- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1506.pdf
June 01, 2015 - Rather, the reports will help to inform and 
guide the planning and prioritization of research resources … and tracking of about 2,250 topics across the 14 AHRQ priority areas and 1 cross-
cutting area; more than … No more than two experts with a possible COI are considered out of a total of the five to eight 
experts … The nonprofit Alzheimer’s Association also has estimated that more than 
5 million Americans were living … with AD in 2013, including about 11% of Americans older than age 
65 years and 32% of Americans aged
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update_executive.pdf
January 01, 2018 - The primary focus in KQ2 was harms across all 
conditions, rather than within each condition, because … instances (e.g., 
hyperactivity, aggression) we used subscale items on one 
or more questionnaires, rather … corresponding 95% 
credible intervals (95% CrI; Bayesian approaches provide 
variances using credible rather … Sensitivity analysis by removing the study 
examining maintenance, rather than acute, treatment 
with … than ADHD.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer-update_disposition.pdf
December 09, 2014 - Rather SBRT is used to 
give “tumoricidal” doses in short 
periods of time compared to 
standard IMRT … We did 
not extract details on chemotherapy 
dosages or schedules, but rather 
ascertained their degree … than 25 or more fractions. … We believe the findings from 
this prospective study are significant and 
should be considered rather … than 
1.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/schwitzer_eccs2012.pdf
July 23, 2012 - It would be
more than a year following surgery before he had the energy to play a
set of tennis	
  again … Discussed a woman with a diagnosis of ductal carcinoma in situ who
chose to pursue active surveillance rather … than an immediate,
aggressive intervention, such as bilateral prophylactic mastectomy
Source: Eisenberg … Industry-‐Independent	
  Experts
Slide 24:
“I honestly believe it	
  is better to know	
  nothing	
  than
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
October 01, 2007 - confounding that often affect observational studies, where
treatments are chosen in the course of usual care rather … than
randomly assigned by an investigator. … relevant trial
evidence by designing trials that enroll representative pa-
tients, replicate “real-world” rather … Individual patients need to know more than that a
therapy works on average. … Subgroup analysis of trials indicates that the
benefits are much greater in asymptomatic men than in
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/developmental-delays-horizon-scan-high-impact-1506.pdf
December 01, 2015 - Rather, the reports will help to inform and 
guide the planning and prioritization of research resources … Since that implementation, review of more than 21,000 leads about potential topics has resulted in … and tracking of about 2,250 topics across the 14 AHRQ priority areas and 1 cross-
cutting area; more than … No more than two experts with a possible COI are considered out of a total of the five to eight 
experts
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-health-children_disposition-comments.pdf
December 19, 2016 - (e.g., a short 
descriptor of the strategy) might be helpful in 
orienting the reader to the study, rather … used seem more appropriate for highly 
controlled clinical trials used to test the efficacy of 
drugs rather … publications component, repeated twice, is 
confusing and probably best left to the more detailed 
rather … than summarized text. … : December 19, 2016 
28 
Commentator 
& Affiliation Section Comment Response 
TEP 6 General  So, rather
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-imaging_disposition-comments.pdf
October 01, 2014 - they had seen situations in which 
patients without adequate insurance coverage received 
bone scans rather … We considered looking at literature published earlier than 
2003. … Statement suggests the evidence is better than it appears. … Rather, imaging modalities should be considered in the context of 
the information they add to the clinical … However, we offer that this is not a gap, but rather includes 
endpoints which are inappropriate to evaluate
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-272-genitourinary-syndrome-executive-summary.pdf
July 01, 2024 - • A broad array of non-hormonal interventions other than moisturizers, including 
natural products … For 
studies that evaluated non-hormonal interventions (other than vaginal moisturizers), we 
created … We derived 
COE from statistical rather than clinical significance or effect magnitude, in part because … and are counted more than once 
in the description above. … Bazedoxifene may improve QoL less than placebo (low COE).
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-depression-research-protocol.pdf
February 07, 2018 - Approximately 15–20 
percent of adults older than age 65 in the United States have experienced depression … .1  
Multiple systematic reviews have shown that antidepressant medications are better than 
placebo … patients with a specific 
subtype of MDD (e.g., catatonic, melancholic, psychotic, or atypical features) rather … than 
MDD generally; or 4) patients with bipolar depression. … Patients younger than 65 years 
Studies that focus enrollment on patients with a 
subtype of MDD rather
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/clifford.pdf
October 08, 2025 - They were taking 10 milligrams 
because their neuro said you don't need more than 10. … More than 10 milligrams 
is gonna cause weakness in your legs. 
