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161. CER 205 Disposition of Comments for Physiologic Predictors of Severe Injury: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-205-predictors-trauma-care-disposition-comments.pdf
     April 01, 2018 - Thank you. 3 Comment ator & Affiliation Section Comment Response Peer Reviewer #1 … be clearer and to provide more detail. 4 Comment ator & Affiliation Section Comment Response … TEP Reviewer #4 Introduction Pg 27, line 19 I would include the risk of injury due to rapid transport … edited, p. 2 5 Comment ator & Affiliation Section Comment Response Peer Reviewer #3 … Thank you. 9 Comment ator & Affiliation Section Comment Response Peer Reviewer #2

162. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - In T2DM, hyperglycemia is a result of insulin resistance or a diminished response to insulin. … Also, two pharmacokinetic-pharmacodynamic studies will be initiated to characterize dose response and … MannKind Corporation receives complete response letter from the FDA for Afrezza. [internet]. … acetonide intravitreal implant for treating chronic diabetic macular oedema after an inadequate response … acetonide intravitreal implant for treating chronic diabetic macular oedema after an inadequate response

163. Executive Summary_Comparative Effectiveness Review No. 254: Improving Rural Health Through Telehealth-Guided Provider-to-Provider Communication (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-254-rural-telehealth-executive-summary.pdf
     December 01, 2022 - involvement: o For patients with diabetes:  Some improvement in medication adherence and treatment response … o Hepatitis C viral response and serious adverse events rates at “spoke” site with ECHO participation … The rapid increase in the use of telehealth in response to the COVID-19 pandemic is likely to produce

164. Disposition of Comments: Technical Brief 37 Prevention, Diagnosis, and Management of Opioids, Opioid Misuse, and Opioid Use Disorder in Older Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/tech-brief-37-opiod-use-adults-comments.pdf
     November 03, 2020 - (see discussion in Next Steps) Thank you, and please see the response immediately below. … preventable deaths and brain damage due to opioid overdose in post-surgical unitsxxxi as well as reduce rapid … Amid nationwide incentives to reduce opioid prescribing (currently at an 18-year low), rapid and non-consensual … Any discussion of opioid risks should also include the risks of rapid, inappropriate, forced tapering … Peer-reviewed studies increasingly show rapid and/or inappropriate nonconsensual opioid taper associated

165. Misuse of Prescription Stimulants in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/misuse-prescription-protocol.pdf
     September 13, 2024 - Misuse of Prescription Stimulants in Adults Evidence-based Practice Center (EPC) Rapid Review Protocol … Food and Drug Administration (FDA) has commissioned a rapid review on the misuse of attention-deficit … This rapid review will focus on misuse of stimulants usually prescribed for ADHD. … Data Synthesis Due to the time and resource constraints of a Rapid Review, we will not conduct meta … periodical index"[pt]) Filters: from 2020 - 2024 Evidence-based Practice Center (EPC) Rapid

166. Antipsychotics-Adults Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_surveillance.pdf
     August 30, 2014 - adj5 bipolar).tw. 384 22 (rapid adj2 cycling adj5 bipolar).tw. 385 23 (mixed adj2 state* adj3 bipolar … adj5 bipolar).tw. 431 29 (rapid adj2 cycling adj5 bipolar).tw. 432 30 (mixed adj2 state* adj3 bipolar … Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation). … The most commonly reported other outcome was response rate. … reported other outcome was response rate.

167. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
     December 01, 2010 - rates with corresponding dose, duration of response, remission, relapse, speed of response time, time … 1st Generation and 2nd Generation Antipsychotics Intermediate outcomes  Core illness symptom- response … rates with corresponding dose, duration of response, remission, relapse, speed of response, time … • Bipolar disorder, including manic or depressive phases, rapid cycling, and mixed states. … (rapid-cycling adj5 bipolar).tw. 22. (rapid adj2 cycling adj5 bipolar).tw. 23.

168. Disposition of Comments Technical Brief 41: Evaluation of Mental Health Mobile Applications (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-health-mobile-apps-disposition-of-comments.pdf
     May 20, 2022 - mental-health-apps/report Published Online: May 20, 2022 2 Summary of Peer Reviewer Comments and Author Response … Given the rapid advancements in technology and regulations around the use of such apps, we expect … products/mental-health-apps/report Published Online: May 20, 2022 5 Public Comments and Author Response … reports with sequential peer review and public comment Commentator & Affiliation Section Comment Response … We are concerned that the response to the following question - Is the app either being used or been

169. Ch 4-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_4-user-guide-to-ocer_130129.pdf
     January 01, 2010 - benefits of the vaccination may not be realized until there has been an appropriate immunological response … the individual, and the exposure definition should be created based on the expected timing of the response … In panel G, the depicted relationship shows a dose- response in which the risk or benefit increases … Dosage and Dose-Response The concept of dose is an important consideration for the measurement of … Cumulative dose exposure definitions can be used to explore a dose-response relationship between the

170. Psoriatic Arthritis Surveillance Assesment_CER 54_Low (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_surveillance.pdf
     March 01, 2013 - A new meta-analysis9 found PsA Response Criteria (PsARC) response at 12-14 weeks was significantly … ACR20 response at 12-16 weeks was greater for both anti-TNFs and other biologics. … Psoriasis area and severity index (PASI) response was greater the FDA in October, 2012. … Assessment of the Need to Update Comparative Effectiveness Reviews: Report of an Initial Rapid Program … ACR50 response rates were Did not conduct statistical tests on adverse events data.

