons … The reasons for
even a small increased risk of hospitalization were unclear
in these two trials with … As noted previously for
the comparison of the combination with usual care,
the reasons for the small … Reasons for these differences include the addition of
a large volume of newer evidence, the use of a … The reasons for a potential increased risk of hospitalization
are unclear because the studies were not
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effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-251-integrated-pain-management-evidence-summary.pdf
October 01, 2021 - Reasons include the costs, logistics, leadership
support, staffing, and provider training required to
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_disposition-comments.pdf
October 23, 2012 - studies
were excluded because they did not meet these criteria;
some might have been excluded for other reasons … studies
were excluded because they did not meet these criteria;
some might have been excluded for other reasons … studies were excluded because they did not meet
these criteria; some might have been excluded for other
reasons … studies were excluded because
they did not meet these criteria; some might have been
excluded for other reasons
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s29.pdf
October 01, 2007 - “I could see
where you might want to say that this is going to be our
preferred drug and one of the reasons
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_disposition-comments.pdf
November 20, 2014 - Beets-Tan; the reasons for exclusion
are listed in the Appendixes (one was not a
clinical study, and … Asymmetry of funnel plots could be due to
publication bias or other reasons. … The dates for grouping the studies for the
sub-group analysis were chosen for the
following reasons
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June 30, 2015 - This is stated
with a negative bias which for the reasons articulated
above regarding condition specific
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January 01, 2019 - For feasibility reasons and to apply our methods to a range of interventions, we will include only KQ … effectiveness of available treatment strategies for women who are subfertile/infertile for unknown reasons
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_disposition-comments.pdf
January 27, 2016 - Added list of reasons per
May 2014, Hicks 2015, and
Barlam 2015
30. … Added list of reasons per
May 2014, Hicks 2015, and
Barlam 2015
31. … Added list of reasons per
May 2014, Hicks 2015, and
Barlam 2015
32. … Added list of reasons per
May 2014, Hicks 2015, and
Barlam 2015
34. … There are
multiple reasons that only a
few of the existing reviews
were useful to us in this
review
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January 01, 2009 - population)
Run-in periods with high exclusion rates Run-in period: attrition rate before randomization and reasons … Next, ascertain whether there was a run-in period and if so the reasons for attrition before randomization
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July 18, 2017 - Skip to main content
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
February 01, 2014 - We did
not expand our update to evaluate add-on combination
therapy for two reasons: (1) the upcoming … Full-Text Screening
439
Excluded
3,396
Included
Articles/Studies
59/55
Excluded
380
Reasons … monotherapy and
combination regimens, no abstractable data) = 115
Reasons … Three reasons to abandon
low-density lipoprotein targets: an open letter to the Adult
Treatment Panel
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effectivehealthcare-admin.ahrq.gov/products/home-based-care/research-protocol
December 01, 2019 - The specific reasons a patient needs HBPC and the potential advantages vary. … A record of studies excluded at the full-text level with reasons for exclusion will be maintained and
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effectivehealthcare-admin.ahrq.gov/sites/default/files/tech-brief-37-opiod-use-adults-comments.pdf
November 03, 2020 - It is the case that we did not distinguish
among reasons for opioid use (except to the
degree that … help
Appendix D includes a flow diagram (Figure
D-1) and Appendix E lists rejected articles
with reasons … they may have been reasons that also are risks
for overdose (i.e. diversion or use of illegal
drugs … Current
literature provides many more reasons, including
demographic changes, drug availability,
increased … steps should be
taken to mitigate the risk of misuse and overdose
in Medicare beneficiaries.x For the reasons
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effectivehealthcare-admin.ahrq.gov/products/thromboembolism-update/research-protocol
January 01, 2021 - For similar reasons, we will not update the Key Question comparing thromboprophylaxis to no thromboprophylaxis … Possible reasons for statistical heterogeneity will be explored qualitatively and, if appropriate data
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
July 01, 2012 - Negative correlation between sensitivity and specificity across studies may be expected for
reasons … threshold variation in these studies (from 120 to 550 ng/mL,
when stated; Figure 8–1), or due to other reasons
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01_0.pdf
May 01, 2005 - For several reasons,
we caution against simple-to-follow rules such as equating industry sponsorship … conduct, and rate
as low, moderate, high, or unknown risk of bias within study design; document
the reasons … accounted for in the analyses
• Outcome data are reasonably completeh and proportion of
participants and reasons
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/chronic-cough_disposition-comments.pdf
January 07, 2013 - Almost all were excluded for
one of the following reasons 1) not an
evaluation study 2) outcome of … Regarding last question, the overall study is in doubt for reasons
outlined above and therefore utilizing
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May 01, 2005 - For several reasons,
we caution against simple-to-follow rules such as equating industry sponsorship … conduct, and rate
as low, moderate, high, or unknown risk of bias within study design; document
the reasons … accounted for in the analyses
• Outcome data are reasonably completeh and proportion of
participants and reasons