- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
January 01, 2013 - may seem to be a natural choice when there is a dramatic s
hift from one treatment to another (e.g., rapid … Evaluation of response time data involving transient states: an illustration using heart-transplant data
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/congestive-heart-failure-medicines_research.pdf
March 01, 2010 - It is a collaborative network of research centers that 
support the rapid development of new scientific … hydralazine/isosorbide dinitrate (H-ISDN) combination* 
VARIABLE GROUP 
    Variable 
        Categorical response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_surveillance.pdf
January 01, 2013 - Assessment of the Need to Update Comparative 
Effectiveness Reviews: Report of an Initial Rapid Program
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-quality-indicator-testing_research.pdf
April 01, 2010 - It is a collaborative network of research centers that 
support the rapid development of new scientific … plan for 
depression should be documented  
If a patient with cancer is treated for depression, then response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-prognostic_methods.pdf
July 01, 2012 - Use of 
molecular biomarkers for predicting the 
response to radiotherapy with or without 
chemotherapy
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_research-protocol.pdf
March 22, 2016 - Other factors that may be 
considered in assessing strength of evidence include dose-response relationship
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin-future_research.pdf
August 01, 2014 - from draft CER for procalcitonin as a diagnostic  
indicator for infection and as an indicator of response … from draft CER for procalcitonin as a diagnostic  
indicator for infection and as an indicator of response … The response rate was 100 percent 
(n=9); 8 (of 10) research needs received votes. … The response rate was 100 percent (n=9); all questions received votes. … Host cytokine response affects 
PCT levels, so PCT cut-offs 
may differ in these 
populations.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/angina-heart-attack-treatments_research-protocol.pdf
December 11, 2012 - Ticagrelor is a reversible P2Y12 
receptor antagonist that, when compared with clopidogrel, provides a more rapid … Initial pharmacokinetic/pharmacodynamic studies have suggested a reduction in 
the antiplatelet response … Based on comments received in 
response to this posting, the following change was made to the KQs: … Additionally, when appropriate, the studies will be evaluated for dose-response association, the 
presence
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/functional-limitations-horizon-scan-high-impact-1306.pdf
June 01, 2013 - If 
C1INH is deficient, an acute inflammatory response occurs that leads to swelling, which is 
the … If C1INH is deficient, C1 
proteases set off the complement pathway, causing an acute inflammatory response … Part of the inflammatory response is the release of uncontrolled levels of bradykinin (BK), 
a potent … The combination of rapid relief of symptoms and self-administration 
is expected to improve health outcomes … the retina using tests for refraction, color vision, visual field, visual acuity, and 
pupil-reflex response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_surveillance.pdf
August 01, 2012 - subject matter 
experts referred to a publication outlining perceived shortcomings of the report and a response … The 
response from the epilepsy organizations highlighted that the report failed to recognize the 
different … individual 
patient or subset of patients would have an over- 
or under-accentuated pharmacokinetic response … Assessment of the Need to Update 
Comparative Effectiveness Reviews: Report 
of an Initial Rapid Program … individual patient or subset of patients would have an 
over- or under-accentuated pharmacokinetic response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_surveillance.pdf
August 01, 2012 - subject matter 
experts referred to a publication outlining perceived shortcomings of the report and a response … The 
response from the epilepsy organizations highlighted that the report failed to recognize the 
different … individual 
patient or subset of patients would have an over- 
or under-accentuated pharmacokinetic response … Assessment of the Need to Update 
Comparative Effectiveness Reviews: Report 
of an Initial Rapid Program … individual patient or subset of patients would have an 
over- or under-accentuated pharmacokinetic response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/incident-user-design_research.pdf
May 01, 2012 - It is a collaborative network of research centers that 
support the rapid development of new scientific … early events, especially treatment 
discontinuations, because of problems with tolerability or poor response … Predictors of response to anti-TNF-α therapy 
among patients with rheumatoid arthritis: 
results from
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
August 18, 2011 - helping patients to better adhere to recommended treatment.
4-6
  
 
Over the past half century, rapid … and alternatives 
to the prescribed medication; and lack of access to a provider who will monitor the response … It also considers other optional domains that may 
be relevant for some scenarios, such as a dose-response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
November 01, 2013 - considered for some bodies of evidence and increase confidence in the findings include 
increasing dose-response … required, domains are 
most relevant to bodies of evidence consisting of observational studies: dose-response … The second set of domains, which supplement the five required domains, has three 
components: dose-response … Score as one of two levels: 
• Present: Dose-response pattern observed 
• Undetected: No dose-response … pattern observed 
(dose-response relationship not present or could not 
be determined) 
Plausible