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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
    February 01, 2014 - rates from randomized trials showed a much higher NNH for GI bleeds because the baseline incidence rate … Since we did not have access to individual time-to-event patient data, we approximated incidence rate … To estimate the incidence rate we assumed a 50 percent increase from age category 65-74 years based … This was a little less than what would be calculated by simply multiplying the incidence rate of 6.2 … Incidence rate of all outcomes without treatment did not change over time.
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
    January 28, 2019 - , and/or respiratory rate, altered mental status, agitation)? … , respiratory rate, respiratory depression, hypotension, nausea, vomiting, emergence delirium, … analgesic effect, dissociative experiences scale, self-recall of pain episode KQ 2 and 4: Heart rate … , respiratory rate, respiratory depression, hypotension, nausea, vomiting, emergence of delirium, … Key Questions Outcomes for KQ2 and 4 included: heart rate, respiratory rate, respiratory depression
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/diagnostic-tests-accuracy_research.pdf
    January 01, 2013 - In addition, we define the “jointly true positive rate” (JTPR), and “jointly false positive rate” ( … FPR: false-positive rate (one minus specificity); TPR: true-positive rate (sensitivity). ! … JTPR = joint-[false|true]-positive rate. … (1-specificity); TPR = true-positive rate (sensitivity). … (The type I error rate for the rectangle !
  4. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-2007_executive.pdf
    January 01, 2007 - valsartan (Diovan®). 3Outcomes considered include: Intermediate outcomes—Blood pressure control; rateRate of use of a single High There was no statistically evident difference in the rate of antihypertensive … angiotensin-converting enzyme inhibitor; ARB = angiotensin II receptor blocker/antagonist; GFR = glomerular filtration rate
  5. effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
    January 01, 2015 - Systolic Blood Pressure and Heart Rate Systolic blood pressure and heart rate were evaluated only for … Moderate Heart rate Increases in heart rate were minimal and similar for metformin and GLP-1 receptor … Increased heart rate is associated with increased mortality.38 However, whether heart rate is an independent … rate for the newer medications. … Temporal changes in resting heart rate and deaths from ischemic heart disease.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-executive-170523.pdf
    May 01, 2017 - Casselbrant 1992 reported the rate of new episodes per arm was 1.08 in the placebo group versus 1.02 … The one year incidence rate (infections per child per year) was 0.55 (95% CI 0.93 to 0.17) lower in … The attack rate was 0.86 infections per child in the TT group and 1.4 in prophylaxis group (P = 0.08 … Amoxicillin and a rate of 1.02 in their TT group (P = 0.001). 12 El-Sayed found no difference … The odds of clinical cure were 12-fold (95% CrI: 1.9 – 82) higher [NNT 2.2 (assuming a baseline rate
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-dystocia_research-protocol.pdf
    July 28, 2016 - Although there is no consensus on the “optimal” cesarean section rate (conceptually, the rate which … and because rates of vaginal birth after cesarean (VBAC) have been declining, safely reducing the rate … specified quantile of the distribution of rates of cervical change in the first stage of labor or rate … Parity • Obesity Intermediate Outcomes • Duration of labor • Mode of delivery • Fetal heart rate … Indications contributing to the increasing cesarean delivery rate.
  8. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/suicide-prevention_research-protocol.pdf
    December 23, 2015 - California has a lower suicide rate in the same region (9.83/100k). … a lower suicide rate in the Midwest region (8.76/100k); and finally Delaware has a higher suicide rate … Note that the national crude average rate of suicide in 2013 is 12.6 per 100k population. … rate % of HS students per year 4 year adjusted cohort graduation rate State education agencies … (SEAs) report ACGR data for each school, LEA, and for the state total cohort rate.