171. BLUEPRINT FOR A FUTURE DISTRIBUTED RESEARCH NETWORK (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/distributed-network-blueprint_research.pdf
     June 01, 2010 - It is a collaborative network of research centers that support the rapid development of new scientific … Potential population-based electronic data sources for rapid pandemic influenza vaccine adverse event

172. Disposition of comments_Comparative Effectiveness Review No. 244: Safety of Vaccines Used for Routine Immunization in the United States: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-of-vaccines.pdf
     May 25, 2021 - No response needed. … No response needed. … No response needed. … For example, the Post- Licensure Rapid Immunization Safety Monitoring (PRISM) program and Vaccine Safety … It may be possible that IIS data can be leveraged on a larger scale to support rapid, population-level

173. Disposition of Comments for Management of Suspected Opioid Overdose With Naloxone by Emergency Medical Services Personnel (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-193-disposition-comments-naloxone.pdf
     November 27, 2017 - This strongly suggests that, while EMS response is optimal, it is not “critical.” … The urgency is further heightened by the rapid emergence of highly potent synthetic opioids, such as … State EMS Officials General Comments 1Burns G, et al., Could chest wall rigidity be a factor in rapid … We did not make revisions in response to this comment. … to naloxone was defined, or did not define adequate response.”

174. Disposition of Comments Report for Comparative Effectiveness of Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_disposition-comments.pdf
     June 05, 2013 - At least one study has demonstrated increased or rapid gastric emptying following gastric sleeve resection … No response needed. … No response needed. … Metabolic & Bariatric Surgery General It has been clearly demonstrated that RYGB and SG result in rapid … No response needed.

175. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
     January 01, 2014 - productID=1734 Published Online: November 4, 2013 Commentator & Affiliation Section Comment Response … Peer Reviewer 6 Executive Summary ES-3 line 45 “rapid and potent” is used again; it was stated in … reversibly-binding reversible P2Y12 receptor antagonist that, when compared with clopidogrel, provides a more rapid … reversibly-binding reversible P2Y12 receptor antagonist that, when compared with clopidogrel, provides a more rapid … While this response is relatively standard when the data analyzed are imperfect, there are pragmatic

176. Updating Current Effectiveness Reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-assessment-research-updates_research.pdf
     September 15, 2008 - Reviews Assessment of the Need to Update Comparative Effectiveness Reviews: Report of an Initial Rapid … In parallel with the methods effort, an initial, rapid program assessment was commissioned to assess … , 2008 Assessment of the Need to Update Comparative Effectiveness Reviews: Report of an Initial Rapid

177. Cer-243-Prehospital-Airway-Management-Appendix-F-1 0 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-243-prehospital-airway-management-appendix-f-1_0.xlsx
     January 01, 2016 - laryngeal mask airway 5671 ETI Orotracheal intubation, video laryngoscopy, nasotracheal intubation, rapid … laryngeal mask airway 820 ETI Orotracheal intubation, video laryngoscopy, nasotracheal intubation, rapid … laryngeal mask airway 306 ETI Orotracheal intubation, video laryngoscopy, nasotracheal intubation, rapid … or laryngeal mask airway 4 ETI Orotracheal intubation, video laryngoscopy, nasotracheal intubation, rapid … or laryngeal mask airway 8 ETI Orotracheal intubation, video laryngoscopy, nasotracheal intubation, rapid

178. Disposition of Comments_Technical Brief No. 48_Use of Life Cycle Assessment in the Healthcare Industry: Environmental Impacts and Emissions Associated With Products, Processes and Waste (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-disposition-comments.pdf
     November 20, 2024 - tech-brief Published Online: November 20, 2024 2 Peer Reviewer and Public Comments and Author Response … Commentator and Affiliation Section Comment Response Peer reviewer #1 General This study conducted … tech-brief Published Online: November 20, 2024 3 Commentator and Affiliation Section Comment Response … tech-brief Published Online: November 20, 2024 4 Commentator and Affiliation Section Comment Response … tech-brief Published Online: November 20, 2024 5 Commentator and Affiliation Section Comment Response

179. Misuse of Prescription Stimulants in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/misuse-prescription-protocol-amendment.pdf
     November 26, 2024 - Misuse of Prescription Stimulants in Adults Evidence-based Practice Center (EPC) Draft Rapid … Food and Drug Administration (FDA) has commissioned a rapid review on the misuse of attention-deficit … This rapid review will focus on misuse of stimulants usually prescribed for ADHD. … Data Synthesis Due to the time and resource constraints of a Rapid Review, we will not conduct meta … index"[pt]) Filters: from 2020 - 2024 Evidence-based Practice Center (EPC) Draft Rapid

180. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis—An Update of the 2006 Report. (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-disposition-120516.pdf
     October 01, 2011 - See response to similar comment by reviewer above. … See response to previous similar comment from this reviewer. … review, a detailed post publication review by the editors of BMJ found “The criticisms raised in the rapid … We noted, too, that the authors had posted an "authors' reply" Rapid Response addressing the criticisms … See response to previous comment from this reviewer regarding conflicting studies.