- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/accountable-care-registries-guide-3rd-ed-addendum-white-paper-2018-5.pdf
January 01, 2018 - ACO registries can also be used for 
rapid cycle patient-oriented outcomes research, efforts that are
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
June 01, 2010 - the public comment period, comparative 
effectiveness research reviews are revised by the authors in response … The table below includes the response by 
the authors of the review to each comment submitted for the … Source: www.effectivehealthcare.ahrq.gov  
Published Online  June 1, 2010  
 
Section Comment Response … The (admittedly informal) response I 
have gotten is that 80% of patients in the US are off-label, but … In trauma, uncontrolled bleeding leads to rapid death.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs-future_research.pdf
February 01, 2013 - ES-2 
reduced RLS symptoms, increased the percentage of patients with a clinically important response … and etiology of disease, age, obesity, and other characteristics that appear to 
have an effect on response … rotigotine) reduced RLS symptoms, increased the percentage of patients with a 
clinically important response … evidence demonstrated that pregabalin increased the 
percentage of patients with a clinically important response … stakeholders to clarify or supplement the 
call summaries or to suggest additional research questions in response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
January 01, 2013 - may seem to be a natural choice when there is a dramatic s
hift from one treatment to another (e.g., rapid … Evaluation of response time data involving transient states: an illustration using heart-transplant data
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-abnormalities-tests-update_research-protocol.pdf
July 01, 2010 - Background and Objectives 
In response to Section 1013 of the Medicare Modernization Act, the Agency … asymptomatic women; breast cancer staging; 
evaluation for a possible recurrence of breast cancer; monitoring response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/congestive-heart-failure-medicines_research.pdf
March 01, 2010 - It is a collaborative network of research centers that 
support the rapid development of new scientific … hydralazine/isosorbide dinitrate (H-ISDN) combination* 
VARIABLE GROUP 
    Variable 
        Categorical response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
January 01, 2009 - period: attrition rate before randomization and reasons (e.g., nonadherence, adverse drug events, no response … If high levels of nonadherence, adverse effects, or lack of response are found, then this reduces applicability
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_executive.pdf
November 01, 2012 - • There is limited indirect comparison evidence that 
the effect on clinically important response may … Most studies used flexible up-titration based on symptom 
response and adverse effects, with doses ranging … Compared with placebo, the 
percentage of patients with a favorable treatment response 
was greater with … studies as the basis for increasing drug doses or altering 
administration timing if symptom response … Moreover, clinicians and 
patients should be aware of such a large placebo response.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-quality-indicator-testing_research.pdf
April 01, 2010 - It is a collaborative network of research centers that 
support the rapid development of new scientific … plan for 
depression should be documented  
If a patient with cancer is treated for depression, then response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-prognostic_methods.pdf
July 01, 2012 - Use of 
molecular biomarkers for predicting the 
response to radiotherapy with or without 
chemotherapy
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_research-protocol.pdf
March 22, 2016 - Other factors that may be 
considered in assessing strength of evidence include dose-response relationship
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/angina-heart-attack-treatments_research-protocol.pdf
December 11, 2012 - Ticagrelor is a reversible P2Y12 
receptor antagonist that, when compared with clopidogrel, provides a more rapid … Initial pharmacokinetic/pharmacodynamic studies have suggested a reduction in 
the antiplatelet response … Based on comments received in 
response to this posting, the following change was made to the KQs: … Additionally, when appropriate, the studies will be evaluated for dose-response association, the 
presence
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/incident-user-design_research.pdf
May 01, 2012 - It is a collaborative network of research centers that 
support the rapid development of new scientific … early events, especially treatment 
discontinuations, because of problems with tolerability or poor response … Predictors of response to anti-TNF-α therapy 
among patients with rheumatoid arthritis: 
results from
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
August 18, 2011 - helping patients to better adhere to recommended treatment.
4-6
  
 
Over the past half century, rapid … and alternatives 
to the prescribed medication; and lack of access to a provider who will monitor the response … It also considers other optional domains that may 
be relevant for some scenarios, such as a dose-response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_surveillance.pdf
January 01, 2013 - Assessment of the Need to Update Comparative 
Effectiveness Reviews: Report of an Initial Rapid Program
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_surveillance.pdf
August 01, 2012 - subject matter 
experts referred to a publication outlining perceived shortcomings of the report and a response … The 
response from the epilepsy organizations highlighted that the report failed to recognize the 
different … individual 
patient or subset of patients would have an over- 
or under-accentuated pharmacokinetic response … Assessment of the Need to Update 
Comparative Effectiveness Reviews: Report 
of an Initial Rapid Program … individual patient or subset of patients would have an 
over- or under-accentuated pharmacokinetic response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_surveillance.pdf
August 01, 2012 - subject matter 
experts referred to a publication outlining perceived shortcomings of the report and a response … The 
response from the epilepsy organizations highlighted that the report failed to recognize the 
different … individual 
patient or subset of patients would have an over- 
or under-accentuated pharmacokinetic response … Assessment of the Need to Update 
Comparative Effectiveness Reviews: Report 
of an Initial Rapid Program … individual patient or subset of patients would have an 
over- or under-accentuated pharmacokinetic response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/functional-limitations-horizon-scan-high-impact-1306.pdf
June 01, 2013 - If 
C1INH is deficient, an acute inflammatory response occurs that leads to swelling, which is 
the … If C1INH is deficient, C1 
proteases set off the complement pathway, causing an acute inflammatory response … Part of the inflammatory response is the release of uncontrolled levels of bradykinin (BK), 
a potent … The combination of rapid relief of symptoms and self-administration 
is expected to improve health outcomes … the retina using tests for refraction, color vision, visual field, visual acuity, and 
pupil-reflex response
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin-future_research.pdf
August 01, 2014 - from draft CER for procalcitonin as a diagnostic  
indicator for infection and as an indicator of response … from draft CER for procalcitonin as a diagnostic  
indicator for infection and as an indicator of response … The response rate was 100 percent 
(n=9); 8 (of 10) research needs received votes. … The response rate was 100 percent (n=9); all questions received votes. … Host cytokine response affects 
PCT levels, so PCT cut-offs 
may differ in these 
populations.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_executive.pdf
August 01, 2012 - Nitrous oxide has a rapid onset and end of action.