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effectivehealthcare.ahrq.gov/sites/default/files/grading-quiz.ppt
May 29, 2025 - Grading Strength of Evidence: Interactive Quiz
Grading Strength of Evidence
Interactive Quiz
Prepared for:
The Agency for Healthcare Research and Quality (AHRQ)
Training Modules for Systematic Reviews Methods Guide
www.ahrq.gov
Grading Strength of Evidence: Interactive Quiz
Is grading the strength of evidence t…
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effectivehealthcare.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
January 01, 2012 - Smoking Cessation
Key Facts: Although many smokers have attempted to quit, successful cessation rates … experts strongly agreed that the unmet need for
interventions that will improve smoking-cessation rates … suggested that the quit rate seen in trials suggests the program’s potential
to improve smoking-cessation rates … underinsured or may not
otherwise have access to smoking-cessation interventions and that smoking rates … of cost, most experts thought that if the program were successful in improving
smoking-cessation rates
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
March 24, 2017 - TEP #2 Results –
KQ2
When listing harms, only the rates and dropout rates
in the active groups are … How did these
compare with placebo rates? … Similarly, were dropout
rates due to lack of efficacy assessed? … We did not assess dropout rates due
to lack of efficacy, as this would have been
accounted for in the … With the expected low event rates for ulcers and
amputations, wouldn't this add some weight to use of
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effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
March 24, 2017 - TEP #2 Results –
KQ2
When listing harms, only the rates and dropout rates
in the active groups are … How did these
compare with placebo rates? … Similarly, were dropout
rates due to lack of efficacy assessed? … We did not assess dropout rates due
to lack of efficacy, as this would have been
accounted for in the … With the expected low event rates for ulcers and
amputations, wouldn't this add some weight to use of
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effectivehealthcare.ahrq.gov/sites/default/files/s108.pdf
October 01, 2007 - severity of illness, the consequence of which was heteroge-
neity across individuals in the hazard rates … , �2, and �3) specified in the
simulation represented individual-level effects on discharge
hazard rates … was to identify methods that
yield unbiased estimates of the effect of the adverse event on
discharge rates … According to Simulation Conditions and Method of Analysis
Model
Ratio of Individual
Discharge Hazard Rates
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/breastfeeding_research-protocol.pdf
January 01, 2020 - new studies have reported on outcomes not
addressed in the 2007 AHRQ review, including hypertension, rates … are racial and ethnic differences in breastfeeding initiation (starting)
and duration (continuing) rates … In addition
to setting targets for breastfeeding initiation rates and duration of breastfeeding, other … Such trends are of
concern, in that breastfeeding rates in the United States have changed dramatically … Baby-friendly hospital initiative improves breastfeeding
initiation rates in a US hospital setting.
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effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1406.pdf
January 01, 2020 - prevalent in metropolitan areas, including Baltimore, MD, and Staten Island,
NY, higher overdose rates … of opioid overdose; additionally, epidemiologists have noted that
opioid overdose rates have risen … Responding to
above-average overdose fatalities rates in Wilkes County, NC, community leaders partnered … Pilot program data
demonstrated decreased opioid overdose mortality rates in Wilkes County between … Project
Lazarus’ efforts also contributed to these declines, despite opioid prescribing rates remaining
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-prepub-final-research-table-rct.xlsx
May 29, 2025 - RCT
Author, year Is randomization adequate?
Yes/No/Unclear Is allocation concealment adequate?
Yes/No/Unclear Are groups similar at baseline?
Yes/No/Unclear Is the outcome assessor (interviewer) masked?
Yes/No/Unclear Is the data analyst masked?
Yes/No/Unclear Are attrition and crossovers reported?
Yes/No/Uncl…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - NPP
Table E-1. Neuropathic pain study characteristics
Author, Year
Country
Trial Type
Quality Rating Type(s) of Pain Demographics Other Population Characteristics N Randomized
N Analyzed Intervention Duration (Weeks) Funding Source
Hussain, 2021
Pakistan
Placebo-controlled
Fair NPP (DPN) Age, mean: 45
Female: 0%
R…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_clinician.pdf
May 01, 2016 - ��
�� Vacuum-assisted core-needle breast biopsy procedures
are associated with slightly increased rates … Table 3: Underestimation Rates in Women at Average Risk of Breast Cancer
Biopsy Method
Average Underestimation
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
October 01, 2011 - However, CLASS found difference in rates of ulcer
complications alone at either 6 or 12 months. … However, because the event rates increases in older
patients, even if the relative risk estimates are … the
same, the absolute event rates are higher. … Two trials found high rates of recurrent ulcer
bleeding in patients randomized to either celecoxib
(4.9% … Acetaminophen can
increase INR levels, but effects on bleeding rates have
not been studied.