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
    December 01, 2009 - Impacts on Function with Tiotropium (UPLIFT) study showed tiotropium was associated with a reduced rate … The difference equates to a rate ratio of 1.25 for those switched to a tiotropium regimen relative to … Similar rate ratios were seen for exacerbation and hospitalization rates between groups. … The reduced rate of exacerbations was similar to the 16% reduction we observed in this analysis for … Mortality Rate* RR Crude Exacerbation Rate* RR Crude Hospitalization Rate* RR ICS+LABA
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/engaging-caregivers-appendix-b.xlsx
    May 29, 2025 - B Any postdischarge incident (rate per discharge) 0.95 (95% CI 0.73 to 1.23) vs. 1.51 (95% CI 1.27 to … 1.77), p=0.003 Nonharmful errors (rate per discharge) 0.54 (95% CI 0.38 to 0.77) vs. 0.79 (95% CI 0.63 … to 0.99), p=0.08 Total AEs (rate per discharge) 0.10 (95% CI 0.05 to 0.23) vs. 0.23 (95% CI 0.15 to … 0.35), p=0.07 Preventable AEs (rate per discharge) 0.03 (95% CI 0.01 to 0.14) vs. 0.08 (95% CI 0.04 … to 0.17), p=0.33 Nonpreventable AEs (rate per discharge) 0.07 (95% CI 0.03 to 0.18) vs. 0.15 (95% CI
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
    September 01, 2014 - These and other factors may affect test performance and the rate of complications. … that the conclusions of the original report may be out of date, particularly for the underestimation rate … We defined the underestimation rate for high risk lesions (most often atypical ductal hyperplasia, [ … Use of vacuum assistance was associated with a greater rate of bleeding and hematoma formation. … We did not rate the strength of evidence for other Key Question 3 outcomes because of the diversity
  12. effectivehealthcare.ahrq.gov/sites/default/files/suppl-1-user-guide-to-ocer_130129.pdf
    January 01, 2011 - The effect of a change in the T utilization rate (which thereby changes the A rate); for example, T … The effect of a change in the T utilization rate (which thereby changes the A rate) that results from … Objective 4 relates to evaluating the effects of treatment rate changes. … Many years ago, John Wennberg correctly posed objective 4 with the question “Which rate is right?” … Which rate is right? N Engl J Med. 1986;315(13):810-5. 6. Heckman JJ.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-2007_research-2007-1.pdf
    January 01, 2007 - • Rate of use of a single antihypertensive for blood pressure control. … rate difference is estimated to be 1.1 percent (NNT = 87). … For the median withdrawal rate (8 percent for ACEIs) the absolute difference in withdrawal rate is estimated … Rate of use of a single antihypertensive? … when we use the rate of cough with ACEIs equal to the cohort studies (1.7 percent) the absolute rate
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
    September 20, 2013 - that these and other variations in how a core-needle biopsy is performed may affect the accuracy and rate … could be included in the updated report regarding the following topics: o The underestimation rate … of ADH that are found to be malignant according to the reference standard)  The underestimation rate … We will rate each study as being of low, intermediate, or high risk of bias on the basis of adherence … Finally, we will rate the body of evidence using four strength-of-evidence levels: high, moderate, low
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_disposition-comments.pdf
    September 01, 2011 - Amended Peer Reviewer 4 Introduction Over the last 20 years the preterm birth rate in the U. … S. has risen, but in 2007 and 2008 there was modest decrease in the preterm birth rate (Martin5) and … The basal rate was Source: www.effectivehealthcare.ahrq.gov … The basal rate was kept constant…” (3) Seems like patients had phone contact with nurse “Patients … For an incidence rate of 1-2/1000...the studies were inadequately powered.
  16. effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_executive.pdf
    February 01, 2016 - complete metabolic panel, complete blood count, coagulation parameters, erythrocyte sedimentation rate … Studies varied in the reporting of both continuous (estimated glomerular filtration rate, and serum … The strength of evidence was moderate that partial nephrectomy had the highest blood transfusion rate … Patients should be counseled that an equivalent local control rate with thermal ablation may require … Renal mass sampling is a safe and sensitive procedure, but has a high nondiagnostic rate.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_surveillance.pdf
    June 01, 2012 - Rate of Systolic BP slope divergence: Not assessed None One expert said the conclusion was not … of Diastolic BP slope divergence: “The slopes for diastolic blood pressure diverged at a rate of … Renal artery stenting slows the rate of renal function decline. … Rate of Systolic BP slope divergence: 0.27 mm Hg per year; 95% 28 Author year Study name … of Diastolic BP slope divergence: “The slopes for diastolic blood pressure diverged at a rate of
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
    July 01, 2019 - hypothesis-driven, and scientifically defensible.14,18 • Subgroup analysis also has a high false-positive rate … dx.doi.org/10.1056/NEJM199207233270406 Baseline risk meta-regression ► The baseline risk (or the “control rate … An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis … • A simplified two-step approach to control-rate meta-regression that involves scatter plotting and … An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
    October 01, 2012 - An acute fall in estimated glomerular filtration rate during treatment 21 with losartan … protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate … The degree of reduction in UAE was independently associated with the rate of eGFR decline (P=0.0037 … Thus, the greater the acute fall in eGFR during losartan treatment, the slower the rate of long-term … , 7.2[95% CI 6.6-7.8] vs 2.9 [95% CI 2.7-3.0] per 1000 person-years, respectively; rate ratio, 2.5
  20. effectivehealthcare.ahrq.gov/sites/default/files/study-size-planning-chapter-9.pptx
    January 01, 2013 - For occurrence of event outcomes (e.g., death), estimation of the assumed event rate in the control group … trial arm; when outcome is the necessary occurrence of an event (e.g., death), then an assumed event rate … Needed study size depends on the chosen type 1 error rate (α) and required statistical power. … Calculations in Randomized Controlled Trials (3 of 3) The needed study size depends on the chosen type 1 error rate … Report the expected absolute risk or rate for the reference or control cohort, including the expected

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