-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
February 01, 2014 - rates from randomized trials showed a much higher
NNH for GI bleeds because the baseline incidence rate … Since we did not have access to individual time-to-event patient data, we approximated
incidence rate … To
estimate the incidence rate we assumed a 50 percent increase from age category 65-74 years based … This was a
little less than what would be calculated by simply multiplying the incidence rate of 6.2 … Incidence rate of all outcomes without treatment did not
change over time.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
January 28, 2019 - , and/or respiratory rate, altered mental status, agitation)? … , respiratory rate,
respiratory depression,
hypotension, nausea,
vomiting, emergence
delirium, … analgesic
effect, dissociative experiences scale,
self-recall of pain episode
KQ 2 and 4: Heart rate … , respiratory rate,
respiratory depression, hypotension,
nausea, vomiting, emergence of
delirium, … Key Questions Outcomes for KQ2 and
4 included: heart rate,
respiratory rate,
respiratory depression
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/diagnostic-tests-accuracy_research.pdf
January 01, 2013 - In addition, we define
the “jointly true positive rate” (JTPR), and “jointly false positive rate” ( … FPR: false-positive rate (one minus specificity); TPR: true-positive rate (sensitivity).
! … JTPR = joint-[false|true]-positive rate. … (1-specificity); TPR = true-positive rate (sensitivity). … (The type I error rate for the rectangle
!
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-2007_executive.pdf
January 01, 2007 - valsartan
(Diovan®).
3Outcomes considered include:
Intermediate outcomes—Blood pressure control; rate … Rate of use of a single High There was no statistically evident difference in the rate of
antihypertensive … angiotensin-converting enzyme inhibitor; ARB = angiotensin II receptor blocker/antagonist; GFR =
glomerular filtration rate
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
January 01, 2015 - Systolic Blood Pressure and Heart Rate
Systolic blood pressure and heart rate were evaluated only
for … Moderate
Heart rate Increases in heart rate were minimal and similar for metformin and GLP-1 receptor … Increased heart rate is associated with increased
mortality.38 However, whether heart rate is an independent … rate for the newer medications. … Temporal changes in resting
heart rate and deaths from ischemic heart disease.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-executive-170523.pdf
May 01, 2017 - Casselbrant 1992 reported the rate of new episodes per
arm was 1.08 in the placebo group versus 1.02 … The one year incidence rate
(infections per child per year) was 0.55 (95% CI 0.93 to
0.17) lower in … The attack rate
was 0.86 infections per child in the TT group and 1.4 in
prophylaxis group (P = 0.08 … Amoxicillin and a rate of 1.02 in their TT group (P =
0.001).
12
El-Sayed found no difference … The odds of clinical cure were 12-fold (95% CrI: 1.9 –
82) higher [NNT 2.2 (assuming a baseline rate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-dystocia_research-protocol.pdf
July 28, 2016 - Although there is no consensus on the “optimal” cesarean section rate (conceptually, the
rate which … and because rates of vaginal birth after cesarean (VBAC) have been
declining, safely reducing the rate … specified quantile of the distribution of rates of
cervical change in the first stage of labor or rate … Parity
• Obesity
Intermediate
Outcomes
• Duration of
labor
• Mode of
delivery
• Fetal heart
rate … Indications contributing to the
increasing cesarean delivery rate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/suicide-prevention_research-protocol.pdf
December 23, 2015 - California has a lower suicide rate in the same region
(9.83/100k). … a lower suicide rate in the Midwest region (8.76/100k); and finally Delaware
has a higher suicide rate … Note that the national crude average rate of suicide in 2013 is 12.6 per
100k population. … rate
% of HS students per year
4 year adjusted
cohort graduation
rate
State education agencies … (SEAs) report ACGR data for each school, LEA, and for the state
total cohort rate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
December 01, 2009 - Impacts on Function with Tiotropium (UPLIFT) study showed tiotropium
was associated with a reduced rate … The difference equates to a rate ratio of 1.25 for those switched to a tiotropium
regimen relative to … Similar rate ratios were seen for
exacerbation and hospitalization rates between groups. … The
reduced rate of exacerbations was similar to the 16% reduction we observed in this
analysis for … Mortality
Rate*
RR
Crude
Exacerbation
Rate*
RR
Crude
Hospitalization
Rate*
RR
ICS+LABA
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/engaging-caregivers-appendix-b.xlsx
May 29, 2025 - B
Any postdischarge incident (rate per discharge)
0.95 (95% CI 0.73 to 1.23) vs. 1.51 (95% CI 1.27 to … 1.77), p=0.003
Nonharmful errors (rate per discharge)
0.54 (95% CI 0.38 to 0.77) vs. 0.79 (95% CI 0.63 … to 0.99), p=0.08
Total AEs (rate per discharge)
0.10 (95% CI 0.05 to 0.23) vs. 0.23 (95% CI 0.15 to … 0.35), p=0.07
Preventable AEs (rate per discharge)
0.03 (95% CI 0.01 to 0.14) vs. 0.08 (95% CI 0.04 … to 0.17), p=0.33
Nonpreventable AEs (rate per discharge)
0.07 (95% CI 0.03 to 0.18) vs. 0.15 (95% CI
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
September 01, 2014 - These and other factors may affect test performance
and the rate of complications. … that the conclusions of the
original report may be out of date, particularly for the
underestimation rate … We defined the underestimation rate for high risk lesions
(most often atypical ductal hyperplasia, [ … Use of vacuum
assistance was associated with a greater rate of bleeding
and hematoma formation. … We did not rate the strength of evidence for
other Key Question 3 outcomes because of the diversity
-
effectivehealthcare.ahrq.gov/sites/default/files/suppl-1-user-guide-to-ocer_130129.pdf
January 01, 2011 - The effect of a change in the T utilization
rate (which thereby changes the A rate); for
example, T … The effect of a change in the T utilization rate
(which thereby changes the A rate) that results
from … Objective 4 relates to evaluating the effects of
treatment rate changes. … Many years ago,
John Wennberg correctly posed objective 4 with
the question “Which rate is right?” … Which rate is right? N Engl J Med.
