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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-2007_executive.pdf
January 01, 2007 - Of these, 89 were head-to-head randomized
controlled trials (RCTs) and 57 were placebo-controlled
RCTs … Evidence from six head-to-head trials and one
placebo-controlled trial (all fair quality) suggests that … Step
2 and Step 3 treatments were randomly assigned using
an equipoise stratified randomized design. … In this,
1,439 patients were randomized in Step 2, which
included seven possible treatment alternatives … Step 4 used only a single
randomization; 123 patients were randomized to
tranylcypromine or venlafaxine
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effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
January 01, 2013 - Self-controlled designs include case-crossover, case-time-controlled, and self-controlled case series … The limited generalizability of findings from a randomized controlled trial, for example, to older adults … Cohort designs are easy to conceptualize and are readily compared to the randomized controlled trial, … Poor health, such as frailty, is also associated with nonadherence in randomized controlled trials; thus … , those adhering to randomized treatment will appear to have better outcomes, including those adhering
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
December 15, 2010 - or nonrandomized controlled trial) and observational (cohort, case-control, cross-
sectional) comparative … Grey literature will be identified through a search of trial registries (including ClinicalTrials.gov … There is evidence that randomized controlled trials published in some Chinese journals
lacked an adequate … Many non-randomized controlled trials
were published as randomized controlled trials.3
http://www.effectivehealthcare.ahrq.gov … Randomized trials published in some Chinese journals: how many are
randomized?
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effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-evidence-summary.pdf
December 01, 2020 - due to adverse events, nausea, dizziness, and somnolence,
but serious adverse events are uncommon in randomized … Methods
Electronic databases (Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane
Central Register of Controlled … Randomized controlled trials (RCTs) of opioid therapy versus nonopioid
pharmacologic or nonpharmacologic … Neck pain (5 trials): No trial evaluated pharmacologic therapy for acute neck pain.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-249-malnutrition-disposition-comments_0_0.pdf
October 13, 2021 - For inclusion in KQ3 studies were
required to be randomized controlled trials (RCTs)
comparing an intervention … And, while it is possible to control for
KNOWN potential confounding variables in non-
randomized studies … controlled trials. … Peer Reviewer 3 Results While the following papers are not randomized trials,
they do lend additional … In KQ3, we used
randomized controlled trials to understand whether
certain interventions on patients
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_executive.pdf
December 01, 2015 - Literature flow diagram
RCT = randomized controlled trial; SR = systematic review
older adults with … Chinese herbal medicine
for insomnia: a systematic review of randomized controlled trials. … Cognitive behavior
therapy and pharmacotherapy for insomnia: a randomized
controlled trial and direct … Behavioral and
pharmacological therapies for late-life insomnia: a randomized
controlled trial. … controlled trial.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-navigation-model-lung-cancer-rapid.pdf
December 01, 2018 - Primary Studies
We identified two completed studies (one randomized controlled trial [RCT]20 and one … Controlled Trial
12
Protocols and Clinical Trials
Our search identified two ongoing studies … Controlled Trial
Question 3. … controlled trial. … controlled trial.pt.
16 controlled clinical trial.pt.
17 randomized controlled trials as topic/
18
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
October 20, 2011 - to identify systematic reviews, we will search the Cochrane Databases of
Systematic Reviews and Controlled … Controlled Trials, Clinical Trial Results, WHO Trial Registries),
grants databases (NIH RePORTER, … Methodological Risk of Bias of Individual Studies
We will assess the risk of bias of systematic reviews, randomized … Carotid Surgery
Trial Collaborative Group. … Evaluating non-randomized intervention studies. Health Technol Assess 2003;7(27):iii-x, 1-173.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f-surv-rept-1-acute-pain.xlsx
May 29, 2025 - Risk of bias assessment for randomized controlled trials
Author, Year
(Full Citations Are Listed in
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating-disposition-160504.pdf
December 09, 2015 - , Double-Blind, Placebo-Controlled Trial. … , Double-
Blind, Placebo-Controlled Trial. … , Double-Blind,
Placebo-Controlled Trial. … We have added examples of questions included in the
randomized controlled trial and observational study … (2011) “Allegiance Bias and Therapist Effects; Results of a
Randomized Controlled Trial of Binge Eating
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_research-protocol.pdf
October 01, 2013 - We will include
randomized controlled trials and prospective cohort studies for all key questions. … Randomized controlled trials have been recognized as
providing the highest standard of evidence and … Nephrotoxicity of ionic and nonionic
contrast media in 1196 patients: a randomized trial. … Observational studies versus randomized controlled
trials: avenues to causal inference in nephrology … CT=computerized tomography; KQ=Key Question; AKI=acute kidney injury; RCT=randomized controlled trial
-
effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_disposition-comments.pdf
February 29, 2016 - The
Results for TENS are based on
randomized controlled trials,
including trials conducted in the … controlled
trial. … The review was restricted to
randomized controlled trials for
effectiveness. … A randomized controlled
trial of exercise for low back pain. Spine.