15
Table
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
September 01, 2011 - events
(32% vs. 5% over differing lengths of followup),
and methotrexate being associated with higher rates … We did not identify any studies that
provide reliable information on the comparative
safety or rates … Our findings suggest that short-term mortality rates
associated with DMARDs are very low—we identified … However, the available evidence is inadequate to
determine whether the rates and types of adverse events
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-computerized-cds-protocol.pdf
May 08, 2023 - or alternative clinical
decision support
N/A
Outcome • Clinical outcomes
o Adverse drug event rates … o Medication error rates
• Provider outcomes
o Changes in prescribing
behavior
• Implementation … outcomes
o Rates of valid and/or useful
alerts
o Unsubstantiated override
rates
• Unintended
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-pharm-non-pharm-treatment-update-disposition-comments.pdf
August 28, 2024 - Affiliation Section Comment Response
Peer Reviewer
#2
General Finally, I am unclear as to why attrition rates … Treatment
completion and
adherence rates are
provided in study
interventions. … Peer Reviewer
#2
Results Details that were not included and may be helpful are
attrition rates and … and adherence rates
are provided in study
interventions.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-executive-170523.pdf
May 01, 2017 - Kujala 2012 reported failure rates (defined as at least
two episodes of AOM in 2 months, three in 6 … In their model,
younger age and white race were significantly associated
with higher rates of recurrent … Parker 1994 reported identical
mean otorrhea rates in nonswimmers and swimmers. … It is notable that events rates
in the RCTs are systematically higher in both control
and intervention … arms in the RCTs compared with event
rates in NRCSs.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
May 01, 2013 - suggest that incidence and
prevalence of major depression in the postpartum period
are comparable to rates … Strength-of-evidence domains for the effect of timing of screening
on rates of referral and treatment … In one observational study, referral
rates were significantly higher in women with abnormal
screening … Event rates for postpartum depression differ
significantly between countries due to dissimilarities … -based study that demonstrated high rates
of receipt of appropriate services and significant reductions
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/multiple-sclerosis_executive.pdf
April 01, 2015 - MRI
to identify MS-related lesions has been shown to correlate
with short-term relapse rates (6 months … to 2 years).7
However, long-term MRI followup results as a surrogate
marker for relapse rates or, … The survival rate for the placebo arm was consistent with
survival rates reported in MS natural history … When reported,
discontinuation rates during long-term followup were low,
about 3 to 4 percent, but … rates due to adverse events were
not separate from total discontinuation rates, which would
also include
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_appendixes.pdf
March 01, 2009 - • Event rates much higher or lower than observed in population-based studies. … The original model was further modified to predict expected rates of invasive breast
cancer only (not … Barrett-
Connor,
2006**46
5057 5044 5.6 47 1.67 65 2.32 1.37 0.94-
1.99
Annualized
rates
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_surveillance.pdf
July 01, 2012 - because few
trials report
treatment
duration,
completion rates,
or other measures
of adherence … Discontinuation
rates for
tamoxifen or
raloxifene are
generally higher
than placebo. … Incidence
rates/risks of
gynecologic
conditions
Median 81
month follow-
up reported
Good/Good … Comparisons of adherence and
persistence rates across medications in
prevention trials are limited … because few
trials report treatment duration,
completion rates, or other measures of
adherence and
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/health-careassociated-infections_disposition-comments.pdf
November 30, 2012 - evidence that certain specified interventions
reduce adherence to recommended practices and infection
rates … What are folks in hospitals around the
world doing to reduce infection rates since there is so little … in evaluating the impact of QI
strategies on adherence to preventive interventions
and infection rates … base strategies were
associated with moderate strength of evidence for reducing
CLABSI infection rates … Now how do you change infection rates in health care
settings?