1986;315(13):810-5.
6. Heckman JJ.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-2007_research-2007-1.pdf
January 01, 2007 - • Rate of use of a single antihypertensive for blood pressure control. … rate difference is
estimated to be 1.1 percent (NNT = 87). … For the median withdrawal rate (8 percent for ACEIs) the absolute
difference in withdrawal rate is estimated … Rate of use of a single
antihypertensive? … when we use the
rate of cough with ACEIs equal to the cohort studies (1.7 percent) the absolute rate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
September 20, 2013 - that these and other variations in how a core-needle biopsy is performed may affect
the accuracy and rate … could be included in the updated report regarding the
following topics:
o The underestimation rate … of ADH that are found to be malignant according to the
reference standard)
The underestimation rate … We will rate
each study as being of low, intermediate, or high risk of bias on the basis of adherence … Finally, we will rate the body of evidence using four strength-of-evidence levels: high, moderate, low
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_disposition-comments.pdf
September 01, 2011 - Amended
Peer Reviewer 4 Introduction Over the last 20 years the preterm birth rate in the U. … S. has risen,
but in 2007 and 2008 there was modest decrease in the preterm birth
rate (Martin5) and … The basal rate was
Source: www.effectivehealthcare.ahrq.gov … The basal rate was
kept constant…”
(3) Seems like patients had phone contact
with nurse
“Patients … For an incidence rate of
1-2/1000...the studies were inadequately
powered.
-
effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_executive.pdf
February 01, 2016 - complete metabolic panel, complete blood count,
coagulation parameters, erythrocyte sedimentation
rate … Studies varied in the reporting of both
continuous (estimated glomerular filtration rate, and serum … The strength of evidence was moderate that
partial nephrectomy had the highest blood transfusion rate … Patients should be counseled that an equivalent
local control rate with thermal ablation may require … Renal mass sampling is a
safe and sensitive procedure, but has a high nondiagnostic
rate.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_surveillance.pdf
June 01, 2012 - Rate of Systolic BP slope
divergence:
Not assessed None One expert said the
conclusion was not … of Diastolic BP slope
divergence:
“The slopes for diastolic blood
pressure diverged at a rate of … Renal artery stenting slows the rate of renal function
decline. … Rate of Systolic BP slope divergence:
0.27 mm Hg per year; 95%
28
Author year
Study name … of Diastolic BP slope divergence:
“The slopes for diastolic blood pressure
diverged at a rate of
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
July 01, 2019 - hypothesis-driven, and scientifically defensible.14,18
• Subgroup analysis also has a high false-positive rate … dx.doi.org/10.1056/NEJM199207233270406
Baseline risk meta-regression
► The baseline risk (or the “control rate … An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis … • A simplified two-step approach to control-rate meta-regression that involves scatter
plotting and … An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
October 01, 2012 - An acute fall in estimated
glomerular filtration rate during treatment
21
with losartan … protein intake has no
effect on serum cystatin C levels
independent of the glomerular filtration rate … The degree of reduction in UAE was
independently associated with the rate of
eGFR decline (P=0.0037 … Thus, the greater the
acute fall in eGFR during losartan treatment,
the slower the rate of long-term … , 7.2[95% CI 6.6-7.8] vs
2.9 [95% CI 2.7-3.0] per 1000 person-years,
respectively; rate ratio, 2.5
-
effectivehealthcare.ahrq.gov/sites/default/files/study-size-planning-chapter-9.pptx
January 01, 2013 - For occurrence of event outcomes (e.g., death), estimation of the assumed event rate in the control group … trial arm; when outcome is the necessary occurrence of an event (e.g., death), then an assumed event rate … Needed study size depends on the chosen type 1 error rate (α) and required statistical power. … Calculations in Randomized Controlled Trials (3 of 3)
The needed study size depends on the chosen type 1 error rate … Report the expected absolute risk or rate for the reference or control cohort, including the expected