 
 
 
 They came to the site. … Here it is in 
a -- in a graph rather than here's something someone told me online on 
2diabetes.com … again and 
weren't telling their neurologist are now saying I'm having seizures more 
frequently than … the appropriate question to ask from a research perspective is 
did you have fewer hospitalizations than
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pelvic-pain_disposition-comments.pdf
January 01, 2012 - The 
reviewer acknowleges that the data would be even more meger 
than the one on LUNA. … Public Reviewer 
#2 
Results Better than 86% of patients are pain free in 1.8 clinic visits. … table 10 
Assessment in the Stratton study was 18 months after patient 
completed 6 months of treatment rather … than 12 months after 
patient completed 6 months of treatment 
We have clarified this statement in … The report does not 
offer practitioners easy answers to their clinical questions - rather 
it poses
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
March 01, 2012 - than one occasion. … If the drug was 
working in the first place, why would the patient be put back on 
the old drug rather … than a new one be tried? … Pooling Saetre 2007 with 
Brodie (1999) rather than Brodie (2007) might yield more 
consistent results … Rather, we were challenged with 
evaluating the literature that currently exists.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
March 01, 2012 - fracture, independent of BMD.3 Because the majority 
of fractures occur in patients with low bone mass rather … In an effort to ease the 
process of trial implementation, the Guidance Document, 
rather than requiring … effectiveness, we included only 
studies that compared two or more interventions within the 
same study, rather … (Studies that addressed 
more than one Key Question were counted more than 
once.) … identified for this report, which tended to 
focus on postmenopausal women with established 
osteoporosis (rather
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-therapy-management_executive.pdf
November 01, 2014 - Most RCTs compared an MTM intervention 
with usual care rather than with a different active 
intervention … than fewer outpatient visits. … as insufficient for 
most outcomes because of inconsistency in direction, 
magnitude, and precision, rather … than lack of evidence. … program success or 
failure using qualitative or single-arm designs may offer 
hypothesis-generating rather
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/thromboembolism-update-disposition.pdf
June 22, 2017 - than suggestive of consistent 
networks.” … prophylaxis 
provides the best outcome for the 
surgery-this is not a reflection of the 
study but rather … We aimed to 
focus on decisionmaking in the face of 
incomplete evidence rather than make 
any comments … We aimed to 
focus on decisionmaking in the face of 
incomplete evidence rather than make 
any comments … Is one 
better than the other?
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/case-management_disposition-comments.pdf
January 01, 2013 - when the 
intervention was more prolonged, included more 
patient contact, and included face-to-face (rather … than telephone only) interactions. … researchers stated 
that they used the description of the case 
management intervention and its components 
rather … For the number of studies reviewed, this section is 
rather short with only three limitations discussed … The issue is not 
that AHRQ has failed to define case management; 
rather, the problem is that a consistent
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/05_depression_potential_high_impact_2012-12-10.pdf
January 01, 2012 - Rather, the reports will help to inform and 
guide the planning and prioritization of research resources … Since that implementation, review of more than 15,000 leads about potential topics has resulted in … management for these patients, not only because it provides a new treatment 
modality (surgical implant rather … cost-change estimates to 
pharmacotherapy, although DBS is not likely to compete with pharmacotherapy but rather … adequate treatment.
50
 The majority of reserve soldiers who seek care do so in 
the civilian sector, rather
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/ch_10-user-guide-to-ocer_130129.pdf
January 01, 2011 - Propensity scores 
often perform better than logistic regression when 
the outcome is relatively rare … better than 
propensity score analysis when the outcome is 
common but the exposure is rare.7
Choice … These difficulties can be addressed by using 
inverse-probability-of-treatment weighting 
(IPTW),16 rather … than regression adjustment, for 
confounding control. … becomes more complex.45 Moreover, when 
two-stage least squares procedures are applied 
to binary rather
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_disposition-comments.pdf
August 23, 2012 - than 
the Rooks article. … than background information. … than a ‘chapter’? … The conclusions are 
valid though perhaps raise more questions rather than enable policy and 
practice … I 
understand that this is relying on anecdotal evidence, rather than high-
quality clinical trials.