2004;29(23):2593-602.) … randomized controlled trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_research-protocol.pdf
April 03, 2014 - The objective of this review is to
identify previous systematic reviews and randomized-controlled trials … Two investigators will independently assess risk of bias for randomized
controlled trials using questionnaires … trial. … controlled trials. … Chinese herbal medicine for insomnia: a
systematic review of randomized
controlled trials.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_protocol-140716.pdf
April 03, 2014 - The objective of this review is to
identify previous systematic reviews and randomized-controlled trials … Two investigators will independently assess risk of bias for randomized
controlled trials using questionnaires … trial. … controlled trials. … systematic review of randomized 30. Pinto Jr LR, Alves RC, Caixeta E, et al.
controlled trials.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_clinician.pdf
March 01, 2016 - LRTI = lower respiratory tract infection; OR = odds ratio;
PCR = polymerase chain reaction; RCT = randomized … controlled trial; RR = relative risk; RTI = respiratory tract infection; SOE = strength of evidence; … AOM = acute otitis media; CI = confidence interval; RCT = randomized controlled trial; RR = relative … = confidence interval; CRP = C-reactive protein; OBS = observational study; OR = odds ratio; RCT = randomized … controlled trial;
RTI = respiratory tract infection; SOE = strength of evidence; URTI = upper respiratory
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/fatty-acids-cardiovascular-disease_research-protocol.pdf
April 02, 2015 - Several recent systematic reviews of randomized controlled trials (RCTs) in
individuals and patients … Randomised controlled trial of
cardioprotective diet in patients with recent acute myocardial infarction … controlled trials/
60. exp Randomized Controlled Trials as Topic/
61. exp random allocation/
62. … [mp=ti, ot, ab, nm, hw, kw, kf, px, rx, ui, an, tx, sh, ct, bt, id, cc]
26. exp randomized controlled … method/
30. exp single-blind method/
31. randomized controlled trial.pt.
32. clinical trial.mp.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
February 01, 2018 - ► Data from clustered randomized trials should be adjusted for the design effect.*
*More information … Where:
N = total trial sample size
Ratio of means
• Ratio of means (RoM) is an alternative to the … Special topics:
Crossover trials
• In a crossover trial all participants receive both the treatment … errors.5
► Generally the correlation is positive, resulting in smaller SEs than in a
standard parallel trial … trial of the same size
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-surveillance_research-protocol.pdf
May 19, 2011 - Randomized controlled trials, nonrandomized comparative studies, and cohort
studies; for adverse events … A comprehensive search of the scientific literature in Medline, the Cochrane Central Register
of Controlled … These systematic reviews, collectively, analyzed a small number of randomized
controlled trials and … controlled trials, the Methods Guide
mainly considers the methods used for randomization, allocation … controlled
trials (e.g., that A vs.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
December 16, 2011 - Inclusion Criteria for RCTs:
Randomized controlled trials (parallel-group as well as crossover) of … Controlled Trials as Topic/ (76575)
4 randomized controlled trial/ (316968)
5 random allocation … , phase i.pt. (11643)
9 clinical trial, phase ii.pt. (18390)
10 clinical trial, phase iii.pt … . (6549)
11 clinical trial, phase iv.pt. (642)
12 controlled clinical trial.pt. (83518) … 13 randomized controlled trial.pt. (316968)
14 multicenter study.pt. (136622)
15 clinical
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effectivehealthcare.ahrq.gov/sites/default/files/technical-brief-34-health-worker-certification-summary.pdf
March 01, 2020 - , benefits, and implications
• Opportunities for additional research include:
Conducting pragmatic randomized … controlled trials to test the types and components of certification processes
and the impact of CHW … Community health worker home visits for adults with uncontrolled asthma: the HomeBASE Trial
randomized … clinical trial.